LOCUS       NM_001370281            5490 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 23, mRNA.
ACCESSION   NM_001370281
VERSION     NM_001370281.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5490)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5490)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5490)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5490)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5490)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5490)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5490)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5490)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5490)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5490)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2157437, SAMEA2467143
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-1523           AC004828.2         149884-149937       c
            1524-1674           AC004828.2         148358-148508       c
            1675-5490           AC004828.2         123448-127263       c
FEATURES             Location/Qualifiers
     source          1..5490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5490
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1700
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 16 is encoded by transcript variant 23;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 16"
                     /protein_id="NP_001357210.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVNVQNTRPAGAWSIFMAALPMAVWLRTPRSCHGLS
                     ESRLLGLPSLHDGLREVVFQHSTR"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1523
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1674
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..5490
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2889..2894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2908
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5462..5467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5490
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaagc cagaaagtga gcaaggtcgt agaacttccc
     1501 tagaaaagtt cactcgcagt gtgaatgtgc agaacacaag gcctgcgggt gcctggtcta
     1561 tcttcatggc tgctttgcca atggccgtgt ggctccgcac accaagaagc tgccacgggc
     1621 tgtcagagtc aaggcttctg ggacttcctt cactccatga tggcctgaga gaagttgtat
     1681 tccaacactc cactcgctaa gaggccctga tcccagctca ttcaggggag aacacgtcgt
     1741 ggggttcctg tcacgactat cacttgagat tatattatta tcctcactcc ctcgctgtct
     1801 ggagacggtc acaccttctg gcaaattcaa gaggcatgag tggaccgaga gcacatccag
     1861 catttgcatc acctccctgg cacctcccat agttacagcc actacatccc caccgccgcc
     1921 tgtcatccct cacgtctctg tggccacccg ggtgtcactg ccagcaccag gcactgcttt
     1981 cacgtaaaat gtccaaatca catcttcagc aagaaagcaa cctcacggat tgccccgcct
     2041 caaggtcttt ccaccctctt tgagatcagc gttcggagag gtccccgcca gcccggtggc
     2101 tgccctcagg tcccgtcaca tgtctcaagg gtccagcgtt cgaggaagca ctgttgtaga
     2161 tgacagagct ttttgtttca cagctgcggg gattctgctg accatctttt agaaaattat
     2221 ttcataattt attctggctt tgcccccttg ctccttggtt tattccctca tgttttactc
     2281 aaaataaaca tggccatgaa ctcaggggcc attgggattc tcccctctgg cagccccagg
     2341 tgggagctgg gagggtcccc agcccaggag gtggctggat tgcagggctg gcagccccca
     2401 cgtggtggca tcctgacagg cacagtgaga cccttgctgg gtcaggtctc ctttgtgtgt
     2461 gaagctgggg cagagtatgc tacgaaggga ccaggccagg ccacagggct ctcctcccag
     2521 tctttatctg aaggcccagc caaagcaccc ctctaaaccg gtcacctagg ggaaatgcaa
     2581 aaacctgcaa aagatccacc tgtattccct gtgtgtgtgt gtcaaaatga ccatttgcca
     2641 acctggctgt gaggtaatgt atgtaaagca ccgagtcagg tgcctgatac gcagtaggtg
     2701 cttagcaaac ggtagctaat actatcatca ttgtcattgt tattgtgaca cccatgagcc
     2761 cacagacaga gctgtattaa gtaacctgtt ttgaatccag acattcactc ccccacttgc
     2821 tatgactacc ctcctttgat ctatttttgg tcataggtaa aaaaaaaaat ctctcttggg
     2881 agcatataaa caaaaaacat agaagcaata aagcgatcgc tggtatttct tttctcatgc
     2941 agccaaattc gccagctggt gaccaaaggc tcagatgctt gcttatttgc agacccggcc
     3001 tcctgggtgc tccccagtga cccatctttc caccccacca cctccaagtc ctgtctatgt
     3061 ctgcttccac acagccctgt ccccagggca ccagccttct gtccctcaca gcagtgccat
     3121 cgcgggcatt aggagtcttc gttatgttgt atccttgtga gttcttgact accatgccca
     3181 agtttccccc actggcaatg gttcctctct tggaggtaca gtggaaacca gagagatgac
     3241 agatgttgag tcctcagtgt ctcagaggca gcaattcttg ctggacacct gcacatgctc
     3301 agcacagagg ctggtacttt ggaggcacta accacttgat gagtaaatca atggcataaa
     3361 gccccattcc aagttatggg gtcttttgac aggccccttt catcctcttt ctctttgtat
     3421 aaacctcatg tttcagaaca aaattacagt ctaagttcat ttgcccccag ccttgcccaa
     3481 ggatccccgg gctgtgctga cccctaggca tagggcaaag ggtgttccca agcagcaggc
     3541 acctcagtgc cctcagttat ccagggcaag gggcctggct gccccctgct cctccccatg
     3601 atgcaggggc tttctaagcc aggctgcaga cagggcaggg ttggcttctt ggccattccc
     3661 tctgtgcccc cttctccttc tgactggtct caccctggag atccccagag gatctgacca
     3721 gagccaggtg gactgtggcc ctgagatgga gctggctgca ggcttacaag cacctctggg
     3781 gacatccaga ggggagggtc agtaagcaca acggagctag ggagacttca gatggactca
     3841 aacccagagc aataatactc tcacaccacc ccacagctaa ggcactcatg ttccccagta
     3901 gatcaagcca gaagctttgc aagaagggag tggaacgagg ctgcctatcc aaggtccatc
     3961 taccacgcag aacttggtca tgcaagtaca tttggaaaat ctggtcttgg cccgtccccc
     4021 attggcctgg tctacacagc caaaaattca gactagatta gatgtttgca ggcaattctg
     4081 tagcaaagca aattccccta ccccgtccct tccccctaga agctgcctta gcctccctga
     4141 ctgggtgtgg tctctgggcc taggactcct ccctatgagg aaaagtgctc tccagccaca
     4201 tcttggcagc cccacaacca cagcatcagg gcagctgcag caagtgacca cccacccgtc
     4261 gggttagaca cacaaggcac caggcactgg catctgacta aaataacctt tccctacatg
     4321 ggaagaggaa agcttgtagg ctggcacata taaacgtcca gccgcagcca gatggcctga
     4381 actaagcagc aggaactctc tgggctgggg aggagcctcc tgcccttcta gaaagtgatg
     4441 cgtcagcttt gttctcctgg gaaggtgttg ctatacccca ggaacaaagc agggcccaac
     4501 tgccagtgca gtcagctggg cctgcgctcc aggctcacca ccgctaagtg gtcaggtacc
     4561 gggccagcat cctgggaggg acctcttgcg actctgagtt gcagcttgga ctagctgaac
     4621 acatggggac atgctccagg ggcttcttcc ctggcaggat tcctgggatt tcaaactacc
     4681 tcaccaacag gacgctgaac caggagcctg ccacccaact ggcccccttg gtgattgtgg
     4741 aaggtgatgt ttttcctaaa atgcatccct cctgttctgc tccatataca tgtgcttcaa
     4801 aaaccaccac caggaaagcc ttcccagaag agggaaagga ttaagggctc tcttcctttg
     4861 ggccctgcag aatgtattgg agggaggtgt tgctgcaagg tccaggagct gggaaactct
     4921 gggctcgggg ggagataatg caccaccagc ctcaaaaagg agctgcccaa gttgaatatg
     4981 tagcaaagac catgggataa gttgaatagt ggccagacga atcactaata actcaccatg
     5041 ggaccctctg aagagaggcc tgtgctcgtg taaccatagc aacagcagat gccagcaacc
     5101 tactcattag taccacccag tgataaggca tcccctgggc tagacccagg ggccataaag
     5161 tagcaaagta gcaaatgtag caataaaggg cccgggtcta tacggggaca gggtccaaat
     5221 gaccaggact tggccctctc cccagccccg atgagggctc agagccagct gctgtcagct
     5281 gtctggggag ggaaggccct gctccatacc aggggtccct gttctatact ctaagcccac
     5341 tcaccgcatg atcacggact catcggaatg gcctcctctt agtgcatgtg gttctcttta
     5401 gtttattttt ctggaatttg gggattggac cccagaacca aacatgctgg tacagtctaa
     5461 aaataaatga cttgaaccca cttcaatcca
//
