LOCUS       NM_001204422            5174 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 8, mRNA.
ACCESSION   NM_001204422
VERSION     NM_001204422.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5174)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5174)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5174)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5174)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5174)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5174)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5174)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5174)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5174)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5174)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced NM_001204422.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1081            AC004828.2         179699-179824       c
            1082-1268           AC004828.2         171441-171627       c
            1269-1358           AC004828.2         153703-153792       c
            1359-5174           AC004828.2         123448-127263       c
FEATURES             Location/Qualifiers
     source          1..5174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5174
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1394
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 8 is encoded by transcript variant 8;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 8"
                     /protein_id="NP_001191351.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQD
                     LKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHI
                     YKLMKSDSYARFLRSNAYQDLLLAKKKLYSNTPLAKRP"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1081
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1268
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1358
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..5174
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2573..2578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2592
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5146..5151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5174
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagcaaag
      961 agcccagcca acagcgagta aaaagatggg gcttctcttt cgatgagata ttgaaggacc
     1021 aggtggggcg ggaccagttt ctacgattcc tggagtccga attcagttca gaaaacctca
     1081 ggttctggct ggctgtccaa gatcttaaga aacaacccct acaggatgtg gccaagaggg
     1141 tagaagaaat ctggcaagag tttctggctc caggggctcc aagtgcaatc aacctggatt
     1201 ctcacagcta tgagataacc agtcaaaatg tcaaagatgg agggagatat acatttgaag
     1261 acgcccagga gcacatctac aagctgatga agagtgacag ctatgcccgc ttcctccggt
     1321 caaatgctta ccaggatttg ctgctggcca agaagaagtt gtattccaac actccactcg
     1381 ctaagaggcc ctgatcccag ctcattcagg ggagaacacg tcgtggggtt cctgtcacga
     1441 ctatcacttg agattatatt attatcctca ctccctcgct gtctggagac ggtcacacct
     1501 tctggcaaat tcaagaggca tgagtggacc gagagcacat ccagcatttg catcacctcc
     1561 ctggcacctc ccatagttac agccactaca tccccaccgc cgcctgtcat ccctcacgtc
     1621 tctgtggcca cccgggtgtc actgccagca ccaggcactg ctttcacgta aaatgtccaa
     1681 atcacatctt cagcaagaaa gcaacctcac ggattgcccc gcctcaaggt ctttccaccc
     1741 tctttgagat cagcgttcgg agaggtcccc gccagcccgg tggctgccct caggtcccgt
     1801 cacatgtctc aagggtccag cgttcgagga agcactgttg tagatgacag agctttttgt
     1861 ttcacagctg cggggattct gctgaccatc ttttagaaaa ttatttcata atttattctg
     1921 gctttgcccc cttgctcctt ggtttattcc ctcatgtttt actcaaaata aacatggcca
     1981 tgaactcagg ggccattggg attctcccct ctggcagccc caggtgggag ctgggagggt
     2041 ccccagccca ggaggtggct ggattgcagg gctggcagcc cccacgtggt ggcatcctga
     2101 caggcacagt gagacccttg ctgggtcagg tctcctttgt gtgtgaagct ggggcagagt
     2161 atgctacgaa gggaccaggc caggccacag ggctctcctc ccagtcttta tctgaaggcc
     2221 cagccaaagc acccctctaa accggtcacc taggggaaat gcaaaaacct gcaaaagatc
     2281 cacctgtatt ccctgtgtgt gtgtgtcaaa atgaccattt gccaacctgg ctgtgaggta
     2341 atgtatgtaa agcaccgagt caggtgcctg atacgcagta ggtgcttagc aaacggtagc
     2401 taatactatc atcattgtca ttgttattgt gacacccatg agcccacaga cagagctgta
     2461 ttaagtaacc tgttttgaat ccagacattc actcccccac ttgctatgac taccctcctt
     2521 tgatctattt ttggtcatag gtaaaaaaaa aaatctctct tgggagcata taaacaaaaa
     2581 acatagaagc aataaagcga tcgctggtat ttcttttctc atgcagccaa attcgccagc
     2641 tggtgaccaa aggctcagat gcttgcttat ttgcagaccc ggcctcctgg gtgctcccca
     2701 gtgacccatc tttccacccc accacctcca agtcctgtct atgtctgctt ccacacagcc
     2761 ctgtccccag ggcaccagcc ttctgtccct cacagcagtg ccatcgcggg cattaggagt
     2821 cttcgttatg ttgtatcctt gtgagttctt gactaccatg cccaagtttc ccccactggc
     2881 aatggttcct ctcttggagg tacagtggaa accagagaga tgacagatgt tgagtcctca
     2941 gtgtctcaga ggcagcaatt cttgctggac acctgcacat gctcagcaca gaggctggta
     3001 ctttggaggc actaaccact tgatgagtaa atcaatggca taaagcccca ttccaagtta
     3061 tggggtcttt tgacaggccc ctttcatcct ctttctcttt gtataaacct catgtttcag
     3121 aacaaaatta cagtctaagt tcatttgccc ccagccttgc ccaaggatcc ccgggctgtg
     3181 ctgaccccta ggcatagggc aaagggtgtt cccaagcagc aggcacctca gtgccctcag
     3241 ttatccaggg caaggggcct ggctgccccc tgctcctccc catgatgcag gggctttcta
     3301 agccaggctg cagacagggc agggttggct tcttggccat tccctctgtg cccccttctc
     3361 cttctgactg gtctcaccct ggagatcccc agaggatctg accagagcca ggtggactgt
     3421 ggccctgaga tggagctggc tgcaggctta caagcacctc tggggacatc cagaggggag
     3481 ggtcagtaag cacaacggag ctagggagac ttcagatgga ctcaaaccca gagcaataat
     3541 actctcacac caccccacag ctaaggcact catgttcccc agtagatcaa gccagaagct
     3601 ttgcaagaag ggagtggaac gaggctgcct atccaaggtc catctaccac gcagaacttg
     3661 gtcatgcaag tacatttgga aaatctggtc ttggcccgtc ccccattggc ctggtctaca
     3721 cagccaaaaa ttcagactag attagatgtt tgcaggcaat tctgtagcaa agcaaattcc
     3781 cctaccccgt cccttccccc tagaagctgc cttagcctcc ctgactgggt gtggtctctg
     3841 ggcctaggac tcctccctat gaggaaaagt gctctccagc cacatcttgg cagccccaca
     3901 accacagcat cagggcagct gcagcaagtg accacccacc cgtcgggtta gacacacaag
     3961 gcaccaggca ctggcatctg actaaaataa cctttcccta catgggaaga ggaaagcttg
     4021 taggctggca catataaacg tccagccgca gccagatggc ctgaactaag cagcaggaac
     4081 tctctgggct ggggaggagc ctcctgccct tctagaaagt gatgcgtcag ctttgttctc
     4141 ctgggaaggt gttgctatac cccaggaaca aagcagggcc caactgccag tgcagtcagc
     4201 tgggcctgcg ctccaggctc accaccgcta agtggtcagg taccgggcca gcatcctggg
     4261 agggacctct tgcgactctg agttgcagct tggactagct gaacacatgg ggacatgctc
     4321 caggggcttc ttccctggca ggattcctgg gatttcaaac tacctcacca acaggacgct
     4381 gaaccaggag cctgccaccc aactggcccc cttggtgatt gtggaaggtg atgtttttcc
     4441 taaaatgcat ccctcctgtt ctgctccata tacatgtgct tcaaaaacca ccaccaggaa
     4501 agccttccca gaagagggaa aggattaagg gctctcttcc tttgggccct gcagaatgta
     4561 ttggagggag gtgttgctgc aaggtccagg agctgggaaa ctctgggctc ggggggagat
     4621 aatgcaccac cagcctcaaa aaggagctgc ccaagttgaa tatgtagcaa agaccatggg
     4681 ataagttgaa tagtggccag acgaatcact aataactcac catgggaccc tctgaagaga
     4741 ggcctgtgct cgtgtaacca tagcaacagc agatgccagc aacctactca ttagtaccac
     4801 ccagtgataa ggcatcccct gggctagacc caggggccat aaagtagcaa agtagcaaat
     4861 gtagcaataa agggcccggg tctatacggg gacagggtcc aaatgaccag gacttggccc
     4921 tctccccagc cccgatgagg gctcagagcc agctgctgtc agctgtctgg ggagggaagg
     4981 ccctgctcca taccaggggt ccctgttcta tactctaagc ccactcaccg catgatcacg
     5041 gactcatcgg aatggcctcc tcttagtgca tgtggttctc tttagtttat ttttctggaa
     5101 tttggggatt ggaccccaga accaaacatg ctggtacagt ctaaaaataa atgacttgaa
     5161 cccacttcaa tcca
//
