LOCUS       NM_001370276            5575 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 18, mRNA.
ACCESSION   NM_001370276 XM_017021819
VERSION     NM_001370276.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5575)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5575)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5575)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5575)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5575)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5575)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5575)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5575)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5575)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5575)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_017021819.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-1523           AC004828.2         149884-149937       c
            1524-1590           AC004828.2         136622-136688       c
            1591-1759           AC004828.2         127393-127561       c
            1760-5575           AC004828.2         123448-127263       c
FEATURES             Location/Qualifiers
     source          1..5575
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5575
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2072
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 11 is encoded by transcript variant 18;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 11"
                     /protein_id="NP_001357205.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGP
                     DAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGDLVTVKEKDCIPTLHSLRGPDP
                     SSFRGEHVVGFLSRLSLEIILLSSLPRCLETVTPSGKFKRHEWTESTSSICITSLAPP
                     IVTATTSPPPPVIPHVSVATRVSLPAPGTAFT"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1523
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1590
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1759
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..5575
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2974..2979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2993
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5547..5552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5575
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaagc cagaaagtga gcaaggtcgt agaacttccc
     1501 tagaaaagtt cactcgcagt gtgtgctgct ggcgcagagt cagaatggcc gctgcatttc
     1561 acccccgagg tggcttcctt ccagcagtgg ggaaagtcgc tggcgggcaa gcgcctcacg
     1621 ggcctgatgc agtcctcctg accgttccta ccgcaggtcc agggcctggg cccgcggacc
     1681 ccacaggcag gcggcggcgc tccacatctg cggacagagt ttccttacga ggagacttgg
     1741 tcactgtgaa ggagaaagat tgtattccaa cactccactc gctaagaggc cctgatccca
     1801 gctcattcag gggagaacac gtcgtggggt tcctgtcacg actatcactt gagattatat
     1861 tattatcctc actccctcgc tgtctggaga cggtcacacc ttctggcaaa ttcaagaggc
     1921 atgagtggac cgagagcaca tccagcattt gcatcacctc cctggcacct cccatagtta
     1981 cagccactac atccccaccg ccgcctgtca tccctcacgt ctctgtggcc acccgggtgt
     2041 cactgccagc accaggcact gctttcacgt aaaatgtcca aatcacatct tcagcaagaa
     2101 agcaacctca cggattgccc cgcctcaagg tctttccacc ctctttgaga tcagcgttcg
     2161 gagaggtccc cgccagcccg gtggctgccc tcaggtcccg tcacatgtct caagggtcca
     2221 gcgttcgagg aagcactgtt gtagatgaca gagctttttg tttcacagct gcggggattc
     2281 tgctgaccat cttttagaaa attatttcat aatttattct ggctttgccc ccttgctcct
     2341 tggtttattc cctcatgttt tactcaaaat aaacatggcc atgaactcag gggccattgg
     2401 gattctcccc tctggcagcc ccaggtggga gctgggaggg tccccagccc aggaggtggc
     2461 tggattgcag ggctggcagc ccccacgtgg tggcatcctg acaggcacag tgagaccctt
     2521 gctgggtcag gtctcctttg tgtgtgaagc tggggcagag tatgctacga agggaccagg
     2581 ccaggccaca gggctctcct cccagtcttt atctgaaggc ccagccaaag cacccctcta
     2641 aaccggtcac ctaggggaaa tgcaaaaacc tgcaaaagat ccacctgtat tccctgtgtg
     2701 tgtgtgtcaa aatgaccatt tgccaacctg gctgtgaggt aatgtatgta aagcaccgag
     2761 tcaggtgcct gatacgcagt aggtgcttag caaacggtag ctaatactat catcattgtc
     2821 attgttattg tgacacccat gagcccacag acagagctgt attaagtaac ctgttttgaa
     2881 tccagacatt cactccccca cttgctatga ctaccctcct ttgatctatt tttggtcata
     2941 ggtaaaaaaa aaaatctctc ttgggagcat ataaacaaaa aacatagaag caataaagcg
     3001 atcgctggta tttcttttct catgcagcca aattcgccag ctggtgacca aaggctcaga
     3061 tgcttgctta tttgcagacc cggcctcctg ggtgctcccc agtgacccat ctttccaccc
     3121 caccacctcc aagtcctgtc tatgtctgct tccacacagc cctgtcccca gggcaccagc
     3181 cttctgtccc tcacagcagt gccatcgcgg gcattaggag tcttcgttat gttgtatcct
     3241 tgtgagttct tgactaccat gcccaagttt cccccactgg caatggttcc tctcttggag
     3301 gtacagtgga aaccagagag atgacagatg ttgagtcctc agtgtctcag aggcagcaat
     3361 tcttgctgga cacctgcaca tgctcagcac agaggctggt actttggagg cactaaccac
     3421 ttgatgagta aatcaatggc ataaagcccc attccaagtt atggggtctt ttgacaggcc
     3481 cctttcatcc tctttctctt tgtataaacc tcatgtttca gaacaaaatt acagtctaag
     3541 ttcatttgcc cccagccttg cccaaggatc cccgggctgt gctgacccct aggcataggg
     3601 caaagggtgt tcccaagcag caggcacctc agtgccctca gttatccagg gcaaggggcc
     3661 tggctgcccc ctgctcctcc ccatgatgca ggggctttct aagccaggct gcagacaggg
     3721 cagggttggc ttcttggcca ttccctctgt gcccccttct ccttctgact ggtctcaccc
     3781 tggagatccc cagaggatct gaccagagcc aggtggactg tggccctgag atggagctgg
     3841 ctgcaggctt acaagcacct ctggggacat ccagagggga gggtcagtaa gcacaacgga
     3901 gctagggaga cttcagatgg actcaaaccc agagcaataa tactctcaca ccaccccaca
     3961 gctaaggcac tcatgttccc cagtagatca agccagaagc tttgcaagaa gggagtggaa
     4021 cgaggctgcc tatccaaggt ccatctacca cgcagaactt ggtcatgcaa gtacatttgg
     4081 aaaatctggt cttggcccgt cccccattgg cctggtctac acagccaaaa attcagacta
     4141 gattagatgt ttgcaggcaa ttctgtagca aagcaaattc ccctaccccg tcccttcccc
     4201 ctagaagctg ccttagcctc cctgactggg tgtggtctct gggcctagga ctcctcccta
     4261 tgaggaaaag tgctctccag ccacatcttg gcagccccac aaccacagca tcagggcagc
     4321 tgcagcaagt gaccacccac ccgtcgggtt agacacacaa ggcaccaggc actggcatct
     4381 gactaaaata acctttccct acatgggaag aggaaagctt gtaggctggc acatataaac
     4441 gtccagccgc agccagatgg cctgaactaa gcagcaggaa ctctctgggc tggggaggag
     4501 cctcctgccc ttctagaaag tgatgcgtca gctttgttct cctgggaagg tgttgctata
     4561 ccccaggaac aaagcagggc ccaactgcca gtgcagtcag ctgggcctgc gctccaggct
     4621 caccaccgct aagtggtcag gtaccgggcc agcatcctgg gagggacctc ttgcgactct
     4681 gagttgcagc ttggactagc tgaacacatg gggacatgct ccaggggctt cttccctggc
     4741 aggattcctg ggatttcaaa ctacctcacc aacaggacgc tgaaccagga gcctgccacc
     4801 caactggccc ccttggtgat tgtggaaggt gatgtttttc ctaaaatgca tccctcctgt
     4861 tctgctccat atacatgtgc ttcaaaaacc accaccagga aagccttccc agaagaggga
     4921 aaggattaag ggctctcttc ctttgggccc tgcagaatgt attggaggga ggtgttgctg
     4981 caaggtccag gagctgggaa actctgggct cggggggaga taatgcacca ccagcctcaa
     5041 aaaggagctg cccaagttga atatgtagca aagaccatgg gataagttga atagtggcca
     5101 gacgaatcac taataactca ccatgggacc ctctgaagag aggcctgtgc tcgtgtaacc
     5161 atagcaacag cagatgccag caacctactc attagtacca cccagtgata aggcatcccc
     5221 tgggctagac ccaggggcca taaagtagca aagtagcaaa tgtagcaata aagggcccgg
     5281 gtctatacgg ggacagggtc caaatgacca ggacttggcc ctctccccag ccccgatgag
     5341 ggctcagagc cagctgctgt cagctgtctg gggagggaag gccctgctcc ataccagggg
     5401 tccctgttct atactctaag cccactcacc gcatgatcac ggactcatcg gaatggcctc
     5461 ctcttagtgc atgtggttct ctttagttta tttttctgga atttggggat tggaccccag
     5521 aaccaaacat gctggtacag tctaaaaata aatgacttga acccacttca atcca
//
