LOCUS       NM_001370278            5788 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 20, mRNA.
ACCESSION   NM_001370278
VERSION     NM_001370278.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5788)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5788)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5788)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5788)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5788)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5788)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5788)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5788)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5788)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5788)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-1523           AC004828.2         149884-149937       c
            1524-1674           AC004828.2         148358-148508       c
            1675-5788           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5788
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1847
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 13 is encoded by transcript variant 20;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 13"
                     /protein_id="NP_001357207.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVNVQNTRPAGAWSIFMAALPMAVWLRTPRSCHGLS
                     ESRLLGLPSLHDGLREGKVAGGQAPHGPDAVLLTVPTAGPGPGPADPTGRRRRSTSAD
                     RVSLRGDLVTVKEKE"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1523
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1674
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..5788
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3187..3192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3206
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5760..5765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5788
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaagc cagaaagtga gcaaggtcgt agaacttccc
     1501 tagaaaagtt cactcgcagt gtgaatgtgc agaacacaag gcctgcgggt gcctggtcta
     1561 tcttcatggc tgctttgcca atggccgtgt ggctccgcac accaagaagc tgccacgggc
     1621 tgtcagagtc aaggcttctg ggacttcctt cactccatga tggcctgaga gaagggaaag
     1681 tcgctggcgg gcaagcgcct cacgggcctg atgcagtcct cctgaccgtt cctaccgcag
     1741 gtccagggcc tgggcccgcg gaccccacag gcaggcggcg gcgctccaca tctgcggaca
     1801 gagtttcctt acgaggagac ttggtcactg tgaaggagaa agagtgaggg caatgaaggg
     1861 cgatggtggg gagactcggt gggtgaatgg ggagaccaga aagaaagagt ccacagagcc
     1921 tgggctgggc ccggtggagg ctcctgttta cagccctctc ttctttgtac agttgtattc
     1981 caacactcca ctcgctaaga ggccctgatc ccagctcatt caggggagaa cacgtcgtgg
     2041 ggttcctgtc acgactatca cttgagatta tattattatc ctcactccct cgctgtctgg
     2101 agacggtcac accttctggc aaattcaaga ggcatgagtg gaccgagagc acatccagca
     2161 tttgcatcac ctccctggca cctcccatag ttacagccac tacatcccca ccgccgcctg
     2221 tcatccctca cgtctctgtg gccacccggg tgtcactgcc agcaccaggc actgctttca
     2281 cgtaaaatgt ccaaatcaca tcttcagcaa gaaagcaacc tcacggattg ccccgcctca
     2341 aggtctttcc accctctttg agatcagcgt tcggagaggt ccccgccagc ccggtggctg
     2401 ccctcaggtc ccgtcacatg tctcaagggt ccagcgttcg aggaagcact gttgtagatg
     2461 acagagcttt ttgtttcaca gctgcgggga ttctgctgac catcttttag aaaattattt
     2521 cataatttat tctggctttg cccccttgct ccttggttta ttccctcatg ttttactcaa
     2581 aataaacatg gccatgaact caggggccat tgggattctc ccctctggca gccccaggtg
     2641 ggagctggga gggtccccag cccaggaggt ggctggattg cagggctggc agcccccacg
     2701 tggtggcatc ctgacaggca cagtgagacc cttgctgggt caggtctcct ttgtgtgtga
     2761 agctggggca gagtatgcta cgaagggacc aggccaggcc acagggctct cctcccagtc
     2821 tttatctgaa ggcccagcca aagcacccct ctaaaccggt cacctagggg aaatgcaaaa
     2881 acctgcaaaa gatccacctg tattccctgt gtgtgtgtgt caaaatgacc atttgccaac
     2941 ctggctgtga ggtaatgtat gtaaagcacc gagtcaggtg cctgatacgc agtaggtgct
     3001 tagcaaacgg tagctaatac tatcatcatt gtcattgtta ttgtgacacc catgagccca
     3061 cagacagagc tgtattaagt aacctgtttt gaatccagac attcactccc ccacttgcta
     3121 tgactaccct cctttgatct atttttggtc ataggtaaaa aaaaaaatct ctcttgggag
     3181 catataaaca aaaaacatag aagcaataaa gcgatcgctg gtatttcttt tctcatgcag
     3241 ccaaattcgc cagctggtga ccaaaggctc agatgcttgc ttatttgcag acccggcctc
     3301 ctgggtgctc cccagtgacc catctttcca ccccaccacc tccaagtcct gtctatgtct
     3361 gcttccacac agccctgtcc ccagggcacc agccttctgt ccctcacagc agtgccatcg
     3421 cgggcattag gagtcttcgt tatgttgtat ccttgtgagt tcttgactac catgcccaag
     3481 tttcccccac tggcaatggt tcctctcttg gaggtacagt ggaaaccaga gagatgacag
     3541 atgttgagtc ctcagtgtct cagaggcagc aattcttgct ggacacctgc acatgctcag
     3601 cacagaggct ggtactttgg aggcactaac cacttgatga gtaaatcaat ggcataaagc
     3661 cccattccaa gttatggggt cttttgacag gcccctttca tcctctttct ctttgtataa
     3721 acctcatgtt tcagaacaaa attacagtct aagttcattt gcccccagcc ttgcccaagg
     3781 atccccgggc tgtgctgacc cctaggcata gggcaaaggg tgttcccaag cagcaggcac
     3841 ctcagtgccc tcagttatcc agggcaaggg gcctggctgc cccctgctcc tccccatgat
     3901 gcaggggctt tctaagccag gctgcagaca gggcagggtt ggcttcttgg ccattccctc
     3961 tgtgccccct tctccttctg actggtctca ccctggagat ccccagagga tctgaccaga
     4021 gccaggtgga ctgtggccct gagatggagc tggctgcagg cttacaagca cctctgggga
     4081 catccagagg ggagggtcag taagcacaac ggagctaggg agacttcaga tggactcaaa
     4141 cccagagcaa taatactctc acaccacccc acagctaagg cactcatgtt ccccagtaga
     4201 tcaagccaga agctttgcaa gaagggagtg gaacgaggct gcctatccaa ggtccatcta
     4261 ccacgcagaa cttggtcatg caagtacatt tggaaaatct ggtcttggcc cgtcccccat
     4321 tggcctggtc tacacagcca aaaattcaga ctagattaga tgtttgcagg caattctgta
     4381 gcaaagcaaa ttcccctacc ccgtcccttc cccctagaag ctgccttagc ctccctgact
     4441 gggtgtggtc tctgggccta ggactcctcc ctatgaggaa aagtgctctc cagccacatc
     4501 ttggcagccc cacaaccaca gcatcagggc agctgcagca agtgaccacc cacccgtcgg
     4561 gttagacaca caaggcacca ggcactggca tctgactaaa ataacctttc cctacatggg
     4621 aagaggaaag cttgtaggct ggcacatata aacgtccagc cgcagccaga tggcctgaac
     4681 taagcagcag gaactctctg ggctggggag gagcctcctg cccttctaga aagtgatgcg
     4741 tcagctttgt tctcctggga aggtgttgct ataccccagg aacaaagcag ggcccaactg
     4801 ccagtgcagt cagctgggcc tgcgctccag gctcaccacc gctaagtggt caggtaccgg
     4861 gccagcatcc tgggagggac ctcttgcgac tctgagttgc agcttggact agctgaacac
     4921 atggggacat gctccagggg cttcttccct ggcaggattc ctgggatttc aaactacctc
     4981 accaacagga cgctgaacca ggagcctgcc acccaactgg cccccttggt gattgtggaa
     5041 ggtgatgttt ttcctaaaat gcatccctcc tgttctgctc catatacatg tgcttcaaaa
     5101 accaccacca ggaaagcctt cccagaagag ggaaaggatt aagggctctc ttcctttggg
     5161 ccctgcagaa tgtattggag ggaggtgttg ctgcaaggtc caggagctgg gaaactctgg
     5221 gctcgggggg agataatgca ccaccagcct caaaaaggag ctgcccaagt tgaatatgta
     5281 gcaaagacca tgggataagt tgaatagtgg ccagacgaat cactaataac tcaccatggg
     5341 accctctgaa gagaggcctg tgctcgtgta accatagcaa cagcagatgc cagcaaccta
     5401 ctcattagta ccacccagtg ataaggcatc ccctgggcta gacccagggg ccataaagta
     5461 gcaaagtagc aaatgtagca ataaagggcc cgggtctata cggggacagg gtccaaatga
     5521 ccaggacttg gccctctccc cagccccgat gagggctcag agccagctgc tgtcagctgt
     5581 ctggggaggg aaggccctgc tccataccag gggtccctgt tctatactct aagcccactc
     5641 accgcatgat cacggactca tcggaatggc ctcctcttag tgcatgtggt tctctttagt
     5701 ttatttttct ggaatttggg gattggaccc cagaaccaaa catgctggta cagtctaaaa
     5761 ataaatgact tgaacccact tcaatcca
//
