LOCUS       NM_001204419            5526 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 5, mRNA.
ACCESSION   NM_001204419
VERSION     NM_001204419.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5526)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5526)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5526)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5526)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5526)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5526)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5526)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5526)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5526)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5526)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced NM_001204419.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.256584.1,
                                           SRR1803611.209895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154361, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1081            AC004828.2         179699-179824       c
            1082-1268           AC004828.2         171441-171627       c
            1269-1358           AC004828.2         153703-153792       c
            1359-1412           AC004828.2         149884-149937       c
            1413-5526           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5526
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1463
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 5 is encoded by transcript variant 5;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 5"
                     /protein_id="NP_001191348.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQD
                     LKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHI
                     YKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLM
                     QSS"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1081
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1268
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1358
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1412
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..5526
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2944
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5498..5503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5526
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagcaaag
      961 agcccagcca acagcgagta aaaagatggg gcttctcttt cgatgagata ttgaaggacc
     1021 aggtggggcg ggaccagttt ctacgattcc tggagtccga attcagttca gaaaacctca
     1081 ggttctggct ggctgtccaa gatcttaaga aacaacccct acaggatgtg gccaagaggg
     1141 tagaagaaat ctggcaagag tttctggctc caggggctcc aagtgcaatc aacctggatt
     1201 ctcacagcta tgagataacc agtcaaaatg tcaaagatgg agggagatat acatttgaag
     1261 acgcccagga gcacatctac aagctgatga agagtgacag ctatgcccgc ttcctccggt
     1321 caaatgctta ccaggatttg ctgctggcca agaagaagcc agaaagtgag caaggtcgta
     1381 gaacttccct agaaaagttc actcgcagtg tgggaaagtc gctggcgggc aagcgcctca
     1441 cgggcctgat gcagtcctcc tgaccgttcc taccgcaggt ccagggcctg ggcccgcgga
     1501 ccccacaggc aggcggcggc gctccacatc tgcggacaga gtttccttac gaggagactt
     1561 ggtcactgtg aaggagaaag agtgagggca atgaagggcg atggtgggga gactcggtgg
     1621 gtgaatgggg agaccagaaa gaaagagtcc acagagcctg ggctgggccc ggtggaggct
     1681 cctgtttaca gccctctctt ctttgtacag ttgtattcca acactccact cgctaagagg
     1741 ccctgatccc agctcattca ggggagaaca cgtcgtgggg ttcctgtcac gactatcact
     1801 tgagattata ttattatcct cactccctcg ctgtctggag acggtcacac cttctggcaa
     1861 attcaagagg catgagtgga ccgagagcac atccagcatt tgcatcacct ccctggcacc
     1921 tcccatagtt acagccacta catccccacc gccgcctgtc atccctcacg tctctgtggc
     1981 cacccgggtg tcactgccag caccaggcac tgctttcacg taaaatgtcc aaatcacatc
     2041 ttcagcaaga aagcaacctc acggattgcc ccgcctcaag gtctttccac cctctttgag
     2101 atcagcgttc ggagaggtcc ccgccagccc ggtggctgcc ctcaggtccc gtcacatgtc
     2161 tcaagggtcc agcgttcgag gaagcactgt tgtagatgac agagcttttt gtttcacagc
     2221 tgcggggatt ctgctgacca tcttttagaa aattatttca taatttattc tggctttgcc
     2281 cccttgctcc ttggtttatt ccctcatgtt ttactcaaaa taaacatggc catgaactca
     2341 ggggccattg ggattctccc ctctggcagc cccaggtggg agctgggagg gtccccagcc
     2401 caggaggtgg ctggattgca gggctggcag cccccacgtg gtggcatcct gacaggcaca
     2461 gtgagaccct tgctgggtca ggtctccttt gtgtgtgaag ctggggcaga gtatgctacg
     2521 aagggaccag gccaggccac agggctctcc tcccagtctt tatctgaagg cccagccaaa
     2581 gcacccctct aaaccggtca cctaggggaa atgcaaaaac ctgcaaaaga tccacctgta
     2641 ttccctgtgt gtgtgtgtca aaatgaccat ttgccaacct ggctgtgagg taatgtatgt
     2701 aaagcaccga gtcaggtgcc tgatacgcag taggtgctta gcaaacggta gctaatacta
     2761 tcatcattgt cattgttatt gtgacaccca tgagcccaca gacagagctg tattaagtaa
     2821 cctgttttga atccagacat tcactccccc acttgctatg actaccctcc tttgatctat
     2881 ttttggtcat aggtaaaaaa aaaaatctct cttgggagca tataaacaaa aaacatagaa
     2941 gcaataaagc gatcgctggt atttcttttc tcatgcagcc aaattcgcca gctggtgacc
     3001 aaaggctcag atgcttgctt atttgcagac ccggcctcct gggtgctccc cagtgaccca
     3061 tctttccacc ccaccacctc caagtcctgt ctatgtctgc ttccacacag ccctgtcccc
     3121 agggcaccag ccttctgtcc ctcacagcag tgccatcgcg ggcattagga gtcttcgtta
     3181 tgttgtatcc ttgtgagttc ttgactacca tgcccaagtt tcccccactg gcaatggttc
     3241 ctctcttgga ggtacagtgg aaaccagaga gatgacagat gttgagtcct cagtgtctca
     3301 gaggcagcaa ttcttgctgg acacctgcac atgctcagca cagaggctgg tactttggag
     3361 gcactaacca cttgatgagt aaatcaatgg cataaagccc cattccaagt tatggggtct
     3421 tttgacaggc ccctttcatc ctctttctct ttgtataaac ctcatgtttc agaacaaaat
     3481 tacagtctaa gttcatttgc ccccagcctt gcccaaggat ccccgggctg tgctgacccc
     3541 taggcatagg gcaaagggtg ttcccaagca gcaggcacct cagtgccctc agttatccag
     3601 ggcaaggggc ctggctgccc cctgctcctc cccatgatgc aggggctttc taagccaggc
     3661 tgcagacagg gcagggttgg cttcttggcc attccctctg tgcccccttc tccttctgac
     3721 tggtctcacc ctggagatcc ccagaggatc tgaccagagc caggtggact gtggccctga
     3781 gatggagctg gctgcaggct tacaagcacc tctggggaca tccagagggg agggtcagta
     3841 agcacaacgg agctagggag acttcagatg gactcaaacc cagagcaata atactctcac
     3901 accaccccac agctaaggca ctcatgttcc ccagtagatc aagccagaag ctttgcaaga
     3961 agggagtgga acgaggctgc ctatccaagg tccatctacc acgcagaact tggtcatgca
     4021 agtacatttg gaaaatctgg tcttggcccg tcccccattg gcctggtcta cacagccaaa
     4081 aattcagact agattagatg tttgcaggca attctgtagc aaagcaaatt cccctacccc
     4141 gtcccttccc cctagaagct gccttagcct ccctgactgg gtgtggtctc tgggcctagg
     4201 actcctccct atgaggaaaa gtgctctcca gccacatctt ggcagcccca caaccacagc
     4261 atcagggcag ctgcagcaag tgaccaccca cccgtcgggt tagacacaca aggcaccagg
     4321 cactggcatc tgactaaaat aacctttccc tacatgggaa gaggaaagct tgtaggctgg
     4381 cacatataaa cgtccagccg cagccagatg gcctgaacta agcagcagga actctctggg
     4441 ctggggagga gcctcctgcc cttctagaaa gtgatgcgtc agctttgttc tcctgggaag
     4501 gtgttgctat accccaggaa caaagcaggg cccaactgcc agtgcagtca gctgggcctg
     4561 cgctccaggc tcaccaccgc taagtggtca ggtaccgggc cagcatcctg ggagggacct
     4621 cttgcgactc tgagttgcag cttggactag ctgaacacat ggggacatgc tccaggggct
     4681 tcttccctgg caggattcct gggatttcaa actacctcac caacaggacg ctgaaccagg
     4741 agcctgccac ccaactggcc cccttggtga ttgtggaagg tgatgttttt cctaaaatgc
     4801 atccctcctg ttctgctcca tatacatgtg cttcaaaaac caccaccagg aaagccttcc
     4861 cagaagaggg aaaggattaa gggctctctt cctttgggcc ctgcagaatg tattggaggg
     4921 aggtgttgct gcaaggtcca ggagctggga aactctgggc tcggggggag ataatgcacc
     4981 accagcctca aaaaggagct gcccaagttg aatatgtagc aaagaccatg ggataagttg
     5041 aatagtggcc agacgaatca ctaataactc accatgggac cctctgaaga gaggcctgtg
     5101 ctcgtgtaac catagcaaca gcagatgcca gcaacctact cattagtacc acccagtgat
     5161 aaggcatccc ctgggctaga cccaggggcc ataaagtagc aaagtagcaa atgtagcaat
     5221 aaagggcccg ggtctatacg gggacagggt ccaaatgacc aggacttggc cctctcccca
     5281 gccccgatga gggctcagag ccagctgctg tcagctgtct ggggagggaa ggccctgctc
     5341 cataccaggg gtccctgttc tatactctaa gcccactcac cgcatgatca cggactcatc
     5401 ggaatggcct cctcttagtg catgtggttc tctttagttt atttttctgg aatttgggga
     5461 ttggacccca gaaccaaaca tgctggtaca gtctaaaaat aaatgacttg aacccacttc
     5521 aatcca
//
