LOCUS       NM_001370270            5686 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 12, mRNA.
ACCESSION   NM_001370270 XM_024449766
VERSION     NM_001370270.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5686)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5686)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5686)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5686)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5686)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5686)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5686)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5686)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5686)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5686)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449766.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2467143
                              [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC005993.2         14210-14272         c
            64-167              AC005477.1         87628-87731         c
            168-267             AC005157.1         72588-72687         c
            268-318             AC005533.2         52351-52401         c
            319-425             AC005533.2         48552-48658         c
            426-477             AC005533.2         47246-47297         c
            478-542             AC005533.2         41107-41171         c
            543-619             AC005533.2         36846-36922         c
            620-701             AC005533.2         33976-34057         c
            702-776             AC005533.2         32230-32304         c
            777-875             AC005533.2         30089-30187         c
            876-937             AC005533.2         28600-28661         c
            938-1048            AC005533.2         11667-11777         c
            1049-1174           AC004828.2         179699-179824       c
            1175-1361           AC004828.2         171441-171627       c
            1362-1451           AC004828.2         153703-153792       c
            1452-1505           AC004828.2         149884-149937       c
            1506-1572           AC004828.2         136622-136688       c
            1573-5686           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5686
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..63
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            64..167
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1745
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 10 is encoded by transcript variant 12;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 10"
                     /protein_id="NP_001357199.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPHGP
                     DAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRGDLVTVKEKE"
     exon            168..267
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            268..318
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            319..425
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            426..477
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            478..542
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            543..619
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            620..701
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            702..776
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            777..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..937
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1048
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1174
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1361
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1451
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1505
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1572
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..5686
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3085..3090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3104
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5658..5663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5686
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 atttctaggt tttctcctcc tcgagcaaat cacggtctgc gccttccgcg gctctgggaa
       61 cagtgtgagt gaagacactc aggatggctc aaggatccgg ggatcaaaga gcagtggggg
      121 ttgctgaccc agaggagagt tctccaaaca tgatcgttta ctgcaaaatt gaagacatca
      181 ttacaaagat gcaagatgac aagacagggg gtgtgcccat cagaacagtc aagagctttc
      241 tctccaaaat ccccagtgtc gtcacaggta ctgacattgt gcagtggctt atgaagaacc
      301 tttccattga ggacccagtt gaagcaatac acttggggag ccttatcgct gcccagggct
      361 acatctttcc aatctcagac catgttctca ccatgaagga tgatggcacc ttttatcgtt
      421 tccaggctcc gtacttctgg ccttcgaact gctgggaacc tgaaaacact gactatgcca
      481 tctatctctg taagaggaca atgcaaaata aagcaaggct ggaactggca gattatgaag
      541 cagaaaactt agcaagactc cagagggcct ttgcgaggaa gtgggaattc atctttatgc
      601 aagcagaagc acaagtaaag attgaccgga aaaaagacaa gacagaaagg aaaattttgg
      661 atagtcaaga acgagccttt tgggatgtcc acaggcctgt gccaggctgt gtgaacacaa
      721 cagaaatgga tatccgaaaa tgtcgacgtt tgaagaatcc acaaaaggtt aaaaagtccg
      781 tgtatggcgt gactgaagag tcccaggcac agagcccggt gcatgtactc agccaaccaa
      841 tcaggaaaac aacaaaagag gacatccgga aacagataac atttttgaac gcacagatcg
      901 acagacattg tttgaaaatg tccaaagtgg ctgaaagttt aattgcctac acggaacaat
      961 atgtggaata tgaccctttg ataacaccag ctgagccatc caacccttgg atcagcgatg
     1021 acgttgcttt gtgggacata gagatgagca aagagcccag ccaacagcga gtaaaaagat
     1081 ggggcttctc tttcgatgag atattgaagg accaggtggg gcgggaccag tttctacgat
     1141 tcctggagtc cgaattcagt tcagaaaacc tcaggttctg gctggctgtc caagatctta
     1201 agaaacaacc cctacaggat gtggccaaga gggtagaaga aatctggcaa gagtttctgg
     1261 ctccaggggc tccaagtgca atcaacctgg attctcacag ctatgagata accagtcaaa
     1321 atgtcaaaga tggagggaga tatacatttg aagacgccca ggagcacatc tacaagctga
     1381 tgaagagtga cagctatgcc cgcttcctcc ggtcaaatgc ttaccaggat ttgctgctgg
     1441 ccaagaagaa gccagaaagt gagcaaggtc gtagaacttc cctagaaaag ttcactcgca
     1501 gtgtgtgctg ctggcgcaga gtcagaatgg ccgctgcatt tcacccccga ggtggcttcc
     1561 ttccagcagt ggggaaagtc gctggcgggc aagcgcctca cgggcctgat gcagtcctcc
     1621 tgaccgttcc taccgcaggt ccagggcctg ggcccgcgga ccccacaggc aggcggcggc
     1681 gctccacatc tgcggacaga gtttccttac gaggagactt ggtcactgtg aaggagaaag
     1741 agtgagggca atgaagggcg atggtgggga gactcggtgg gtgaatgggg agaccagaaa
     1801 gaaagagtcc acagagcctg ggctgggccc ggtggaggct cctgtttaca gccctctctt
     1861 ctttgtacag ttgtattcca acactccact cgctaagagg ccctgatccc agctcattca
     1921 ggggagaaca cgtcgtgggg ttcctgtcac gactatcact tgagattata ttattatcct
     1981 cactccctcg ctgtctggag acggtcacac cttctggcaa attcaagagg catgagtgga
     2041 ccgagagcac atccagcatt tgcatcacct ccctggcacc tcccatagtt acagccacta
     2101 catccccacc gccgcctgtc atccctcacg tctctgtggc cacccgggtg tcactgccag
     2161 caccaggcac tgctttcacg taaaatgtcc aaatcacatc ttcagcaaga aagcaacctc
     2221 acggattgcc ccgcctcaag gtctttccac cctctttgag atcagcgttc ggagaggtcc
     2281 ccgccagccc ggtggctgcc ctcaggtccc gtcacatgtc tcaagggtcc agcgttcgag
     2341 gaagcactgt tgtagatgac agagcttttt gtttcacagc tgcggggatt ctgctgacca
     2401 tcttttagaa aattatttca taatttattc tggctttgcc cccttgctcc ttggtttatt
     2461 ccctcatgtt ttactcaaaa taaacatggc catgaactca ggggccattg ggattctccc
     2521 ctctggcagc cccaggtggg agctgggagg gtccccagcc caggaggtgg ctggattgca
     2581 gggctggcag cccccacgtg gtggcatcct gacaggcaca gtgagaccct tgctgggtca
     2641 ggtctccttt gtgtgtgaag ctggggcaga gtatgctacg aagggaccag gccaggccac
     2701 agggctctcc tcccagtctt tatctgaagg cccagccaaa gcacccctct aaaccggtca
     2761 cctaggggaa atgcaaaaac ctgcaaaaga tccacctgta ttccctgtgt gtgtgtgtca
     2821 aaatgaccat ttgccaacct ggctgtgagg taatgtatgt aaagcaccga gtcaggtgcc
     2881 tgatacgcag taggtgctta gcaaacggta gctaatacta tcatcattgt cattgttatt
     2941 gtgacaccca tgagcccaca gacagagctg tattaagtaa cctgttttga atccagacat
     3001 tcactccccc acttgctatg actaccctcc tttgatctat ttttggtcat aggtaaaaaa
     3061 aaaaatctct cttgggagca tataaacaaa aaacatagaa gcaataaagc gatcgctggt
     3121 atttcttttc tcatgcagcc aaattcgcca gctggtgacc aaaggctcag atgcttgctt
     3181 atttgcagac ccggcctcct gggtgctccc cagtgaccca tctttccacc ccaccacctc
     3241 caagtcctgt ctatgtctgc ttccacacag ccctgtcccc agggcaccag ccttctgtcc
     3301 ctcacagcag tgccatcgcg ggcattagga gtcttcgtta tgttgtatcc ttgtgagttc
     3361 ttgactacca tgcccaagtt tcccccactg gcaatggttc ctctcttgga ggtacagtgg
     3421 aaaccagaga gatgacagat gttgagtcct cagtgtctca gaggcagcaa ttcttgctgg
     3481 acacctgcac atgctcagca cagaggctgg tactttggag gcactaacca cttgatgagt
     3541 aaatcaatgg cataaagccc cattccaagt tatggggtct tttgacaggc ccctttcatc
     3601 ctctttctct ttgtataaac ctcatgtttc agaacaaaat tacagtctaa gttcatttgc
     3661 ccccagcctt gcccaaggat ccccgggctg tgctgacccc taggcatagg gcaaagggtg
     3721 ttcccaagca gcaggcacct cagtgccctc agttatccag ggcaaggggc ctggctgccc
     3781 cctgctcctc cccatgatgc aggggctttc taagccaggc tgcagacagg gcagggttgg
     3841 cttcttggcc attccctctg tgcccccttc tccttctgac tggtctcacc ctggagatcc
     3901 ccagaggatc tgaccagagc caggtggact gtggccctga gatggagctg gctgcaggct
     3961 tacaagcacc tctggggaca tccagagggg agggtcagta agcacaacgg agctagggag
     4021 acttcagatg gactcaaacc cagagcaata atactctcac accaccccac agctaaggca
     4081 ctcatgttcc ccagtagatc aagccagaag ctttgcaaga agggagtgga acgaggctgc
     4141 ctatccaagg tccatctacc acgcagaact tggtcatgca agtacatttg gaaaatctgg
     4201 tcttggcccg tcccccattg gcctggtcta cacagccaaa aattcagact agattagatg
     4261 tttgcaggca attctgtagc aaagcaaatt cccctacccc gtcccttccc cctagaagct
     4321 gccttagcct ccctgactgg gtgtggtctc tgggcctagg actcctccct atgaggaaaa
     4381 gtgctctcca gccacatctt ggcagcccca caaccacagc atcagggcag ctgcagcaag
     4441 tgaccaccca cccgtcgggt tagacacaca aggcaccagg cactggcatc tgactaaaat
     4501 aacctttccc tacatgggaa gaggaaagct tgtaggctgg cacatataaa cgtccagccg
     4561 cagccagatg gcctgaacta agcagcagga actctctggg ctggggagga gcctcctgcc
     4621 cttctagaaa gtgatgcgtc agctttgttc tcctgggaag gtgttgctat accccaggaa
     4681 caaagcaggg cccaactgcc agtgcagtca gctgggcctg cgctccaggc tcaccaccgc
     4741 taagtggtca ggtaccgggc cagcatcctg ggagggacct cttgcgactc tgagttgcag
     4801 cttggactag ctgaacacat ggggacatgc tccaggggct tcttccctgg caggattcct
     4861 gggatttcaa actacctcac caacaggacg ctgaaccagg agcctgccac ccaactggcc
     4921 cccttggtga ttgtggaagg tgatgttttt cctaaaatgc atccctcctg ttctgctcca
     4981 tatacatgtg cttcaaaaac caccaccagg aaagccttcc cagaagaggg aaaggattaa
     5041 gggctctctt cctttgggcc ctgcagaatg tattggaggg aggtgttgct gcaaggtcca
     5101 ggagctggga aactctgggc tcggggggag ataatgcacc accagcctca aaaaggagct
     5161 gcccaagttg aatatgtagc aaagaccatg ggataagttg aatagtggcc agacgaatca
     5221 ctaataactc accatgggac cctctgaaga gaggcctgtg ctcgtgtaac catagcaaca
     5281 gcagatgcca gcaacctact cattagtacc acccagtgat aaggcatccc ctgggctaga
     5341 cccaggggcc ataaagtagc aaagtagcaa atgtagcaat aaagggcccg ggtctatacg
     5401 gggacagggt ccaaatgacc aggacttggc cctctcccca gccccgatga gggctcagag
     5461 ccagctgctg tcagctgtct ggggagggaa ggccctgctc cataccaggg gtccctgttc
     5521 tatactctaa gcccactcac cgcatgatca cggactcatc ggaatggcct cctcttagtg
     5581 catgtggttc tctttagttt atttttctgg aatttgggga ttggacccca gaaccaaaca
     5641 tgctggtaca gtctaaaaat aaatgacttg aacccacttc aatcca
//
