LOCUS       NM_001370286            5926 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 27, mRNA.
ACCESSION   NM_001370286
VERSION     NM_001370286.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5926)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5926)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5926)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5926)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5926)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5926)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5926)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5926)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5926)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5926)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1288           AC005533.2         28600-28661         c
            1289-1414           AC004828.2         179699-179824       c
            1415-1601           AC004828.2         171441-171627       c
            1602-1691           AC004828.2         153703-153792       c
            1692-1745           AC004828.2         149884-149937       c
            1746-1812           AC004828.2         136622-136688       c
            1813-5926           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5926
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..1985
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 19 is encoded by transcript variant 27;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 19"
                     /protein_id="NP_001357215.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKITFLNAQIDRHCLKMSKVAESKEPSQQRVKRWGFSFDEILKDQVG
                     RDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDS
                     HSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQG
                     RRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGPDAVLLTVPTAGP
                     GPGPADPTGRRRRSTSADRVSLRGDLVTVKEKE"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1288
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1414
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1601
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1691
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1745
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1812
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..5926
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3325..3330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3344
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5898..5903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5926
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagataa catttttgaa cgcacagatc gacagacatt
     1261 gtttgaaaat gtccaaagtg gctgaaagca aagagcccag ccaacagcga gtaaaaagat
     1321 ggggcttctc tttcgatgag atattgaagg accaggtggg gcgggaccag tttctacgat
     1381 tcctggagtc cgaattcagt tcagaaaacc tcaggttctg gctggctgtc caagatctta
     1441 agaaacaacc cctacaggat gtggccaaga gggtagaaga aatctggcaa gagtttctgg
     1501 ctccaggggc tccaagtgca atcaacctgg attctcacag ctatgagata accagtcaaa
     1561 atgtcaaaga tggagggaga tatacatttg aagacgccca ggagcacatc tacaagctga
     1621 tgaagagtga cagctatgcc cgcttcctcc ggtcaaatgc ttaccaggat ttgctgctgg
     1681 ccaagaagaa gccagaaagt gagcaaggtc gtagaacttc cctagaaaag ttcactcgca
     1741 gtgtgtgctg ctggcgcaga gtcagaatgg ccgctgcatt tcacccccga ggtggcttcc
     1801 ttccagcagt ggggaaagtc gctggcgggc aagcgcctca cgggcctgat gcagtcctcc
     1861 tgaccgttcc taccgcaggt ccagggcctg ggcccgcgga ccccacaggc aggcggcggc
     1921 gctccacatc tgcggacaga gtttccttac gaggagactt ggtcactgtg aaggagaaag
     1981 agtgagggca atgaagggcg atggtgggga gactcggtgg gtgaatgggg agaccagaaa
     2041 gaaagagtcc acagagcctg ggctgggccc ggtggaggct cctgtttaca gccctctctt
     2101 ctttgtacag ttgtattcca acactccact cgctaagagg ccctgatccc agctcattca
     2161 ggggagaaca cgtcgtgggg ttcctgtcac gactatcact tgagattata ttattatcct
     2221 cactccctcg ctgtctggag acggtcacac cttctggcaa attcaagagg catgagtgga
     2281 ccgagagcac atccagcatt tgcatcacct ccctggcacc tcccatagtt acagccacta
     2341 catccccacc gccgcctgtc atccctcacg tctctgtggc cacccgggtg tcactgccag
     2401 caccaggcac tgctttcacg taaaatgtcc aaatcacatc ttcagcaaga aagcaacctc
     2461 acggattgcc ccgcctcaag gtctttccac cctctttgag atcagcgttc ggagaggtcc
     2521 ccgccagccc ggtggctgcc ctcaggtccc gtcacatgtc tcaagggtcc agcgttcgag
     2581 gaagcactgt tgtagatgac agagcttttt gtttcacagc tgcggggatt ctgctgacca
     2641 tcttttagaa aattatttca taatttattc tggctttgcc cccttgctcc ttggtttatt
     2701 ccctcatgtt ttactcaaaa taaacatggc catgaactca ggggccattg ggattctccc
     2761 ctctggcagc cccaggtggg agctgggagg gtccccagcc caggaggtgg ctggattgca
     2821 gggctggcag cccccacgtg gtggcatcct gacaggcaca gtgagaccct tgctgggtca
     2881 ggtctccttt gtgtgtgaag ctggggcaga gtatgctacg aagggaccag gccaggccac
     2941 agggctctcc tcccagtctt tatctgaagg cccagccaaa gcacccctct aaaccggtca
     3001 cctaggggaa atgcaaaaac ctgcaaaaga tccacctgta ttccctgtgt gtgtgtgtca
     3061 aaatgaccat ttgccaacct ggctgtgagg taatgtatgt aaagcaccga gtcaggtgcc
     3121 tgatacgcag taggtgctta gcaaacggta gctaatacta tcatcattgt cattgttatt
     3181 gtgacaccca tgagcccaca gacagagctg tattaagtaa cctgttttga atccagacat
     3241 tcactccccc acttgctatg actaccctcc tttgatctat ttttggtcat aggtaaaaaa
     3301 aaaaatctct cttgggagca tataaacaaa aaacatagaa gcaataaagc gatcgctggt
     3361 atttcttttc tcatgcagcc aaattcgcca gctggtgacc aaaggctcag atgcttgctt
     3421 atttgcagac ccggcctcct gggtgctccc cagtgaccca tctttccacc ccaccacctc
     3481 caagtcctgt ctatgtctgc ttccacacag ccctgtcccc agggcaccag ccttctgtcc
     3541 ctcacagcag tgccatcgcg ggcattagga gtcttcgtta tgttgtatcc ttgtgagttc
     3601 ttgactacca tgcccaagtt tcccccactg gcaatggttc ctctcttgga ggtacagtgg
     3661 aaaccagaga gatgacagat gttgagtcct cagtgtctca gaggcagcaa ttcttgctgg
     3721 acacctgcac atgctcagca cagaggctgg tactttggag gcactaacca cttgatgagt
     3781 aaatcaatgg cataaagccc cattccaagt tatggggtct tttgacaggc ccctttcatc
     3841 ctctttctct ttgtataaac ctcatgtttc agaacaaaat tacagtctaa gttcatttgc
     3901 ccccagcctt gcccaaggat ccccgggctg tgctgacccc taggcatagg gcaaagggtg
     3961 ttcccaagca gcaggcacct cagtgccctc agttatccag ggcaaggggc ctggctgccc
     4021 cctgctcctc cccatgatgc aggggctttc taagccaggc tgcagacagg gcagggttgg
     4081 cttcttggcc attccctctg tgcccccttc tccttctgac tggtctcacc ctggagatcc
     4141 ccagaggatc tgaccagagc caggtggact gtggccctga gatggagctg gctgcaggct
     4201 tacaagcacc tctggggaca tccagagggg agggtcagta agcacaacgg agctagggag
     4261 acttcagatg gactcaaacc cagagcaata atactctcac accaccccac agctaaggca
     4321 ctcatgttcc ccagtagatc aagccagaag ctttgcaaga agggagtgga acgaggctgc
     4381 ctatccaagg tccatctacc acgcagaact tggtcatgca agtacatttg gaaaatctgg
     4441 tcttggcccg tcccccattg gcctggtcta cacagccaaa aattcagact agattagatg
     4501 tttgcaggca attctgtagc aaagcaaatt cccctacccc gtcccttccc cctagaagct
     4561 gccttagcct ccctgactgg gtgtggtctc tgggcctagg actcctccct atgaggaaaa
     4621 gtgctctcca gccacatctt ggcagcccca caaccacagc atcagggcag ctgcagcaag
     4681 tgaccaccca cccgtcgggt tagacacaca aggcaccagg cactggcatc tgactaaaat
     4741 aacctttccc tacatgggaa gaggaaagct tgtaggctgg cacatataaa cgtccagccg
     4801 cagccagatg gcctgaacta agcagcagga actctctggg ctggggagga gcctcctgcc
     4861 cttctagaaa gtgatgcgtc agctttgttc tcctgggaag gtgttgctat accccaggaa
     4921 caaagcaggg cccaactgcc agtgcagtca gctgggcctg cgctccaggc tcaccaccgc
     4981 taagtggtca ggtaccgggc cagcatcctg ggagggacct cttgcgactc tgagttgcag
     5041 cttggactag ctgaacacat ggggacatgc tccaggggct tcttccctgg caggattcct
     5101 gggatttcaa actacctcac caacaggacg ctgaaccagg agcctgccac ccaactggcc
     5161 cccttggtga ttgtggaagg tgatgttttt cctaaaatgc atccctcctg ttctgctcca
     5221 tatacatgtg cttcaaaaac caccaccagg aaagccttcc cagaagaggg aaaggattaa
     5281 gggctctctt cctttgggcc ctgcagaatg tattggaggg aggtgttgct gcaaggtcca
     5341 ggagctggga aactctgggc tcggggggag ataatgcacc accagcctca aaaaggagct
     5401 gcccaagttg aatatgtagc aaagaccatg ggataagttg aatagtggcc agacgaatca
     5461 ctaataactc accatgggac cctctgaaga gaggcctgtg ctcgtgtaac catagcaaca
     5521 gcagatgcca gcaacctact cattagtacc acccagtgat aaggcatccc ctgggctaga
     5581 cccaggggcc ataaagtagc aaagtagcaa atgtagcaat aaagggcccg ggtctatacg
     5641 gggacagggt ccaaatgacc aggacttggc cctctcccca gccccgatga gggctcagag
     5701 ccagctgctg tcagctgtct ggggagggaa ggccctgctc cataccaggg gtccctgttc
     5761 tatactctaa gcccactcac cgcatgatca cggactcatc ggaatggcct cctcttagtg
     5821 catgtggttc tctttagttt atttttctgg aatttgggga ttggacccca gaaccaaaca
     5881 tgctggtaca gtctaaaaat aaatgacttg aacccacttc aatcca
//
