LOCUS       NM_003617               5670 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens regulator of G protein signaling 5 (RGS5), transcript
            variant 1, mRNA.
ACCESSION   NM_003617
VERSION     NM_003617.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5670)
  AUTHORS   Song,J., Tang,Y. and Song,F.
  TITLE     Lnc-RGS5 sponges miR-542-5p to promote FoxM1/VEGFA signaling and
            breast cancer cell proliferation
  JOURNAL   Int J Oncol 63 (4) (2023)
   PUBMED   37594134
  REMARK    GeneRIF: Lnc-RGS5 sponges miR-542-5p to promote FoxM1/VEGFA
            signaling and breast cancer cell proliferation.
REFERENCE   2  (bases 1 to 5670)
  AUTHORS   Enstrom,A., Carlsson,R., Ozen,I. and Paul,G.
  TITLE     RGS5: a novel role as a hypoxia-responsive protein that suppresses
            chemokinetic and chemotactic migration in brain pericytes
  JOURNAL   Biol Open 11 (10) (2022)
   PUBMED   36111549
  REMARK    GeneRIF: RGS5: a novel role as a hypoxia-responsive protein that
            suppresses chemokinetic and chemotactic migration in brain
            pericytes.
REFERENCE   3  (bases 1 to 5670)
  AUTHORS   Li,X., Lu,Y., Zhang,L., Song,A., Zhang,H., Pang,B., Liu,J., Sun,X.,
            Ji,H., Huang,L. and Yang,M.
  TITLE     Implications of regulator of G-protein signaling 5 expression in
            the pathogenesis of primary and secondary hyperparathyroidism
  JOURNAL   BMC Endocr Disord 22 (1), 156 (2022)
   PUBMED   35681135
  REMARK    GeneRIF: Implications of regulator of G-protein signaling 5
            expression in the pathogenesis of primary and secondary
            hyperparathyroidism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5670)
  AUTHORS   Demirel,E., Arnold,C., Garg,J., Jager,M.A., Sticht,C., Li,R.,
            Kuk,H., Wettschureck,N., Hecker,M. and Korff,T.
  TITLE     RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth
            Arrest of Vascular Smooth Muscle Cells
  JOURNAL   Cells 10 (7), 1748 (2021)
   PUBMED   34359918
  REMARK    GeneRIF: RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes
            Growth Arrest of Vascular Smooth Muscle Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5670)
  AUTHORS   Liang,Y., Li,C., Guzman,V.M., Chang,W.W., Evinger,A.J. 3rd, Sao,D.
            and Woodward,D.F.
  TITLE     Identification of a novel alternative splicing variant of RGS5 mRNA
            in human ocular tissues
  JOURNAL   FEBS J 272 (3), 791-799 (2005)
   PUBMED   15670159
REFERENCE   6  (bases 1 to 5670)
  AUTHORS   Zhou,J., Moroi,K., Nishiyama,M., Usui,H., Seki,N., Ishida,J.,
            Fukamizu,A. and Kimura,S.
  TITLE     Characterization of RGS5 in regulation of G protein-coupled
            receptor signaling
  JOURNAL   Life Sci 68 (13), 1457-1469 (2001)
   PUBMED   11253162
REFERENCE   7  (bases 1 to 5670)
  AUTHORS   Adams,L.D., Geary,R.L., McManus,B. and Schwartz,S.M.
  TITLE     A comparison of aorta and vena cava medial message expression by
            cDNA array analysis identifies a set of 68 consistently
            differentially expressed genes, all in aortic media
  JOURNAL   Circ Res 87 (7), 623-631 (2000)
   PUBMED   11009569
REFERENCE   8  (bases 1 to 5670)
  AUTHORS   Cismowski,M.J., Takesono,A., Ma,C., Lizano,J.S., Xie,X.,
            Fuernkranz,H., Lanier,S.M. and Duzic,E.
  TITLE     Genetic screens in yeast to identify mammalian nonreceptor
            modulators of G-protein signaling
  JOURNAL   Nat Biotechnol 17 (9), 878-883 (1999)
   PUBMED   10471929
REFERENCE   9  (bases 1 to 5670)
  AUTHORS   Seki,N., Sugano,S., Suzuki,Y., Nakagawara,A., Ohira,M.,
            Muramatsu,M., Saito,T. and Hori,T.
  TITLE     Isolation, tissue expression, and chromosomal assignment of human
            RGS5, a novel G-protein signaling regulator gene
  JOURNAL   J Hum Genet 43 (3), 202-205 (1998)
   PUBMED   9747037
REFERENCE   10 (bases 1 to 5670)
  AUTHORS   Chen,C., Zheng,B., Han,J. and Lin,S.C.
  TITLE     Characterization of a novel mammalian RGS protein that binds to
            Galpha proteins and inhibits pheromone signaling in yeast
  JOURNAL   J Biol Chem 272 (13), 8679-8685 (1997)
   PUBMED   9079700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL451063.4, BC030059.1 and
            AL583850.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003617.3.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring LOC127814295 (uncharacterized
            LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes
            on chromosome 1. Some variants of the readthrough transcript encode
            novel proteins with unique N-termini. [provided by RefSeq, Nov
            2022].
            
            Transcript Variant: This variant (1) encodes isoform 1 (also known
            as RGS5), which is present in both the membrane and cytosolic
            fractions.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.108252.1,
                                           SRR1660803.20891.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313961.10/ ENSP00000319308.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL451063.4         11992-12009         c
            19-1265             BC030059.1         1-1247
            1266-5670           AL583850.5         155049-159453       c
FEATURES             Location/Qualifiers
     source          1..5670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..5670
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /note="regulator of G protein signaling 5"
                     /db_xref="GeneID:8490"
                     /db_xref="HGNC:HGNC:10001"
                     /db_xref="MIM:603276"
     exon            1..125
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..627
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulator of G-protein signalling 5"
                     /codon_start=1
                     /product="regulator of G-protein signaling 5 isoform 1"
                     /protein_id="NP_003608.1"
                     /db_xref="CCDS:CCDS1244.1"
                     /db_xref="GeneID:8490"
                     /db_xref="HGNC:HGNC:10001"
                     /db_xref="MIM:603276"
                     /translation="MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKP
                     EKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKK
                     IKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHA
                     LMEKDSLPRFVRSEFYQELIK"
     exon            126..236
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /inference="alignment:Splign:2.1.0"
     exon            237..298
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /inference="alignment:Splign:2.1.0"
     exon            299..465
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /inference="alignment:Splign:2.1.0"
     exon            466..5670
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2051..2056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /note="hexamer: AATAAA"
     polyA_site      2077
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /note="major polyA site"
     regulatory      5645..5650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /note="hexamer: ATTAAA"
     regulatory      5649..5654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
                     /note="hexamer: AATATA"
     polyA_site      5662
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
     polyA_site      5670
                     /gene="RGS5"
                     /gene_synonym="MST092; MST106; MST129; MSTP032; MSTP092;
                     MSTP106; MSTP129"
ORIGIN      
        1 agacagtttt gaagttttca aagactggct ctgctgttaa gaagttgtac ttaaagcgga
       61 ggagctaagc cacctgccaa aatgtgcaaa ggacttgcag ctttgcccca ctcatgcctg
      121 gaaagggcca aggagattaa gatcaagttg ggaattctcc tccagaagcc agactcagtt
      181 ggtgaccttg tcattccgta caatgagaag ccagagaaac cagccaagac ccagaaaacc
      241 tcgctggacg aggccctgca gtggcgtgat tccctggaca aactcctgca gaacaactat
      301 ggacttgcca gtttcaaaag tttcctgaag tctgaattca gtgaggaaaa ccttgagttc
      361 tggattgcct gtgaggatta caagaagatc aagtcccctg ccaagatggc tgagaaggca
      421 aagcaaattt atgaagaatt cattcaaacg gaggctccta aagaggtgaa tattgaccac
      481 ttcactaagg acatcacaat gaagaacctg gtggaacctt ccctgagcag ctttgacatg
      541 gcccagaaaa gaatccatgc cctgatggaa aaggattctc tgcctcgctt tgtgcgctct
      601 gagttttatc aggagttaat caagtagtaa tttagccagg ctatgaaatc atcctgtgag
      661 ttatttcctc cataataacc ctgcatttcc cattaatcta catatcttcc cacagcagct
      721 ttgctcagtg atacccacat gggaaaaatc ccaggggatg ttgcttactc tttttgccca
      781 cactgctttg gatacttatc tactgtccga aggccttctt tccccactca attcttcctg
      841 ccctgttatt aattaagata tcttcagctt gtagtcagac acaatcagaa tcacagaaaa
      901 atcctgccta aggcaaagaa atataagaca agactatgat atcaatgaat gtgggttaag
      961 taatagattt ccagctaaat tggtctaaaa aagaatatta agtgtggaca gacctatttc
     1021 aaaggagctt aattgatctc acttgtttta gttctgatcc agggagatca cccctctaat
     1081 tatttctgaa cttggttaat aaaagtttat aagattttta tgaagcagcc actgtatgat
     1141 attttaagca aatatgttat ttaaaatatt gatccttccc ttggaccacc ttcatgttag
     1201 ttgggtatta taaataagag atacaaccat gaatatatta tgtttataca aaatcaatct
     1261 gaacacaatt cataaagatt tctcttttat accttcctca ctggccccct ccacctgccc
     1321 atagtcacca aattctgttt taaatcaatg acctaagatc aacaatgaag tattttataa
     1381 atgtatttat gctgctagac tgtgggtcaa atgtttccat tttcaaatta tttagaattc
     1441 ttatgagttt aaaatttgta aatttctaaa tccaatcatg taaaatgaaa ctgttgctcc
     1501 attggagtag tctcccacct aaatatcaag atggctatat gctaaaaaga gaaaatatgg
     1561 tcaagtctaa aatggctaat tgtcctatga tgctattatc atagactaat gacatttatc
     1621 ttcaaaacac caaattgtct ttagaaaaat taatgtgatt acaggtagag gccttctagg
     1681 tgagacactt ttaaggtaca ctgcattttg caaaaaaaaa aaaaaaaagt aatcttttag
     1741 caaccccagt attccttcac tatttcgctt cctgcattag caaattttac ttacagtcaa
     1801 aagtgcagat ttatactcct gacgtgtctc attcacagct aaataatagg ccataggact
     1861 tttggtaggt ttaaactttt aattctgtat ttcatgatta taagtcttgc tagaattttt
     1921 tctaatcttt agtagatttg attaaataat gattcacaga atttagtaac agaatcaaac
     1981 taagccatgt atgagggtaa tcgagatgag gatattaact caaaagaaat agggtgattt
     2041 ttaaaggatt aataaaattc tgaaatgtta agtagaagat tacattgtct agtcttgtat
     2101 ttcctccttc tgttgctctc tttcattcac acactctcag tttctcatat ttgtagctca
     2161 tttatttggt tatttcctaa gaatattgaa agtgaagcaa ctatgtgact gtattcttca
     2221 ggtaaacact gactgcgctt gttggatttt ccctattttt gtgacttcaa gaataatatg
     2281 ccctgctgaa tacatgccat ttcacattct gaaactgggt agagtggttg ggtgttctgc
     2341 caacaattgc tagtggtgtg aattcattca tatttgccag tattgctcac ttcaaagaaa
     2401 ctccttcatc aagcagtcca gagctaggcc agatcaatgc tacaatcatg aagttctcat
     2461 tgcatgcaat tgtgtaggat tgacaaggaa ctcagataaa aatttccagg gtgcacttcc
     2521 agaaccagct tcaacatatg tctacattgc ccccaagtta ataaagtgcc aaccctttac
     2581 tctctcatac agccagaaat gttagaaatc caaaatcttg gtgcattatt ttttcataaa
     2641 cgctaaaaca tttgaagaaa caatttaatt atttaaaatt caagtatttt attcacatta
     2701 tttgcaatat ccaaatgttt aaaaattccc agataattaa ctagctatta cagatctcac
     2761 ctagagggtt gatgttatga agactccagt ggactgtact cacaaattga ctggacaccc
     2821 tatgaaagtg ggtagacctc tcagcggaaa ataagaaggg cttttaccta cagggcagga
     2881 cagggtccca tgagagcagt tctgtggaga tataaaaaga atggaagaag gaatgcctta
     2941 tagtgatatt gtgacattat atctatatat ctacatatat ctatctatct atatctacat
     3001 ctatataatc ttacatttaa aattgtattc ctacacatat tagaaactct tctaataaat
     3061 gaagtaaaaa aattaaaaag aatacaaata ttccagcccc aaatgagaaa tcaaacatat
     3121 taaaattgtt caagaaaatt tctttgaaca cttctgaaag tttttggaaa cttagaaaag
     3181 agggaaaaaa atccagtgtt actagtaatt tccatggtaa tacagataaa atacattctt
     3241 ttaattctgg gaaattagaa aaagtggggt gatctttcca ggaaaaacat gtgtaacatc
     3301 tgcttatcac tccagctccc tcctcctcct cctctccacg ttcccttgag taaatgtctg
     3361 ggaaagcatg aagcttgatg caagaaccct gttgtactgg cgttttcctc ccctgtgaaa
     3421 acgtaactac tgttgggagt gaattgagga tgtagaaagg tggtggaacc aaattgtggt
     3481 caatggaaat aggagaatat ggttctcact cttgagaaaa aaacctaaga ttagcccagg
     3541 tagttgcctg taacttcagt ttttctgcct gggtttgata tagtttaggg ttggggttag
     3601 attaagatct aaattacatc aggacaaaga gacagactat taactccaca gttaattaag
     3661 gacgtatgtt ccatgtttat ttgttaaagc agtgtgaata gccttcaagc atgtgaataa
     3721 tcttccatct tccccgccac acatacacac acacactttt tgtttctttc aggtagacac
     3781 cttttaaaat gcagaactaa ctgaggcatt tcagtaactt tgctttcaaa tcaataaagt
     3841 caaatgtatg gaaacatttt gtgccctact ctccataccc cgtgtactca aattctctac
     3901 tgtatgaatt atgctttaag tagaattcag tgccaaggag aacttggtga aataaattat
     3961 tttaattttt tttttatcct ttacaaagcc atggatttta tttggttgat gtgtgctctg
     4021 tacacaagcc atttcaatag gatggagctg ttaattattt tccaaagagt aatagacatg
     4081 caaaagtttc aataaaaact gggccattaa caaataaatt aataaactaa taagcattcc
     4141 cttctaggtt tttgccaaac tgcctatcca ataacaaatt tgagaatcgt tgtaaaagct
     4201 agttatattt cagagaaatg attttcatta ttgaaactgt tctccctagc aggccatttt
     4261 ccctttttcc tgggagttta gcaagtttag gagagaatag tcatgaaaag aaagggaaga
     4321 aaggggagaa gggaagaggt taaaaagtaa gtgctcagac ctatgaacgt aatccctttg
     4381 ctacaaatat ttaagagcag ctcagcttgg ttgaaactga gttttgtcat cttccatatt
     4441 tgcaggaagg tattttctga cttgcaatgc agctagatgt aaaattttat tttatcatcc
     4501 tagaaagcct tgactagaaa aatgaataaa tattgagggt ttcctgtcca tatctggctt
     4561 gcatgtgcca gaaagcagag aatagaaaat gtaatctcca acatccaagc atcgaaaccc
     4621 aaggggtagg caattctatg taggttttgg acatgaagtt tggtgcatct tggtttatgc
     4681 tggctcaact gctattaaac ctctctggct tatagtctct tcattctatt agacaagcac
     4741 gtatcgaaca cttgcttcgc acaaggctct ttagttaaca atttagcagc tactgtttgt
     4801 gttaaacaca cttttcacca aataggttct gaggcaaacg agagcaatga ctatttaaag
     4861 aaaggctttc ccagcatcac ttacacatcc caaaactaaa aagatcaact cttccaactg
     4921 agaaaagact cctggctttg aatggaaact tacagcagag agtcacaggc cacggcaaca
     4981 acaacgacaa caacaaacat ttggaatatt attctcaact cacgttttaa taatacatct
     5041 tattattttt ctagtagaga aactacaaat cagcctcttc aacatttata tacagtttaa
     5101 taagcctctt gcaagttact tgttctctca cctgaggtat ttttttcctc cccaccttgc
     5161 ccctgttcct cccttcctct tctccctttg caagaggaaa tatttaacat atttgggtcc
     5221 aacttcaata atgtaataat taatacatta aaagcattta acttcctttc tagaaaaatg
     5281 cacaggctaa ggcatagaca aaacaaagag aaatgctgag aaatttgcca ctggagacaa
     5341 gcaatctgaa taaatatttg ccaaaagttc tttttatgtc atatagtgtc aggatttgaa
     5401 ggagctattt ttttttaatg ttgcaactag caactcatct tcggaagaca cagccaggag
     5461 aatgaagtag aagtgaaagg tttataaatc catttgtaag catttatccc atatatttta
     5521 aattcaagaa aaattgtgtt tatctttaga attttgtatt caatacttta tgtactatgt
     5581 gactcatgct tctggataaa taaagcacca aatatgtatc tgtaaccaca atcacacata
     5641 ttatattaaa tatatatcta tataacagcc
//
