LOCUS       NM_001204421            5228 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 7, mRNA.
ACCESSION   NM_001204421
VERSION     NM_001204421.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5228)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5228)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5228)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5228)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5228)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5228)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5228)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5228)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5228)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5228)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced NM_001204421.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2467143,
                              SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1081            AC004828.2         179699-179824       c
            1082-1268           AC004828.2         171441-171627       c
            1269-1358           AC004828.2         153703-153792       c
            1359-1412           AC004828.2         149884-149937       c
            1413-5228           AC004828.2         123448-127263       c
FEATURES             Location/Qualifiers
     source          1..5228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5228
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1448
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 7 is encoded by transcript variant 7;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 7"
                     /protein_id="NP_001191350.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQD
                     LKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHI
                     YKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVLYSNTPLAKRP"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1081
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1268
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1358
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1412
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..5228
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2627..2632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2646
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5200..5205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5228
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagcaaag
      961 agcccagcca acagcgagta aaaagatggg gcttctcttt cgatgagata ttgaaggacc
     1021 aggtggggcg ggaccagttt ctacgattcc tggagtccga attcagttca gaaaacctca
     1081 ggttctggct ggctgtccaa gatcttaaga aacaacccct acaggatgtg gccaagaggg
     1141 tagaagaaat ctggcaagag tttctggctc caggggctcc aagtgcaatc aacctggatt
     1201 ctcacagcta tgagataacc agtcaaaatg tcaaagatgg agggagatat acatttgaag
     1261 acgcccagga gcacatctac aagctgatga agagtgacag ctatgcccgc ttcctccggt
     1321 caaatgctta ccaggatttg ctgctggcca agaagaagcc agaaagtgag caaggtcgta
     1381 gaacttccct agaaaagttc actcgcagtg tgttgtattc caacactcca ctcgctaaga
     1441 ggccctgatc ccagctcatt caggggagaa cacgtcgtgg ggttcctgtc acgactatca
     1501 cttgagatta tattattatc ctcactccct cgctgtctgg agacggtcac accttctggc
     1561 aaattcaaga ggcatgagtg gaccgagagc acatccagca tttgcatcac ctccctggca
     1621 cctcccatag ttacagccac tacatcccca ccgccgcctg tcatccctca cgtctctgtg
     1681 gccacccggg tgtcactgcc agcaccaggc actgctttca cgtaaaatgt ccaaatcaca
     1741 tcttcagcaa gaaagcaacc tcacggattg ccccgcctca aggtctttcc accctctttg
     1801 agatcagcgt tcggagaggt ccccgccagc ccggtggctg ccctcaggtc ccgtcacatg
     1861 tctcaagggt ccagcgttcg aggaagcact gttgtagatg acagagcttt ttgtttcaca
     1921 gctgcgggga ttctgctgac catcttttag aaaattattt cataatttat tctggctttg
     1981 cccccttgct ccttggttta ttccctcatg ttttactcaa aataaacatg gccatgaact
     2041 caggggccat tgggattctc ccctctggca gccccaggtg ggagctggga gggtccccag
     2101 cccaggaggt ggctggattg cagggctggc agcccccacg tggtggcatc ctgacaggca
     2161 cagtgagacc cttgctgggt caggtctcct ttgtgtgtga agctggggca gagtatgcta
     2221 cgaagggacc aggccaggcc acagggctct cctcccagtc tttatctgaa ggcccagcca
     2281 aagcacccct ctaaaccggt cacctagggg aaatgcaaaa acctgcaaaa gatccacctg
     2341 tattccctgt gtgtgtgtgt caaaatgacc atttgccaac ctggctgtga ggtaatgtat
     2401 gtaaagcacc gagtcaggtg cctgatacgc agtaggtgct tagcaaacgg tagctaatac
     2461 tatcatcatt gtcattgtta ttgtgacacc catgagccca cagacagagc tgtattaagt
     2521 aacctgtttt gaatccagac attcactccc ccacttgcta tgactaccct cctttgatct
     2581 atttttggtc ataggtaaaa aaaaaaatct ctcttgggag catataaaca aaaaacatag
     2641 aagcaataaa gcgatcgctg gtatttcttt tctcatgcag ccaaattcgc cagctggtga
     2701 ccaaaggctc agatgcttgc ttatttgcag acccggcctc ctgggtgctc cccagtgacc
     2761 catctttcca ccccaccacc tccaagtcct gtctatgtct gcttccacac agccctgtcc
     2821 ccagggcacc agccttctgt ccctcacagc agtgccatcg cgggcattag gagtcttcgt
     2881 tatgttgtat ccttgtgagt tcttgactac catgcccaag tttcccccac tggcaatggt
     2941 tcctctcttg gaggtacagt ggaaaccaga gagatgacag atgttgagtc ctcagtgtct
     3001 cagaggcagc aattcttgct ggacacctgc acatgctcag cacagaggct ggtactttgg
     3061 aggcactaac cacttgatga gtaaatcaat ggcataaagc cccattccaa gttatggggt
     3121 cttttgacag gcccctttca tcctctttct ctttgtataa acctcatgtt tcagaacaaa
     3181 attacagtct aagttcattt gcccccagcc ttgcccaagg atccccgggc tgtgctgacc
     3241 cctaggcata gggcaaaggg tgttcccaag cagcaggcac ctcagtgccc tcagttatcc
     3301 agggcaaggg gcctggctgc cccctgctcc tccccatgat gcaggggctt tctaagccag
     3361 gctgcagaca gggcagggtt ggcttcttgg ccattccctc tgtgccccct tctccttctg
     3421 actggtctca ccctggagat ccccagagga tctgaccaga gccaggtgga ctgtggccct
     3481 gagatggagc tggctgcagg cttacaagca cctctgggga catccagagg ggagggtcag
     3541 taagcacaac ggagctaggg agacttcaga tggactcaaa cccagagcaa taatactctc
     3601 acaccacccc acagctaagg cactcatgtt ccccagtaga tcaagccaga agctttgcaa
     3661 gaagggagtg gaacgaggct gcctatccaa ggtccatcta ccacgcagaa cttggtcatg
     3721 caagtacatt tggaaaatct ggtcttggcc cgtcccccat tggcctggtc tacacagcca
     3781 aaaattcaga ctagattaga tgtttgcagg caattctgta gcaaagcaaa ttcccctacc
     3841 ccgtcccttc cccctagaag ctgccttagc ctccctgact gggtgtggtc tctgggccta
     3901 ggactcctcc ctatgaggaa aagtgctctc cagccacatc ttggcagccc cacaaccaca
     3961 gcatcagggc agctgcagca agtgaccacc cacccgtcgg gttagacaca caaggcacca
     4021 ggcactggca tctgactaaa ataacctttc cctacatggg aagaggaaag cttgtaggct
     4081 ggcacatata aacgtccagc cgcagccaga tggcctgaac taagcagcag gaactctctg
     4141 ggctggggag gagcctcctg cccttctaga aagtgatgcg tcagctttgt tctcctggga
     4201 aggtgttgct ataccccagg aacaaagcag ggcccaactg ccagtgcagt cagctgggcc
     4261 tgcgctccag gctcaccacc gctaagtggt caggtaccgg gccagcatcc tgggagggac
     4321 ctcttgcgac tctgagttgc agcttggact agctgaacac atggggacat gctccagggg
     4381 cttcttccct ggcaggattc ctgggatttc aaactacctc accaacagga cgctgaacca
     4441 ggagcctgcc acccaactgg cccccttggt gattgtggaa ggtgatgttt ttcctaaaat
     4501 gcatccctcc tgttctgctc catatacatg tgcttcaaaa accaccacca ggaaagcctt
     4561 cccagaagag ggaaaggatt aagggctctc ttcctttggg ccctgcagaa tgtattggag
     4621 ggaggtgttg ctgcaaggtc caggagctgg gaaactctgg gctcgggggg agataatgca
     4681 ccaccagcct caaaaaggag ctgcccaagt tgaatatgta gcaaagacca tgggataagt
     4741 tgaatagtgg ccagacgaat cactaataac tcaccatggg accctctgaa gagaggcctg
     4801 tgctcgtgta accatagcaa cagcagatgc cagcaaccta ctcattagta ccacccagtg
     4861 ataaggcatc ccctgggcta gacccagggg ccataaagta gcaaagtagc aaatgtagca
     4921 ataaagggcc cgggtctata cggggacagg gtccaaatga ccaggacttg gccctctccc
     4981 cagccccgat gagggctcag agccagctgc tgtcagctgt ctggggaggg aaggccctgc
     5041 tccataccag gggtccctgt tctatactct aagcccactc accgcatgat cacggactca
     5101 tcggaatggc ctcctcttag tgcatgtggt tctctttagt ttatttttct ggaatttggg
     5161 gattggaccc cagaaccaaa catgctggta cagtctaaaa ataaatgact tgaacccact
     5221 tcaatcca
//
