LOCUS       NM_001370282            6227 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 24, mRNA.
ACCESSION   NM_001370282 XM_024449767
VERSION     NM_001370282.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6227)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6227)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6227)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6227)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6227)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 6227)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 6227)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 6227)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 6227)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 6227)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449767.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1325           AC005533.2         30089-30187         c
            1326-1387           AC005533.2         28600-28661         c
            1388-1498           AC005533.2         11667-11777         c
            1499-1624           AC004828.2         179699-179824       c
            1625-1811           AC004828.2         171441-171627       c
            1812-1901           AC004828.2         153703-153792       c
            1902-1955           AC004828.2         149884-149937       c
            1956-2113           AC004828.2         148358-148515       c
            2114-6227           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..6227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6227
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..2099
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 17 is encoded by transcript variant 24;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 17"
                     /protein_id="NP_001357211.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVKSECAEHKACGCLVYLHGCFANGRVAPHTKKLPR
                     AVRVKASGTSFTP"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1498
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1624
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1811
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1901
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2113
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..6227
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3626..3631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3645
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      6199..6204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      6227
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaagttt aattgcctac acggaacaat atgtggaata tgaccctttg ataacaccag
     1441 ctgagccatc caacccttgg atcagcgatg acgttgcttt gtgggacata gagatgagca
     1501 aagagcccag ccaacagcga gtaaaaagat ggggcttctc tttcgatgag atattgaagg
     1561 accaggtggg gcgggaccag tttctacgat tcctggagtc cgaattcagt tcagaaaacc
     1621 tcaggttctg gctggctgtc caagatctta agaaacaacc cctacaggat gtggccaaga
     1681 gggtagaaga aatctggcaa gagtttctgg ctccaggggc tccaagtgca atcaacctgg
     1741 attctcacag ctatgagata accagtcaaa atgtcaaaga tggagggaga tatacatttg
     1801 aagacgccca ggagcacatc tacaagctga tgaagagtga cagctatgcc cgcttcctcc
     1861 ggtcaaatgc ttaccaggat ttgctgctgg ccaagaagaa gccagaaagt gagcaaggtc
     1921 gtagaacttc cctagaaaag ttcactcgca gtgtgaaatc agaatgtgca gaacacaagg
     1981 cctgcgggtg cctggtctat cttcatggct gctttgccaa tggccgtgtg gctccgcaca
     2041 ccaagaagct gccacgggct gtcagagtca aggcttctgg gacttccttc actccatgat
     2101 ggcctgagag aagggaaagt cgctggcggg caagcgcctc acgggcctga tgcagtcctc
     2161 ctgaccgttc ctaccgcagg tccagggcct gggcccgcgg accccacagg caggcggcgg
     2221 cgctccacat ctgcggacag agtttcctta cgaggagact tggtcactgt gaaggagaaa
     2281 gagtgagggc aatgaagggc gatggtgggg agactcggtg ggtgaatggg gagaccagaa
     2341 agaaagagtc cacagagcct gggctgggcc cggtggaggc tcctgtttac agccctctct
     2401 tctttgtaca gttgtattcc aacactccac tcgctaagag gccctgatcc cagctcattc
     2461 aggggagaac acgtcgtggg gttcctgtca cgactatcac ttgagattat attattatcc
     2521 tcactccctc gctgtctgga gacggtcaca ccttctggca aattcaagag gcatgagtgg
     2581 accgagagca catccagcat ttgcatcacc tccctggcac ctcccatagt tacagccact
     2641 acatccccac cgccgcctgt catccctcac gtctctgtgg ccacccgggt gtcactgcca
     2701 gcaccaggca ctgctttcac gtaaaatgtc caaatcacat cttcagcaag aaagcaacct
     2761 cacggattgc cccgcctcaa ggtctttcca ccctctttga gatcagcgtt cggagaggtc
     2821 cccgccagcc cggtggctgc cctcaggtcc cgtcacatgt ctcaagggtc cagcgttcga
     2881 ggaagcactg ttgtagatga cagagctttt tgtttcacag ctgcggggat tctgctgacc
     2941 atcttttaga aaattatttc ataatttatt ctggctttgc ccccttgctc cttggtttat
     3001 tccctcatgt tttactcaaa ataaacatgg ccatgaactc aggggccatt gggattctcc
     3061 cctctggcag ccccaggtgg gagctgggag ggtccccagc ccaggaggtg gctggattgc
     3121 agggctggca gcccccacgt ggtggcatcc tgacaggcac agtgagaccc ttgctgggtc
     3181 aggtctcctt tgtgtgtgaa gctggggcag agtatgctac gaagggacca ggccaggcca
     3241 cagggctctc ctcccagtct ttatctgaag gcccagccaa agcacccctc taaaccggtc
     3301 acctagggga aatgcaaaaa cctgcaaaag atccacctgt attccctgtg tgtgtgtgtc
     3361 aaaatgacca tttgccaacc tggctgtgag gtaatgtatg taaagcaccg agtcaggtgc
     3421 ctgatacgca gtaggtgctt agcaaacggt agctaatact atcatcattg tcattgttat
     3481 tgtgacaccc atgagcccac agacagagct gtattaagta acctgttttg aatccagaca
     3541 ttcactcccc cacttgctat gactaccctc ctttgatcta tttttggtca taggtaaaaa
     3601 aaaaaatctc tcttgggagc atataaacaa aaaacataga agcaataaag cgatcgctgg
     3661 tatttctttt ctcatgcagc caaattcgcc agctggtgac caaaggctca gatgcttgct
     3721 tatttgcaga cccggcctcc tgggtgctcc ccagtgaccc atctttccac cccaccacct
     3781 ccaagtcctg tctatgtctg cttccacaca gccctgtccc cagggcacca gccttctgtc
     3841 cctcacagca gtgccatcgc gggcattagg agtcttcgtt atgttgtatc cttgtgagtt
     3901 cttgactacc atgcccaagt ttcccccact ggcaatggtt cctctcttgg aggtacagtg
     3961 gaaaccagag agatgacaga tgttgagtcc tcagtgtctc agaggcagca attcttgctg
     4021 gacacctgca catgctcagc acagaggctg gtactttgga ggcactaacc acttgatgag
     4081 taaatcaatg gcataaagcc ccattccaag ttatggggtc ttttgacagg cccctttcat
     4141 cctctttctc tttgtataaa cctcatgttt cagaacaaaa ttacagtcta agttcatttg
     4201 cccccagcct tgcccaagga tccccgggct gtgctgaccc ctaggcatag ggcaaagggt
     4261 gttcccaagc agcaggcacc tcagtgccct cagttatcca gggcaagggg cctggctgcc
     4321 ccctgctcct ccccatgatg caggggcttt ctaagccagg ctgcagacag ggcagggttg
     4381 gcttcttggc cattccctct gtgccccctt ctccttctga ctggtctcac cctggagatc
     4441 cccagaggat ctgaccagag ccaggtggac tgtggccctg agatggagct ggctgcaggc
     4501 ttacaagcac ctctggggac atccagaggg gagggtcagt aagcacaacg gagctaggga
     4561 gacttcagat ggactcaaac ccagagcaat aatactctca caccacccca cagctaaggc
     4621 actcatgttc cccagtagat caagccagaa gctttgcaag aagggagtgg aacgaggctg
     4681 cctatccaag gtccatctac cacgcagaac ttggtcatgc aagtacattt ggaaaatctg
     4741 gtcttggccc gtcccccatt ggcctggtct acacagccaa aaattcagac tagattagat
     4801 gtttgcaggc aattctgtag caaagcaaat tcccctaccc cgtcccttcc ccctagaagc
     4861 tgccttagcc tccctgactg ggtgtggtct ctgggcctag gactcctccc tatgaggaaa
     4921 agtgctctcc agccacatct tggcagcccc acaaccacag catcagggca gctgcagcaa
     4981 gtgaccaccc acccgtcggg ttagacacac aaggcaccag gcactggcat ctgactaaaa
     5041 taacctttcc ctacatggga agaggaaagc ttgtaggctg gcacatataa acgtccagcc
     5101 gcagccagat ggcctgaact aagcagcagg aactctctgg gctggggagg agcctcctgc
     5161 ccttctagaa agtgatgcgt cagctttgtt ctcctgggaa ggtgttgcta taccccagga
     5221 acaaagcagg gcccaactgc cagtgcagtc agctgggcct gcgctccagg ctcaccaccg
     5281 ctaagtggtc aggtaccggg ccagcatcct gggagggacc tcttgcgact ctgagttgca
     5341 gcttggacta gctgaacaca tggggacatg ctccaggggc ttcttccctg gcaggattcc
     5401 tgggatttca aactacctca ccaacaggac gctgaaccag gagcctgcca cccaactggc
     5461 ccccttggtg attgtggaag gtgatgtttt tcctaaaatg catccctcct gttctgctcc
     5521 atatacatgt gcttcaaaaa ccaccaccag gaaagccttc ccagaagagg gaaaggatta
     5581 agggctctct tcctttgggc cctgcagaat gtattggagg gaggtgttgc tgcaaggtcc
     5641 aggagctggg aaactctggg ctcgggggga gataatgcac caccagcctc aaaaaggagc
     5701 tgcccaagtt gaatatgtag caaagaccat gggataagtt gaatagtggc cagacgaatc
     5761 actaataact caccatggga ccctctgaag agaggcctgt gctcgtgtaa ccatagcaac
     5821 agcagatgcc agcaacctac tcattagtac cacccagtga taaggcatcc cctgggctag
     5881 acccaggggc cataaagtag caaagtagca aatgtagcaa taaagggccc gggtctatac
     5941 ggggacaggg tccaaatgac caggacttgg ccctctcccc agccccgatg agggctcaga
     6001 gccagctgct gtcagctgtc tggggaggga aggccctgct ccataccagg ggtccctgtt
     6061 ctatactcta agcccactca ccgcatgatc acggactcat cggaatggcc tcctcttagt
     6121 gcatgtggtt ctctttagtt tatttttctg gaatttgggg attggacccc agaaccaaac
     6181 atgctggtac agtctaaaaa taaatgactt gaacccactt caatcca
//
