LOCUS       NM_001204418            5285 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 4, mRNA.
ACCESSION   NM_001204418
VERSION     NM_001204418.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5285)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5285)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5285)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5285)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5285)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5285)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5285)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5285)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5285)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5285)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced NM_001204418.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-5285           AC004828.2         123448-127263       c
FEATURES             Location/Qualifiers
     source          1..5285
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1505
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 4 is encoded by transcript variant 4;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 4"
                     /protein_id="NP_001191347.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKLYSNTPLAKRP"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..5285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2684..2689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      2703
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5257..5262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaagt tgtattccaa cactccactc gctaagaggc
     1501 cctgatccca gctcattcag gggagaacac gtcgtggggt tcctgtcacg actatcactt
     1561 gagattatat tattatcctc actccctcgc tgtctggaga cggtcacacc ttctggcaaa
     1621 ttcaagaggc atgagtggac cgagagcaca tccagcattt gcatcacctc cctggcacct
     1681 cccatagtta cagccactac atccccaccg ccgcctgtca tccctcacgt ctctgtggcc
     1741 acccgggtgt cactgccagc accaggcact gctttcacgt aaaatgtcca aatcacatct
     1801 tcagcaagaa agcaacctca cggattgccc cgcctcaagg tctttccacc ctctttgaga
     1861 tcagcgttcg gagaggtccc cgccagcccg gtggctgccc tcaggtcccg tcacatgtct
     1921 caagggtcca gcgttcgagg aagcactgtt gtagatgaca gagctttttg tttcacagct
     1981 gcggggattc tgctgaccat cttttagaaa attatttcat aatttattct ggctttgccc
     2041 ccttgctcct tggtttattc cctcatgttt tactcaaaat aaacatggcc atgaactcag
     2101 gggccattgg gattctcccc tctggcagcc ccaggtggga gctgggaggg tccccagccc
     2161 aggaggtggc tggattgcag ggctggcagc ccccacgtgg tggcatcctg acaggcacag
     2221 tgagaccctt gctgggtcag gtctcctttg tgtgtgaagc tggggcagag tatgctacga
     2281 agggaccagg ccaggccaca gggctctcct cccagtcttt atctgaaggc ccagccaaag
     2341 cacccctcta aaccggtcac ctaggggaaa tgcaaaaacc tgcaaaagat ccacctgtat
     2401 tccctgtgtg tgtgtgtcaa aatgaccatt tgccaacctg gctgtgaggt aatgtatgta
     2461 aagcaccgag tcaggtgcct gatacgcagt aggtgcttag caaacggtag ctaatactat
     2521 catcattgtc attgttattg tgacacccat gagcccacag acagagctgt attaagtaac
     2581 ctgttttgaa tccagacatt cactccccca cttgctatga ctaccctcct ttgatctatt
     2641 tttggtcata ggtaaaaaaa aaaatctctc ttgggagcat ataaacaaaa aacatagaag
     2701 caataaagcg atcgctggta tttcttttct catgcagcca aattcgccag ctggtgacca
     2761 aaggctcaga tgcttgctta tttgcagacc cggcctcctg ggtgctcccc agtgacccat
     2821 ctttccaccc caccacctcc aagtcctgtc tatgtctgct tccacacagc cctgtcccca
     2881 gggcaccagc cttctgtccc tcacagcagt gccatcgcgg gcattaggag tcttcgttat
     2941 gttgtatcct tgtgagttct tgactaccat gcccaagttt cccccactgg caatggttcc
     3001 tctcttggag gtacagtgga aaccagagag atgacagatg ttgagtcctc agtgtctcag
     3061 aggcagcaat tcttgctgga cacctgcaca tgctcagcac agaggctggt actttggagg
     3121 cactaaccac ttgatgagta aatcaatggc ataaagcccc attccaagtt atggggtctt
     3181 ttgacaggcc cctttcatcc tctttctctt tgtataaacc tcatgtttca gaacaaaatt
     3241 acagtctaag ttcatttgcc cccagccttg cccaaggatc cccgggctgt gctgacccct
     3301 aggcataggg caaagggtgt tcccaagcag caggcacctc agtgccctca gttatccagg
     3361 gcaaggggcc tggctgcccc ctgctcctcc ccatgatgca ggggctttct aagccaggct
     3421 gcagacaggg cagggttggc ttcttggcca ttccctctgt gcccccttct ccttctgact
     3481 ggtctcaccc tggagatccc cagaggatct gaccagagcc aggtggactg tggccctgag
     3541 atggagctgg ctgcaggctt acaagcacct ctggggacat ccagagggga gggtcagtaa
     3601 gcacaacgga gctagggaga cttcagatgg actcaaaccc agagcaataa tactctcaca
     3661 ccaccccaca gctaaggcac tcatgttccc cagtagatca agccagaagc tttgcaagaa
     3721 gggagtggaa cgaggctgcc tatccaaggt ccatctacca cgcagaactt ggtcatgcaa
     3781 gtacatttgg aaaatctggt cttggcccgt cccccattgg cctggtctac acagccaaaa
     3841 attcagacta gattagatgt ttgcaggcaa ttctgtagca aagcaaattc ccctaccccg
     3901 tcccttcccc ctagaagctg ccttagcctc cctgactggg tgtggtctct gggcctagga
     3961 ctcctcccta tgaggaaaag tgctctccag ccacatcttg gcagccccac aaccacagca
     4021 tcagggcagc tgcagcaagt gaccacccac ccgtcgggtt agacacacaa ggcaccaggc
     4081 actggcatct gactaaaata acctttccct acatgggaag aggaaagctt gtaggctggc
     4141 acatataaac gtccagccgc agccagatgg cctgaactaa gcagcaggaa ctctctgggc
     4201 tggggaggag cctcctgccc ttctagaaag tgatgcgtca gctttgttct cctgggaagg
     4261 tgttgctata ccccaggaac aaagcagggc ccaactgcca gtgcagtcag ctgggcctgc
     4321 gctccaggct caccaccgct aagtggtcag gtaccgggcc agcatcctgg gagggacctc
     4381 ttgcgactct gagttgcagc ttggactagc tgaacacatg gggacatgct ccaggggctt
     4441 cttccctggc aggattcctg ggatttcaaa ctacctcacc aacaggacgc tgaaccagga
     4501 gcctgccacc caactggccc ccttggtgat tgtggaaggt gatgtttttc ctaaaatgca
     4561 tccctcctgt tctgctccat atacatgtgc ttcaaaaacc accaccagga aagccttccc
     4621 agaagaggga aaggattaag ggctctcttc ctttgggccc tgcagaatgt attggaggga
     4681 ggtgttgctg caaggtccag gagctgggaa actctgggct cggggggaga taatgcacca
     4741 ccagcctcaa aaaggagctg cccaagttga atatgtagca aagaccatgg gataagttga
     4801 atagtggcca gacgaatcac taataactca ccatgggacc ctctgaagag aggcctgtgc
     4861 tcgtgtaacc atagcaacag cagatgccag caacctactc attagtacca cccagtgata
     4921 aggcatcccc tgggctagac ccaggggcca taaagtagca aagtagcaaa tgtagcaata
     4981 aagggcccgg gtctatacgg ggacagggtc caaatgacca ggacttggcc ctctccccag
     5041 ccccgatgag ggctcagagc cagctgctgt cagctgtctg gggagggaag gccctgctcc
     5101 ataccagggg tccctgttct atactctaag cccactcacc gcatgatcac ggactcatcg
     5161 gaatggcctc ctcttagtgc atgtggttct ctttagttta tttttctgga atttggggat
     5221 tggaccccag aaccaaacat gctggtacag tctaaaaata aatgacttga acccacttca
     5281 atcca
//
