LOCUS       NM_001370275            6007 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 17, mRNA.
ACCESSION   NM_001370275 XM_024449762
VERSION     NM_001370275.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6007)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6007)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6007)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6007)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6007)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 6007)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 6007)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 6007)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 6007)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 6007)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449762.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1325           AC005533.2         30089-30187         c
            1326-1387           AC005533.2         28600-28661         c
            1388-1498           AC005533.2         11667-11777         c
            1499-1624           AC004828.2         179699-179824       c
            1625-1811           AC004828.2         171441-171627       c
            1812-1901           AC004828.2         153703-153792       c
            1902-1955           AC004828.2         149884-149937       c
            1956-2022           AC004828.2         136622-136688       c
            2023-2191           AC004828.2         127393-127561       c
            2192-6007           AC004828.2         123448-127263       c
FEATURES             Location/Qualifiers
     source          1..6007
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6007
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..2504
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 11 is encoded by transcript variant 17;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 11"
                     /protein_id="NP_001357204.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGP
                     DAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGDLVTVKEKDCIPTLHSLRGPDP
                     SSFRGEHVVGFLSRLSLEIILLSSLPRCLETVTPSGKFKRHEWTESTSSICITSLAPP
                     IVTATTSPPPPVIPHVSVATRVSLPAPGTAFT"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1498
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1624
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1811
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1901
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2022
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2191
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..6007
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3406..3411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3425
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5979..5984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      6007
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaagttt aattgcctac acggaacaat atgtggaata tgaccctttg ataacaccag
     1441 ctgagccatc caacccttgg atcagcgatg acgttgcttt gtgggacata gagatgagca
     1501 aagagcccag ccaacagcga gtaaaaagat ggggcttctc tttcgatgag atattgaagg
     1561 accaggtggg gcgggaccag tttctacgat tcctggagtc cgaattcagt tcagaaaacc
     1621 tcaggttctg gctggctgtc caagatctta agaaacaacc cctacaggat gtggccaaga
     1681 gggtagaaga aatctggcaa gagtttctgg ctccaggggc tccaagtgca atcaacctgg
     1741 attctcacag ctatgagata accagtcaaa atgtcaaaga tggagggaga tatacatttg
     1801 aagacgccca ggagcacatc tacaagctga tgaagagtga cagctatgcc cgcttcctcc
     1861 ggtcaaatgc ttaccaggat ttgctgctgg ccaagaagaa gccagaaagt gagcaaggtc
     1921 gtagaacttc cctagaaaag ttcactcgca gtgtgtgctg ctggcgcaga gtcagaatgg
     1981 ccgctgcatt tcacccccga ggtggcttcc ttccagcagt ggggaaagtc gctggcgggc
     2041 aagcgcctca cgggcctgat gcagtcctcc tgaccgttcc taccgcaggt ccagggcctg
     2101 ggcccgcgga ccccacaggc aggcggcggc gctccacatc tgcggacaga gtttccttac
     2161 gaggagactt ggtcactgtg aaggagaaag attgtattcc aacactccac tcgctaagag
     2221 gccctgatcc cagctcattc aggggagaac acgtcgtggg gttcctgtca cgactatcac
     2281 ttgagattat attattatcc tcactccctc gctgtctgga gacggtcaca ccttctggca
     2341 aattcaagag gcatgagtgg accgagagca catccagcat ttgcatcacc tccctggcac
     2401 ctcccatagt tacagccact acatccccac cgccgcctgt catccctcac gtctctgtgg
     2461 ccacccgggt gtcactgcca gcaccaggca ctgctttcac gtaaaatgtc caaatcacat
     2521 cttcagcaag aaagcaacct cacggattgc cccgcctcaa ggtctttcca ccctctttga
     2581 gatcagcgtt cggagaggtc cccgccagcc cggtggctgc cctcaggtcc cgtcacatgt
     2641 ctcaagggtc cagcgttcga ggaagcactg ttgtagatga cagagctttt tgtttcacag
     2701 ctgcggggat tctgctgacc atcttttaga aaattatttc ataatttatt ctggctttgc
     2761 ccccttgctc cttggtttat tccctcatgt tttactcaaa ataaacatgg ccatgaactc
     2821 aggggccatt gggattctcc cctctggcag ccccaggtgg gagctgggag ggtccccagc
     2881 ccaggaggtg gctggattgc agggctggca gcccccacgt ggtggcatcc tgacaggcac
     2941 agtgagaccc ttgctgggtc aggtctcctt tgtgtgtgaa gctggggcag agtatgctac
     3001 gaagggacca ggccaggcca cagggctctc ctcccagtct ttatctgaag gcccagccaa
     3061 agcacccctc taaaccggtc acctagggga aatgcaaaaa cctgcaaaag atccacctgt
     3121 attccctgtg tgtgtgtgtc aaaatgacca tttgccaacc tggctgtgag gtaatgtatg
     3181 taaagcaccg agtcaggtgc ctgatacgca gtaggtgctt agcaaacggt agctaatact
     3241 atcatcattg tcattgttat tgtgacaccc atgagcccac agacagagct gtattaagta
     3301 acctgttttg aatccagaca ttcactcccc cacttgctat gactaccctc ctttgatcta
     3361 tttttggtca taggtaaaaa aaaaaatctc tcttgggagc atataaacaa aaaacataga
     3421 agcaataaag cgatcgctgg tatttctttt ctcatgcagc caaattcgcc agctggtgac
     3481 caaaggctca gatgcttgct tatttgcaga cccggcctcc tgggtgctcc ccagtgaccc
     3541 atctttccac cccaccacct ccaagtcctg tctatgtctg cttccacaca gccctgtccc
     3601 cagggcacca gccttctgtc cctcacagca gtgccatcgc gggcattagg agtcttcgtt
     3661 atgttgtatc cttgtgagtt cttgactacc atgcccaagt ttcccccact ggcaatggtt
     3721 cctctcttgg aggtacagtg gaaaccagag agatgacaga tgttgagtcc tcagtgtctc
     3781 agaggcagca attcttgctg gacacctgca catgctcagc acagaggctg gtactttgga
     3841 ggcactaacc acttgatgag taaatcaatg gcataaagcc ccattccaag ttatggggtc
     3901 ttttgacagg cccctttcat cctctttctc tttgtataaa cctcatgttt cagaacaaaa
     3961 ttacagtcta agttcatttg cccccagcct tgcccaagga tccccgggct gtgctgaccc
     4021 ctaggcatag ggcaaagggt gttcccaagc agcaggcacc tcagtgccct cagttatcca
     4081 gggcaagggg cctggctgcc ccctgctcct ccccatgatg caggggcttt ctaagccagg
     4141 ctgcagacag ggcagggttg gcttcttggc cattccctct gtgccccctt ctccttctga
     4201 ctggtctcac cctggagatc cccagaggat ctgaccagag ccaggtggac tgtggccctg
     4261 agatggagct ggctgcaggc ttacaagcac ctctggggac atccagaggg gagggtcagt
     4321 aagcacaacg gagctaggga gacttcagat ggactcaaac ccagagcaat aatactctca
     4381 caccacccca cagctaaggc actcatgttc cccagtagat caagccagaa gctttgcaag
     4441 aagggagtgg aacgaggctg cctatccaag gtccatctac cacgcagaac ttggtcatgc
     4501 aagtacattt ggaaaatctg gtcttggccc gtcccccatt ggcctggtct acacagccaa
     4561 aaattcagac tagattagat gtttgcaggc aattctgtag caaagcaaat tcccctaccc
     4621 cgtcccttcc ccctagaagc tgccttagcc tccctgactg ggtgtggtct ctgggcctag
     4681 gactcctccc tatgaggaaa agtgctctcc agccacatct tggcagcccc acaaccacag
     4741 catcagggca gctgcagcaa gtgaccaccc acccgtcggg ttagacacac aaggcaccag
     4801 gcactggcat ctgactaaaa taacctttcc ctacatggga agaggaaagc ttgtaggctg
     4861 gcacatataa acgtccagcc gcagccagat ggcctgaact aagcagcagg aactctctgg
     4921 gctggggagg agcctcctgc ccttctagaa agtgatgcgt cagctttgtt ctcctgggaa
     4981 ggtgttgcta taccccagga acaaagcagg gcccaactgc cagtgcagtc agctgggcct
     5041 gcgctccagg ctcaccaccg ctaagtggtc aggtaccggg ccagcatcct gggagggacc
     5101 tcttgcgact ctgagttgca gcttggacta gctgaacaca tggggacatg ctccaggggc
     5161 ttcttccctg gcaggattcc tgggatttca aactacctca ccaacaggac gctgaaccag
     5221 gagcctgcca cccaactggc ccccttggtg attgtggaag gtgatgtttt tcctaaaatg
     5281 catccctcct gttctgctcc atatacatgt gcttcaaaaa ccaccaccag gaaagccttc
     5341 ccagaagagg gaaaggatta agggctctct tcctttgggc cctgcagaat gtattggagg
     5401 gaggtgttgc tgcaaggtcc aggagctggg aaactctggg ctcgggggga gataatgcac
     5461 caccagcctc aaaaaggagc tgcccaagtt gaatatgtag caaagaccat gggataagtt
     5521 gaatagtggc cagacgaatc actaataact caccatggga ccctctgaag agaggcctgt
     5581 gctcgtgtaa ccatagcaac agcagatgcc agcaacctac tcattagtac cacccagtga
     5641 taaggcatcc cctgggctag acccaggggc cataaagtag caaagtagca aatgtagcaa
     5701 taaagggccc gggtctatac ggggacaggg tccaaatgac caggacttgg ccctctcccc
     5761 agccccgatg agggctcaga gccagctgct gtcagctgtc tggggaggga aggccctgct
     5821 ccataccagg ggtccctgtt ctatactcta agcccactca ccgcatgatc acggactcat
     5881 cggaatggcc tcctcttagt gcatgtggtt ctctttagtt tatttttctg gaatttgggg
     5941 attggacccc agaaccaaac atgctggtac agtctaaaaa taaatgactt gaacccactt
     6001 caatcca
//
