LOCUS       NM_001370273            6136 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 15, mRNA.
ACCESSION   NM_001370273
VERSION     NM_001370273.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6136)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6136)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6136)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6136)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6136)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 6136)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 6136)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 6136)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 6136)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 6136)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.47305.1,
                                           SRR1803612.98790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1325           AC005533.2         30089-30187         c
            1326-1387           AC005533.2         28600-28661         c
            1388-1498           AC005533.2         11667-11777         c
            1499-1624           AC004828.2         179699-179824       c
            1625-1811           AC004828.2         171441-171627       c
            1812-1901           AC004828.2         153703-153792       c
            1902-1955           AC004828.2         149884-149937       c
            1956-2022           AC004828.2         136622-136688       c
            2023-6136           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..6136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6136
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..2195
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 10 is encoded by transcript variant 15;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 10"
                     /protein_id="NP_001357202.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGP
                     DAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGDLVTVKEKE"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1498
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1624
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1811
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1901
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2022
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..6136
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3535..3540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3554
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      6108..6113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      6136
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaagttt aattgcctac acggaacaat atgtggaata tgaccctttg ataacaccag
     1441 ctgagccatc caacccttgg atcagcgatg acgttgcttt gtgggacata gagatgagca
     1501 aagagcccag ccaacagcga gtaaaaagat ggggcttctc tttcgatgag atattgaagg
     1561 accaggtggg gcgggaccag tttctacgat tcctggagtc cgaattcagt tcagaaaacc
     1621 tcaggttctg gctggctgtc caagatctta agaaacaacc cctacaggat gtggccaaga
     1681 gggtagaaga aatctggcaa gagtttctgg ctccaggggc tccaagtgca atcaacctgg
     1741 attctcacag ctatgagata accagtcaaa atgtcaaaga tggagggaga tatacatttg
     1801 aagacgccca ggagcacatc tacaagctga tgaagagtga cagctatgcc cgcttcctcc
     1861 ggtcaaatgc ttaccaggat ttgctgctgg ccaagaagaa gccagaaagt gagcaaggtc
     1921 gtagaacttc cctagaaaag ttcactcgca gtgtgtgctg ctggcgcaga gtcagaatgg
     1981 ccgctgcatt tcacccccga ggtggcttcc ttccagcagt ggggaaagtc gctggcgggc
     2041 aagcgcctca cgggcctgat gcagtcctcc tgaccgttcc taccgcaggt ccagggcctg
     2101 ggcccgcgga ccccacaggc aggcggcggc gctccacatc tgcggacaga gtttccttac
     2161 gaggagactt ggtcactgtg aaggagaaag agtgagggca atgaagggcg atggtgggga
     2221 gactcggtgg gtgaatgggg agaccagaaa gaaagagtcc acagagcctg ggctgggccc
     2281 ggtggaggct cctgtttaca gccctctctt ctttgtacag ttgtattcca acactccact
     2341 cgctaagagg ccctgatccc agctcattca ggggagaaca cgtcgtgggg ttcctgtcac
     2401 gactatcact tgagattata ttattatcct cactccctcg ctgtctggag acggtcacac
     2461 cttctggcaa attcaagagg catgagtgga ccgagagcac atccagcatt tgcatcacct
     2521 ccctggcacc tcccatagtt acagccacta catccccacc gccgcctgtc atccctcacg
     2581 tctctgtggc cacccgggtg tcactgccag caccaggcac tgctttcacg taaaatgtcc
     2641 aaatcacatc ttcagcaaga aagcaacctc acggattgcc ccgcctcaag gtctttccac
     2701 cctctttgag atcagcgttc ggagaggtcc ccgccagccc ggtggctgcc ctcaggtccc
     2761 gtcacatgtc tcaagggtcc agcgttcgag gaagcactgt tgtagatgac agagcttttt
     2821 gtttcacagc tgcggggatt ctgctgacca tcttttagaa aattatttca taatttattc
     2881 tggctttgcc cccttgctcc ttggtttatt ccctcatgtt ttactcaaaa taaacatggc
     2941 catgaactca ggggccattg ggattctccc ctctggcagc cccaggtggg agctgggagg
     3001 gtccccagcc caggaggtgg ctggattgca gggctggcag cccccacgtg gtggcatcct
     3061 gacaggcaca gtgagaccct tgctgggtca ggtctccttt gtgtgtgaag ctggggcaga
     3121 gtatgctacg aagggaccag gccaggccac agggctctcc tcccagtctt tatctgaagg
     3181 cccagccaaa gcacccctct aaaccggtca cctaggggaa atgcaaaaac ctgcaaaaga
     3241 tccacctgta ttccctgtgt gtgtgtgtca aaatgaccat ttgccaacct ggctgtgagg
     3301 taatgtatgt aaagcaccga gtcaggtgcc tgatacgcag taggtgctta gcaaacggta
     3361 gctaatacta tcatcattgt cattgttatt gtgacaccca tgagcccaca gacagagctg
     3421 tattaagtaa cctgttttga atccagacat tcactccccc acttgctatg actaccctcc
     3481 tttgatctat ttttggtcat aggtaaaaaa aaaaatctct cttgggagca tataaacaaa
     3541 aaacatagaa gcaataaagc gatcgctggt atttcttttc tcatgcagcc aaattcgcca
     3601 gctggtgacc aaaggctcag atgcttgctt atttgcagac ccggcctcct gggtgctccc
     3661 cagtgaccca tctttccacc ccaccacctc caagtcctgt ctatgtctgc ttccacacag
     3721 ccctgtcccc agggcaccag ccttctgtcc ctcacagcag tgccatcgcg ggcattagga
     3781 gtcttcgtta tgttgtatcc ttgtgagttc ttgactacca tgcccaagtt tcccccactg
     3841 gcaatggttc ctctcttgga ggtacagtgg aaaccagaga gatgacagat gttgagtcct
     3901 cagtgtctca gaggcagcaa ttcttgctgg acacctgcac atgctcagca cagaggctgg
     3961 tactttggag gcactaacca cttgatgagt aaatcaatgg cataaagccc cattccaagt
     4021 tatggggtct tttgacaggc ccctttcatc ctctttctct ttgtataaac ctcatgtttc
     4081 agaacaaaat tacagtctaa gttcatttgc ccccagcctt gcccaaggat ccccgggctg
     4141 tgctgacccc taggcatagg gcaaagggtg ttcccaagca gcaggcacct cagtgccctc
     4201 agttatccag ggcaaggggc ctggctgccc cctgctcctc cccatgatgc aggggctttc
     4261 taagccaggc tgcagacagg gcagggttgg cttcttggcc attccctctg tgcccccttc
     4321 tccttctgac tggtctcacc ctggagatcc ccagaggatc tgaccagagc caggtggact
     4381 gtggccctga gatggagctg gctgcaggct tacaagcacc tctggggaca tccagagggg
     4441 agggtcagta agcacaacgg agctagggag acttcagatg gactcaaacc cagagcaata
     4501 atactctcac accaccccac agctaaggca ctcatgttcc ccagtagatc aagccagaag
     4561 ctttgcaaga agggagtgga acgaggctgc ctatccaagg tccatctacc acgcagaact
     4621 tggtcatgca agtacatttg gaaaatctgg tcttggcccg tcccccattg gcctggtcta
     4681 cacagccaaa aattcagact agattagatg tttgcaggca attctgtagc aaagcaaatt
     4741 cccctacccc gtcccttccc cctagaagct gccttagcct ccctgactgg gtgtggtctc
     4801 tgggcctagg actcctccct atgaggaaaa gtgctctcca gccacatctt ggcagcccca
     4861 caaccacagc atcagggcag ctgcagcaag tgaccaccca cccgtcgggt tagacacaca
     4921 aggcaccagg cactggcatc tgactaaaat aacctttccc tacatgggaa gaggaaagct
     4981 tgtaggctgg cacatataaa cgtccagccg cagccagatg gcctgaacta agcagcagga
     5041 actctctggg ctggggagga gcctcctgcc cttctagaaa gtgatgcgtc agctttgttc
     5101 tcctgggaag gtgttgctat accccaggaa caaagcaggg cccaactgcc agtgcagtca
     5161 gctgggcctg cgctccaggc tcaccaccgc taagtggtca ggtaccgggc cagcatcctg
     5221 ggagggacct cttgcgactc tgagttgcag cttggactag ctgaacacat ggggacatgc
     5281 tccaggggct tcttccctgg caggattcct gggatttcaa actacctcac caacaggacg
     5341 ctgaaccagg agcctgccac ccaactggcc cccttggtga ttgtggaagg tgatgttttt
     5401 cctaaaatgc atccctcctg ttctgctcca tatacatgtg cttcaaaaac caccaccagg
     5461 aaagccttcc cagaagaggg aaaggattaa gggctctctt cctttgggcc ctgcagaatg
     5521 tattggaggg aggtgttgct gcaaggtcca ggagctggga aactctgggc tcggggggag
     5581 ataatgcacc accagcctca aaaaggagct gcccaagttg aatatgtagc aaagaccatg
     5641 ggataagttg aatagtggcc agacgaatca ctaataactc accatgggac cctctgaaga
     5701 gaggcctgtg ctcgtgtaac catagcaaca gcagatgcca gcaacctact cattagtacc
     5761 acccagtgat aaggcatccc ctgggctaga cccaggggcc ataaagtagc aaagtagcaa
     5821 atgtagcaat aaagggcccg ggtctatacg gggacagggt ccaaatgacc aggacttggc
     5881 cctctcccca gccccgatga gggctcagag ccagctgctg tcagctgtct ggggagggaa
     5941 ggccctgctc cataccaggg gtccctgttc tatactctaa gcccactcac cgcatgatca
     6001 cggactcatc ggaatggcct cctcttagtg catgtggttc tctttagttt atttttctgg
     6061 aatttgggga ttggacccca gaaccaaaca tgctggtaca gtctaaaaat aaatgacttg
     6121 aacccacttc aatcca
//
