LOCUS       NM_001370277            6152 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 19, mRNA.
ACCESSION   NM_001370277
VERSION     NM_001370277.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6152)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6152)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6152)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6152)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6152)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 6152)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 6152)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 6152)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 6152)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 6152)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC005993.2         12683-12916         c
            235-338             AC005477.1         87628-87731         c
            339-438             AC005157.1         72588-72687         c
            439-489             AC005533.2         52351-52401         c
            490-596             AC005533.2         48552-48658         c
            597-648             AC005533.2         47246-47297         c
            649-713             AC005533.2         41107-41171         c
            714-790             AC005533.2         36846-36922         c
            791-872             AC005533.2         33976-34057         c
            873-947             AC005533.2         32230-32304         c
            948-1046            AC005533.2         30089-30187         c
            1047-1108           AC005533.2         28600-28661         c
            1109-1219           AC005533.2         11667-11777         c
            1220-1345           AC004828.2         179699-179824       c
            1346-1532           AC004828.2         171441-171627       c
            1533-1622           AC004828.2         153703-153792       c
            1623-1676           AC004828.2         149884-149937       c
            1677-1827           AC004828.2         148358-148508       c
            1828-2038           AC004828.2         142611-142821       c
            2039-6152           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..6152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6152
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..234
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            235..338
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..2075
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 12 is encoded by transcript variant 19;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 12"
                     /protein_id="NP_001357206.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVNVQNTRPAGAWSIFMAALPMAVWLRTPRSCHGLS
                     ESRLLGLPSLHDGLREGQSLPQSCPGSSSTAAEGARERASNGRSLARRQHCQCHGQGE
                     ETQLCLWSRLESSKRSQRASSLRTSKAKKESRWRASASRA"
     exon            339..438
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            439..489
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            490..596
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            597..648
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            649..713
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            714..790
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            791..872
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            873..947
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1046
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1108
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1219
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1345
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1532
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1622
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1676
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1827
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2038
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..6152
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3551..3556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3570
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      6124..6129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      6152
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttacag tcaccagcag gctgcgtaaa gaagtggccc agtgagacag ggaaagtgac
       61 ccagaaaatt tagttttgtt cagaatgaaa gctgctgtat ttcatttttg tttcttaatt
      121 tgacggagta ggaacgttat tttccttctc tgtcattgag accagtagca tttctatgtt
      181 acaaactgaa gatatttggg gtctcgtcgg cttgggatta tcaatgcttg ggagtgtgag
      241 tgaagacact caggatggct caaggatccg gggatcaaag agcagtgggg gttgctgacc
      301 cagaggagag ttctccaaac atgatcgttt actgcaaaat tgaagacatc attacaaaga
      361 tgcaagatga caagacaggg ggtgtgccca tcagaacagt caagagcttt ctctccaaaa
      421 tccccagtgt cgtcacaggt actgacattg tgcagtggct tatgaagaac ctttccattg
      481 aggacccagt tgaagcaata cacttgggga gccttatcgc tgcccagggc tacatctttc
      541 caatctcaga ccatgttctc accatgaagg atgatggcac cttttatcgt ttccaggctc
      601 cgtacttctg gccttcgaac tgctgggaac ctgaaaacac tgactatgcc atctatctct
      661 gtaagaggac aatgcaaaat aaagcaaggc tggaactggc agattatgaa gcagaaaact
      721 tagcaagact ccagagggcc tttgcgagga agtgggaatt catctttatg caagcagaag
      781 cacaagtaaa gattgaccgg aaaaaagaca agacagaaag gaaaattttg gatagtcaag
      841 aacgagcctt ttgggatgtc cacaggcctg tgccaggctg tgtgaacaca acagaaatgg
      901 atatccgaaa atgtcgacgt ttgaagaatc cacaaaaggt taaaaagtcc gtgtatggcg
      961 tgactgaaga gtcccaggca cagagcccgg tgcatgtact cagccaacca atcaggaaaa
     1021 caacaaaaga ggacatccgg aaacagataa catttttgaa cgcacagatc gacagacatt
     1081 gtttgaaaat gtccaaagtg gctgaaagtt taattgccta cacggaacaa tatgtggaat
     1141 atgacccttt gataacacca gctgagccat ccaacccttg gatcagcgat gacgttgctt
     1201 tgtgggacat agagatgagc aaagagccca gccaacagcg agtaaaaaga tggggcttct
     1261 ctttcgatga gatattgaag gaccaggtgg ggcgggacca gtttctacga ttcctggagt
     1321 ccgaattcag ttcagaaaac ctcaggttct ggctggctgt ccaagatctt aagaaacaac
     1381 ccctacagga tgtggccaag agggtagaag aaatctggca agagtttctg gctccagggg
     1441 ctccaagtgc aatcaacctg gattctcaca gctatgagat aaccagtcaa aatgtcaaag
     1501 atggagggag atatacattt gaagacgccc aggagcacat ctacaagctg atgaagagtg
     1561 acagctatgc ccgcttcctc cggtcaaatg cttaccagga tttgctgctg gccaagaaga
     1621 agccagaaag tgagcaaggt cgtagaactt ccctagaaaa gttcactcgc agtgtgaatg
     1681 tgcagaacac aaggcctgcg ggtgcctggt ctatcttcat ggctgctttg ccaatggccg
     1741 tgtggctccg cacaccaaga agctgccacg ggctgtcaga gtcaaggctt ctgggacttc
     1801 cttcactcca tgatggcctg agagaaggac agagcctgcc tcagtcctgt ccggggagca
     1861 gcagcaccgc agcagagggg gccagagaaa gagcatccaa tggcaggagt ctggcaaggc
     1921 gacagcactg ccaatgtcac ggtcaaggag aggagaccca actctgcctg tggtccagac
     1981 tggaaagttc aaagagaagt cagagagctt caagtctgag gacttcaaag gctaagaagg
     2041 aaagtcgctg gcgggcaagc gcctcacggg cctgatgcag tcctcctgac cgttcctacc
     2101 gcaggtccag ggcctgggcc cgcggacccc acaggcaggc ggcggcgctc cacatctgcg
     2161 gacagagttt ccttacgagg agacttggtc actgtgaagg agaaagagtg agggcaatga
     2221 agggcgatgg tggggagact cggtgggtga atggggagac cagaaagaaa gagtccacag
     2281 agcctgggct gggcccggtg gaggctcctg tttacagccc tctcttcttt gtacagttgt
     2341 attccaacac tccactcgct aagaggccct gatcccagct cattcagggg agaacacgtc
     2401 gtggggttcc tgtcacgact atcacttgag attatattat tatcctcact ccctcgctgt
     2461 ctggagacgg tcacaccttc tggcaaattc aagaggcatg agtggaccga gagcacatcc
     2521 agcatttgca tcacctccct ggcacctccc atagttacag ccactacatc cccaccgccg
     2581 cctgtcatcc ctcacgtctc tgtggccacc cgggtgtcac tgccagcacc aggcactgct
     2641 ttcacgtaaa atgtccaaat cacatcttca gcaagaaagc aacctcacgg attgccccgc
     2701 ctcaaggtct ttccaccctc tttgagatca gcgttcggag aggtccccgc cagcccggtg
     2761 gctgccctca ggtcccgtca catgtctcaa gggtccagcg ttcgaggaag cactgttgta
     2821 gatgacagag ctttttgttt cacagctgcg gggattctgc tgaccatctt ttagaaaatt
     2881 atttcataat ttattctggc tttgccccct tgctccttgg tttattccct catgttttac
     2941 tcaaaataaa catggccatg aactcagggg ccattgggat tctcccctct ggcagcccca
     3001 ggtgggagct gggagggtcc ccagcccagg aggtggctgg attgcagggc tggcagcccc
     3061 cacgtggtgg catcctgaca ggcacagtga gacccttgct gggtcaggtc tcctttgtgt
     3121 gtgaagctgg ggcagagtat gctacgaagg gaccaggcca ggccacaggg ctctcctccc
     3181 agtctttatc tgaaggccca gccaaagcac ccctctaaac cggtcaccta ggggaaatgc
     3241 aaaaacctgc aaaagatcca cctgtattcc ctgtgtgtgt gtgtcaaaat gaccatttgc
     3301 caacctggct gtgaggtaat gtatgtaaag caccgagtca ggtgcctgat acgcagtagg
     3361 tgcttagcaa acggtagcta atactatcat cattgtcatt gttattgtga cacccatgag
     3421 cccacagaca gagctgtatt aagtaacctg ttttgaatcc agacattcac tcccccactt
     3481 gctatgacta ccctcctttg atctattttt ggtcataggt aaaaaaaaaa atctctcttg
     3541 ggagcatata aacaaaaaac atagaagcaa taaagcgatc gctggtattt cttttctcat
     3601 gcagccaaat tcgccagctg gtgaccaaag gctcagatgc ttgcttattt gcagacccgg
     3661 cctcctgggt gctccccagt gacccatctt tccaccccac cacctccaag tcctgtctat
     3721 gtctgcttcc acacagccct gtccccaggg caccagcctt ctgtccctca cagcagtgcc
     3781 atcgcgggca ttaggagtct tcgttatgtt gtatccttgt gagttcttga ctaccatgcc
     3841 caagtttccc ccactggcaa tggttcctct cttggaggta cagtggaaac cagagagatg
     3901 acagatgttg agtcctcagt gtctcagagg cagcaattct tgctggacac ctgcacatgc
     3961 tcagcacaga ggctggtact ttggaggcac taaccacttg atgagtaaat caatggcata
     4021 aagccccatt ccaagttatg gggtcttttg acaggcccct ttcatcctct ttctctttgt
     4081 ataaacctca tgtttcagaa caaaattaca gtctaagttc atttgccccc agccttgccc
     4141 aaggatcccc gggctgtgct gacccctagg catagggcaa agggtgttcc caagcagcag
     4201 gcacctcagt gccctcagtt atccagggca aggggcctgg ctgccccctg ctcctcccca
     4261 tgatgcaggg gctttctaag ccaggctgca gacagggcag ggttggcttc ttggccattc
     4321 cctctgtgcc cccttctcct tctgactggt ctcaccctgg agatccccag aggatctgac
     4381 cagagccagg tggactgtgg ccctgagatg gagctggctg caggcttaca agcacctctg
     4441 gggacatcca gaggggaggg tcagtaagca caacggagct agggagactt cagatggact
     4501 caaacccaga gcaataatac tctcacacca ccccacagct aaggcactca tgttccccag
     4561 tagatcaagc cagaagcttt gcaagaaggg agtggaacga ggctgcctat ccaaggtcca
     4621 tctaccacgc agaacttggt catgcaagta catttggaaa atctggtctt ggcccgtccc
     4681 ccattggcct ggtctacaca gccaaaaatt cagactagat tagatgtttg caggcaattc
     4741 tgtagcaaag caaattcccc taccccgtcc cttcccccta gaagctgcct tagcctccct
     4801 gactgggtgt ggtctctggg cctaggactc ctccctatga ggaaaagtgc tctccagcca
     4861 catcttggca gccccacaac cacagcatca gggcagctgc agcaagtgac cacccacccg
     4921 tcgggttaga cacacaaggc accaggcact ggcatctgac taaaataacc tttccctaca
     4981 tgggaagagg aaagcttgta ggctggcaca tataaacgtc cagccgcagc cagatggcct
     5041 gaactaagca gcaggaactc tctgggctgg ggaggagcct cctgcccttc tagaaagtga
     5101 tgcgtcagct ttgttctcct gggaaggtgt tgctataccc caggaacaaa gcagggccca
     5161 actgccagtg cagtcagctg ggcctgcgct ccaggctcac caccgctaag tggtcaggta
     5221 ccgggccagc atcctgggag ggacctcttg cgactctgag ttgcagcttg gactagctga
     5281 acacatgggg acatgctcca ggggcttctt ccctggcagg attcctggga tttcaaacta
     5341 cctcaccaac aggacgctga accaggagcc tgccacccaa ctggccccct tggtgattgt
     5401 ggaaggtgat gtttttccta aaatgcatcc ctcctgttct gctccatata catgtgcttc
     5461 aaaaaccacc accaggaaag ccttcccaga agagggaaag gattaagggc tctcttcctt
     5521 tgggccctgc agaatgtatt ggagggaggt gttgctgcaa ggtccaggag ctgggaaact
     5581 ctgggctcgg ggggagataa tgcaccacca gcctcaaaaa ggagctgccc aagttgaata
     5641 tgtagcaaag accatgggat aagttgaata gtggccagac gaatcactaa taactcacca
     5701 tgggaccctc tgaagagagg cctgtgctcg tgtaaccata gcaacagcag atgccagcaa
     5761 cctactcatt agtaccaccc agtgataagg catcccctgg gctagaccca ggggccataa
     5821 agtagcaaag tagcaaatgt agcaataaag ggcccgggtc tatacgggga cagggtccaa
     5881 atgaccagga cttggccctc tccccagccc cgatgagggc tcagagccag ctgctgtcag
     5941 ctgtctgggg agggaaggcc ctgctccata ccaggggtcc ctgttctata ctctaagccc
     6001 actcaccgca tgatcacgga ctcatcggaa tggcctcctc ttagtgcatg tggttctctt
     6061 tagtttattt ttctggaatt tggggattgg accccagaac caaacatgct ggtacagtct
     6121 aaaaataaat gacttgaacc cacttcaatc ca
//
