LOCUS       NM_001370272            5610 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 14, mRNA.
ACCESSION   NM_001370272
VERSION     NM_001370272.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5610)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5610)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5610)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5610)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5610)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5610)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5610)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5610)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5610)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5610)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-1523           AC004828.2         149884-149937       c
            1524-1590           AC004828.2         136622-136688       c
            1591-1794           AC004828.2         127358-127561       c
            1795-5610           AC004828.2         123448-127263       c
FEATURES             Location/Qualifiers
     source          1..5610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5610
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1763
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 10 is encoded by transcript variant 14;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 10"
                     /protein_id="NP_001357201.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGP
                     DAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGDLVTVKEKE"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1523
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1590
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..5610
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3028
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5582..5587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5610
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaagc cagaaagtga gcaaggtcgt agaacttccc
     1501 tagaaaagtt cactcgcagt gtgtgctgct ggcgcagagt cagaatggcc gctgcatttc
     1561 acccccgagg tggcttcctt ccagcagtgg ggaaagtcgc tggcgggcaa gcgcctcacg
     1621 ggcctgatgc agtcctcctg accgttccta ccgcaggtcc agggcctggg cccgcggacc
     1681 ccacaggcag gcggcggcgc tccacatctg cggacagagt ttccttacga ggagacttgg
     1741 tcactgtgaa ggagaaagag tgagggcaat gaagggcgat ggtggggaga ctcgttgtat
     1801 tccaacactc cactcgctaa gaggccctga tcccagctca ttcaggggag aacacgtcgt
     1861 ggggttcctg tcacgactat cacttgagat tatattatta tcctcactcc ctcgctgtct
     1921 ggagacggtc acaccttctg gcaaattcaa gaggcatgag tggaccgaga gcacatccag
     1981 catttgcatc acctccctgg cacctcccat agttacagcc actacatccc caccgccgcc
     2041 tgtcatccct cacgtctctg tggccacccg ggtgtcactg ccagcaccag gcactgcttt
     2101 cacgtaaaat gtccaaatca catcttcagc aagaaagcaa cctcacggat tgccccgcct
     2161 caaggtcttt ccaccctctt tgagatcagc gttcggagag gtccccgcca gcccggtggc
     2221 tgccctcagg tcccgtcaca tgtctcaagg gtccagcgtt cgaggaagca ctgttgtaga
     2281 tgacagagct ttttgtttca cagctgcggg gattctgctg accatctttt agaaaattat
     2341 ttcataattt attctggctt tgcccccttg ctccttggtt tattccctca tgttttactc
     2401 aaaataaaca tggccatgaa ctcaggggcc attgggattc tcccctctgg cagccccagg
     2461 tgggagctgg gagggtcccc agcccaggag gtggctggat tgcagggctg gcagccccca
     2521 cgtggtggca tcctgacagg cacagtgaga cccttgctgg gtcaggtctc ctttgtgtgt
     2581 gaagctgggg cagagtatgc tacgaaggga ccaggccagg ccacagggct ctcctcccag
     2641 tctttatctg aaggcccagc caaagcaccc ctctaaaccg gtcacctagg ggaaatgcaa
     2701 aaacctgcaa aagatccacc tgtattccct gtgtgtgtgt gtcaaaatga ccatttgcca
     2761 acctggctgt gaggtaatgt atgtaaagca ccgagtcagg tgcctgatac gcagtaggtg
     2821 cttagcaaac ggtagctaat actatcatca ttgtcattgt tattgtgaca cccatgagcc
     2881 cacagacaga gctgtattaa gtaacctgtt ttgaatccag acattcactc ccccacttgc
     2941 tatgactacc ctcctttgat ctatttttgg tcataggtaa aaaaaaaaat ctctcttggg
     3001 agcatataaa caaaaaacat agaagcaata aagcgatcgc tggtatttct tttctcatgc
     3061 agccaaattc gccagctggt gaccaaaggc tcagatgctt gcttatttgc agacccggcc
     3121 tcctgggtgc tccccagtga cccatctttc caccccacca cctccaagtc ctgtctatgt
     3181 ctgcttccac acagccctgt ccccagggca ccagccttct gtccctcaca gcagtgccat
     3241 cgcgggcatt aggagtcttc gttatgttgt atccttgtga gttcttgact accatgccca
     3301 agtttccccc actggcaatg gttcctctct tggaggtaca gtggaaacca gagagatgac
     3361 agatgttgag tcctcagtgt ctcagaggca gcaattcttg ctggacacct gcacatgctc
     3421 agcacagagg ctggtacttt ggaggcacta accacttgat gagtaaatca atggcataaa
     3481 gccccattcc aagttatggg gtcttttgac aggccccttt catcctcttt ctctttgtat
     3541 aaacctcatg tttcagaaca aaattacagt ctaagttcat ttgcccccag ccttgcccaa
     3601 ggatccccgg gctgtgctga cccctaggca tagggcaaag ggtgttccca agcagcaggc
     3661 acctcagtgc cctcagttat ccagggcaag gggcctggct gccccctgct cctccccatg
     3721 atgcaggggc tttctaagcc aggctgcaga cagggcaggg ttggcttctt ggccattccc
     3781 tctgtgcccc cttctccttc tgactggtct caccctggag atccccagag gatctgacca
     3841 gagccaggtg gactgtggcc ctgagatgga gctggctgca ggcttacaag cacctctggg
     3901 gacatccaga ggggagggtc agtaagcaca acggagctag ggagacttca gatggactca
     3961 aacccagagc aataatactc tcacaccacc ccacagctaa ggcactcatg ttccccagta
     4021 gatcaagcca gaagctttgc aagaagggag tggaacgagg ctgcctatcc aaggtccatc
     4081 taccacgcag aacttggtca tgcaagtaca tttggaaaat ctggtcttgg cccgtccccc
     4141 attggcctgg tctacacagc caaaaattca gactagatta gatgtttgca ggcaattctg
     4201 tagcaaagca aattccccta ccccgtccct tccccctaga agctgcctta gcctccctga
     4261 ctgggtgtgg tctctgggcc taggactcct ccctatgagg aaaagtgctc tccagccaca
     4321 tcttggcagc cccacaacca cagcatcagg gcagctgcag caagtgacca cccacccgtc
     4381 gggttagaca cacaaggcac caggcactgg catctgacta aaataacctt tccctacatg
     4441 ggaagaggaa agcttgtagg ctggcacata taaacgtcca gccgcagcca gatggcctga
     4501 actaagcagc aggaactctc tgggctgggg aggagcctcc tgcccttcta gaaagtgatg
     4561 cgtcagcttt gttctcctgg gaaggtgttg ctatacccca ggaacaaagc agggcccaac
     4621 tgccagtgca gtcagctggg cctgcgctcc aggctcacca ccgctaagtg gtcaggtacc
     4681 gggccagcat cctgggaggg acctcttgcg actctgagtt gcagcttgga ctagctgaac
     4741 acatggggac atgctccagg ggcttcttcc ctggcaggat tcctgggatt tcaaactacc
     4801 tcaccaacag gacgctgaac caggagcctg ccacccaact ggcccccttg gtgattgtgg
     4861 aaggtgatgt ttttcctaaa atgcatccct cctgttctgc tccatataca tgtgcttcaa
     4921 aaaccaccac caggaaagcc ttcccagaag agggaaagga ttaagggctc tcttcctttg
     4981 ggccctgcag aatgtattgg agggaggtgt tgctgcaagg tccaggagct gggaaactct
     5041 gggctcgggg ggagataatg caccaccagc ctcaaaaagg agctgcccaa gttgaatatg
     5101 tagcaaagac catgggataa gttgaatagt ggccagacga atcactaata actcaccatg
     5161 ggaccctctg aagagaggcc tgtgctcgtg taaccatagc aacagcagat gccagcaacc
     5221 tactcattag taccacccag tgataaggca tcccctgggc tagacccagg ggccataaag
     5281 tagcaaagta gcaaatgtag caataaaggg cccgggtcta tacggggaca gggtccaaat
     5341 gaccaggact tggccctctc cccagccccg atgagggctc agagccagct gctgtcagct
     5401 gtctggggag ggaaggccct gctccatacc aggggtccct gttctatact ctaagcccac
     5461 tcaccgcatg atcacggact catcggaatg gcctcctctt agtgcatgtg gttctcttta
     5521 gtttattttt ctggaatttg gggattggac cccagaacca aacatgctgg tacagtctaa
     5581 aaataaatga cttgaaccca cttcaatcca
//
