LOCUS       NM_001370289            5565 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 30, mRNA.
ACCESSION   NM_001370289 XM_024449773
VERSION     NM_001370289.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5565)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5565)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5565)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5565)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5565)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5565)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5565)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5565)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5565)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5565)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449773.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF156932.1, AF107620.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2142680, SAMEA2153980 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC005993.2         14210-14272         c
            64-167              AC005477.1         87628-87731         c
            168-267             AC005157.1         72588-72687         c
            268-318             AC005533.2         52351-52401         c
            319-425             AC005533.2         48552-48658         c
            426-477             AC005533.2         47246-47297         c
            478-542             AC005533.2         41107-41171         c
            543-619             AC005533.2         36846-36922         c
            620-701             AC005533.2         33976-34057         c
            702-776             AC005533.2         32230-32304         c
            777-875             AC005533.2         30089-30187         c
            876-937             AC005533.2         28600-28661         c
            938-1048            AC005533.2         11667-11777         c
            1049-1174           AC004828.2         179699-179824       c
            1175-1361           AC004828.2         171441-171627       c
            1362-1451           AC004828.2         153703-153792       c
            1452-5565           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5565
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..63
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            64..167
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1502
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 2 is encoded by transcript variant 30;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 2"
                     /protein_id="NP_001357218.1"
                     /db_xref="CCDS:CCDS9808.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKGKSLAGKRLTGLMQSS"
     exon            168..267
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            268..318
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            319..425
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            426..477
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            478..542
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            543..619
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            620..701
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            702..776
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            777..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..937
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1048
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1174
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1361
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1451
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..5565
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2964..2969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2983
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5537..5542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5565
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 atttctaggt tttctcctcc tcgagcaaat cacggtctgc gccttccgcg gctctgggaa
       61 cagtgtgagt gaagacactc aggatggctc aaggatccgg ggatcaaaga gcagtggggg
      121 ttgctgaccc agaggagagt tctccaaaca tgatcgttta ctgcaaaatt gaagacatca
      181 ttacaaagat gcaagatgac aagacagggg gtgtgcccat cagaacagtc aagagctttc
      241 tctccaaaat ccccagtgtc gtcacaggta ctgacattgt gcagtggctt atgaagaacc
      301 tttccattga ggacccagtt gaagcaatac acttggggag ccttatcgct gcccagggct
      361 acatctttcc aatctcagac catgttctca ccatgaagga tgatggcacc ttttatcgtt
      421 tccaggctcc gtacttctgg ccttcgaact gctgggaacc tgaaaacact gactatgcca
      481 tctatctctg taagaggaca atgcaaaata aagcaaggct ggaactggca gattatgaag
      541 cagaaaactt agcaagactc cagagggcct ttgcgaggaa gtgggaattc atctttatgc
      601 aagcagaagc acaagtaaag attgaccgga aaaaagacaa gacagaaagg aaaattttgg
      661 atagtcaaga acgagccttt tgggatgtcc acaggcctgt gccaggctgt gtgaacacaa
      721 cagaaatgga tatccgaaaa tgtcgacgtt tgaagaatcc acaaaaggtt aaaaagtccg
      781 tgtatggcgt gactgaagag tcccaggcac agagcccggt gcatgtactc agccaaccaa
      841 tcaggaaaac aacaaaagag gacatccgga aacagataac atttttgaac gcacagatcg
      901 acagacattg tttgaaaatg tccaaagtgg ctgaaagttt aattgcctac acggaacaat
      961 atgtggaata tgaccctttg ataacaccag ctgagccatc caacccttgg atcagcgatg
     1021 acgttgcttt gtgggacata gagatgagca aagagcccag ccaacagcga gtaaaaagat
     1081 ggggcttctc tttcgatgag atattgaagg accaggtggg gcgggaccag tttctacgat
     1141 tcctggagtc cgaattcagt tcagaaaacc tcaggttctg gctggctgtc caagatctta
     1201 agaaacaacc cctacaggat gtggccaaga gggtagaaga aatctggcaa gagtttctgg
     1261 ctccaggggc tccaagtgca atcaacctgg attctcacag ctatgagata accagtcaaa
     1321 atgtcaaaga tggagggaga tatacatttg aagacgccca ggagcacatc tacaagctga
     1381 tgaagagtga cagctatgcc cgcttcctcc ggtcaaatgc ttaccaggat ttgctgctgg
     1441 ccaagaagaa gggaaagtcg ctggcgggca agcgcctcac gggcctgatg cagtcctcct
     1501 gaccgttcct accgcaggtc cagggcctgg gcccgcggac cccacaggca ggcggcggcg
     1561 ctccacatct gcggacagag tttccttacg aggagacttg gtcactgtga aggagaaaga
     1621 gtgagggcaa tgaagggcga tggtggggag actcggtggg tgaatgggga gaccagaaag
     1681 aaagagtcca cagagcctgg gctgggcccg gtggaggctc ctgtttacag ccctctcttc
     1741 tttgtacagt tgtattccaa cactccactc gctaagaggc cctgatccca gctcattcag
     1801 gggagaacac gtcgtggggt tcctgtcacg actatcactt gagattatat tattatcctc
     1861 actccctcgc tgtctggaga cggtcacacc ttctggcaaa ttcaagaggc atgagtggac
     1921 cgagagcaca tccagcattt gcatcacctc cctggcacct cccatagtta cagccactac
     1981 atccccaccg ccgcctgtca tccctcacgt ctctgtggcc acccgggtgt cactgccagc
     2041 accaggcact gctttcacgt aaaatgtcca aatcacatct tcagcaagaa agcaacctca
     2101 cggattgccc cgcctcaagg tctttccacc ctctttgaga tcagcgttcg gagaggtccc
     2161 cgccagcccg gtggctgccc tcaggtcccg tcacatgtct caagggtcca gcgttcgagg
     2221 aagcactgtt gtagatgaca gagctttttg tttcacagct gcggggattc tgctgaccat
     2281 cttttagaaa attatttcat aatttattct ggctttgccc ccttgctcct tggtttattc
     2341 cctcatgttt tactcaaaat aaacatggcc atgaactcag gggccattgg gattctcccc
     2401 tctggcagcc ccaggtggga gctgggaggg tccccagccc aggaggtggc tggattgcag
     2461 ggctggcagc ccccacgtgg tggcatcctg acaggcacag tgagaccctt gctgggtcag
     2521 gtctcctttg tgtgtgaagc tggggcagag tatgctacga agggaccagg ccaggccaca
     2581 gggctctcct cccagtcttt atctgaaggc ccagccaaag cacccctcta aaccggtcac
     2641 ctaggggaaa tgcaaaaacc tgcaaaagat ccacctgtat tccctgtgtg tgtgtgtcaa
     2701 aatgaccatt tgccaacctg gctgtgaggt aatgtatgta aagcaccgag tcaggtgcct
     2761 gatacgcagt aggtgcttag caaacggtag ctaatactat catcattgtc attgttattg
     2821 tgacacccat gagcccacag acagagctgt attaagtaac ctgttttgaa tccagacatt
     2881 cactccccca cttgctatga ctaccctcct ttgatctatt tttggtcata ggtaaaaaaa
     2941 aaaatctctc ttgggagcat ataaacaaaa aacatagaag caataaagcg atcgctggta
     3001 tttcttttct catgcagcca aattcgccag ctggtgacca aaggctcaga tgcttgctta
     3061 tttgcagacc cggcctcctg ggtgctcccc agtgacccat ctttccaccc caccacctcc
     3121 aagtcctgtc tatgtctgct tccacacagc cctgtcccca gggcaccagc cttctgtccc
     3181 tcacagcagt gccatcgcgg gcattaggag tcttcgttat gttgtatcct tgtgagttct
     3241 tgactaccat gcccaagttt cccccactgg caatggttcc tctcttggag gtacagtgga
     3301 aaccagagag atgacagatg ttgagtcctc agtgtctcag aggcagcaat tcttgctgga
     3361 cacctgcaca tgctcagcac agaggctggt actttggagg cactaaccac ttgatgagta
     3421 aatcaatggc ataaagcccc attccaagtt atggggtctt ttgacaggcc cctttcatcc
     3481 tctttctctt tgtataaacc tcatgtttca gaacaaaatt acagtctaag ttcatttgcc
     3541 cccagccttg cccaaggatc cccgggctgt gctgacccct aggcataggg caaagggtgt
     3601 tcccaagcag caggcacctc agtgccctca gttatccagg gcaaggggcc tggctgcccc
     3661 ctgctcctcc ccatgatgca ggggctttct aagccaggct gcagacaggg cagggttggc
     3721 ttcttggcca ttccctctgt gcccccttct ccttctgact ggtctcaccc tggagatccc
     3781 cagaggatct gaccagagcc aggtggactg tggccctgag atggagctgg ctgcaggctt
     3841 acaagcacct ctggggacat ccagagggga gggtcagtaa gcacaacgga gctagggaga
     3901 cttcagatgg actcaaaccc agagcaataa tactctcaca ccaccccaca gctaaggcac
     3961 tcatgttccc cagtagatca agccagaagc tttgcaagaa gggagtggaa cgaggctgcc
     4021 tatccaaggt ccatctacca cgcagaactt ggtcatgcaa gtacatttgg aaaatctggt
     4081 cttggcccgt cccccattgg cctggtctac acagccaaaa attcagacta gattagatgt
     4141 ttgcaggcaa ttctgtagca aagcaaattc ccctaccccg tcccttcccc ctagaagctg
     4201 ccttagcctc cctgactggg tgtggtctct gggcctagga ctcctcccta tgaggaaaag
     4261 tgctctccag ccacatcttg gcagccccac aaccacagca tcagggcagc tgcagcaagt
     4321 gaccacccac ccgtcgggtt agacacacaa ggcaccaggc actggcatct gactaaaata
     4381 acctttccct acatgggaag aggaaagctt gtaggctggc acatataaac gtccagccgc
     4441 agccagatgg cctgaactaa gcagcaggaa ctctctgggc tggggaggag cctcctgccc
     4501 ttctagaaag tgatgcgtca gctttgttct cctgggaagg tgttgctata ccccaggaac
     4561 aaagcagggc ccaactgcca gtgcagtcag ctgggcctgc gctccaggct caccaccgct
     4621 aagtggtcag gtaccgggcc agcatcctgg gagggacctc ttgcgactct gagttgcagc
     4681 ttggactagc tgaacacatg gggacatgct ccaggggctt cttccctggc aggattcctg
     4741 ggatttcaaa ctacctcacc aacaggacgc tgaaccagga gcctgccacc caactggccc
     4801 ccttggtgat tgtggaaggt gatgtttttc ctaaaatgca tccctcctgt tctgctccat
     4861 atacatgtgc ttcaaaaacc accaccagga aagccttccc agaagaggga aaggattaag
     4921 ggctctcttc ctttgggccc tgcagaatgt attggaggga ggtgttgctg caaggtccag
     4981 gagctgggaa actctgggct cggggggaga taatgcacca ccagcctcaa aaaggagctg
     5041 cccaagttga atatgtagca aagaccatgg gataagttga atagtggcca gacgaatcac
     5101 taataactca ccatgggacc ctctgaagag aggcctgtgc tcgtgtaacc atagcaacag
     5161 cagatgccag caacctactc attagtacca cccagtgata aggcatcccc tgggctagac
     5221 ccaggggcca taaagtagca aagtagcaaa tgtagcaata aagggcccgg gtctatacgg
     5281 ggacagggtc caaatgacca ggacttggcc ctctccccag ccccgatgag ggctcagagc
     5341 cagctgctgt cagctgtctg gggagggaag gccctgctcc ataccagggg tccctgttct
     5401 atactctaag cccactcacc gcatgatcac ggactcatcg gaatggcctc ctcttagtgc
     5461 atgtggttct ctttagttta tttttctgga atttggggat tggaccccag aaccaaacat
     5521 gctggtacag tctaaaaata aatgacttga acccacttca atcca
//
