LOCUS       NM_001370287            6015 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 28, mRNA.
ACCESSION   NM_001370287 XM_024449771
VERSION     NM_001370287.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6015)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6015)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6015)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6015)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6015)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 6015)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 6015)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 6015)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 6015)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 6015)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449771.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.274175.1,
                                           SRR1803613.207447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1325           AC005533.2         30089-30187         c
            1326-1387           AC005533.2         28600-28661         c
            1388-1498           AC005533.2         11667-11777         c
            1499-1624           AC004828.2         179699-179824       c
            1625-1811           AC004828.2         171441-171627       c
            1812-1901           AC004828.2         153703-153792       c
            1902-6015           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..6015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6015
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..1952
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 2 is encoded by transcript variant 28;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 2"
                     /protein_id="NP_001357216.1"
                     /db_xref="CCDS:CCDS9808.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKGKSLAGKRLTGLMQSS"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1498
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1624
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1811
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1901
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..6015
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3414..3419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3433
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5987..5992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      6015
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaagttt aattgcctac acggaacaat atgtggaata tgaccctttg ataacaccag
     1441 ctgagccatc caacccttgg atcagcgatg acgttgcttt gtgggacata gagatgagca
     1501 aagagcccag ccaacagcga gtaaaaagat ggggcttctc tttcgatgag atattgaagg
     1561 accaggtggg gcgggaccag tttctacgat tcctggagtc cgaattcagt tcagaaaacc
     1621 tcaggttctg gctggctgtc caagatctta agaaacaacc cctacaggat gtggccaaga
     1681 gggtagaaga aatctggcaa gagtttctgg ctccaggggc tccaagtgca atcaacctgg
     1741 attctcacag ctatgagata accagtcaaa atgtcaaaga tggagggaga tatacatttg
     1801 aagacgccca ggagcacatc tacaagctga tgaagagtga cagctatgcc cgcttcctcc
     1861 ggtcaaatgc ttaccaggat ttgctgctgg ccaagaagaa gggaaagtcg ctggcgggca
     1921 agcgcctcac gggcctgatg cagtcctcct gaccgttcct accgcaggtc cagggcctgg
     1981 gcccgcggac cccacaggca ggcggcggcg ctccacatct gcggacagag tttccttacg
     2041 aggagacttg gtcactgtga aggagaaaga gtgagggcaa tgaagggcga tggtggggag
     2101 actcggtggg tgaatgggga gaccagaaag aaagagtcca cagagcctgg gctgggcccg
     2161 gtggaggctc ctgtttacag ccctctcttc tttgtacagt tgtattccaa cactccactc
     2221 gctaagaggc cctgatccca gctcattcag gggagaacac gtcgtggggt tcctgtcacg
     2281 actatcactt gagattatat tattatcctc actccctcgc tgtctggaga cggtcacacc
     2341 ttctggcaaa ttcaagaggc atgagtggac cgagagcaca tccagcattt gcatcacctc
     2401 cctggcacct cccatagtta cagccactac atccccaccg ccgcctgtca tccctcacgt
     2461 ctctgtggcc acccgggtgt cactgccagc accaggcact gctttcacgt aaaatgtcca
     2521 aatcacatct tcagcaagaa agcaacctca cggattgccc cgcctcaagg tctttccacc
     2581 ctctttgaga tcagcgttcg gagaggtccc cgccagcccg gtggctgccc tcaggtcccg
     2641 tcacatgtct caagggtcca gcgttcgagg aagcactgtt gtagatgaca gagctttttg
     2701 tttcacagct gcggggattc tgctgaccat cttttagaaa attatttcat aatttattct
     2761 ggctttgccc ccttgctcct tggtttattc cctcatgttt tactcaaaat aaacatggcc
     2821 atgaactcag gggccattgg gattctcccc tctggcagcc ccaggtggga gctgggaggg
     2881 tccccagccc aggaggtggc tggattgcag ggctggcagc ccccacgtgg tggcatcctg
     2941 acaggcacag tgagaccctt gctgggtcag gtctcctttg tgtgtgaagc tggggcagag
     3001 tatgctacga agggaccagg ccaggccaca gggctctcct cccagtcttt atctgaaggc
     3061 ccagccaaag cacccctcta aaccggtcac ctaggggaaa tgcaaaaacc tgcaaaagat
     3121 ccacctgtat tccctgtgtg tgtgtgtcaa aatgaccatt tgccaacctg gctgtgaggt
     3181 aatgtatgta aagcaccgag tcaggtgcct gatacgcagt aggtgcttag caaacggtag
     3241 ctaatactat catcattgtc attgttattg tgacacccat gagcccacag acagagctgt
     3301 attaagtaac ctgttttgaa tccagacatt cactccccca cttgctatga ctaccctcct
     3361 ttgatctatt tttggtcata ggtaaaaaaa aaaatctctc ttgggagcat ataaacaaaa
     3421 aacatagaag caataaagcg atcgctggta tttcttttct catgcagcca aattcgccag
     3481 ctggtgacca aaggctcaga tgcttgctta tttgcagacc cggcctcctg ggtgctcccc
     3541 agtgacccat ctttccaccc caccacctcc aagtcctgtc tatgtctgct tccacacagc
     3601 cctgtcccca gggcaccagc cttctgtccc tcacagcagt gccatcgcgg gcattaggag
     3661 tcttcgttat gttgtatcct tgtgagttct tgactaccat gcccaagttt cccccactgg
     3721 caatggttcc tctcttggag gtacagtgga aaccagagag atgacagatg ttgagtcctc
     3781 agtgtctcag aggcagcaat tcttgctgga cacctgcaca tgctcagcac agaggctggt
     3841 actttggagg cactaaccac ttgatgagta aatcaatggc ataaagcccc attccaagtt
     3901 atggggtctt ttgacaggcc cctttcatcc tctttctctt tgtataaacc tcatgtttca
     3961 gaacaaaatt acagtctaag ttcatttgcc cccagccttg cccaaggatc cccgggctgt
     4021 gctgacccct aggcataggg caaagggtgt tcccaagcag caggcacctc agtgccctca
     4081 gttatccagg gcaaggggcc tggctgcccc ctgctcctcc ccatgatgca ggggctttct
     4141 aagccaggct gcagacaggg cagggttggc ttcttggcca ttccctctgt gcccccttct
     4201 ccttctgact ggtctcaccc tggagatccc cagaggatct gaccagagcc aggtggactg
     4261 tggccctgag atggagctgg ctgcaggctt acaagcacct ctggggacat ccagagggga
     4321 gggtcagtaa gcacaacgga gctagggaga cttcagatgg actcaaaccc agagcaataa
     4381 tactctcaca ccaccccaca gctaaggcac tcatgttccc cagtagatca agccagaagc
     4441 tttgcaagaa gggagtggaa cgaggctgcc tatccaaggt ccatctacca cgcagaactt
     4501 ggtcatgcaa gtacatttgg aaaatctggt cttggcccgt cccccattgg cctggtctac
     4561 acagccaaaa attcagacta gattagatgt ttgcaggcaa ttctgtagca aagcaaattc
     4621 ccctaccccg tcccttcccc ctagaagctg ccttagcctc cctgactggg tgtggtctct
     4681 gggcctagga ctcctcccta tgaggaaaag tgctctccag ccacatcttg gcagccccac
     4741 aaccacagca tcagggcagc tgcagcaagt gaccacccac ccgtcgggtt agacacacaa
     4801 ggcaccaggc actggcatct gactaaaata acctttccct acatgggaag aggaaagctt
     4861 gtaggctggc acatataaac gtccagccgc agccagatgg cctgaactaa gcagcaggaa
     4921 ctctctgggc tggggaggag cctcctgccc ttctagaaag tgatgcgtca gctttgttct
     4981 cctgggaagg tgttgctata ccccaggaac aaagcagggc ccaactgcca gtgcagtcag
     5041 ctgggcctgc gctccaggct caccaccgct aagtggtcag gtaccgggcc agcatcctgg
     5101 gagggacctc ttgcgactct gagttgcagc ttggactagc tgaacacatg gggacatgct
     5161 ccaggggctt cttccctggc aggattcctg ggatttcaaa ctacctcacc aacaggacgc
     5221 tgaaccagga gcctgccacc caactggccc ccttggtgat tgtggaaggt gatgtttttc
     5281 ctaaaatgca tccctcctgt tctgctccat atacatgtgc ttcaaaaacc accaccagga
     5341 aagccttccc agaagaggga aaggattaag ggctctcttc ctttgggccc tgcagaatgt
     5401 attggaggga ggtgttgctg caaggtccag gagctgggaa actctgggct cggggggaga
     5461 taatgcacca ccagcctcaa aaaggagctg cccaagttga atatgtagca aagaccatgg
     5521 gataagttga atagtggcca gacgaatcac taataactca ccatgggacc ctctgaagag
     5581 aggcctgtgc tcgtgtaacc atagcaacag cagatgccag caacctactc attagtacca
     5641 cccagtgata aggcatcccc tgggctagac ccaggggcca taaagtagca aagtagcaaa
     5701 tgtagcaata aagggcccgg gtctatacgg ggacagggtc caaatgacca ggacttggcc
     5761 ctctccccag ccccgatgag ggctcagagc cagctgctgt cagctgtctg gggagggaag
     5821 gccctgctcc ataccagggg tccctgttct atactctaag cccactcacc gcatgatcac
     5881 ggactcatcg gaatggcctc ctcttagtgc atgtggttct ctttagttta tttttctgga
     5941 atttggggat tggaccccag aaccaaacat gctggtacag tctaaaaata aatgacttga
     6001 acccacttca atcca
//
