LOCUS       NM_001370284            5790 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 26, mRNA.
ACCESSION   NM_001370284 XM_024449769
VERSION     NM_001370284.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5790)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5790)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5790)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5790)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5790)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5790)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5790)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5790)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5790)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5790)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449769.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF107619.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2142680, SAMEA2145774 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC005993.2         12683-12916         c
            235-338             AC005477.1         87628-87731         c
            339-438             AC005157.1         72588-72687         c
            439-489             AC005533.2         52351-52401         c
            490-596             AC005533.2         48552-48658         c
            597-648             AC005533.2         47246-47297         c
            649-713             AC005533.2         41107-41171         c
            714-790             AC005533.2         36846-36922         c
            791-872             AC005533.2         33976-34057         c
            873-947             AC005533.2         32230-32304         c
            948-1046            AC005533.2         30089-30187         c
            1047-1108           AC005533.2         28600-28661         c
            1109-1219           AC005533.2         11667-11777         c
            1220-1345           AC004828.2         179699-179824       c
            1346-1532           AC004828.2         171441-171627       c
            1533-1622           AC004828.2         153703-153792       c
            1623-1676           AC004828.2         149884-149937       c
            1677-5790           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5790
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..234
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            235..338
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1727
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 1 is encoded by transcript variant 26;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 1"
                     /protein_id="NP_001357213.1"
                     /db_xref="CCDS:CCDS55924.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLMQSS"
     exon            339..438
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            439..489
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            490..596
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            597..648
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            649..713
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            714..790
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            791..872
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            873..947
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1046
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1108
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1219
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1345
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1532
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1622
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1676
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..5790
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3208
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5762..5767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5790
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttacag tcaccagcag gctgcgtaaa gaagtggccc agtgagacag ggaaagtgac
       61 ccagaaaatt tagttttgtt cagaatgaaa gctgctgtat ttcatttttg tttcttaatt
      121 tgacggagta ggaacgttat tttccttctc tgtcattgag accagtagca tttctatgtt
      181 acaaactgaa gatatttggg gtctcgtcgg cttgggatta tcaatgcttg ggagtgtgag
      241 tgaagacact caggatggct caaggatccg gggatcaaag agcagtgggg gttgctgacc
      301 cagaggagag ttctccaaac atgatcgttt actgcaaaat tgaagacatc attacaaaga
      361 tgcaagatga caagacaggg ggtgtgccca tcagaacagt caagagcttt ctctccaaaa
      421 tccccagtgt cgtcacaggt actgacattg tgcagtggct tatgaagaac ctttccattg
      481 aggacccagt tgaagcaata cacttgggga gccttatcgc tgcccagggc tacatctttc
      541 caatctcaga ccatgttctc accatgaagg atgatggcac cttttatcgt ttccaggctc
      601 cgtacttctg gccttcgaac tgctgggaac ctgaaaacac tgactatgcc atctatctct
      661 gtaagaggac aatgcaaaat aaagcaaggc tggaactggc agattatgaa gcagaaaact
      721 tagcaagact ccagagggcc tttgcgagga agtgggaatt catctttatg caagcagaag
      781 cacaagtaaa gattgaccgg aaaaaagaca agacagaaag gaaaattttg gatagtcaag
      841 aacgagcctt ttgggatgtc cacaggcctg tgccaggctg tgtgaacaca acagaaatgg
      901 atatccgaaa atgtcgacgt ttgaagaatc cacaaaaggt taaaaagtcc gtgtatggcg
      961 tgactgaaga gtcccaggca cagagcccgg tgcatgtact cagccaacca atcaggaaaa
     1021 caacaaaaga ggacatccgg aaacagataa catttttgaa cgcacagatc gacagacatt
     1081 gtttgaaaat gtccaaagtg gctgaaagtt taattgccta cacggaacaa tatgtggaat
     1141 atgacccttt gataacacca gctgagccat ccaacccttg gatcagcgat gacgttgctt
     1201 tgtgggacat agagatgagc aaagagccca gccaacagcg agtaaaaaga tggggcttct
     1261 ctttcgatga gatattgaag gaccaggtgg ggcgggacca gtttctacga ttcctggagt
     1321 ccgaattcag ttcagaaaac ctcaggttct ggctggctgt ccaagatctt aagaaacaac
     1381 ccctacagga tgtggccaag agggtagaag aaatctggca agagtttctg gctccagggg
     1441 ctccaagtgc aatcaacctg gattctcaca gctatgagat aaccagtcaa aatgtcaaag
     1501 atggagggag atatacattt gaagacgccc aggagcacat ctacaagctg atgaagagtg
     1561 acagctatgc ccgcttcctc cggtcaaatg cttaccagga tttgctgctg gccaagaaga
     1621 agccagaaag tgagcaaggt cgtagaactt ccctagaaaa gttcactcgc agtgtgggaa
     1681 agtcgctggc gggcaagcgc ctcacgggcc tgatgcagtc ctcctgaccg ttcctaccgc
     1741 aggtccaggg cctgggcccg cggaccccac aggcaggcgg cggcgctcca catctgcgga
     1801 cagagtttcc ttacgaggag acttggtcac tgtgaaggag aaagagtgag ggcaatgaag
     1861 ggcgatggtg gggagactcg gtgggtgaat ggggagacca gaaagaaaga gtccacagag
     1921 cctgggctgg gcccggtgga ggctcctgtt tacagccctc tcttctttgt acagttgtat
     1981 tccaacactc cactcgctaa gaggccctga tcccagctca ttcaggggag aacacgtcgt
     2041 ggggttcctg tcacgactat cacttgagat tatattatta tcctcactcc ctcgctgtct
     2101 ggagacggtc acaccttctg gcaaattcaa gaggcatgag tggaccgaga gcacatccag
     2161 catttgcatc acctccctgg cacctcccat agttacagcc actacatccc caccgccgcc
     2221 tgtcatccct cacgtctctg tggccacccg ggtgtcactg ccagcaccag gcactgcttt
     2281 cacgtaaaat gtccaaatca catcttcagc aagaaagcaa cctcacggat tgccccgcct
     2341 caaggtcttt ccaccctctt tgagatcagc gttcggagag gtccccgcca gcccggtggc
     2401 tgccctcagg tcccgtcaca tgtctcaagg gtccagcgtt cgaggaagca ctgttgtaga
     2461 tgacagagct ttttgtttca cagctgcggg gattctgctg accatctttt agaaaattat
     2521 ttcataattt attctggctt tgcccccttg ctccttggtt tattccctca tgttttactc
     2581 aaaataaaca tggccatgaa ctcaggggcc attgggattc tcccctctgg cagccccagg
     2641 tgggagctgg gagggtcccc agcccaggag gtggctggat tgcagggctg gcagccccca
     2701 cgtggtggca tcctgacagg cacagtgaga cccttgctgg gtcaggtctc ctttgtgtgt
     2761 gaagctgggg cagagtatgc tacgaaggga ccaggccagg ccacagggct ctcctcccag
     2821 tctttatctg aaggcccagc caaagcaccc ctctaaaccg gtcacctagg ggaaatgcaa
     2881 aaacctgcaa aagatccacc tgtattccct gtgtgtgtgt gtcaaaatga ccatttgcca
     2941 acctggctgt gaggtaatgt atgtaaagca ccgagtcagg tgcctgatac gcagtaggtg
     3001 cttagcaaac ggtagctaat actatcatca ttgtcattgt tattgtgaca cccatgagcc
     3061 cacagacaga gctgtattaa gtaacctgtt ttgaatccag acattcactc ccccacttgc
     3121 tatgactacc ctcctttgat ctatttttgg tcataggtaa aaaaaaaaat ctctcttggg
     3181 agcatataaa caaaaaacat agaagcaata aagcgatcgc tggtatttct tttctcatgc
     3241 agccaaattc gccagctggt gaccaaaggc tcagatgctt gcttatttgc agacccggcc
     3301 tcctgggtgc tccccagtga cccatctttc caccccacca cctccaagtc ctgtctatgt
     3361 ctgcttccac acagccctgt ccccagggca ccagccttct gtccctcaca gcagtgccat
     3421 cgcgggcatt aggagtcttc gttatgttgt atccttgtga gttcttgact accatgccca
     3481 agtttccccc actggcaatg gttcctctct tggaggtaca gtggaaacca gagagatgac
     3541 agatgttgag tcctcagtgt ctcagaggca gcaattcttg ctggacacct gcacatgctc
     3601 agcacagagg ctggtacttt ggaggcacta accacttgat gagtaaatca atggcataaa
     3661 gccccattcc aagttatggg gtcttttgac aggccccttt catcctcttt ctctttgtat
     3721 aaacctcatg tttcagaaca aaattacagt ctaagttcat ttgcccccag ccttgcccaa
     3781 ggatccccgg gctgtgctga cccctaggca tagggcaaag ggtgttccca agcagcaggc
     3841 acctcagtgc cctcagttat ccagggcaag gggcctggct gccccctgct cctccccatg
     3901 atgcaggggc tttctaagcc aggctgcaga cagggcaggg ttggcttctt ggccattccc
     3961 tctgtgcccc cttctccttc tgactggtct caccctggag atccccagag gatctgacca
     4021 gagccaggtg gactgtggcc ctgagatgga gctggctgca ggcttacaag cacctctggg
     4081 gacatccaga ggggagggtc agtaagcaca acggagctag ggagacttca gatggactca
     4141 aacccagagc aataatactc tcacaccacc ccacagctaa ggcactcatg ttccccagta
     4201 gatcaagcca gaagctttgc aagaagggag tggaacgagg ctgcctatcc aaggtccatc
     4261 taccacgcag aacttggtca tgcaagtaca tttggaaaat ctggtcttgg cccgtccccc
     4321 attggcctgg tctacacagc caaaaattca gactagatta gatgtttgca ggcaattctg
     4381 tagcaaagca aattccccta ccccgtccct tccccctaga agctgcctta gcctccctga
     4441 ctgggtgtgg tctctgggcc taggactcct ccctatgagg aaaagtgctc tccagccaca
     4501 tcttggcagc cccacaacca cagcatcagg gcagctgcag caagtgacca cccacccgtc
     4561 gggttagaca cacaaggcac caggcactgg catctgacta aaataacctt tccctacatg
     4621 ggaagaggaa agcttgtagg ctggcacata taaacgtcca gccgcagcca gatggcctga
     4681 actaagcagc aggaactctc tgggctgggg aggagcctcc tgcccttcta gaaagtgatg
     4741 cgtcagcttt gttctcctgg gaaggtgttg ctatacccca ggaacaaagc agggcccaac
     4801 tgccagtgca gtcagctggg cctgcgctcc aggctcacca ccgctaagtg gtcaggtacc
     4861 gggccagcat cctgggaggg acctcttgcg actctgagtt gcagcttgga ctagctgaac
     4921 acatggggac atgctccagg ggcttcttcc ctggcaggat tcctgggatt tcaaactacc
     4981 tcaccaacag gacgctgaac caggagcctg ccacccaact ggcccccttg gtgattgtgg
     5041 aaggtgatgt ttttcctaaa atgcatccct cctgttctgc tccatataca tgtgcttcaa
     5101 aaaccaccac caggaaagcc ttcccagaag agggaaagga ttaagggctc tcttcctttg
     5161 ggccctgcag aatgtattgg agggaggtgt tgctgcaagg tccaggagct gggaaactct
     5221 gggctcgggg ggagataatg caccaccagc ctcaaaaagg agctgcccaa gttgaatatg
     5281 tagcaaagac catgggataa gttgaatagt ggccagacga atcactaata actcaccatg
     5341 ggaccctctg aagagaggcc tgtgctcgtg taaccatagc aacagcagat gccagcaacc
     5401 tactcattag taccacccag tgataaggca tcccctgggc tagacccagg ggccataaag
     5461 tagcaaagta gcaaatgtag caataaaggg cccgggtcta tacggggaca gggtccaaat
     5521 gaccaggact tggccctctc cccagccccg atgagggctc agagccagct gctgtcagct
     5581 gtctggggag ggaaggccct gctccatacc aggggtccct gttctatact ctaagcccac
     5641 tcaccgcatg atcacggact catcggaatg gcctcctctt agtgcatgtg gttctcttta
     5701 gtttattttt ctggaatttg gggattggac cccagaacca aacatgctgg tacagtctaa
     5761 aaataaatga cttgaaccca cttcaatcca
//
