LOCUS       NM_001370271            5857 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 13, mRNA.
ACCESSION   NM_001370271 XM_024449765
VERSION     NM_001370271.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5857)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5857)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5857)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5857)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5857)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5857)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5857)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5857)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5857)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5857)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449765.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC005993.2         12683-12916         c
            235-338             AC005477.1         87628-87731         c
            339-438             AC005157.1         72588-72687         c
            439-489             AC005533.2         52351-52401         c
            490-596             AC005533.2         48552-48658         c
            597-648             AC005533.2         47246-47297         c
            649-713             AC005533.2         41107-41171         c
            714-790             AC005533.2         36846-36922         c
            791-872             AC005533.2         33976-34057         c
            873-947             AC005533.2         32230-32304         c
            948-1046            AC005533.2         30089-30187         c
            1047-1108           AC005533.2         28600-28661         c
            1109-1219           AC005533.2         11667-11777         c
            1220-1345           AC004828.2         179699-179824       c
            1346-1532           AC004828.2         171441-171627       c
            1533-1622           AC004828.2         153703-153792       c
            1623-1676           AC004828.2         149884-149937       c
            1677-1743           AC004828.2         136622-136688       c
            1744-5857           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5857
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..234
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            235..338
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1916
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 10 is encoded by transcript variant 13;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 10"
                     /protein_id="NP_001357200.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGP
                     DAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGDLVTVKEKE"
     exon            339..438
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            439..489
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            490..596
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            597..648
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            649..713
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            714..790
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            791..872
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            873..947
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1046
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1108
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1219
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1345
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1532
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1622
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1676
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1743
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..5857
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3256..3261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3275
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5829..5834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5857
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttacag tcaccagcag gctgcgtaaa gaagtggccc agtgagacag ggaaagtgac
       61 ccagaaaatt tagttttgtt cagaatgaaa gctgctgtat ttcatttttg tttcttaatt
      121 tgacggagta ggaacgttat tttccttctc tgtcattgag accagtagca tttctatgtt
      181 acaaactgaa gatatttggg gtctcgtcgg cttgggatta tcaatgcttg ggagtgtgag
      241 tgaagacact caggatggct caaggatccg gggatcaaag agcagtgggg gttgctgacc
      301 cagaggagag ttctccaaac atgatcgttt actgcaaaat tgaagacatc attacaaaga
      361 tgcaagatga caagacaggg ggtgtgccca tcagaacagt caagagcttt ctctccaaaa
      421 tccccagtgt cgtcacaggt actgacattg tgcagtggct tatgaagaac ctttccattg
      481 aggacccagt tgaagcaata cacttgggga gccttatcgc tgcccagggc tacatctttc
      541 caatctcaga ccatgttctc accatgaagg atgatggcac cttttatcgt ttccaggctc
      601 cgtacttctg gccttcgaac tgctgggaac ctgaaaacac tgactatgcc atctatctct
      661 gtaagaggac aatgcaaaat aaagcaaggc tggaactggc agattatgaa gcagaaaact
      721 tagcaagact ccagagggcc tttgcgagga agtgggaatt catctttatg caagcagaag
      781 cacaagtaaa gattgaccgg aaaaaagaca agacagaaag gaaaattttg gatagtcaag
      841 aacgagcctt ttgggatgtc cacaggcctg tgccaggctg tgtgaacaca acagaaatgg
      901 atatccgaaa atgtcgacgt ttgaagaatc cacaaaaggt taaaaagtcc gtgtatggcg
      961 tgactgaaga gtcccaggca cagagcccgg tgcatgtact cagccaacca atcaggaaaa
     1021 caacaaaaga ggacatccgg aaacagataa catttttgaa cgcacagatc gacagacatt
     1081 gtttgaaaat gtccaaagtg gctgaaagtt taattgccta cacggaacaa tatgtggaat
     1141 atgacccttt gataacacca gctgagccat ccaacccttg gatcagcgat gacgttgctt
     1201 tgtgggacat agagatgagc aaagagccca gccaacagcg agtaaaaaga tggggcttct
     1261 ctttcgatga gatattgaag gaccaggtgg ggcgggacca gtttctacga ttcctggagt
     1321 ccgaattcag ttcagaaaac ctcaggttct ggctggctgt ccaagatctt aagaaacaac
     1381 ccctacagga tgtggccaag agggtagaag aaatctggca agagtttctg gctccagggg
     1441 ctccaagtgc aatcaacctg gattctcaca gctatgagat aaccagtcaa aatgtcaaag
     1501 atggagggag atatacattt gaagacgccc aggagcacat ctacaagctg atgaagagtg
     1561 acagctatgc ccgcttcctc cggtcaaatg cttaccagga tttgctgctg gccaagaaga
     1621 agccagaaag tgagcaaggt cgtagaactt ccctagaaaa gttcactcgc agtgtgtgct
     1681 gctggcgcag agtcagaatg gccgctgcat ttcacccccg aggtggcttc cttccagcag
     1741 tggggaaagt cgctggcggg caagcgcctc acgggcctga tgcagtcctc ctgaccgttc
     1801 ctaccgcagg tccagggcct gggcccgcgg accccacagg caggcggcgg cgctccacat
     1861 ctgcggacag agtttcctta cgaggagact tggtcactgt gaaggagaaa gagtgagggc
     1921 aatgaagggc gatggtgggg agactcggtg ggtgaatggg gagaccagaa agaaagagtc
     1981 cacagagcct gggctgggcc cggtggaggc tcctgtttac agccctctct tctttgtaca
     2041 gttgtattcc aacactccac tcgctaagag gccctgatcc cagctcattc aggggagaac
     2101 acgtcgtggg gttcctgtca cgactatcac ttgagattat attattatcc tcactccctc
     2161 gctgtctgga gacggtcaca ccttctggca aattcaagag gcatgagtgg accgagagca
     2221 catccagcat ttgcatcacc tccctggcac ctcccatagt tacagccact acatccccac
     2281 cgccgcctgt catccctcac gtctctgtgg ccacccgggt gtcactgcca gcaccaggca
     2341 ctgctttcac gtaaaatgtc caaatcacat cttcagcaag aaagcaacct cacggattgc
     2401 cccgcctcaa ggtctttcca ccctctttga gatcagcgtt cggagaggtc cccgccagcc
     2461 cggtggctgc cctcaggtcc cgtcacatgt ctcaagggtc cagcgttcga ggaagcactg
     2521 ttgtagatga cagagctttt tgtttcacag ctgcggggat tctgctgacc atcttttaga
     2581 aaattatttc ataatttatt ctggctttgc ccccttgctc cttggtttat tccctcatgt
     2641 tttactcaaa ataaacatgg ccatgaactc aggggccatt gggattctcc cctctggcag
     2701 ccccaggtgg gagctgggag ggtccccagc ccaggaggtg gctggattgc agggctggca
     2761 gcccccacgt ggtggcatcc tgacaggcac agtgagaccc ttgctgggtc aggtctcctt
     2821 tgtgtgtgaa gctggggcag agtatgctac gaagggacca ggccaggcca cagggctctc
     2881 ctcccagtct ttatctgaag gcccagccaa agcacccctc taaaccggtc acctagggga
     2941 aatgcaaaaa cctgcaaaag atccacctgt attccctgtg tgtgtgtgtc aaaatgacca
     3001 tttgccaacc tggctgtgag gtaatgtatg taaagcaccg agtcaggtgc ctgatacgca
     3061 gtaggtgctt agcaaacggt agctaatact atcatcattg tcattgttat tgtgacaccc
     3121 atgagcccac agacagagct gtattaagta acctgttttg aatccagaca ttcactcccc
     3181 cacttgctat gactaccctc ctttgatcta tttttggtca taggtaaaaa aaaaaatctc
     3241 tcttgggagc atataaacaa aaaacataga agcaataaag cgatcgctgg tatttctttt
     3301 ctcatgcagc caaattcgcc agctggtgac caaaggctca gatgcttgct tatttgcaga
     3361 cccggcctcc tgggtgctcc ccagtgaccc atctttccac cccaccacct ccaagtcctg
     3421 tctatgtctg cttccacaca gccctgtccc cagggcacca gccttctgtc cctcacagca
     3481 gtgccatcgc gggcattagg agtcttcgtt atgttgtatc cttgtgagtt cttgactacc
     3541 atgcccaagt ttcccccact ggcaatggtt cctctcttgg aggtacagtg gaaaccagag
     3601 agatgacaga tgttgagtcc tcagtgtctc agaggcagca attcttgctg gacacctgca
     3661 catgctcagc acagaggctg gtactttgga ggcactaacc acttgatgag taaatcaatg
     3721 gcataaagcc ccattccaag ttatggggtc ttttgacagg cccctttcat cctctttctc
     3781 tttgtataaa cctcatgttt cagaacaaaa ttacagtcta agttcatttg cccccagcct
     3841 tgcccaagga tccccgggct gtgctgaccc ctaggcatag ggcaaagggt gttcccaagc
     3901 agcaggcacc tcagtgccct cagttatcca gggcaagggg cctggctgcc ccctgctcct
     3961 ccccatgatg caggggcttt ctaagccagg ctgcagacag ggcagggttg gcttcttggc
     4021 cattccctct gtgccccctt ctccttctga ctggtctcac cctggagatc cccagaggat
     4081 ctgaccagag ccaggtggac tgtggccctg agatggagct ggctgcaggc ttacaagcac
     4141 ctctggggac atccagaggg gagggtcagt aagcacaacg gagctaggga gacttcagat
     4201 ggactcaaac ccagagcaat aatactctca caccacccca cagctaaggc actcatgttc
     4261 cccagtagat caagccagaa gctttgcaag aagggagtgg aacgaggctg cctatccaag
     4321 gtccatctac cacgcagaac ttggtcatgc aagtacattt ggaaaatctg gtcttggccc
     4381 gtcccccatt ggcctggtct acacagccaa aaattcagac tagattagat gtttgcaggc
     4441 aattctgtag caaagcaaat tcccctaccc cgtcccttcc ccctagaagc tgccttagcc
     4501 tccctgactg ggtgtggtct ctgggcctag gactcctccc tatgaggaaa agtgctctcc
     4561 agccacatct tggcagcccc acaaccacag catcagggca gctgcagcaa gtgaccaccc
     4621 acccgtcggg ttagacacac aaggcaccag gcactggcat ctgactaaaa taacctttcc
     4681 ctacatggga agaggaaagc ttgtaggctg gcacatataa acgtccagcc gcagccagat
     4741 ggcctgaact aagcagcagg aactctctgg gctggggagg agcctcctgc ccttctagaa
     4801 agtgatgcgt cagctttgtt ctcctgggaa ggtgttgcta taccccagga acaaagcagg
     4861 gcccaactgc cagtgcagtc agctgggcct gcgctccagg ctcaccaccg ctaagtggtc
     4921 aggtaccggg ccagcatcct gggagggacc tcttgcgact ctgagttgca gcttggacta
     4981 gctgaacaca tggggacatg ctccaggggc ttcttccctg gcaggattcc tgggatttca
     5041 aactacctca ccaacaggac gctgaaccag gagcctgcca cccaactggc ccccttggtg
     5101 attgtggaag gtgatgtttt tcctaaaatg catccctcct gttctgctcc atatacatgt
     5161 gcttcaaaaa ccaccaccag gaaagccttc ccagaagagg gaaaggatta agggctctct
     5221 tcctttgggc cctgcagaat gtattggagg gaggtgttgc tgcaaggtcc aggagctggg
     5281 aaactctggg ctcgggggga gataatgcac caccagcctc aaaaaggagc tgcccaagtt
     5341 gaatatgtag caaagaccat gggataagtt gaatagtggc cagacgaatc actaataact
     5401 caccatggga ccctctgaag agaggcctgt gctcgtgtaa ccatagcaac agcagatgcc
     5461 agcaacctac tcattagtac cacccagtga taaggcatcc cctgggctag acccaggggc
     5521 cataaagtag caaagtagca aatgtagcaa taaagggccc gggtctatac ggggacaggg
     5581 tccaaatgac caggacttgg ccctctcccc agccccgatg agggctcaga gccagctgct
     5641 gtcagctgtc tggggaggga aggccctgct ccataccagg ggtccctgtt ctatactcta
     5701 agcccactca ccgcatgatc acggactcat cggaatggcc tcctcttagt gcatgtggtt
     5761 ctctttagtt tatttttctg gaatttgggg attggacccc agaaccaaac atgctggtac
     5821 agtctaaaaa taaatgactt gaacccactt caatcca
//
