LOCUS       NM_001370280            6094 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 22, mRNA.
ACCESSION   NM_001370280
VERSION     NM_001370280.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6094)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6094)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6094)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6094)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6094)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 6094)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 6094)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 6094)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 6094)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 6094)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1325           AC005533.2         30089-30187         c
            1326-1387           AC005533.2         28600-28661         c
            1388-1498           AC005533.2         11667-11777         c
            1499-1685           AC004828.2         171441-171627       c
            1686-1775           AC004828.2         153703-153792       c
            1776-1829           AC004828.2         149884-149937       c
            1830-1980           AC004828.2         148358-148508       c
            1981-6094           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..6094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6094
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..2153
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 15 is encoded by transcript variant 22;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 15"
                     /protein_id="NP_001357209.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMRFWLAVQDLKKQP
                     LQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMK
                     SDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVNVQNTRPAGAWSIFMAAL
                     PMAVWLRTPRSCHGLSESRLLGLPSLHDGLREGKVAGGQAPHGPDAVLLTVPTAGPGP
                     GPADPTGRRRRSTSADRVSLRGDLVTVKEKE"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1498
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1685
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1775
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1829
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1980
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..6094
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3512
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      6066..6071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      6094
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaagttt aattgcctac acggaacaat atgtggaata tgaccctttg ataacaccag
     1441 ctgagccatc caacccttgg atcagcgatg acgttgcttt gtgggacata gagatgaggt
     1501 tctggctggc tgtccaagat cttaagaaac aacccctaca ggatgtggcc aagagggtag
     1561 aagaaatctg gcaagagttt ctggctccag gggctccaag tgcaatcaac ctggattctc
     1621 acagctatga gataaccagt caaaatgtca aagatggagg gagatataca tttgaagacg
     1681 cccaggagca catctacaag ctgatgaaga gtgacagcta tgcccgcttc ctccggtcaa
     1741 atgcttacca ggatttgctg ctggccaaga agaagccaga aagtgagcaa ggtcgtagaa
     1801 cttccctaga aaagttcact cgcagtgtga atgtgcagaa cacaaggcct gcgggtgcct
     1861 ggtctatctt catggctgct ttgccaatgg ccgtgtggct ccgcacacca agaagctgcc
     1921 acgggctgtc agagtcaagg cttctgggac ttccttcact ccatgatggc ctgagagaag
     1981 ggaaagtcgc tggcgggcaa gcgcctcacg ggcctgatgc agtcctcctg accgttccta
     2041 ccgcaggtcc agggcctggg cccgcggacc ccacaggcag gcggcggcgc tccacatctg
     2101 cggacagagt ttccttacga ggagacttgg tcactgtgaa ggagaaagag tgagggcaat
     2161 gaagggcgat ggtggggaga ctcggtgggt gaatggggag accagaaaga aagagtccac
     2221 agagcctggg ctgggcccgg tggaggctcc tgtttacagc cctctcttct ttgtacagtt
     2281 gtattccaac actccactcg ctaagaggcc ctgatcccag ctcattcagg ggagaacacg
     2341 tcgtggggtt cctgtcacga ctatcacttg agattatatt attatcctca ctccctcgct
     2401 gtctggagac ggtcacacct tctggcaaat tcaagaggca tgagtggacc gagagcacat
     2461 ccagcatttg catcacctcc ctggcacctc ccatagttac agccactaca tccccaccgc
     2521 cgcctgtcat ccctcacgtc tctgtggcca cccgggtgtc actgccagca ccaggcactg
     2581 ctttcacgta aaatgtccaa atcacatctt cagcaagaaa gcaacctcac ggattgcccc
     2641 gcctcaaggt ctttccaccc tctttgagat cagcgttcgg agaggtcccc gccagcccgg
     2701 tggctgccct caggtcccgt cacatgtctc aagggtccag cgttcgagga agcactgttg
     2761 tagatgacag agctttttgt ttcacagctg cggggattct gctgaccatc ttttagaaaa
     2821 ttatttcata atttattctg gctttgcccc cttgctcctt ggtttattcc ctcatgtttt
     2881 actcaaaata aacatggcca tgaactcagg ggccattggg attctcccct ctggcagccc
     2941 caggtgggag ctgggagggt ccccagccca ggaggtggct ggattgcagg gctggcagcc
     3001 cccacgtggt ggcatcctga caggcacagt gagacccttg ctgggtcagg tctcctttgt
     3061 gtgtgaagct ggggcagagt atgctacgaa gggaccaggc caggccacag ggctctcctc
     3121 ccagtcttta tctgaaggcc cagccaaagc acccctctaa accggtcacc taggggaaat
     3181 gcaaaaacct gcaaaagatc cacctgtatt ccctgtgtgt gtgtgtcaaa atgaccattt
     3241 gccaacctgg ctgtgaggta atgtatgtaa agcaccgagt caggtgcctg atacgcagta
     3301 ggtgcttagc aaacggtagc taatactatc atcattgtca ttgttattgt gacacccatg
     3361 agcccacaga cagagctgta ttaagtaacc tgttttgaat ccagacattc actcccccac
     3421 ttgctatgac taccctcctt tgatctattt ttggtcatag gtaaaaaaaa aaatctctct
     3481 tgggagcata taaacaaaaa acatagaagc aataaagcga tcgctggtat ttcttttctc
     3541 atgcagccaa attcgccagc tggtgaccaa aggctcagat gcttgcttat ttgcagaccc
     3601 ggcctcctgg gtgctcccca gtgacccatc tttccacccc accacctcca agtcctgtct
     3661 atgtctgctt ccacacagcc ctgtccccag ggcaccagcc ttctgtccct cacagcagtg
     3721 ccatcgcggg cattaggagt cttcgttatg ttgtatcctt gtgagttctt gactaccatg
     3781 cccaagtttc ccccactggc aatggttcct ctcttggagg tacagtggaa accagagaga
     3841 tgacagatgt tgagtcctca gtgtctcaga ggcagcaatt cttgctggac acctgcacat
     3901 gctcagcaca gaggctggta ctttggaggc actaaccact tgatgagtaa atcaatggca
     3961 taaagcccca ttccaagtta tggggtcttt tgacaggccc ctttcatcct ctttctcttt
     4021 gtataaacct catgtttcag aacaaaatta cagtctaagt tcatttgccc ccagccttgc
     4081 ccaaggatcc ccgggctgtg ctgaccccta ggcatagggc aaagggtgtt cccaagcagc
     4141 aggcacctca gtgccctcag ttatccaggg caaggggcct ggctgccccc tgctcctccc
     4201 catgatgcag gggctttcta agccaggctg cagacagggc agggttggct tcttggccat
     4261 tccctctgtg cccccttctc cttctgactg gtctcaccct ggagatcccc agaggatctg
     4321 accagagcca ggtggactgt ggccctgaga tggagctggc tgcaggctta caagcacctc
     4381 tggggacatc cagaggggag ggtcagtaag cacaacggag ctagggagac ttcagatgga
     4441 ctcaaaccca gagcaataat actctcacac caccccacag ctaaggcact catgttcccc
     4501 agtagatcaa gccagaagct ttgcaagaag ggagtggaac gaggctgcct atccaaggtc
     4561 catctaccac gcagaacttg gtcatgcaag tacatttgga aaatctggtc ttggcccgtc
     4621 ccccattggc ctggtctaca cagccaaaaa ttcagactag attagatgtt tgcaggcaat
     4681 tctgtagcaa agcaaattcc cctaccccgt cccttccccc tagaagctgc cttagcctcc
     4741 ctgactgggt gtggtctctg ggcctaggac tcctccctat gaggaaaagt gctctccagc
     4801 cacatcttgg cagccccaca accacagcat cagggcagct gcagcaagtg accacccacc
     4861 cgtcgggtta gacacacaag gcaccaggca ctggcatctg actaaaataa cctttcccta
     4921 catgggaaga ggaaagcttg taggctggca catataaacg tccagccgca gccagatggc
     4981 ctgaactaag cagcaggaac tctctgggct ggggaggagc ctcctgccct tctagaaagt
     5041 gatgcgtcag ctttgttctc ctgggaaggt gttgctatac cccaggaaca aagcagggcc
     5101 caactgccag tgcagtcagc tgggcctgcg ctccaggctc accaccgcta agtggtcagg
     5161 taccgggcca gcatcctggg agggacctct tgcgactctg agttgcagct tggactagct
     5221 gaacacatgg ggacatgctc caggggcttc ttccctggca ggattcctgg gatttcaaac
     5281 tacctcacca acaggacgct gaaccaggag cctgccaccc aactggcccc cttggtgatt
     5341 gtggaaggtg atgtttttcc taaaatgcat ccctcctgtt ctgctccata tacatgtgct
     5401 tcaaaaacca ccaccaggaa agccttccca gaagagggaa aggattaagg gctctcttcc
     5461 tttgggccct gcagaatgta ttggagggag gtgttgctgc aaggtccagg agctgggaaa
     5521 ctctgggctc ggggggagat aatgcaccac cagcctcaaa aaggagctgc ccaagttgaa
     5581 tatgtagcaa agaccatggg ataagttgaa tagtggccag acgaatcact aataactcac
     5641 catgggaccc tctgaagaga ggcctgtgct cgtgtaacca tagcaacagc agatgccagc
     5701 aacctactca ttagtaccac ccagtgataa ggcatcccct gggctagacc caggggccat
     5761 aaagtagcaa agtagcaaat gtagcaataa agggcccggg tctatacggg gacagggtcc
     5821 aaatgaccag gacttggccc tctccccagc cccgatgagg gctcagagcc agctgctgtc
     5881 agctgtctgg ggagggaagg ccctgctcca taccaggggt ccctgttcta tactctaagc
     5941 ccactcaccg catgatcacg gactcatcgg aatggcctcc tcttagtgca tgtggttctc
     6001 tttagtttat ttttctggaa tttggggatt ggaccccaga accaaacatg ctggtacagt
     6061 ctaaaaataa atgacttgaa cccacttcaa tcca
//
