LOCUS       NM_001370283            5593 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 25, mRNA.
ACCESSION   NM_001370283 XM_017021824
VERSION     NM_001370283.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5593)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5593)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5593)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5593)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5593)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5593)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5593)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5593)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5593)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5593)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_017021824.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The genomic coordinates were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1081            AC004828.2         179699-179824       c
            1082-1268           AC004828.2         171441-171627       c
            1269-1358           AC004828.2         153703-153792       c
            1359-1412           AC004828.2         149884-149937       c
            1413-1479           AC004828.2         136622-136688       c
            1480-5593           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5593
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1652
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 18 is encoded by transcript variant 25;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 18"
                     /protein_id="NP_001357212.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQD
                     LKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHI
                     YKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFH
                     PRGGFLPAVGKVAGGQAPHGPDAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGD
                     LVTVKEKE"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1081
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1268
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1358
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1412
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1479
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..5593
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3011
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5565..5570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5593
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagcaaag
      961 agcccagcca acagcgagta aaaagatggg gcttctcttt cgatgagata ttgaaggacc
     1021 aggtggggcg ggaccagttt ctacgattcc tggagtccga attcagttca gaaaacctca
     1081 ggttctggct ggctgtccaa gatcttaaga aacaacccct acaggatgtg gccaagaggg
     1141 tagaagaaat ctggcaagag tttctggctc caggggctcc aagtgcaatc aacctggatt
     1201 ctcacagcta tgagataacc agtcaaaatg tcaaagatgg agggagatat acatttgaag
     1261 acgcccagga gcacatctac aagctgatga agagtgacag ctatgcccgc ttcctccggt
     1321 caaatgctta ccaggatttg ctgctggcca agaagaagcc agaaagtgag caaggtcgta
     1381 gaacttccct agaaaagttc actcgcagtg tgtgctgctg gcgcagagtc agaatggccg
     1441 ctgcatttca cccccgaggt ggcttccttc cagcagtggg gaaagtcgct ggcgggcaag
     1501 cgcctcacgg gcctgatgca gtcctcctga ccgttcctac cgcaggtcca gggcctgggc
     1561 ccgcggaccc cacaggcagg cggcggcgct ccacatctgc ggacagagtt tccttacgag
     1621 gagacttggt cactgtgaag gagaaagagt gagggcaatg aagggcgatg gtggggagac
     1681 tcggtgggtg aatggggaga ccagaaagaa agagtccaca gagcctgggc tgggcccggt
     1741 ggaggctcct gtttacagcc ctctcttctt tgtacagttg tattccaaca ctccactcgc
     1801 taagaggccc tgatcccagc tcattcaggg gagaacacgt cgtggggttc ctgtcacgac
     1861 tatcacttga gattatatta ttatcctcac tccctcgctg tctggagacg gtcacacctt
     1921 ctggcaaatt caagaggcat gagtggaccg agagcacatc cagcatttgc atcacctccc
     1981 tggcacctcc catagttaca gccactacat ccccaccgcc gcctgtcatc cctcacgtct
     2041 ctgtggccac ccgggtgtca ctgccagcac caggcactgc tttcacgtaa aatgtccaaa
     2101 tcacatcttc agcaagaaag caacctcacg gattgccccg cctcaaggtc tttccaccct
     2161 ctttgagatc agcgttcgga gaggtccccg ccagcccggt ggctgccctc aggtcccgtc
     2221 acatgtctca agggtccagc gttcgaggaa gcactgttgt agatgacaga gctttttgtt
     2281 tcacagctgc ggggattctg ctgaccatct tttagaaaat tatttcataa tttattctgg
     2341 ctttgccccc ttgctccttg gtttattccc tcatgtttta ctcaaaataa acatggccat
     2401 gaactcaggg gccattggga ttctcccctc tggcagcccc aggtgggagc tgggagggtc
     2461 cccagcccag gaggtggctg gattgcaggg ctggcagccc ccacgtggtg gcatcctgac
     2521 aggcacagtg agacccttgc tgggtcaggt ctcctttgtg tgtgaagctg gggcagagta
     2581 tgctacgaag ggaccaggcc aggccacagg gctctcctcc cagtctttat ctgaaggccc
     2641 agccaaagca cccctctaaa ccggtcacct aggggaaatg caaaaacctg caaaagatcc
     2701 acctgtattc cctgtgtgtg tgtgtcaaaa tgaccatttg ccaacctggc tgtgaggtaa
     2761 tgtatgtaaa gcaccgagtc aggtgcctga tacgcagtag gtgcttagca aacggtagct
     2821 aatactatca tcattgtcat tgttattgtg acacccatga gcccacagac agagctgtat
     2881 taagtaacct gttttgaatc cagacattca ctcccccact tgctatgact accctccttt
     2941 gatctatttt tggtcatagg taaaaaaaaa aatctctctt gggagcatat aaacaaaaaa
     3001 catagaagca ataaagcgat cgctggtatt tcttttctca tgcagccaaa ttcgccagct
     3061 ggtgaccaaa ggctcagatg cttgcttatt tgcagacccg gcctcctggg tgctccccag
     3121 tgacccatct ttccacccca ccacctccaa gtcctgtcta tgtctgcttc cacacagccc
     3181 tgtccccagg gcaccagcct tctgtccctc acagcagtgc catcgcgggc attaggagtc
     3241 ttcgttatgt tgtatccttg tgagttcttg actaccatgc ccaagtttcc cccactggca
     3301 atggttcctc tcttggaggt acagtggaaa ccagagagat gacagatgtt gagtcctcag
     3361 tgtctcagag gcagcaattc ttgctggaca cctgcacatg ctcagcacag aggctggtac
     3421 tttggaggca ctaaccactt gatgagtaaa tcaatggcat aaagccccat tccaagttat
     3481 ggggtctttt gacaggcccc tttcatcctc tttctctttg tataaacctc atgtttcaga
     3541 acaaaattac agtctaagtt catttgcccc cagccttgcc caaggatccc cgggctgtgc
     3601 tgacccctag gcatagggca aagggtgttc ccaagcagca ggcacctcag tgccctcagt
     3661 tatccagggc aaggggcctg gctgccccct gctcctcccc atgatgcagg ggctttctaa
     3721 gccaggctgc agacagggca gggttggctt cttggccatt ccctctgtgc ccccttctcc
     3781 ttctgactgg tctcaccctg gagatcccca gaggatctga ccagagccag gtggactgtg
     3841 gccctgagat ggagctggct gcaggcttac aagcacctct ggggacatcc agaggggagg
     3901 gtcagtaagc acaacggagc tagggagact tcagatggac tcaaacccag agcaataata
     3961 ctctcacacc accccacagc taaggcactc atgttcccca gtagatcaag ccagaagctt
     4021 tgcaagaagg gagtggaacg aggctgccta tccaaggtcc atctaccacg cagaacttgg
     4081 tcatgcaagt acatttggaa aatctggtct tggcccgtcc cccattggcc tggtctacac
     4141 agccaaaaat tcagactaga ttagatgttt gcaggcaatt ctgtagcaaa gcaaattccc
     4201 ctaccccgtc ccttccccct agaagctgcc ttagcctccc tgactgggtg tggtctctgg
     4261 gcctaggact cctccctatg aggaaaagtg ctctccagcc acatcttggc agccccacaa
     4321 ccacagcatc agggcagctg cagcaagtga ccacccaccc gtcgggttag acacacaagg
     4381 caccaggcac tggcatctga ctaaaataac ctttccctac atgggaagag gaaagcttgt
     4441 aggctggcac atataaacgt ccagccgcag ccagatggcc tgaactaagc agcaggaact
     4501 ctctgggctg gggaggagcc tcctgccctt ctagaaagtg atgcgtcagc tttgttctcc
     4561 tgggaaggtg ttgctatacc ccaggaacaa agcagggccc aactgccagt gcagtcagct
     4621 gggcctgcgc tccaggctca ccaccgctaa gtggtcaggt accgggccag catcctggga
     4681 gggacctctt gcgactctga gttgcagctt ggactagctg aacacatggg gacatgctcc
     4741 aggggcttct tccctggcag gattcctggg atttcaaact acctcaccaa caggacgctg
     4801 aaccaggagc ctgccaccca actggccccc ttggtgattg tggaaggtga tgtttttcct
     4861 aaaatgcatc cctcctgttc tgctccatat acatgtgctt caaaaaccac caccaggaaa
     4921 gccttcccag aagagggaaa ggattaaggg ctctcttcct ttgggccctg cagaatgtat
     4981 tggagggagg tgttgctgca aggtccagga gctgggaaac tctgggctcg gggggagata
     5041 atgcaccacc agcctcaaaa aggagctgcc caagttgaat atgtagcaaa gaccatggga
     5101 taagttgaat agtggccaga cgaatcacta ataactcacc atgggaccct ctgaagagag
     5161 gcctgtgctc gtgtaaccat agcaacagca gatgccagca acctactcat tagtaccacc
     5221 cagtgataag gcatcccctg ggctagaccc aggggccata aagtagcaaa gtagcaaatg
     5281 tagcaataaa gggcccgggt ctatacgggg acagggtcca aatgaccagg acttggccct
     5341 ctccccagcc ccgatgaggg ctcagagcca gctgctgtca gctgtctggg gagggaaggc
     5401 cctgctccat accaggggtc cctgttctat actctaagcc cactcaccgc atgatcacgg
     5461 actcatcgga atggcctcct cttagtgcat gtggttctct ttagtttatt tttctggaat
     5521 ttggggattg gaccccagaa ccaaacatgc tggtacagtc taaaaataaa tgacttgaac
     5581 ccacttcaat cca
//
