LOCUS       NM_144489               1512 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens regulator of G protein signaling 3 (RGS3), transcript
            variant 5, mRNA.
ACCESSION   NM_144489
VERSION     NM_144489.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1512)
  AUTHORS   Kanwal,A., Pardo,J.V. and Naz,S.
  TITLE     RGS3 and IL1RAPL1 missense variants implicate defective
            neurotransmission in early-onset inherited schizophrenias
  JOURNAL   J Psychiatry Neurosci 47 (6), E379-E390 (2022)
   PUBMED   36318984
  REMARK    GeneRIF: RGS3 and IL1RAPL1 missense variants implicate defective
            neurotransmission in early-onset inherited schizophrenias.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1512)
  AUTHORS   Hao,F., Wang,N., Gui,H., Zhang,Y., Wu,Z. and Wang,J.
  TITLE     Pseudogene UBE2MP1 derived transcript enhances in vitro cell
            proliferation and apoptosis resistance of hepatocellular carcinoma
            cells through miR-145-5p/RGS3 axis
  JOURNAL   Aging (Albany NY) 14 (19), 7906-7925 (2022)
   PUBMED   36214767
  REMARK    GeneRIF: Pseudogene UBE2MP1 derived transcript enhances in vitro
            cell proliferation and apoptosis resistance of hepatocellular
            carcinoma cells through miR-145-5p/RGS3 axis.
REFERENCE   3  (bases 1 to 1512)
  AUTHORS   Li,C., Vides,A., Kim,D., Xue,J.Y., Zhao,Y. and Lito,P.
  TITLE     The G protein signaling regulator RGS3 enhances the GTPase activity
            of KRAS
  JOURNAL   Science 374 (6564), 197-201 (2021)
   PUBMED   34618566
  REMARK    GeneRIF: The G protein signaling regulator RGS3 enhances the GTPase
            activity of KRAS.
REFERENCE   4  (bases 1 to 1512)
  AUTHORS   Kehrl,J.H., Srikumar,D., Harrison,K., Wilson,G.L. and Shi,C.S.
  TITLE     Additional 5' exons in the RGS3 locus generate multiple mRNA
            transcripts, one of which accounts for the origin of human PDZ-RGS3
  JOURNAL   Genomics 79 (6), 860-868 (2002)
   PUBMED   12036301
REFERENCE   5  (bases 1 to 1512)
  AUTHORS   Mittmann,C., Schuler,C., Chung,C.H., Hoppner,G., Nose,M.,
            Kehrl,J.H. and Wieland,T.
  TITLE     Evidence for a short form of RGS3 preferentially expressed in the
            human heart
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 363 (4), 456-463 (2001)
   PUBMED   11330340
REFERENCE   6  (bases 1 to 1512)
  AUTHORS   Dulin,N.O., Pratt,P., Tiruppathi,C., Niu,J., Voyno-Yasenetskaya,T.
            and Dunn,M.J.
  TITLE     Regulator of G protein signaling RGS3T is localized to the nucleus
            and induces apoptosis
  JOURNAL   J Biol Chem 275 (28), 21317-21323 (2000)
   PUBMED   10749886
REFERENCE   7  (bases 1 to 1512)
  AUTHORS   Dulin,N.O., Sorokin,A., Reed,E., Elliott,S., Kehrl,J.H. and
            Dunn,M.J.
  TITLE     RGS3 inhibits G protein-mediated signaling via translocation to the
            membrane and binding to Galpha11
  JOURNAL   Mol Cell Biol 19 (1), 714-723 (1999)
   PUBMED   9858594
REFERENCE   8  (bases 1 to 1512)
  AUTHORS   Chatterjee,T.K., Eapen,A., Kanis,A.B. and Fisher,R.A.
  TITLE     Genomic organization, 5'-flanking region, and chromosomal
            localization of the human RGS3 gene
  JOURNAL   Genomics 45 (2), 429-433 (1997)
   PUBMED   9344672
REFERENCE   9  (bases 1 to 1512)
  AUTHORS   Chatterjee,T.K., Eapen,A.K. and Fisher,R.A.
  TITLE     A truncated form of RGS3 negatively regulates G protein-coupled
            receptor stimulation of adenylyl cyclase and phosphoinositide
            phospholipase C
  JOURNAL   J Biol Chem 272 (24), 15481-15487 (1997)
   PUBMED   9182581
REFERENCE   10 (bases 1 to 1512)
  AUTHORS   Druey,K.M., Blumer,K.J., Kang,V.H. and Kehrl,J.H.
  TITLE     Inhibition of G-protein-mediated MAP kinase activation by a new
            mammalian gene family
  JOURNAL   Nature 379 (6567), 742-746 (1996)
   PUBMED   8602223
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162727.20.
            
            On Apr 5, 2021 this sequence version replaced NM_144489.3.
            
            Summary: This gene encodes a member of the regulator of G-protein
            signaling (RGS) family. This protein is a GTPase-activating protein
            that inhibits G-protein-mediated signal transduction. Alternative
            splicing and the use of alternative promoters results in multiple
            transcript variants encoding different isoforms. Long isoforms are
            largely cytosolic and plasma membrane-associated with a function in
            Wnt signaling and in the epithelial mesenchymal transition, while
            shorter N-terminally-truncated isoforms can be nuclear. [provided
            by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019039.2, AK054584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AL162727.20        47370-47579
            211-312             AL162727.20        47671-47772
            313-374             AL162727.20        48160-48221
            375-541             AL162727.20        48840-49006
            542-1512            AL162727.20        50009-50979
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1512
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /note="regulator of G protein signaling 3"
                     /db_xref="GeneID:5998"
                     /db_xref="HGNC:HGNC:9999"
                     /db_xref="MIM:602189"
     exon            1..210
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..727
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /note="isoform 5 is encoded by transcript variant 5;
                     regulator of G-protein signalling 3"
                     /codon_start=1
                     /product="regulator of G-protein signaling 3 isoform 5"
                     /protein_id="NP_652760.3"
                     /db_xref="CCDS:CCDS35114.2"
                     /db_xref="GeneID:5998"
                     /db_xref="HGNC:HGNC:9999"
                     /db_xref="MIM:602189"
                     /translation="MLRGMYLTRNGNLQRRHTMKEAKDMKNKLGIFRRRNESPGAPPA
                     GKADKMMKSFKPTSEEALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACED
                     FKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSVTRGCFDLAQKR
                     IFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL"
     exon            211..312
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            313..374
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..541
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..1512
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /note="major polyA site"
ORIGIN      
        1 agtcatcagg ccaggattcc agagagcgtg tgtggctgca gcctgcaccg ttgctgcccg
       61 ctgcccagga cgcggggtgg gggacaggag ccagagtggt gcctcctaca gaccaatctg
      121 cggccccaag gtggggggcc ctacagagat gctccgaggc atgtacctca ctcgcaacgg
      181 gaacctgcag aggcgacaca cgatgaagga agccaaggac atgaagaaca agctggggat
      241 cttcagacgg cggaatgagt cccctggagc ccctcccgcg ggcaaggcag acaaaatgat
      301 gaagtcattc aagcccacct cagaggaagc cctcaagtgg ggcgagtcct tggagaagct
      361 gctggttcac aaatacgggt tagcagtgtt ccaagccttc cttcgcactg agttcagtga
      421 ggagaatctg gagttctggt tggcttgtga ggacttcaag aaggtcaagt cacagtccaa
      481 gatggcatcc aaggccaaga agatctttgc tgaatacatc gcgatccagg catgcaagga
      541 ggtcaacctg gactcctaca cgcgggagca caccaaggac aacctgcaga gcgtcacgcg
      601 gggctgcttc gacctggcac agaagcgcat cttcgggctc atggaaaagg actcgtaccc
      661 tcgctttctc cgttctgacc tctacctgga ccttattaac cagaagaaga tgagtccccc
      721 gctttagggg ccactggagt cgagctcagc gttcacacca ggcgggctgg gtcccctgcc
      781 cacctgcctc cctgccccct gtgacggagg gggcaagcaa gcccccagag gctgtgtctc
      841 tggacagacg gatagacata cggaagcgag gcctggacca agagaggccc aggctactgg
      901 aggagtagaa ggatgggccc cgtggggtcc ccactgcccc ggtacgaggg ggcccaagac
      961 cctggcaggt caggggccct ggccaagcca gatctggagc tgctgctccc tgctgcggag
     1021 accgcggagg cttcgcgttg accaagttcc ttaaagaact ggctgatggg gcaggaggtc
     1081 caggcctggg ctctcgggcc ctcctagagg gccattggag cttgcagctc agacccccac
     1141 tttgagtttt atttatttaa atagtagttg gatgcttggc acgtcgtcct gtaataggaa
     1201 acccttgcct catcagtttt cctgatttac aagtgcaata ttttagccaa tgccttggga
     1261 gaagctgcca tgcaaaggtg gacaccattc tccagcttca ggggatatgc tcgtcccggg
     1321 caccggtggc aggcagctgg ccttctggac taaggcagcc tggggggaca ctgcagtctg
     1381 gctacacaca gagatctggc accccctggg tggagtgtcc ctcgggggct ttgggaaagc
     1441 atggcaccct cagaccacac agtagccaag ttctggagca aataaaaggc ctgtgttatt
     1501 tcttgttctt ga
//
