LOCUS       NM_001370274            5704 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 16, mRNA.
ACCESSION   NM_001370274
VERSION     NM_001370274.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5704)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5704)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5704)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5704)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5704)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5704)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5704)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5704)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5704)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5704)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.89237.1,
                                           SRR1660809.109431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-1523           AC004828.2         149884-149937       c
            1524-1590           AC004828.2         136622-136688       c
            1591-5704           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5704
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1763
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 10 is encoded by transcript variant 16;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 10"
                     /protein_id="NP_001357203.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGP
                     DAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGDLVTVKEKE"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1523
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1590
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..5704
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3103..3108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3122
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5676..5681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5704
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaagc cagaaagtga gcaaggtcgt agaacttccc
     1501 tagaaaagtt cactcgcagt gtgtgctgct ggcgcagagt cagaatggcc gctgcatttc
     1561 acccccgagg tggcttcctt ccagcagtgg ggaaagtcgc tggcgggcaa gcgcctcacg
     1621 ggcctgatgc agtcctcctg accgttccta ccgcaggtcc agggcctggg cccgcggacc
     1681 ccacaggcag gcggcggcgc tccacatctg cggacagagt ttccttacga ggagacttgg
     1741 tcactgtgaa ggagaaagag tgagggcaat gaagggcgat ggtggggaga ctcggtgggt
     1801 gaatggggag accagaaaga aagagtccac agagcctggg ctgggcccgg tggaggctcc
     1861 tgtttacagc cctctcttct ttgtacagtt gtattccaac actccactcg ctaagaggcc
     1921 ctgatcccag ctcattcagg ggagaacacg tcgtggggtt cctgtcacga ctatcacttg
     1981 agattatatt attatcctca ctccctcgct gtctggagac ggtcacacct tctggcaaat
     2041 tcaagaggca tgagtggacc gagagcacat ccagcatttg catcacctcc ctggcacctc
     2101 ccatagttac agccactaca tccccaccgc cgcctgtcat ccctcacgtc tctgtggcca
     2161 cccgggtgtc actgccagca ccaggcactg ctttcacgta aaatgtccaa atcacatctt
     2221 cagcaagaaa gcaacctcac ggattgcccc gcctcaaggt ctttccaccc tctttgagat
     2281 cagcgttcgg agaggtcccc gccagcccgg tggctgccct caggtcccgt cacatgtctc
     2341 aagggtccag cgttcgagga agcactgttg tagatgacag agctttttgt ttcacagctg
     2401 cggggattct gctgaccatc ttttagaaaa ttatttcata atttattctg gctttgcccc
     2461 cttgctcctt ggtttattcc ctcatgtttt actcaaaata aacatggcca tgaactcagg
     2521 ggccattggg attctcccct ctggcagccc caggtgggag ctgggagggt ccccagccca
     2581 ggaggtggct ggattgcagg gctggcagcc cccacgtggt ggcatcctga caggcacagt
     2641 gagacccttg ctgggtcagg tctcctttgt gtgtgaagct ggggcagagt atgctacgaa
     2701 gggaccaggc caggccacag ggctctcctc ccagtcttta tctgaaggcc cagccaaagc
     2761 acccctctaa accggtcacc taggggaaat gcaaaaacct gcaaaagatc cacctgtatt
     2821 ccctgtgtgt gtgtgtcaaa atgaccattt gccaacctgg ctgtgaggta atgtatgtaa
     2881 agcaccgagt caggtgcctg atacgcagta ggtgcttagc aaacggtagc taatactatc
     2941 atcattgtca ttgttattgt gacacccatg agcccacaga cagagctgta ttaagtaacc
     3001 tgttttgaat ccagacattc actcccccac ttgctatgac taccctcctt tgatctattt
     3061 ttggtcatag gtaaaaaaaa aaatctctct tgggagcata taaacaaaaa acatagaagc
     3121 aataaagcga tcgctggtat ttcttttctc atgcagccaa attcgccagc tggtgaccaa
     3181 aggctcagat gcttgcttat ttgcagaccc ggcctcctgg gtgctcccca gtgacccatc
     3241 tttccacccc accacctcca agtcctgtct atgtctgctt ccacacagcc ctgtccccag
     3301 ggcaccagcc ttctgtccct cacagcagtg ccatcgcggg cattaggagt cttcgttatg
     3361 ttgtatcctt gtgagttctt gactaccatg cccaagtttc ccccactggc aatggttcct
     3421 ctcttggagg tacagtggaa accagagaga tgacagatgt tgagtcctca gtgtctcaga
     3481 ggcagcaatt cttgctggac acctgcacat gctcagcaca gaggctggta ctttggaggc
     3541 actaaccact tgatgagtaa atcaatggca taaagcccca ttccaagtta tggggtcttt
     3601 tgacaggccc ctttcatcct ctttctcttt gtataaacct catgtttcag aacaaaatta
     3661 cagtctaagt tcatttgccc ccagccttgc ccaaggatcc ccgggctgtg ctgaccccta
     3721 ggcatagggc aaagggtgtt cccaagcagc aggcacctca gtgccctcag ttatccaggg
     3781 caaggggcct ggctgccccc tgctcctccc catgatgcag gggctttcta agccaggctg
     3841 cagacagggc agggttggct tcttggccat tccctctgtg cccccttctc cttctgactg
     3901 gtctcaccct ggagatcccc agaggatctg accagagcca ggtggactgt ggccctgaga
     3961 tggagctggc tgcaggctta caagcacctc tggggacatc cagaggggag ggtcagtaag
     4021 cacaacggag ctagggagac ttcagatgga ctcaaaccca gagcaataat actctcacac
     4081 caccccacag ctaaggcact catgttcccc agtagatcaa gccagaagct ttgcaagaag
     4141 ggagtggaac gaggctgcct atccaaggtc catctaccac gcagaacttg gtcatgcaag
     4201 tacatttgga aaatctggtc ttggcccgtc ccccattggc ctggtctaca cagccaaaaa
     4261 ttcagactag attagatgtt tgcaggcaat tctgtagcaa agcaaattcc cctaccccgt
     4321 cccttccccc tagaagctgc cttagcctcc ctgactgggt gtggtctctg ggcctaggac
     4381 tcctccctat gaggaaaagt gctctccagc cacatcttgg cagccccaca accacagcat
     4441 cagggcagct gcagcaagtg accacccacc cgtcgggtta gacacacaag gcaccaggca
     4501 ctggcatctg actaaaataa cctttcccta catgggaaga ggaaagcttg taggctggca
     4561 catataaacg tccagccgca gccagatggc ctgaactaag cagcaggaac tctctgggct
     4621 ggggaggagc ctcctgccct tctagaaagt gatgcgtcag ctttgttctc ctgggaaggt
     4681 gttgctatac cccaggaaca aagcagggcc caactgccag tgcagtcagc tgggcctgcg
     4741 ctccaggctc accaccgcta agtggtcagg taccgggcca gcatcctggg agggacctct
     4801 tgcgactctg agttgcagct tggactagct gaacacatgg ggacatgctc caggggcttc
     4861 ttccctggca ggattcctgg gatttcaaac tacctcacca acaggacgct gaaccaggag
     4921 cctgccaccc aactggcccc cttggtgatt gtggaaggtg atgtttttcc taaaatgcat
     4981 ccctcctgtt ctgctccata tacatgtgct tcaaaaacca ccaccaggaa agccttccca
     5041 gaagagggaa aggattaagg gctctcttcc tttgggccct gcagaatgta ttggagggag
     5101 gtgttgctgc aaggtccagg agctgggaaa ctctgggctc ggggggagat aatgcaccac
     5161 cagcctcaaa aaggagctgc ccaagttgaa tatgtagcaa agaccatggg ataagttgaa
     5221 tagtggccag acgaatcact aataactcac catgggaccc tctgaagaga ggcctgtgct
     5281 cgtgtaacca tagcaacagc agatgccagc aacctactca ttagtaccac ccagtgataa
     5341 ggcatcccct gggctagacc caggggccat aaagtagcaa agtagcaaat gtagcaataa
     5401 agggcccggg tctatacggg gacagggtcc aaatgaccag gacttggccc tctccccagc
     5461 cccgatgagg gctcagagcc agctgctgtc agctgtctgg ggagggaagg ccctgctcca
     5521 taccaggggt ccctgttcta tactctaagc ccactcaccg catgatcacg gactcatcgg
     5581 aatggcctcc tcttagtgca tgtggttctc tttagtttat ttttctggaa tttggggatt
     5641 ggaccccaga accaaacatg ctggtacagt ctaaaaataa atgacttgaa cccacttcaa
     5701 tcca
//
