LOCUS       NM_001204423            5461 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 9, mRNA.
ACCESSION   NM_001204423
VERSION     NM_001204423.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5461)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5461)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5461)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5461)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5461)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5461)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5461)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5461)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5461)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5461)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005157.1,
            AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced NM_001204423.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK294895.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC005993.2         14210-14272         c
            64-163              AC005157.1         72588-72687         c
            164-214             AC005533.2         52351-52401         c
            215-321             AC005533.2         48552-48658         c
            322-373             AC005533.2         47246-47297         c
            374-438             AC005533.2         41107-41171         c
            439-515             AC005533.2         36846-36922         c
            516-597             AC005533.2         33976-34057         c
            598-672             AC005533.2         32230-32304         c
            673-771             AC005533.2         30089-30187         c
            772-833             AC005533.2         28600-28661         c
            834-944             AC005533.2         11667-11777         c
            945-1070            AC004828.2         179699-179824       c
            1071-1257           AC004828.2         171441-171627       c
            1258-1347           AC004828.2         153703-153792       c
            1348-5461           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5461
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..63
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            64..163
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1398
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 9 is encoded by transcript variant 9;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 9"
                     /protein_id="NP_001191352.1"
                     /db_xref="CCDS:CCDS73655.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPV
                     EAIHLGSLIAAQGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCK
                     RTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQ
                     ERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPI
                     RKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWIS
                     DDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAV
                     QDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQE
                     HIYKLMKSDSYARFLRSNAYQDLLLAKKKGKSLAGKRLTGLMQSS"
     exon            164..214
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            215..321
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            322..373
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            374..438
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            439..515
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            516..597
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            598..672
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            673..771
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            772..833
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            834..944
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1070
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1257
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1347
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..5461
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2879
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5433..5438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5461
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 atttctaggt tttctcctcc tcgagcaaat cacggtctgc gccttccgcg gctctgggaa
       61 cagattgaag acatcattac aaagatgcaa gatgacaaga cagggggtgt gcccatcaga
      121 acagtcaaga gctttctctc caaaatcccc agtgtcgtca caggtactga cattgtgcag
      181 tggcttatga agaacctttc cattgaggac ccagttgaag caatacactt ggggagcctt
      241 atcgctgccc agggctacat ctttccaatc tcagaccatg ttctcaccat gaaggatgat
      301 ggcacctttt atcgtttcca ggctccgtac ttctggcctt cgaactgctg ggaacctgaa
      361 aacactgact atgccatcta tctctgtaag aggacaatgc aaaataaagc aaggctggaa
      421 ctggcagatt atgaagcaga aaacttagca agactccaga gggcctttgc gaggaagtgg
      481 gaattcatct ttatgcaagc agaagcacaa gtaaagattg accggaaaaa agacaagaca
      541 gaaaggaaaa ttttggatag tcaagaacga gccttttggg atgtccacag gcctgtgcca
      601 ggctgtgtga acacaacaga aatggatatc cgaaaatgtc gacgtttgaa gaatccacaa
      661 aaggttaaaa agtccgtgta tggcgtgact gaagagtccc aggcacagag cccggtgcat
      721 gtactcagcc aaccaatcag gaaaacaaca aaagaggaca tccggaaaca gataacattt
      781 ttgaacgcac agatcgacag acattgtttg aaaatgtcca aagtggctga aagtttaatt
      841 gcctacacgg aacaatatgt ggaatatgac cctttgataa caccagctga gccatccaac
      901 ccttggatca gcgatgacgt tgctttgtgg gacatagaga tgagcaaaga gcccagccaa
      961 cagcgagtaa aaagatgggg cttctctttc gatgagatat tgaaggacca ggtggggcgg
     1021 gaccagtttc tacgattcct ggagtccgaa ttcagttcag aaaacctcag gttctggctg
     1081 gctgtccaag atcttaagaa acaaccccta caggatgtgg ccaagagggt agaagaaatc
     1141 tggcaagagt ttctggctcc aggggctcca agtgcaatca acctggattc tcacagctat
     1201 gagataacca gtcaaaatgt caaagatgga gggagatata catttgaaga cgcccaggag
     1261 cacatctaca agctgatgaa gagtgacagc tatgcccgct tcctccggtc aaatgcttac
     1321 caggatttgc tgctggccaa gaagaaggga aagtcgctgg cgggcaagcg cctcacgggc
     1381 ctgatgcagt cctcctgacc gttcctaccg caggtccagg gcctgggccc gcggacccca
     1441 caggcaggcg gcggcgctcc acatctgcgg acagagtttc cttacgagga gacttggtca
     1501 ctgtgaagga gaaagagtga gggcaatgaa gggcgatggt ggggagactc ggtgggtgaa
     1561 tggggagacc agaaagaaag agtccacaga gcctgggctg ggcccggtgg aggctcctgt
     1621 ttacagccct ctcttctttg tacagttgta ttccaacact ccactcgcta agaggccctg
     1681 atcccagctc attcagggga gaacacgtcg tggggttcct gtcacgacta tcacttgaga
     1741 ttatattatt atcctcactc cctcgctgtc tggagacggt cacaccttct ggcaaattca
     1801 agaggcatga gtggaccgag agcacatcca gcatttgcat cacctccctg gcacctccca
     1861 tagttacagc cactacatcc ccaccgccgc ctgtcatccc tcacgtctct gtggccaccc
     1921 gggtgtcact gccagcacca ggcactgctt tcacgtaaaa tgtccaaatc acatcttcag
     1981 caagaaagca acctcacgga ttgccccgcc tcaaggtctt tccaccctct ttgagatcag
     2041 cgttcggaga ggtccccgcc agcccggtgg ctgccctcag gtcccgtcac atgtctcaag
     2101 ggtccagcgt tcgaggaagc actgttgtag atgacagagc tttttgtttc acagctgcgg
     2161 ggattctgct gaccatcttt tagaaaatta tttcataatt tattctggct ttgccccctt
     2221 gctccttggt ttattccctc atgttttact caaaataaac atggccatga actcaggggc
     2281 cattgggatt ctcccctctg gcagccccag gtgggagctg ggagggtccc cagcccagga
     2341 ggtggctgga ttgcagggct ggcagccccc acgtggtggc atcctgacag gcacagtgag
     2401 acccttgctg ggtcaggtct cctttgtgtg tgaagctggg gcagagtatg ctacgaaggg
     2461 accaggccag gccacagggc tctcctccca gtctttatct gaaggcccag ccaaagcacc
     2521 cctctaaacc ggtcacctag gggaaatgca aaaacctgca aaagatccac ctgtattccc
     2581 tgtgtgtgtg tgtcaaaatg accatttgcc aacctggctg tgaggtaatg tatgtaaagc
     2641 accgagtcag gtgcctgata cgcagtaggt gcttagcaaa cggtagctaa tactatcatc
     2701 attgtcattg ttattgtgac acccatgagc ccacagacag agctgtatta agtaacctgt
     2761 tttgaatcca gacattcact cccccacttg ctatgactac cctcctttga tctatttttg
     2821 gtcataggta aaaaaaaaaa tctctcttgg gagcatataa acaaaaaaca tagaagcaat
     2881 aaagcgatcg ctggtatttc ttttctcatg cagccaaatt cgccagctgg tgaccaaagg
     2941 ctcagatgct tgcttatttg cagacccggc ctcctgggtg ctccccagtg acccatcttt
     3001 ccaccccacc acctccaagt cctgtctatg tctgcttcca cacagccctg tccccagggc
     3061 accagccttc tgtccctcac agcagtgcca tcgcgggcat taggagtctt cgttatgttg
     3121 tatccttgtg agttcttgac taccatgccc aagtttcccc cactggcaat ggttcctctc
     3181 ttggaggtac agtggaaacc agagagatga cagatgttga gtcctcagtg tctcagaggc
     3241 agcaattctt gctggacacc tgcacatgct cagcacagag gctggtactt tggaggcact
     3301 aaccacttga tgagtaaatc aatggcataa agccccattc caagttatgg ggtcttttga
     3361 caggcccctt tcatcctctt tctctttgta taaacctcat gtttcagaac aaaattacag
     3421 tctaagttca tttgccccca gccttgccca aggatccccg ggctgtgctg acccctaggc
     3481 atagggcaaa gggtgttccc aagcagcagg cacctcagtg ccctcagtta tccagggcaa
     3541 ggggcctggc tgccccctgc tcctccccat gatgcagggg ctttctaagc caggctgcag
     3601 acagggcagg gttggcttct tggccattcc ctctgtgccc ccttctcctt ctgactggtc
     3661 tcaccctgga gatccccaga ggatctgacc agagccaggt ggactgtggc cctgagatgg
     3721 agctggctgc aggcttacaa gcacctctgg ggacatccag aggggagggt cagtaagcac
     3781 aacggagcta gggagacttc agatggactc aaacccagag caataatact ctcacaccac
     3841 cccacagcta aggcactcat gttccccagt agatcaagcc agaagctttg caagaaggga
     3901 gtggaacgag gctgcctatc caaggtccat ctaccacgca gaacttggtc atgcaagtac
     3961 atttggaaaa tctggtcttg gcccgtcccc cattggcctg gtctacacag ccaaaaattc
     4021 agactagatt agatgtttgc aggcaattct gtagcaaagc aaattcccct accccgtccc
     4081 ttccccctag aagctgcctt agcctccctg actgggtgtg gtctctgggc ctaggactcc
     4141 tccctatgag gaaaagtgct ctccagccac atcttggcag ccccacaacc acagcatcag
     4201 ggcagctgca gcaagtgacc acccacccgt cgggttagac acacaaggca ccaggcactg
     4261 gcatctgact aaaataacct ttccctacat gggaagagga aagcttgtag gctggcacat
     4321 ataaacgtcc agccgcagcc agatggcctg aactaagcag caggaactct ctgggctggg
     4381 gaggagcctc ctgcccttct agaaagtgat gcgtcagctt tgttctcctg ggaaggtgtt
     4441 gctatacccc aggaacaaag cagggcccaa ctgccagtgc agtcagctgg gcctgcgctc
     4501 caggctcacc accgctaagt ggtcaggtac cgggccagca tcctgggagg gacctcttgc
     4561 gactctgagt tgcagcttgg actagctgaa cacatgggga catgctccag gggcttcttc
     4621 cctggcagga ttcctgggat ttcaaactac ctcaccaaca ggacgctgaa ccaggagcct
     4681 gccacccaac tggccccctt ggtgattgtg gaaggtgatg tttttcctaa aatgcatccc
     4741 tcctgttctg ctccatatac atgtgcttca aaaaccacca ccaggaaagc cttcccagaa
     4801 gagggaaagg attaagggct ctcttccttt gggccctgca gaatgtattg gagggaggtg
     4861 ttgctgcaag gtccaggagc tgggaaactc tgggctcggg gggagataat gcaccaccag
     4921 cctcaaaaag gagctgccca agttgaatat gtagcaaaga ccatgggata agttgaatag
     4981 tggccagacg aatcactaat aactcaccat gggaccctct gaagagaggc ctgtgctcgt
     5041 gtaaccatag caacagcaga tgccagcaac ctactcatta gtaccaccca gtgataaggc
     5101 atcccctggg ctagacccag gggccataaa gtagcaaagt agcaaatgta gcaataaagg
     5161 gcccgggtct atacggggac agggtccaaa tgaccaggac ttggccctct ccccagcccc
     5221 gatgagggct cagagccagc tgctgtcagc tgtctgggga gggaaggccc tgctccatac
     5281 caggggtccc tgttctatac tctaagccca ctcaccgcat gatcacggac tcatcggaat
     5341 ggcctcctct tagtgcatgt ggttctcttt agtttatttt tctggaattt ggggattgga
     5401 ccccagaacc aaacatgctg gtacagtcta aaaataaatg acttgaaccc acttcaatcc
     5461 a
//
