LOCUS       NM_001370290            5633 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 31, mRNA.
ACCESSION   NM_001370290 XM_017021829
VERSION     NM_001370290.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5633)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5633)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5633)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5633)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5633)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5633)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5633)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5633)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5633)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5633)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_017021829.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2162568,
                              SAMEA2467143 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-1519           AC004828.2         149884-149933       c
            1520-5633           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5633
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1499
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 20 is encoded by transcript variant 31;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 20"
                     /protein_id="NP_001357219.1"
                     /db_xref="CCDS:CCDS91897.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKKVSKVVELP"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1519
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..5633
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3032..3037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3051
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5605..5610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5633
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaaga aagtgagcaa ggtcgtagaa cttccctaga
     1501 aaagttcact cgcagtgtgg gaaagtcgct ggcgggcaag cgcctcacgg gcctgatgca
     1561 gtcctcctga ccgttcctac cgcaggtcca gggcctgggc ccgcggaccc cacaggcagg
     1621 cggcggcgct ccacatctgc ggacagagtt tccttacgag gagacttggt cactgtgaag
     1681 gagaaagagt gagggcaatg aagggcgatg gtggggagac tcggtgggtg aatggggaga
     1741 ccagaaagaa agagtccaca gagcctgggc tgggcccggt ggaggctcct gtttacagcc
     1801 ctctcttctt tgtacagttg tattccaaca ctccactcgc taagaggccc tgatcccagc
     1861 tcattcaggg gagaacacgt cgtggggttc ctgtcacgac tatcacttga gattatatta
     1921 ttatcctcac tccctcgctg tctggagacg gtcacacctt ctggcaaatt caagaggcat
     1981 gagtggaccg agagcacatc cagcatttgc atcacctccc tggcacctcc catagttaca
     2041 gccactacat ccccaccgcc gcctgtcatc cctcacgtct ctgtggccac ccgggtgtca
     2101 ctgccagcac caggcactgc tttcacgtaa aatgtccaaa tcacatcttc agcaagaaag
     2161 caacctcacg gattgccccg cctcaaggtc tttccaccct ctttgagatc agcgttcgga
     2221 gaggtccccg ccagcccggt ggctgccctc aggtcccgtc acatgtctca agggtccagc
     2281 gttcgaggaa gcactgttgt agatgacaga gctttttgtt tcacagctgc ggggattctg
     2341 ctgaccatct tttagaaaat tatttcataa tttattctgg ctttgccccc ttgctccttg
     2401 gtttattccc tcatgtttta ctcaaaataa acatggccat gaactcaggg gccattggga
     2461 ttctcccctc tggcagcccc aggtgggagc tgggagggtc cccagcccag gaggtggctg
     2521 gattgcaggg ctggcagccc ccacgtggtg gcatcctgac aggcacagtg agacccttgc
     2581 tgggtcaggt ctcctttgtg tgtgaagctg gggcagagta tgctacgaag ggaccaggcc
     2641 aggccacagg gctctcctcc cagtctttat ctgaaggccc agccaaagca cccctctaaa
     2701 ccggtcacct aggggaaatg caaaaacctg caaaagatcc acctgtattc cctgtgtgtg
     2761 tgtgtcaaaa tgaccatttg ccaacctggc tgtgaggtaa tgtatgtaaa gcaccgagtc
     2821 aggtgcctga tacgcagtag gtgcttagca aacggtagct aatactatca tcattgtcat
     2881 tgttattgtg acacccatga gcccacagac agagctgtat taagtaacct gttttgaatc
     2941 cagacattca ctcccccact tgctatgact accctccttt gatctatttt tggtcatagg
     3001 taaaaaaaaa aatctctctt gggagcatat aaacaaaaaa catagaagca ataaagcgat
     3061 cgctggtatt tcttttctca tgcagccaaa ttcgccagct ggtgaccaaa ggctcagatg
     3121 cttgcttatt tgcagacccg gcctcctggg tgctccccag tgacccatct ttccacccca
     3181 ccacctccaa gtcctgtcta tgtctgcttc cacacagccc tgtccccagg gcaccagcct
     3241 tctgtccctc acagcagtgc catcgcgggc attaggagtc ttcgttatgt tgtatccttg
     3301 tgagttcttg actaccatgc ccaagtttcc cccactggca atggttcctc tcttggaggt
     3361 acagtggaaa ccagagagat gacagatgtt gagtcctcag tgtctcagag gcagcaattc
     3421 ttgctggaca cctgcacatg ctcagcacag aggctggtac tttggaggca ctaaccactt
     3481 gatgagtaaa tcaatggcat aaagccccat tccaagttat ggggtctttt gacaggcccc
     3541 tttcatcctc tttctctttg tataaacctc atgtttcaga acaaaattac agtctaagtt
     3601 catttgcccc cagccttgcc caaggatccc cgggctgtgc tgacccctag gcatagggca
     3661 aagggtgttc ccaagcagca ggcacctcag tgccctcagt tatccagggc aaggggcctg
     3721 gctgccccct gctcctcccc atgatgcagg ggctttctaa gccaggctgc agacagggca
     3781 gggttggctt cttggccatt ccctctgtgc ccccttctcc ttctgactgg tctcaccctg
     3841 gagatcccca gaggatctga ccagagccag gtggactgtg gccctgagat ggagctggct
     3901 gcaggcttac aagcacctct ggggacatcc agaggggagg gtcagtaagc acaacggagc
     3961 tagggagact tcagatggac tcaaacccag agcaataata ctctcacacc accccacagc
     4021 taaggcactc atgttcccca gtagatcaag ccagaagctt tgcaagaagg gagtggaacg
     4081 aggctgccta tccaaggtcc atctaccacg cagaacttgg tcatgcaagt acatttggaa
     4141 aatctggtct tggcccgtcc cccattggcc tggtctacac agccaaaaat tcagactaga
     4201 ttagatgttt gcaggcaatt ctgtagcaaa gcaaattccc ctaccccgtc ccttccccct
     4261 agaagctgcc ttagcctccc tgactgggtg tggtctctgg gcctaggact cctccctatg
     4321 aggaaaagtg ctctccagcc acatcttggc agccccacaa ccacagcatc agggcagctg
     4381 cagcaagtga ccacccaccc gtcgggttag acacacaagg caccaggcac tggcatctga
     4441 ctaaaataac ctttccctac atgggaagag gaaagcttgt aggctggcac atataaacgt
     4501 ccagccgcag ccagatggcc tgaactaagc agcaggaact ctctgggctg gggaggagcc
     4561 tcctgccctt ctagaaagtg atgcgtcagc tttgttctcc tgggaaggtg ttgctatacc
     4621 ccaggaacaa agcagggccc aactgccagt gcagtcagct gggcctgcgc tccaggctca
     4681 ccaccgctaa gtggtcaggt accgggccag catcctggga gggacctctt gcgactctga
     4741 gttgcagctt ggactagctg aacacatggg gacatgctcc aggggcttct tccctggcag
     4801 gattcctggg atttcaaact acctcaccaa caggacgctg aaccaggagc ctgccaccca
     4861 actggccccc ttggtgattg tggaaggtga tgtttttcct aaaatgcatc cctcctgttc
     4921 tgctccatat acatgtgctt caaaaaccac caccaggaaa gccttcccag aagagggaaa
     4981 ggattaaggg ctctcttcct ttgggccctg cagaatgtat tggagggagg tgttgctgca
     5041 aggtccagga gctgggaaac tctgggctcg gggggagata atgcaccacc agcctcaaaa
     5101 aggagctgcc caagttgaat atgtagcaaa gaccatggga taagttgaat agtggccaga
     5161 cgaatcacta ataactcacc atgggaccct ctgaagagag gcctgtgctc gtgtaaccat
     5221 agcaacagca gatgccagca acctactcat tagtaccacc cagtgataag gcatcccctg
     5281 ggctagaccc aggggccata aagtagcaaa gtagcaaatg tagcaataaa gggcccgggt
     5341 ctatacgggg acagggtcca aatgaccagg acttggccct ctccccagcc ccgatgaggg
     5401 ctcagagcca gctgctgtca gctgtctggg gagggaaggc cctgctccat accaggggtc
     5461 cctgttctat actctaagcc cactcaccgc atgatcacgg actcatcgga atggcctcct
     5521 cttagtgcat gtggttctct ttagtttatt tttctggaat ttggggattg gaccccagaa
     5581 ccaaacatgc tggtacagtc taaaaataaa tgacttgaac ccacttcaat cca
//
