LOCUS       NM_001394167            4122 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens regulator of G protein signaling 3 (RGS3), transcript
            variant 14, mRNA.
ACCESSION   NM_001394167
VERSION     NM_001394167.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4122)
  AUTHORS   Kanwal,A., Pardo,J.V. and Naz,S.
  TITLE     RGS3 and IL1RAPL1 missense variants implicate defective
            neurotransmission in early-onset inherited schizophrenias
  JOURNAL   J Psychiatry Neurosci 47 (6), E379-E390 (2022)
   PUBMED   36318984
  REMARK    GeneRIF: RGS3 and IL1RAPL1 missense variants implicate defective
            neurotransmission in early-onset inherited schizophrenias.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4122)
  AUTHORS   Hao,F., Wang,N., Gui,H., Zhang,Y., Wu,Z. and Wang,J.
  TITLE     Pseudogene UBE2MP1 derived transcript enhances in vitro cell
            proliferation and apoptosis resistance of hepatocellular carcinoma
            cells through miR-145-5p/RGS3 axis
  JOURNAL   Aging (Albany NY) 14 (19), 7906-7925 (2022)
   PUBMED   36214767
  REMARK    GeneRIF: Pseudogene UBE2MP1 derived transcript enhances in vitro
            cell proliferation and apoptosis resistance of hepatocellular
            carcinoma cells through miR-145-5p/RGS3 axis.
REFERENCE   3  (bases 1 to 4122)
  AUTHORS   Li,C., Vides,A., Kim,D., Xue,J.Y., Zhao,Y. and Lito,P.
  TITLE     The G protein signaling regulator RGS3 enhances the GTPase activity
            of KRAS
  JOURNAL   Science 374 (6564), 197-201 (2021)
   PUBMED   34618566
  REMARK    GeneRIF: The G protein signaling regulator RGS3 enhances the GTPase
            activity of KRAS.
REFERENCE   4  (bases 1 to 4122)
  AUTHORS   Kehrl,J.H., Srikumar,D., Harrison,K., Wilson,G.L. and Shi,C.S.
  TITLE     Additional 5' exons in the RGS3 locus generate multiple mRNA
            transcripts, one of which accounts for the origin of human PDZ-RGS3
  JOURNAL   Genomics 79 (6), 860-868 (2002)
   PUBMED   12036301
REFERENCE   5  (bases 1 to 4122)
  AUTHORS   Mittmann,C., Schuler,C., Chung,C.H., Hoppner,G., Nose,M.,
            Kehrl,J.H. and Wieland,T.
  TITLE     Evidence for a short form of RGS3 preferentially expressed in the
            human heart
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 363 (4), 456-463 (2001)
   PUBMED   11330340
REFERENCE   6  (bases 1 to 4122)
  AUTHORS   Dulin,N.O., Pratt,P., Tiruppathi,C., Niu,J., Voyno-Yasenetskaya,T.
            and Dunn,M.J.
  TITLE     Regulator of G protein signaling RGS3T is localized to the nucleus
            and induces apoptosis
  JOURNAL   J Biol Chem 275 (28), 21317-21323 (2000)
   PUBMED   10749886
REFERENCE   7  (bases 1 to 4122)
  AUTHORS   Dulin,N.O., Sorokin,A., Reed,E., Elliott,S., Kehrl,J.H. and
            Dunn,M.J.
  TITLE     RGS3 inhibits G protein-mediated signaling via translocation to the
            membrane and binding to Galpha11
  JOURNAL   Mol Cell Biol 19 (1), 714-723 (1999)
   PUBMED   9858594
REFERENCE   8  (bases 1 to 4122)
  AUTHORS   Chatterjee,T.K., Eapen,A., Kanis,A.B. and Fisher,R.A.
  TITLE     Genomic organization, 5'-flanking region, and chromosomal
            localization of the human RGS3 gene
  JOURNAL   Genomics 45 (2), 429-433 (1997)
   PUBMED   9344672
REFERENCE   9  (bases 1 to 4122)
  AUTHORS   Chatterjee,T.K., Eapen,A.K. and Fisher,R.A.
  TITLE     A truncated form of RGS3 negatively regulates G protein-coupled
            receptor stimulation of adenylyl cyclase and phosphoinositide
            phospholipase C
  JOURNAL   J Biol Chem 272 (24), 15481-15487 (1997)
   PUBMED   9182581
REFERENCE   10 (bases 1 to 4122)
  AUTHORS   Druey,K.M., Blumer,K.J., Kang,V.H. and Kehrl,J.H.
  TITLE     Inhibition of G-protein-mediated MAP kinase activation by a new
            mammalian gene family
  JOURNAL   Nature 379 (6567), 742-746 (1996)
   PUBMED   8602223
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137066.15, AL359455.22 and
            AL162727.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the regulator of G-protein
            signaling (RGS) family. This protein is a GTPase-activating protein
            that inhibits G-protein-mediated signal transduction. Alternative
            splicing and the use of alternative promoters results in multiple
            transcript variants encoding different isoforms. Long isoforms are
            largely cytosolic and plasma membrane-associated with a function in
            Wnt signaling and in the epithelial mesenchymal transition, while
            shorter N-terminally-truncated isoforms can be nuclear. [provided
            by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.27708.1,
                                           SRR11853562.32209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695401.1/ ENSP00000511882.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AL137066.15        136449-136603
            156-206             AL359455.22        16495-16545
            207-265             AL359455.22        20063-20121
            266-360             AL359455.22        21142-21236
            361-429             AL359455.22        22629-22697
            430-490             AL359455.22        32790-32850
            491-581             AL359455.22        34318-34408
            582-637             AL359455.22        35029-35084
            638-719             AL359455.22        42446-42527
            720-825             AL359455.22        43392-43497
            826-1177            AL359455.22        44291-44642
            1178-1217           AL359455.22        45545-45584
            1218-1414           AL359455.22        51462-51658
            1415-1498           AL359455.22        54545-54628
            1499-1610           AL359455.22        59934-60045
            1611-1654           AL359455.22        66225-66268
            1655-1777           AL359455.22        73800-73922
            1778-2755           AL162727.20        36691-37668
            2756-2820           AL162727.20        44574-44638
            2821-2922           AL162727.20        47671-47772
            2923-2984           AL162727.20        48160-48221
            2985-3151           AL162727.20        48840-49006
            3152-4122           AL162727.20        50009-50979
FEATURES             Location/Qualifiers
     source          1..4122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..4122
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /note="regulator of G protein signaling 3"
                     /db_xref="GeneID:5998"
                     /db_xref="HGNC:HGNC:9999"
                     /db_xref="MIM:602189"
     exon            1..155
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..3337
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /note="isoform 11 is encoded by transcript variant 14;
                     regulator of G-protein signalling 3"
                     /codon_start=1
                     /product="regulator of G-protein signaling 3 isoform 11"
                     /protein_id="NP_001381096.1"
                     /db_xref="CCDS:CCDS94464.1"
                     /db_xref="GeneID:5998"
                     /db_xref="HGNC:HGNC:9999"
                     /db_xref="MIM:602189"
                     /translation="MERSLHRVSLGSRRAHPDLSFYLTTFGQLRLSIDAQDRVLLLHI
                     IEGKGLISKQPGTCDPYVKISLIPEDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDD
                     QKRLLVTVWNRASQSRQSGLIGCMSFGVKSLLTPDKEISGWYYLLGEHLGRTKHLKVA
                     RRRLRPLRDPLLRMPGGGDTENGKKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPA
                     ERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRMVPQVKPGPDGGVL
                     RRASCKSTHDLQSPPNKREKNCTHGVQARPEQRHSCHLVCDSSDGLLLGGWERYTEVA
                     KRGGQHTLPALSRATAPTDPNYIILAPLNPGSQLLRPVYQEDTIPEESGSPSKGKSYT
                     GLGKKSRLMKTVQTMKGHGNYQNCPVVRPHATHSSYGTYVTLAPKVLVFPVFVQPLDL
                     CNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFTKEDEPGRCDVLRNPLYLQSVK
                     LQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAASPPDS
                     KMFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAP
                     SQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDP
                     LLTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLLAATGDPPAAPRP
                     AFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEAEEVEEGEEGEEDEDEDTSDDNYGER
                     SEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDTTLHCSDGE
                     GAASTWGMPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASRKRKSKN
                     LAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSEEALKWGESLEKLLVHKYGL
                     AVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDS
                     YTREHTKDNLQSVTRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL"
     exon            156..206
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            207..265
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            266..360
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            361..429
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            430..490
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            491..581
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..637
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..825
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1177
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1217
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1414
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1498
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1610
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1654
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1777
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2755
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2820
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2922
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..2984
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3151
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..4122
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4091..4096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /note="hexamer: AATAAA"
     polyA_site      4122
                     /gene="RGS3"
                     /gene_synonym="C2PA; RGP3"
                     /note="major polyA site"
ORIGIN      
        1 ggagactccg gttactgggg agcaacacag ccgcctcggg ttgcagacgc tcctgtccgg
       61 gtcgcagtgg gacgccatgg agcgctccct gcaccgcgtc tccctcggga gccggcgtgc
      121 ccacccggac ttgtccttct acctcaccac ctttggtcag ctgaggctgt ccattgatgc
      181 ccaggaccgg gttctgctgc ttcacattat agaaggtaaa ggcctgatca gcaaacagcc
      241 tggcacctgt gatccgtatg tgaagatttc tttgatccct gaagatagta gactacgcca
      301 ccagaagacg cagaccgttc cagactgcag agacccggct ttccacgagc acttcttctt
      361 tcctgtccaa gaggaggatg atcagaagcg tctcttggtt actgtgtgga acagggccag
      421 ccagtccaga cagagtggac tcattggctg catgagcttt ggggtgaagt ctctcctgac
      481 tccagacaag gagatcagtg gttggtacta cctcctaggg gagcacctgg gccggaccaa
      541 gcacttgaag gtggccaggc ggcgactgcg gccgctgaga gacccgctgc tgagaatgcc
      601 aggaggtggg gacactgaga atgggaagaa actaaagatc accatcccga ggggaaagga
      661 cggctttggc ttcaccatct gctgcgactc tccagttcga gtccaggccg tggattccgg
      721 gggtccggcg gaacgggcag ggctgcagca gctggacacg gtgctgcagc tgaatgagag
      781 gcctgtggag cactggaaat gtgtggagct ggcccacgag atccggagct gccccagtga
      841 gatcatccta ctcgtgtggc gcatggtccc ccaggtcaag ccaggaccag atggcggggt
      901 cctgcggcgg gcctcctgca agtcgacaca tgacctccag tcacccccca acaaacggga
      961 gaagaactgc acccatgggg tccaggcacg gcctgagcag cgccacagct gccacctggt
     1021 atgtgacagc tctgatgggc tgctgctcgg cggctgggag cgctacaccg aggtggccaa
     1081 gcgcgggggc cagcacaccc tgcctgcact gtcccgtgcc actgccccca ccgaccccaa
     1141 ctacatcatc ctggccccgc tgaatcctgg gagccagctg ctccggcctg tgtaccagga
     1201 ggataccatc cccgaagaat cagggagtcc cagtaaaggg aagtcctaca caggcctggg
     1261 gaagaagtcc cggctgatga agacagtgca gaccatgaag ggccacggga actaccaaaa
     1321 ctgcccggtt gtgaggccgc atgccacgca ctcaagctat ggcacctacg tcaccctggc
     1381 ccccaaagtc ctggtgttcc ctgtctttgt tcagcctcta gatctctgta atcctgcccg
     1441 gaccctcctg ctgtcagagg agctgctgct gtatgaaggg aggaacaagg ctgccgaggt
     1501 gacactgttt gcctattcgg acctgctgct cttcaccaag gaggacgagc ctggccgctg
     1561 cgacgtcctg aggaaccccc tctacctcca gagtgtgaag ctgcaggaag gttcttcaga
     1621 agacctgaaa ttctgcgtgc tctatctagc agagaaggca gagtgcttat tcactttgga
     1681 agcgcactcg caggagcaga agaagagagt gtgctggtgc ctgtcggaga acatcgccaa
     1741 gcagcaacag ctggcagcat cacccccgga cagcaagatg tttgagacgg aggcagatga
     1801 gaagagggag atggccttgg aggaagggaa ggggcctggt gccgaggatt ccccacccag
     1861 caaggagccc tctcctggcc aggagcttcc tccaggacaa gaccttccac ccaacaagga
     1921 ctccccttct gggcaggaac ccgctcccag ccaagaacca ctgtccagca aagactcagc
     1981 tacctctgaa ggatcccctc caggcccaga tgctccgccc agcaaggatg tgccaccatg
     2041 ccaggaaccc cctccagccc aagacctctc accctgccag gacctacctg ctggtcaaga
     2101 acccctgcct caccaggacc ctctactcac caaagacctc cctgccatcc aggaatcccc
     2161 cacccgggac cttccaccct gtcaagatct gcctcctagc caggtctccc tgccagccaa
     2221 ggcccttact gaggacacca tgagctccgg ggacctacta gcagctactg gggacccacc
     2281 tgcggccccc aggccagcct tcgtgatccc tgaggtccgg ctggatagca cctacagcca
     2341 gaaggcaggg gcagagcagg gctgctcggg agatgaggag gatgcagaag aggccgagga
     2401 ggtggaggag ggggaggaag gggaggagga cgaggatgag gacaccagcg atgacaacta
     2461 cggagagcgc agtgaggcca agcgcagcag catgatcgag acgggccagg gggctgaggg
     2521 tggcctctca ctgcgtgtgc agaactcgct gcggcgccgg acgcacagcg agggcagcct
     2581 gctgcaggag ccccgagggc cctgctttgc ctccgacacc accttgcact gctcagacgg
     2641 tgagggcgcc gcctccacct ggggcatgcc ttcgcccagc accctcaaga aagagctggg
     2701 ccgcaatggt ggctccatgc accacctttc cctcttcttc acaggacaca ggaagatgag
     2761 cggggctgac accgttgggg atgatgacga agcctcccgg aagagaaaga gcaaaaacct
     2821 agccaaggac atgaagaaca agctggggat cttcagacgg cggaatgagt cccctggagc
     2881 ccctcccgcg ggcaaggcag acaaaatgat gaagtcattc aagcccacct cagaggaagc
     2941 cctcaagtgg ggcgagtcct tggagaagct gctggttcac aaatacgggt tagcagtgtt
     3001 ccaagccttc cttcgcactg agttcagtga ggagaatctg gagttctggt tggcttgtga
     3061 ggacttcaag aaggtcaagt cacagtccaa gatggcatcc aaggccaaga agatctttgc
     3121 tgaatacatc gcgatccagg catgcaagga ggtcaacctg gactcctaca cgcgggagca
     3181 caccaaggac aacctgcaga gcgtcacgcg gggctgcttc gacctggcac agaagcgcat
     3241 cttcgggctc atggaaaagg actcgtaccc tcgctttctc cgttctgacc tctacctgga
     3301 ccttattaac cagaagaaga tgagtccccc gctttagggg ccactggagt cgagctcagc
     3361 gttcacacca ggcgggctgg gtcccctgcc cacctgcctc cctgccccct gtgacggagg
     3421 gggcaagcaa gcccccagag gctgtgtctc tggacagacg gatagacata cggaagcgag
     3481 gcctggacca agagaggccc aggctactgg aggagtagaa ggatgggccc cgtggggtcc
     3541 ccactgcccc ggtacgaggg ggcccaagac cctggcaggt caggggccct ggccaagcca
     3601 gatctggagc tgctgctccc tgctgcggag accgcggagg cttcgcgttg accaagttcc
     3661 ttaaagaact ggctgatggg gcaggaggtc caggcctggg ctctcgggcc ctcctagagg
     3721 gccattggag cttgcagctc agacccccac tttgagtttt atttatttaa atagtagttg
     3781 gatgcttggc acgtcgtcct gtaataggaa acccttgcct catcagtttt cctgatttac
     3841 aagtgcaata ttttagccaa tgccttggga gaagctgcca tgcaaaggtg gacaccattc
     3901 tccagcttca ggggatatgc tcgtcccggg caccggtggc aggcagctgg ccttctggac
     3961 taaggcagcc tggggggaca ctgcagtctg gctacacaca gagatctggc accccctggg
     4021 tggagtgtcc ctcgggggct ttgggaaagc atggcaccct cagaccacac agtagccaag
     4081 ttctggagca aataaaaggc ctgtgttatt tcttgttctt ga
//
