LOCUS       NM_001370288            5736 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 29, mRNA.
ACCESSION   NM_001370288 XM_024449772
VERSION     NM_001370288.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5736)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5736)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5736)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5736)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5736)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5736)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5736)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5736)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5736)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5736)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449772.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.9276.1,
                                           SRR1803614.182571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC005993.2         12683-12916         c
            235-338             AC005477.1         87628-87731         c
            339-438             AC005157.1         72588-72687         c
            439-489             AC005533.2         52351-52401         c
            490-596             AC005533.2         48552-48658         c
            597-648             AC005533.2         47246-47297         c
            649-713             AC005533.2         41107-41171         c
            714-790             AC005533.2         36846-36922         c
            791-872             AC005533.2         33976-34057         c
            873-947             AC005533.2         32230-32304         c
            948-1046            AC005533.2         30089-30187         c
            1047-1108           AC005533.2         28600-28661         c
            1109-1219           AC005533.2         11667-11777         c
            1220-1345           AC004828.2         179699-179824       c
            1346-1532           AC004828.2         171441-171627       c
            1533-1622           AC004828.2         153703-153792       c
            1623-5736           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5736
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..234
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            235..338
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1673
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 2 is encoded by transcript variant 29;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 2"
                     /protein_id="NP_001357217.1"
                     /db_xref="CCDS:CCDS9808.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKGKSLAGKRLTGLMQSS"
     exon            339..438
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            439..489
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            490..596
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            597..648
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            649..713
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            714..790
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            791..872
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            873..947
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1046
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1108
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1219
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1345
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1532
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1622
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..5736
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3135..3140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3154
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5708..5713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5736
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttacag tcaccagcag gctgcgtaaa gaagtggccc agtgagacag ggaaagtgac
       61 ccagaaaatt tagttttgtt cagaatgaaa gctgctgtat ttcatttttg tttcttaatt
      121 tgacggagta ggaacgttat tttccttctc tgtcattgag accagtagca tttctatgtt
      181 acaaactgaa gatatttggg gtctcgtcgg cttgggatta tcaatgcttg ggagtgtgag
      241 tgaagacact caggatggct caaggatccg gggatcaaag agcagtgggg gttgctgacc
      301 cagaggagag ttctccaaac atgatcgttt actgcaaaat tgaagacatc attacaaaga
      361 tgcaagatga caagacaggg ggtgtgccca tcagaacagt caagagcttt ctctccaaaa
      421 tccccagtgt cgtcacaggt actgacattg tgcagtggct tatgaagaac ctttccattg
      481 aggacccagt tgaagcaata cacttgggga gccttatcgc tgcccagggc tacatctttc
      541 caatctcaga ccatgttctc accatgaagg atgatggcac cttttatcgt ttccaggctc
      601 cgtacttctg gccttcgaac tgctgggaac ctgaaaacac tgactatgcc atctatctct
      661 gtaagaggac aatgcaaaat aaagcaaggc tggaactggc agattatgaa gcagaaaact
      721 tagcaagact ccagagggcc tttgcgagga agtgggaatt catctttatg caagcagaag
      781 cacaagtaaa gattgaccgg aaaaaagaca agacagaaag gaaaattttg gatagtcaag
      841 aacgagcctt ttgggatgtc cacaggcctg tgccaggctg tgtgaacaca acagaaatgg
      901 atatccgaaa atgtcgacgt ttgaagaatc cacaaaaggt taaaaagtcc gtgtatggcg
      961 tgactgaaga gtcccaggca cagagcccgg tgcatgtact cagccaacca atcaggaaaa
     1021 caacaaaaga ggacatccgg aaacagataa catttttgaa cgcacagatc gacagacatt
     1081 gtttgaaaat gtccaaagtg gctgaaagtt taattgccta cacggaacaa tatgtggaat
     1141 atgacccttt gataacacca gctgagccat ccaacccttg gatcagcgat gacgttgctt
     1201 tgtgggacat agagatgagc aaagagccca gccaacagcg agtaaaaaga tggggcttct
     1261 ctttcgatga gatattgaag gaccaggtgg ggcgggacca gtttctacga ttcctggagt
     1321 ccgaattcag ttcagaaaac ctcaggttct ggctggctgt ccaagatctt aagaaacaac
     1381 ccctacagga tgtggccaag agggtagaag aaatctggca agagtttctg gctccagggg
     1441 ctccaagtgc aatcaacctg gattctcaca gctatgagat aaccagtcaa aatgtcaaag
     1501 atggagggag atatacattt gaagacgccc aggagcacat ctacaagctg atgaagagtg
     1561 acagctatgc ccgcttcctc cggtcaaatg cttaccagga tttgctgctg gccaagaaga
     1621 agggaaagtc gctggcgggc aagcgcctca cgggcctgat gcagtcctcc tgaccgttcc
     1681 taccgcaggt ccagggcctg ggcccgcgga ccccacaggc aggcggcggc gctccacatc
     1741 tgcggacaga gtttccttac gaggagactt ggtcactgtg aaggagaaag agtgagggca
     1801 atgaagggcg atggtgggga gactcggtgg gtgaatgggg agaccagaaa gaaagagtcc
     1861 acagagcctg ggctgggccc ggtggaggct cctgtttaca gccctctctt ctttgtacag
     1921 ttgtattcca acactccact cgctaagagg ccctgatccc agctcattca ggggagaaca
     1981 cgtcgtgggg ttcctgtcac gactatcact tgagattata ttattatcct cactccctcg
     2041 ctgtctggag acggtcacac cttctggcaa attcaagagg catgagtgga ccgagagcac
     2101 atccagcatt tgcatcacct ccctggcacc tcccatagtt acagccacta catccccacc
     2161 gccgcctgtc atccctcacg tctctgtggc cacccgggtg tcactgccag caccaggcac
     2221 tgctttcacg taaaatgtcc aaatcacatc ttcagcaaga aagcaacctc acggattgcc
     2281 ccgcctcaag gtctttccac cctctttgag atcagcgttc ggagaggtcc ccgccagccc
     2341 ggtggctgcc ctcaggtccc gtcacatgtc tcaagggtcc agcgttcgag gaagcactgt
     2401 tgtagatgac agagcttttt gtttcacagc tgcggggatt ctgctgacca tcttttagaa
     2461 aattatttca taatttattc tggctttgcc cccttgctcc ttggtttatt ccctcatgtt
     2521 ttactcaaaa taaacatggc catgaactca ggggccattg ggattctccc ctctggcagc
     2581 cccaggtggg agctgggagg gtccccagcc caggaggtgg ctggattgca gggctggcag
     2641 cccccacgtg gtggcatcct gacaggcaca gtgagaccct tgctgggtca ggtctccttt
     2701 gtgtgtgaag ctggggcaga gtatgctacg aagggaccag gccaggccac agggctctcc
     2761 tcccagtctt tatctgaagg cccagccaaa gcacccctct aaaccggtca cctaggggaa
     2821 atgcaaaaac ctgcaaaaga tccacctgta ttccctgtgt gtgtgtgtca aaatgaccat
     2881 ttgccaacct ggctgtgagg taatgtatgt aaagcaccga gtcaggtgcc tgatacgcag
     2941 taggtgctta gcaaacggta gctaatacta tcatcattgt cattgttatt gtgacaccca
     3001 tgagcccaca gacagagctg tattaagtaa cctgttttga atccagacat tcactccccc
     3061 acttgctatg actaccctcc tttgatctat ttttggtcat aggtaaaaaa aaaaatctct
     3121 cttgggagca tataaacaaa aaacatagaa gcaataaagc gatcgctggt atttcttttc
     3181 tcatgcagcc aaattcgcca gctggtgacc aaaggctcag atgcttgctt atttgcagac
     3241 ccggcctcct gggtgctccc cagtgaccca tctttccacc ccaccacctc caagtcctgt
     3301 ctatgtctgc ttccacacag ccctgtcccc agggcaccag ccttctgtcc ctcacagcag
     3361 tgccatcgcg ggcattagga gtcttcgtta tgttgtatcc ttgtgagttc ttgactacca
     3421 tgcccaagtt tcccccactg gcaatggttc ctctcttgga ggtacagtgg aaaccagaga
     3481 gatgacagat gttgagtcct cagtgtctca gaggcagcaa ttcttgctgg acacctgcac
     3541 atgctcagca cagaggctgg tactttggag gcactaacca cttgatgagt aaatcaatgg
     3601 cataaagccc cattccaagt tatggggtct tttgacaggc ccctttcatc ctctttctct
     3661 ttgtataaac ctcatgtttc agaacaaaat tacagtctaa gttcatttgc ccccagcctt
     3721 gcccaaggat ccccgggctg tgctgacccc taggcatagg gcaaagggtg ttcccaagca
     3781 gcaggcacct cagtgccctc agttatccag ggcaaggggc ctggctgccc cctgctcctc
     3841 cccatgatgc aggggctttc taagccaggc tgcagacagg gcagggttgg cttcttggcc
     3901 attccctctg tgcccccttc tccttctgac tggtctcacc ctggagatcc ccagaggatc
     3961 tgaccagagc caggtggact gtggccctga gatggagctg gctgcaggct tacaagcacc
     4021 tctggggaca tccagagggg agggtcagta agcacaacgg agctagggag acttcagatg
     4081 gactcaaacc cagagcaata atactctcac accaccccac agctaaggca ctcatgttcc
     4141 ccagtagatc aagccagaag ctttgcaaga agggagtgga acgaggctgc ctatccaagg
     4201 tccatctacc acgcagaact tggtcatgca agtacatttg gaaaatctgg tcttggcccg
     4261 tcccccattg gcctggtcta cacagccaaa aattcagact agattagatg tttgcaggca
     4321 attctgtagc aaagcaaatt cccctacccc gtcccttccc cctagaagct gccttagcct
     4381 ccctgactgg gtgtggtctc tgggcctagg actcctccct atgaggaaaa gtgctctcca
     4441 gccacatctt ggcagcccca caaccacagc atcagggcag ctgcagcaag tgaccaccca
     4501 cccgtcgggt tagacacaca aggcaccagg cactggcatc tgactaaaat aacctttccc
     4561 tacatgggaa gaggaaagct tgtaggctgg cacatataaa cgtccagccg cagccagatg
     4621 gcctgaacta agcagcagga actctctggg ctggggagga gcctcctgcc cttctagaaa
     4681 gtgatgcgtc agctttgttc tcctgggaag gtgttgctat accccaggaa caaagcaggg
     4741 cccaactgcc agtgcagtca gctgggcctg cgctccaggc tcaccaccgc taagtggtca
     4801 ggtaccgggc cagcatcctg ggagggacct cttgcgactc tgagttgcag cttggactag
     4861 ctgaacacat ggggacatgc tccaggggct tcttccctgg caggattcct gggatttcaa
     4921 actacctcac caacaggacg ctgaaccagg agcctgccac ccaactggcc cccttggtga
     4981 ttgtggaagg tgatgttttt cctaaaatgc atccctcctg ttctgctcca tatacatgtg
     5041 cttcaaaaac caccaccagg aaagccttcc cagaagaggg aaaggattaa gggctctctt
     5101 cctttgggcc ctgcagaatg tattggaggg aggtgttgct gcaaggtcca ggagctggga
     5161 aactctgggc tcggggggag ataatgcacc accagcctca aaaaggagct gcccaagttg
     5221 aatatgtagc aaagaccatg ggataagttg aatagtggcc agacgaatca ctaataactc
     5281 accatgggac cctctgaaga gaggcctgtg ctcgtgtaac catagcaaca gcagatgcca
     5341 gcaacctact cattagtacc acccagtgat aaggcatccc ctgggctaga cccaggggcc
     5401 ataaagtagc aaagtagcaa atgtagcaat aaagggcccg ggtctatacg gggacagggt
     5461 ccaaatgacc aggacttggc cctctcccca gccccgatga gggctcagag ccagctgctg
     5521 tcagctgtct ggggagggaa ggccctgctc cataccaggg gtccctgttc tatactctaa
     5581 gcccactcac cgcatgatca cggactcatc ggaatggcct cctcttagtg catgtggttc
     5641 tctttagttt atttttctgg aatttgggga ttggacccca gaaccaaaca tgctggtaca
     5701 gtctaaaaat aaatgacttg aacccacttc aatcca
//
