LOCUS       NM_001370279            5695 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 21, mRNA.
ACCESSION   NM_001370279
VERSION     NM_001370279.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5695)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5695)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5695)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5695)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5695)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5695)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5695)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5695)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5695)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5695)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-785             AC005533.2         32239-32304         c
            786-884             AC005533.2         30089-30187         c
            885-946             AC005533.2         28600-28661         c
            947-1057            AC005533.2         11667-11777         c
            1058-1183           AC004828.2         179699-179824       c
            1184-1370           AC004828.2         171441-171627       c
            1371-1460           AC004828.2         153703-153792       c
            1461-1514           AC004828.2         149884-149937       c
            1515-1581           AC004828.2         136622-136688       c
            1582-5695           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5695
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1754
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 14 is encoded by transcript variant 21;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 14"
                     /protein_id="NP_001357208.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHCLKM
                     SKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSF
                     DEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPG
                     APSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLA
                     KKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGPDAV
                     LLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGDLVTVKEKE"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..785
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            786..884
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            885..946
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1057
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1183
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1370
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1460
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1514
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1581
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..5695
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3113
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5667..5672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5695
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaagtccgt gtatggcgtg actgaagagt cccaggcaca gagcccggtg catgtactca
      841 gccaaccaat caggaaaaca acaaaagagg acatccggaa acagataaca tttttgaacg
      901 cacagatcga cagacattgt ttgaaaatgt ccaaagtggc tgaaagttta attgcctaca
      961 cggaacaata tgtggaatat gaccctttga taacaccagc tgagccatcc aacccttgga
     1021 tcagcgatga cgttgctttg tgggacatag agatgagcaa agagcccagc caacagcgag
     1081 taaaaagatg gggcttctct ttcgatgaga tattgaagga ccaggtgggg cgggaccagt
     1141 ttctacgatt cctggagtcc gaattcagtt cagaaaacct caggttctgg ctggctgtcc
     1201 aagatcttaa gaaacaaccc ctacaggatg tggccaagag ggtagaagaa atctggcaag
     1261 agtttctggc tccaggggct ccaagtgcaa tcaacctgga ttctcacagc tatgagataa
     1321 ccagtcaaaa tgtcaaagat ggagggagat atacatttga agacgcccag gagcacatct
     1381 acaagctgat gaagagtgac agctatgccc gcttcctccg gtcaaatgct taccaggatt
     1441 tgctgctggc caagaagaag ccagaaagtg agcaaggtcg tagaacttcc ctagaaaagt
     1501 tcactcgcag tgtgtgctgc tggcgcagag tcagaatggc cgctgcattt cacccccgag
     1561 gtggcttcct tccagcagtg gggaaagtcg ctggcgggca agcgcctcac gggcctgatg
     1621 cagtcctcct gaccgttcct accgcaggtc cagggcctgg gcccgcggac cccacaggca
     1681 ggcggcggcg ctccacatct gcggacagag tttccttacg aggagacttg gtcactgtga
     1741 aggagaaaga gtgagggcaa tgaagggcga tggtggggag actcggtggg tgaatgggga
     1801 gaccagaaag aaagagtcca cagagcctgg gctgggcccg gtggaggctc ctgtttacag
     1861 ccctctcttc tttgtacagt tgtattccaa cactccactc gctaagaggc cctgatccca
     1921 gctcattcag gggagaacac gtcgtggggt tcctgtcacg actatcactt gagattatat
     1981 tattatcctc actccctcgc tgtctggaga cggtcacacc ttctggcaaa ttcaagaggc
     2041 atgagtggac cgagagcaca tccagcattt gcatcacctc cctggcacct cccatagtta
     2101 cagccactac atccccaccg ccgcctgtca tccctcacgt ctctgtggcc acccgggtgt
     2161 cactgccagc accaggcact gctttcacgt aaaatgtcca aatcacatct tcagcaagaa
     2221 agcaacctca cggattgccc cgcctcaagg tctttccacc ctctttgaga tcagcgttcg
     2281 gagaggtccc cgccagcccg gtggctgccc tcaggtcccg tcacatgtct caagggtcca
     2341 gcgttcgagg aagcactgtt gtagatgaca gagctttttg tttcacagct gcggggattc
     2401 tgctgaccat cttttagaaa attatttcat aatttattct ggctttgccc ccttgctcct
     2461 tggtttattc cctcatgttt tactcaaaat aaacatggcc atgaactcag gggccattgg
     2521 gattctcccc tctggcagcc ccaggtggga gctgggaggg tccccagccc aggaggtggc
     2581 tggattgcag ggctggcagc ccccacgtgg tggcatcctg acaggcacag tgagaccctt
     2641 gctgggtcag gtctcctttg tgtgtgaagc tggggcagag tatgctacga agggaccagg
     2701 ccaggccaca gggctctcct cccagtcttt atctgaaggc ccagccaaag cacccctcta
     2761 aaccggtcac ctaggggaaa tgcaaaaacc tgcaaaagat ccacctgtat tccctgtgtg
     2821 tgtgtgtcaa aatgaccatt tgccaacctg gctgtgaggt aatgtatgta aagcaccgag
     2881 tcaggtgcct gatacgcagt aggtgcttag caaacggtag ctaatactat catcattgtc
     2941 attgttattg tgacacccat gagcccacag acagagctgt attaagtaac ctgttttgaa
     3001 tccagacatt cactccccca cttgctatga ctaccctcct ttgatctatt tttggtcata
     3061 ggtaaaaaaa aaaatctctc ttgggagcat ataaacaaaa aacatagaag caataaagcg
     3121 atcgctggta tttcttttct catgcagcca aattcgccag ctggtgacca aaggctcaga
     3181 tgcttgctta tttgcagacc cggcctcctg ggtgctcccc agtgacccat ctttccaccc
     3241 caccacctcc aagtcctgtc tatgtctgct tccacacagc cctgtcccca gggcaccagc
     3301 cttctgtccc tcacagcagt gccatcgcgg gcattaggag tcttcgttat gttgtatcct
     3361 tgtgagttct tgactaccat gcccaagttt cccccactgg caatggttcc tctcttggag
     3421 gtacagtgga aaccagagag atgacagatg ttgagtcctc agtgtctcag aggcagcaat
     3481 tcttgctgga cacctgcaca tgctcagcac agaggctggt actttggagg cactaaccac
     3541 ttgatgagta aatcaatggc ataaagcccc attccaagtt atggggtctt ttgacaggcc
     3601 cctttcatcc tctttctctt tgtataaacc tcatgtttca gaacaaaatt acagtctaag
     3661 ttcatttgcc cccagccttg cccaaggatc cccgggctgt gctgacccct aggcataggg
     3721 caaagggtgt tcccaagcag caggcacctc agtgccctca gttatccagg gcaaggggcc
     3781 tggctgcccc ctgctcctcc ccatgatgca ggggctttct aagccaggct gcagacaggg
     3841 cagggttggc ttcttggcca ttccctctgt gcccccttct ccttctgact ggtctcaccc
     3901 tggagatccc cagaggatct gaccagagcc aggtggactg tggccctgag atggagctgg
     3961 ctgcaggctt acaagcacct ctggggacat ccagagggga gggtcagtaa gcacaacgga
     4021 gctagggaga cttcagatgg actcaaaccc agagcaataa tactctcaca ccaccccaca
     4081 gctaaggcac tcatgttccc cagtagatca agccagaagc tttgcaagaa gggagtggaa
     4141 cgaggctgcc tatccaaggt ccatctacca cgcagaactt ggtcatgcaa gtacatttgg
     4201 aaaatctggt cttggcccgt cccccattgg cctggtctac acagccaaaa attcagacta
     4261 gattagatgt ttgcaggcaa ttctgtagca aagcaaattc ccctaccccg tcccttcccc
     4321 ctagaagctg ccttagcctc cctgactggg tgtggtctct gggcctagga ctcctcccta
     4381 tgaggaaaag tgctctccag ccacatcttg gcagccccac aaccacagca tcagggcagc
     4441 tgcagcaagt gaccacccac ccgtcgggtt agacacacaa ggcaccaggc actggcatct
     4501 gactaaaata acctttccct acatgggaag aggaaagctt gtaggctggc acatataaac
     4561 gtccagccgc agccagatgg cctgaactaa gcagcaggaa ctctctgggc tggggaggag
     4621 cctcctgccc ttctagaaag tgatgcgtca gctttgttct cctgggaagg tgttgctata
     4681 ccccaggaac aaagcagggc ccaactgcca gtgcagtcag ctgggcctgc gctccaggct
     4741 caccaccgct aagtggtcag gtaccgggcc agcatcctgg gagggacctc ttgcgactct
     4801 gagttgcagc ttggactagc tgaacacatg gggacatgct ccaggggctt cttccctggc
     4861 aggattcctg ggatttcaaa ctacctcacc aacaggacgc tgaaccagga gcctgccacc
     4921 caactggccc ccttggtgat tgtggaaggt gatgtttttc ctaaaatgca tccctcctgt
     4981 tctgctccat atacatgtgc ttcaaaaacc accaccagga aagccttccc agaagaggga
     5041 aaggattaag ggctctcttc ctttgggccc tgcagaatgt attggaggga ggtgttgctg
     5101 caaggtccag gagctgggaa actctgggct cggggggaga taatgcacca ccagcctcaa
     5161 aaaggagctg cccaagttga atatgtagca aagaccatgg gataagttga atagtggcca
     5221 gacgaatcac taataactca ccatgggacc ctctgaagag aggcctgtgc tcgtgtaacc
     5281 atagcaacag cagatgccag caacctactc attagtacca cccagtgata aggcatcccc
     5341 tgggctagac ccaggggcca taaagtagca aagtagcaaa tgtagcaata aagggcccgg
     5401 gtctatacgg ggacagggtc caaatgacca ggacttggcc ctctccccag ccccgatgag
     5461 ggctcagagc cagctgctgt cagctgtctg gggagggaag gccctgctcc ataccagggg
     5521 tccctgttct atactctaag cccactcacc gcatgatcac ggactcatcg gaatggcctc
     5581 ctcttagtgc atgtggttct ctttagttta tttttctgga atttggggat tggaccccag
     5641 aaccaaacat gctggtacag tctaaaaata aatgacttga acccacttca atcca
//
