LOCUS       NM_001204424            6069 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 10, mRNA.
ACCESSION   NM_001204424
VERSION     NM_001204424.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6069)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6069)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6069)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6069)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6069)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 6069)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 6069)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 6069)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 6069)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 6069)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AK294486.1,
            BC104877.1, AF107619.1, AF156932.1, AC004828.2, BX537512.1 and
            BX096120.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001204424.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.150044.1,
                                           SRR1803611.154341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000553525.6/ ENSP00000451030.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC005993.2         14005-14014         c
            11-1272             AK294486.1         1-1262
            1273-1901           BC104877.1         918-1546
            1902-2291           AF107619.1         1369-1758
            2292-3485           AF156932.1         1705-2898
            3486-4509           AC004828.2         125008-126031       c
            4510-6023           BX537512.1         1-1514
            6024-6069           BX096120.1         617-662
FEATURES             Location/Qualifiers
     source          1..6069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..2006
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 1 is encoded by transcript variant 10;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 1"
                     /protein_id="NP_001191353.1"
                     /db_xref="CCDS:CCDS55924.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLMQSS"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1498
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1624
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1811
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1901
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..6069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3468..3473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3487
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      6041..6046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      6069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaagttt aattgcctac acggaacaat atgtggaata tgaccctttg ataacaccag
     1441 ctgagccatc caacccttgg atcagcgatg acgttgcttt gtgggacata gagatgagca
     1501 aagagcccag ccaacagcga gtaaaaagat ggggcttctc tttcgatgag atattgaagg
     1561 accaggtggg gcgggaccag tttctacgat tcctggagtc cgaattcagt tcagaaaacc
     1621 tcaggttctg gctggctgtc caagatctta agaaacaacc cctacaggat gtggccaaga
     1681 gggtagaaga aatctggcaa gagtttctgg ctccaggggc tccaagtgca atcaacctgg
     1741 attctcacag ctatgagata accagtcaaa atgtcaaaga tggagggaga tatacatttg
     1801 aagacgccca ggagcacatc tacaagctga tgaagagtga cagctatgcc cgcttcctcc
     1861 ggtcaaatgc ttaccaggat ttgctgctgg ccaagaagaa gccagaaagt gagcaaggtc
     1921 gtagaacttc cctagaaaag ttcactcgca gtgtgggaaa gtcgctggcg ggcaagcgcc
     1981 tcacgggcct gatgcagtcc tcctgaccgt tcctaccgca ggtccagggc ctgggcccgc
     2041 ggaccccaca ggcaggcggc ggcgctccac atctgcggac agagtttcct tacgaggaga
     2101 cttggtcact gtgaaggaga aagagtgagg gcaatgaagg gcgatggtgg ggagactcgg
     2161 tgggtgaatg gggagaccag aaagaaagag tccacagagc ctgggctggg cccggtggag
     2221 gctcctgttt acagccctct cttctttgta cagttgtatt ccaacactcc actcgctaag
     2281 aggccctgat cccagctcat tcaggggaga acacgtcgtg gggttcctgt cacgactatc
     2341 acttgagatt atattattat cctcactccc tcgctgtctg gagacggtca caccttctgg
     2401 caaattcaag aggcatgagt ggaccgagag cacatccagc atttgcatca cctccctggc
     2461 acctcccata gttacagcca ctacatcccc accgccgcct gtcatccctc acgtctctgt
     2521 ggccacccgg gtgtcactgc cagcaccagg cactgctttc acgtaaaatg tccaaatcac
     2581 atcttcagca agaaagcaac ctcacggatt gccccgcctc aaggtctttc caccctcttt
     2641 gagatcagcg ttcggagagg tccccgccag cccggtggct gccctcaggt cccgtcacat
     2701 gtctcaaggg tccagcgttc gaggaagcac tgttgtagat gacagagctt tttgtttcac
     2761 agctgcgggg attctgctga ccatctttta gaaaattatt tcataattta ttctggcttt
     2821 gcccccttgc tccttggttt attccctcat gttttactca aaataaacat ggccatgaac
     2881 tcaggggcca ttgggattct cccctctggc agccccaggt gggagctggg agggtcccca
     2941 gcccaggagg tggctggatt gcagggctgg cagcccccac gtggtggcat cctgacaggc
     3001 acagtgagac ccttgctggg tcaggtctcc tttgtgtgtg aagctggggc agagtatgct
     3061 acgaagggac caggccaggc cacagggctc tcctcccagt ctttatctga aggcccagcc
     3121 aaagcacccc tctaaaccgg tcacctaggg gaaatgcaaa aacctgcaaa agatccacct
     3181 gtattccctg tgtgtgtgtg tcaaaatgac catttgccaa cctggctgtg aggtaatgta
     3241 tgtaaagcac cgagtcaggt gcctgatacg cagtaggtgc ttagcaaacg gtagctaata
     3301 ctatcatcat tgtcattgtt attgtgacac ccatgagccc acagacagag ctgtattaag
     3361 taacctgttt tgaatccaga cattcactcc cccacttgct atgactaccc tcctttgatc
     3421 tatttttggt cataggtaaa aaaaaaaatc tctcttggga gcatataaac aaaaaacata
     3481 gaagcaataa agcgatcgct ggtatttctt ttctcatgca gccaaattcg ccagctggtg
     3541 accaaaggct cagatgcttg cttatttgca gacccggcct cctgggtgct ccccagtgac
     3601 ccatctttcc accccaccac ctccaagtcc tgtctatgtc tgcttccaca cagccctgtc
     3661 cccagggcac cagccttctg tccctcacag cagtgccatc gcgggcatta ggagtcttcg
     3721 ttatgttgta tccttgtgag ttcttgacta ccatgcccaa gtttccccca ctggcaatgg
     3781 ttcctctctt ggaggtacag tggaaaccag agagatgaca gatgttgagt cctcagtgtc
     3841 tcagaggcag caattcttgc tggacacctg cacatgctca gcacagaggc tggtactttg
     3901 gaggcactaa ccacttgatg agtaaatcaa tggcataaag ccccattcca agttatgggg
     3961 tcttttgaca ggcccctttc atcctctttc tctttgtata aacctcatgt ttcagaacaa
     4021 aattacagtc taagttcatt tgcccccagc cttgcccaag gatccccggg ctgtgctgac
     4081 ccctaggcat agggcaaagg gtgttcccaa gcagcaggca cctcagtgcc ctcagttatc
     4141 cagggcaagg ggcctggctg ccccctgctc ctccccatga tgcaggggct ttctaagcca
     4201 ggctgcagac agggcagggt tggcttcttg gccattccct ctgtgccccc ttctccttct
     4261 gactggtctc accctggaga tccccagagg atctgaccag agccaggtgg actgtggccc
     4321 tgagatggag ctggctgcag gcttacaagc acctctgggg acatccagag gggagggtca
     4381 gtaagcacaa cggagctagg gagacttcag atggactcaa acccagagca ataatactct
     4441 cacaccaccc cacagctaag gcactcatgt tccccagtag atcaagccag aagctttgca
     4501 agaagggagt ggaacgaggc tgcctatcca aggtccatct accacgcaga acttggtcat
     4561 gcaagtacat ttggaaaatc tggtcttggc ccgtccccca ttggcctggt ctacacagcc
     4621 aaaaattcag actagattag atgtttgcag gcaattctgt agcaaagcaa attcccctac
     4681 cccgtccctt ccccctagaa gctgccttag cctccctgac tgggtgtggt ctctgggcct
     4741 aggactcctc cctatgagga aaagtgctct ccagccacat cttggcagcc ccacaaccac
     4801 agcatcaggg cagctgcagc aagtgaccac ccacccgtcg ggttagacac acaaggcacc
     4861 aggcactggc atctgactaa aataaccttt ccctacatgg gaagaggaaa gcttgtaggc
     4921 tggcacatat aaacgtccag ccgcagccag atggcctgaa ctaagcagca ggaactctct
     4981 gggctgggga ggagcctcct gcccttctag aaagtgatgc gtcagctttg ttctcctggg
     5041 aaggtgttgc tataccccag gaacaaagca gggcccaact gccagtgcag tcagctgggc
     5101 ctgcgctcca ggctcaccac cgctaagtgg tcaggtaccg ggccagcatc ctgggaggga
     5161 cctcttgcga ctctgagttg cagcttggac tagctgaaca catggggaca tgctccaggg
     5221 gcttcttccc tggcaggatt cctgggattt caaactacct caccaacagg acgctgaacc
     5281 aggagcctgc cacccaactg gcccccttgg tgattgtgga aggtgatgtt tttcctaaaa
     5341 tgcatccctc ctgttctgct ccatatacat gtgcttcaaa aaccaccacc aggaaagcct
     5401 tcccagaaga gggaaaggat taagggctct cttcctttgg gccctgcaga atgtattgga
     5461 gggaggtgtt gctgcaaggt ccaggagctg ggaaactctg ggctcggggg gagataatgc
     5521 accaccagcc tcaaaaagga gctgcccaag ttgaatatgt agcaaagacc atgggataag
     5581 ttgaatagtg gccagacgaa tcactaataa ctcaccatgg gaccctctga agagaggcct
     5641 gtgctcgtgt aaccatagca acagcagatg ccagcaacct actcattagt accacccagt
     5701 gataaggcat cccctgggct agacccaggg gccataaagt agcaaagtag caaatgtagc
     5761 aataaagggc ccgggtctat acggggacag ggtccaaatg accaggactt ggccctctcc
     5821 ccagccccga tgagggctca gagccagctg ctgtcagctg tctggggagg gaaggccctg
     5881 ctccatacca ggggtccctg ttctatactc taagcccact caccgcatga tcacggactc
     5941 atcggaatgg cctcctctta gtgcatgtgg ttctctttag tttatttttc tggaatttgg
     6001 ggattggacc ccagaaccaa acatgctggt acagtctaaa aataaatgac ttgaacccac
     6061 ttcaatcca
//
