LOCUS       NM_001204420            5472 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 6, mRNA.
ACCESSION   NM_001204420
VERSION     NM_001204420.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5472)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5472)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5472)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5472)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5472)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5472)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5472)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5472)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5472)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5472)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced NM_001204420.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154125 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1081            AC004828.2         179699-179824       c
            1082-1268           AC004828.2         171441-171627       c
            1269-1358           AC004828.2         153703-153792       c
            1359-5472           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5472
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5472
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1409
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 6 is encoded by transcript variant 6;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 6"
                     /protein_id="NP_001191349.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQD
                     LKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHI
                     YKLMKSDSYARFLRSNAYQDLLLAKKKGKSLAGKRLTGLMQSS"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1081
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1268
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1358
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..5472
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2871..2876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2890
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5444..5449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5472
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagcaaag
      961 agcccagcca acagcgagta aaaagatggg gcttctcttt cgatgagata ttgaaggacc
     1021 aggtggggcg ggaccagttt ctacgattcc tggagtccga attcagttca gaaaacctca
     1081 ggttctggct ggctgtccaa gatcttaaga aacaacccct acaggatgtg gccaagaggg
     1141 tagaagaaat ctggcaagag tttctggctc caggggctcc aagtgcaatc aacctggatt
     1201 ctcacagcta tgagataacc agtcaaaatg tcaaagatgg agggagatat acatttgaag
     1261 acgcccagga gcacatctac aagctgatga agagtgacag ctatgcccgc ttcctccggt
     1321 caaatgctta ccaggatttg ctgctggcca agaagaaggg aaagtcgctg gcgggcaagc
     1381 gcctcacggg cctgatgcag tcctcctgac cgttcctacc gcaggtccag ggcctgggcc
     1441 cgcggacccc acaggcaggc ggcggcgctc cacatctgcg gacagagttt ccttacgagg
     1501 agacttggtc actgtgaagg agaaagagtg agggcaatga agggcgatgg tggggagact
     1561 cggtgggtga atggggagac cagaaagaaa gagtccacag agcctgggct gggcccggtg
     1621 gaggctcctg tttacagccc tctcttcttt gtacagttgt attccaacac tccactcgct
     1681 aagaggccct gatcccagct cattcagggg agaacacgtc gtggggttcc tgtcacgact
     1741 atcacttgag attatattat tatcctcact ccctcgctgt ctggagacgg tcacaccttc
     1801 tggcaaattc aagaggcatg agtggaccga gagcacatcc agcatttgca tcacctccct
     1861 ggcacctccc atagttacag ccactacatc cccaccgccg cctgtcatcc ctcacgtctc
     1921 tgtggccacc cgggtgtcac tgccagcacc aggcactgct ttcacgtaaa atgtccaaat
     1981 cacatcttca gcaagaaagc aacctcacgg attgccccgc ctcaaggtct ttccaccctc
     2041 tttgagatca gcgttcggag aggtccccgc cagcccggtg gctgccctca ggtcccgtca
     2101 catgtctcaa gggtccagcg ttcgaggaag cactgttgta gatgacagag ctttttgttt
     2161 cacagctgcg gggattctgc tgaccatctt ttagaaaatt atttcataat ttattctggc
     2221 tttgccccct tgctccttgg tttattccct catgttttac tcaaaataaa catggccatg
     2281 aactcagggg ccattgggat tctcccctct ggcagcccca ggtgggagct gggagggtcc
     2341 ccagcccagg aggtggctgg attgcagggc tggcagcccc cacgtggtgg catcctgaca
     2401 ggcacagtga gacccttgct gggtcaggtc tcctttgtgt gtgaagctgg ggcagagtat
     2461 gctacgaagg gaccaggcca ggccacaggg ctctcctccc agtctttatc tgaaggccca
     2521 gccaaagcac ccctctaaac cggtcaccta ggggaaatgc aaaaacctgc aaaagatcca
     2581 cctgtattcc ctgtgtgtgt gtgtcaaaat gaccatttgc caacctggct gtgaggtaat
     2641 gtatgtaaag caccgagtca ggtgcctgat acgcagtagg tgcttagcaa acggtagcta
     2701 atactatcat cattgtcatt gttattgtga cacccatgag cccacagaca gagctgtatt
     2761 aagtaacctg ttttgaatcc agacattcac tcccccactt gctatgacta ccctcctttg
     2821 atctattttt ggtcataggt aaaaaaaaaa atctctcttg ggagcatata aacaaaaaac
     2881 atagaagcaa taaagcgatc gctggtattt cttttctcat gcagccaaat tcgccagctg
     2941 gtgaccaaag gctcagatgc ttgcttattt gcagacccgg cctcctgggt gctccccagt
     3001 gacccatctt tccaccccac cacctccaag tcctgtctat gtctgcttcc acacagccct
     3061 gtccccaggg caccagcctt ctgtccctca cagcagtgcc atcgcgggca ttaggagtct
     3121 tcgttatgtt gtatccttgt gagttcttga ctaccatgcc caagtttccc ccactggcaa
     3181 tggttcctct cttggaggta cagtggaaac cagagagatg acagatgttg agtcctcagt
     3241 gtctcagagg cagcaattct tgctggacac ctgcacatgc tcagcacaga ggctggtact
     3301 ttggaggcac taaccacttg atgagtaaat caatggcata aagccccatt ccaagttatg
     3361 gggtcttttg acaggcccct ttcatcctct ttctctttgt ataaacctca tgtttcagaa
     3421 caaaattaca gtctaagttc atttgccccc agccttgccc aaggatcccc gggctgtgct
     3481 gacccctagg catagggcaa agggtgttcc caagcagcag gcacctcagt gccctcagtt
     3541 atccagggca aggggcctgg ctgccccctg ctcctcccca tgatgcaggg gctttctaag
     3601 ccaggctgca gacagggcag ggttggcttc ttggccattc cctctgtgcc cccttctcct
     3661 tctgactggt ctcaccctgg agatccccag aggatctgac cagagccagg tggactgtgg
     3721 ccctgagatg gagctggctg caggcttaca agcacctctg gggacatcca gaggggaggg
     3781 tcagtaagca caacggagct agggagactt cagatggact caaacccaga gcaataatac
     3841 tctcacacca ccccacagct aaggcactca tgttccccag tagatcaagc cagaagcttt
     3901 gcaagaaggg agtggaacga ggctgcctat ccaaggtcca tctaccacgc agaacttggt
     3961 catgcaagta catttggaaa atctggtctt ggcccgtccc ccattggcct ggtctacaca
     4021 gccaaaaatt cagactagat tagatgtttg caggcaattc tgtagcaaag caaattcccc
     4081 taccccgtcc cttcccccta gaagctgcct tagcctccct gactgggtgt ggtctctggg
     4141 cctaggactc ctccctatga ggaaaagtgc tctccagcca catcttggca gccccacaac
     4201 cacagcatca gggcagctgc agcaagtgac cacccacccg tcgggttaga cacacaaggc
     4261 accaggcact ggcatctgac taaaataacc tttccctaca tgggaagagg aaagcttgta
     4321 ggctggcaca tataaacgtc cagccgcagc cagatggcct gaactaagca gcaggaactc
     4381 tctgggctgg ggaggagcct cctgcccttc tagaaagtga tgcgtcagct ttgttctcct
     4441 gggaaggtgt tgctataccc caggaacaaa gcagggccca actgccagtg cagtcagctg
     4501 ggcctgcgct ccaggctcac caccgctaag tggtcaggta ccgggccagc atcctgggag
     4561 ggacctcttg cgactctgag ttgcagcttg gactagctga acacatgggg acatgctcca
     4621 ggggcttctt ccctggcagg attcctggga tttcaaacta cctcaccaac aggacgctga
     4681 accaggagcc tgccacccaa ctggccccct tggtgattgt ggaaggtgat gtttttccta
     4741 aaatgcatcc ctcctgttct gctccatata catgtgcttc aaaaaccacc accaggaaag
     4801 ccttcccaga agagggaaag gattaagggc tctcttcctt tgggccctgc agaatgtatt
     4861 ggagggaggt gttgctgcaa ggtccaggag ctgggaaact ctgggctcgg ggggagataa
     4921 tgcaccacca gcctcaaaaa ggagctgccc aagttgaata tgtagcaaag accatgggat
     4981 aagttgaata gtggccagac gaatcactaa taactcacca tgggaccctc tgaagagagg
     5041 cctgtgctcg tgtaaccata gcaacagcag atgccagcaa cctactcatt agtaccaccc
     5101 agtgataagg catcccctgg gctagaccca ggggccataa agtagcaaag tagcaaatgt
     5161 agcaataaag ggcccgggtc tatacgggga cagggtccaa atgaccagga cttggccctc
     5221 tccccagccc cgatgagggc tcagagccag ctgctgtcag ctgtctgggg agggaaggcc
     5281 ctgctccata ccaggggtcc ctgttctata ctctaagccc actcaccgca tgatcacgga
     5341 ctcatcggaa tggcctcctc ttagtgcatg tggttctctt tagtttattt ttctggaatt
     5401 tggggattgg accccagaac caaacatgct ggtacagtct aaaaataaat gacttgaacc
     5461 cacttcaatc ca
//
