LOCUS       NM_001204416            5637 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 1, mRNA.
ACCESSION   NM_001204416
VERSION     NM_001204416.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5637)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5637)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5637)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5637)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5637)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5637)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5637)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5637)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5637)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5637)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced NM_001204416.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.222642.1,
                                           SRR1803611.202695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154361, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-1523           AC004828.2         149884-149937       c
            1524-5637           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1574
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 1"
                     /protein_id="NP_001191345.1"
                     /db_xref="CCDS:CCDS55924.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLMQSS"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1523
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..5637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3055
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5609..5614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaagc cagaaagtga gcaaggtcgt agaacttccc
     1501 tagaaaagtt cactcgcagt gtgggaaagt cgctggcggg caagcgcctc acgggcctga
     1561 tgcagtcctc ctgaccgttc ctaccgcagg tccagggcct gggcccgcgg accccacagg
     1621 caggcggcgg cgctccacat ctgcggacag agtttcctta cgaggagact tggtcactgt
     1681 gaaggagaaa gagtgagggc aatgaagggc gatggtgggg agactcggtg ggtgaatggg
     1741 gagaccagaa agaaagagtc cacagagcct gggctgggcc cggtggaggc tcctgtttac
     1801 agccctctct tctttgtaca gttgtattcc aacactccac tcgctaagag gccctgatcc
     1861 cagctcattc aggggagaac acgtcgtggg gttcctgtca cgactatcac ttgagattat
     1921 attattatcc tcactccctc gctgtctgga gacggtcaca ccttctggca aattcaagag
     1981 gcatgagtgg accgagagca catccagcat ttgcatcacc tccctggcac ctcccatagt
     2041 tacagccact acatccccac cgccgcctgt catccctcac gtctctgtgg ccacccgggt
     2101 gtcactgcca gcaccaggca ctgctttcac gtaaaatgtc caaatcacat cttcagcaag
     2161 aaagcaacct cacggattgc cccgcctcaa ggtctttcca ccctctttga gatcagcgtt
     2221 cggagaggtc cccgccagcc cggtggctgc cctcaggtcc cgtcacatgt ctcaagggtc
     2281 cagcgttcga ggaagcactg ttgtagatga cagagctttt tgtttcacag ctgcggggat
     2341 tctgctgacc atcttttaga aaattatttc ataatttatt ctggctttgc ccccttgctc
     2401 cttggtttat tccctcatgt tttactcaaa ataaacatgg ccatgaactc aggggccatt
     2461 gggattctcc cctctggcag ccccaggtgg gagctgggag ggtccccagc ccaggaggtg
     2521 gctggattgc agggctggca gcccccacgt ggtggcatcc tgacaggcac agtgagaccc
     2581 ttgctgggtc aggtctcctt tgtgtgtgaa gctggggcag agtatgctac gaagggacca
     2641 ggccaggcca cagggctctc ctcccagtct ttatctgaag gcccagccaa agcacccctc
     2701 taaaccggtc acctagggga aatgcaaaaa cctgcaaaag atccacctgt attccctgtg
     2761 tgtgtgtgtc aaaatgacca tttgccaacc tggctgtgag gtaatgtatg taaagcaccg
     2821 agtcaggtgc ctgatacgca gtaggtgctt agcaaacggt agctaatact atcatcattg
     2881 tcattgttat tgtgacaccc atgagcccac agacagagct gtattaagta acctgttttg
     2941 aatccagaca ttcactcccc cacttgctat gactaccctc ctttgatcta tttttggtca
     3001 taggtaaaaa aaaaaatctc tcttgggagc atataaacaa aaaacataga agcaataaag
     3061 cgatcgctgg tatttctttt ctcatgcagc caaattcgcc agctggtgac caaaggctca
     3121 gatgcttgct tatttgcaga cccggcctcc tgggtgctcc ccagtgaccc atctttccac
     3181 cccaccacct ccaagtcctg tctatgtctg cttccacaca gccctgtccc cagggcacca
     3241 gccttctgtc cctcacagca gtgccatcgc gggcattagg agtcttcgtt atgttgtatc
     3301 cttgtgagtt cttgactacc atgcccaagt ttcccccact ggcaatggtt cctctcttgg
     3361 aggtacagtg gaaaccagag agatgacaga tgttgagtcc tcagtgtctc agaggcagca
     3421 attcttgctg gacacctgca catgctcagc acagaggctg gtactttgga ggcactaacc
     3481 acttgatgag taaatcaatg gcataaagcc ccattccaag ttatggggtc ttttgacagg
     3541 cccctttcat cctctttctc tttgtataaa cctcatgttt cagaacaaaa ttacagtcta
     3601 agttcatttg cccccagcct tgcccaagga tccccgggct gtgctgaccc ctaggcatag
     3661 ggcaaagggt gttcccaagc agcaggcacc tcagtgccct cagttatcca gggcaagggg
     3721 cctggctgcc ccctgctcct ccccatgatg caggggcttt ctaagccagg ctgcagacag
     3781 ggcagggttg gcttcttggc cattccctct gtgccccctt ctccttctga ctggtctcac
     3841 cctggagatc cccagaggat ctgaccagag ccaggtggac tgtggccctg agatggagct
     3901 ggctgcaggc ttacaagcac ctctggggac atccagaggg gagggtcagt aagcacaacg
     3961 gagctaggga gacttcagat ggactcaaac ccagagcaat aatactctca caccacccca
     4021 cagctaaggc actcatgttc cccagtagat caagccagaa gctttgcaag aagggagtgg
     4081 aacgaggctg cctatccaag gtccatctac cacgcagaac ttggtcatgc aagtacattt
     4141 ggaaaatctg gtcttggccc gtcccccatt ggcctggtct acacagccaa aaattcagac
     4201 tagattagat gtttgcaggc aattctgtag caaagcaaat tcccctaccc cgtcccttcc
     4261 ccctagaagc tgccttagcc tccctgactg ggtgtggtct ctgggcctag gactcctccc
     4321 tatgaggaaa agtgctctcc agccacatct tggcagcccc acaaccacag catcagggca
     4381 gctgcagcaa gtgaccaccc acccgtcggg ttagacacac aaggcaccag gcactggcat
     4441 ctgactaaaa taacctttcc ctacatggga agaggaaagc ttgtaggctg gcacatataa
     4501 acgtccagcc gcagccagat ggcctgaact aagcagcagg aactctctgg gctggggagg
     4561 agcctcctgc ccttctagaa agtgatgcgt cagctttgtt ctcctgggaa ggtgttgcta
     4621 taccccagga acaaagcagg gcccaactgc cagtgcagtc agctgggcct gcgctccagg
     4681 ctcaccaccg ctaagtggtc aggtaccggg ccagcatcct gggagggacc tcttgcgact
     4741 ctgagttgca gcttggacta gctgaacaca tggggacatg ctccaggggc ttcttccctg
     4801 gcaggattcc tgggatttca aactacctca ccaacaggac gctgaaccag gagcctgcca
     4861 cccaactggc ccccttggtg attgtggaag gtgatgtttt tcctaaaatg catccctcct
     4921 gttctgctcc atatacatgt gcttcaaaaa ccaccaccag gaaagccttc ccagaagagg
     4981 gaaaggatta agggctctct tcctttgggc cctgcagaat gtattggagg gaggtgttgc
     5041 tgcaaggtcc aggagctggg aaactctggg ctcgggggga gataatgcac caccagcctc
     5101 aaaaaggagc tgcccaagtt gaatatgtag caaagaccat gggataagtt gaatagtggc
     5161 cagacgaatc actaataact caccatggga ccctctgaag agaggcctgt gctcgtgtaa
     5221 ccatagcaac agcagatgcc agcaacctac tcattagtac cacccagtga taaggcatcc
     5281 cctgggctag acccaggggc cataaagtag caaagtagca aatgtagcaa taaagggccc
     5341 gggtctatac ggggacaggg tccaaatgac caggacttgg ccctctcccc agccccgatg
     5401 agggctcaga gccagctgct gtcagctgtc tggggaggga aggccctgct ccataccagg
     5461 ggtccctgtt ctatactcta agcccactca ccgcatgatc acggactcat cggaatggcc
     5521 tcctcttagt gcatgtggtt ctctttagtt tatttttctg gaatttgggg attggacccc
     5581 agaaccaaac atgctggtac agtctaaaaa taaatgactt gaacccactt caatcca
//
