LOCUS       NM_015668               4229 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens regulator of G protein signaling 22 (RGS22),
            transcript variant 1, mRNA.
ACCESSION   NM_015668
VERSION     NM_015668.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4229)
  AUTHORS   Li,X., Song,H., Liu,Z. and Bi,Y.
  TITLE     miR-1260b promotes cell migration and invasion of hepatocellular
            carcinoma by targeting the regulator of G-protein signaling 22
  JOURNAL   Biotechnol Lett 40 (1), 57-62 (2018)
   PUBMED   29038925
  REMARK    GeneRIF: Regulator of G-protein signaling 22 (RGS22) was identified
            as a direct target of miR-1260b and was inhibited by miR-1260b.
            Knockdown of RGS22 increased proliferation of hepatocellular
            carcinoma cells.
REFERENCE   2  (bases 1 to 4229)
  AUTHORS   Hu,Y., Xing,J., Chen,L., Zheng,Y. and Zhou,Z.
  TITLE     RGS22 inhibits pancreatic adenocarcinoma cell migration through the
            G12/13 alpha subunit/F-actin pathway
  JOURNAL   Oncol Rep 34 (5), 2507-2514 (2015)
   PUBMED   26323264
  REMARK    GeneRIF: RGS22 acts as a tumor suppressor, repressing human
            pancreatic adenocarcinoma cell migration by coupling to GNA12/13.
REFERENCE   3  (bases 1 to 4229)
  AUTHORS   Stacey,S.N., Sulem,P., Gudbjartsson,D.F., Jonasdottir,A.,
            Thorleifsson,G., Gudjonsson,S.A., Masson,G., Gudmundsson,J.,
            Sigurgeirsson,B., Benediktsdottir,K.R., Thorisdottir,K.,
            Ragnarsson,R., Fuentelsaz,V., Corredera,C., Grasa,M., Planelles,D.,
            Sanmartin,O., Rudnai,P., Gurzau,E., Koppova,K., Hemminki,K.,
            Nexo,B.A., Tjonneland,A., Overvad,K., Johannsdottir,H.,
            Helgadottir,H.T., Thorsteinsdottir,U., Kong,A., Vogel,U., Kumar,R.,
            Nagore,E., Mayordomo,J.I., Rafnar,T., Olafsson,J.H. and
            Stefansson,K.
  TITLE     Germline sequence variants in TGM3 and RGS22 confer risk of basal
            cell carcinoma
  JOURNAL   Hum Mol Genet 23 (11), 3045-3053 (2014)
   PUBMED   24403052
  REMARK    GeneRIF: New basal cell carcinoma susceptibility loci were
            identified at TGM3 (rs214782) and RGS22(rs7006527).
REFERENCE   4  (bases 1 to 4229)
  AUTHORS   Hu,Y., Xing,J., Wang,L., Huang,M., Guo,X., Chen,L., Lin,M.,
            Zhou,Y., Liu,Z., Zhou,Z. and Sha,J.
  TITLE     RGS22, a novel cancer/testis antigen, inhibits epithelial cell
            invasion and metastasis
  JOURNAL   Clin Exp Metastasis 28 (6), 541-549 (2011)
   PUBMED   21533872
  REMARK    GeneRIF: Over-expression of RGS22 in a highly metastatic esophageal
            cancer cell line causes decrease in cell migration and reduction in
            the invasive potential of the cells.
REFERENCE   5  (bases 1 to 4229)
  AUTHORS   Wang,J., Lippman,S.M., Lee,J.J., Yang,H., Khuri,F.R., Kim,E.,
            Lin,J., Chang,D.W., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     Genetic variations in regulator of G-protein signaling genes as
            susceptibility loci for second primary tumor/recurrence in head and
            neck squamous cell carcinoma
  JOURNAL   Carcinogenesis 31 (10), 1755-1761 (2010)
   PUBMED   20627871
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4229)
  AUTHORS   Hu,Y., Xing,J., Chen,L., Guo,X., Du,Y., Zhao,C., Zhu,Y., Lin,M.,
            Zhou,Z. and Sha,J.
  TITLE     RGS22, a novel testis-specific regulator of G-protein signaling
            involved in human and mouse spermiogenesis along with GNA12/13
            subunits
  JOURNAL   Biol Reprod 79 (6), 1021-1029 (2008)
   PUBMED   18703424
  REMARK    GeneRIF: RGS22 may also play a role in GNA13 translocation from the
            cytoplasm to the nucleus during spermiogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021590.10, BC036665.1, AP005356.2 and BM684810.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015668.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092411.1, SRR1803611.276846.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360863.11/ ENSP00000354109.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC021590.10        128207-128295       c
            90-1259             BC036665.1         8-1177
            1260-1260           AC021590.10        85882-85882         c
            1261-3478           BC036665.1         1179-3396
            3479-3479           AP005356.2         144549-144549       c
            3480-4117           BC036665.1         3398-4035
            4118-4217           AP005356.2         123551-123650       c
            4218-4229           BM684810.1         15-26               c
FEATURES             Location/Qualifiers
     source          1..4229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..4229
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /note="regulator of G protein signaling 22"
                     /db_xref="GeneID:26166"
                     /db_xref="HGNC:HGNC:24499"
                     /db_xref="MIM:615650"
     exon            1..153
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..3923
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="regulator of G-protein signaling 22 isoform 1"
                     /protein_id="NP_056483.3"
                     /db_xref="CCDS:CCDS43758.1"
                     /db_xref="GeneID:26166"
                     /db_xref="HGNC:HGNC:24499"
                     /db_xref="MIM:615650"
                     /translation="MPEKRLTAEPPTITEEEFEDSLATDDFLVDYFNEFLSLPTFSEA
                     IRFNADYGVFEVANDAPQFLEKQLKKILQNQQPRNPIYDVVRKGKNEVKPVQMNAPDE
                     DETINVNYNIMCLSREEGIKWIKKERLPAFLESDCYFEYRLAKLVSQVRWSKSGMNFT
                     VGSNFSPWIVKKPPSLPPPATEEDNLVIMKKFYVSLGEASYTQTKDWFALAKQSQQTV
                     STFSLPCCVPYNKLKSPAISSVSENFIFDDGVHPRTKKDPSKTNKLISEFEEEEGEEE
                     EVSVSLQDTPSQALLRVYLEKKQDVDESLTMHFSTCEEFLSSYIYFILRGAIQQIVGK
                     PVGETPDYINFNNITKVSFDDCFESIHGKNFLSELVQTTKERSEEIEQTSLSSKNESA
                     GPESRADWCISHRTYDIGNRKEFERFKKFIKGTLGERYWWLWMDIERLKVLKDPGRHQ
                     RHLEKMKKCYLVSNGDYYLSAEILSKFKLLDGSQWNEEHLRNIQSEVLKPLLLYWAPR
                     FCVTHSASTKYASAELKFWHLRQAKPRKDIDPFPQMATLLPLRPKSCIPQIPEIQKEE
                     FSLSQPPKSPNKSPEVKTATQKPWKRELLYPGSSKDDVIEKGSKYMSESSKVIHLTSF
                     TDISECLKPQLDRRYAYTEEPRVKTVSDVGALGGSDMENLLQSLYVENRAGFFFTKFC
                     EHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQ
                     QEKKKEIYMKIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAYKKVELVEETRQLD
                     STYFRKLQALHKETFSKKAEDTTCEIGTGILSLSNVSKRTEYWDNVPAEYKHFKFSDL
                     LNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKK
                     YFFGPNSPASLYQQNQVMHLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLA
                     SEQFAARQKIKVQMKDIAEELLLQKAEKKIGVWKPVESKWISSSCKIIAFRKALLNPV
                     TSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSI
                     PPALQIDIPVEQAQKIIEHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENI
                     MSVLERRQEYNKQKKKLAVLEDEKSGKDGIKQYANTSVPAIKTALLSDSFLGLQPYGR
                     QPTWCYSKYIEALEQERILLKIQEELEKKLFAGLQPLTNFKASSSTMSLKKNMSAHSS
                     QK"
     exon            154..182
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            183..245
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..467
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..553
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..722
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            723..852
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1480
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1642
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1817
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1951
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2066
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2192
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2294
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2489
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2582
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2755
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2918
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3077
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3146
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3308
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3488
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3647
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3743
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3837
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..3918
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..3968
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4229
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4056..4061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /note="hexamer: AATAAA"
     regulatory      4093..4098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /note="hexamer: AATAAA"
     polyA_site      4094
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /note="major polyA site"
     polyA_site      4117
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /note="major polyA site"
     regulatory      4193..4198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
                     /note="hexamer: AATAAA"
     polyA_site      4229
                     /gene="RGS22"
                     /gene_synonym="CT145; PRTD-NY2"
ORIGIN      
        1 acgctagcca gcgtagctcc ggagcccgcg cgccgtcgcc gcgtcgctca ggccctgacc
       61 cgcgctggac ccgcgcgcta gggccctgac ggcccgcgcg ggctccaggc gcgggcagcg
      121 gggacggcat gcccgagaag aggctcaccg cggagccacc aactattaca gaagaagaat
      181 ttgaagattc tctggcaaca gatgatttcc ttgtagacta ctttaatgaa ttcctaagcc
      241 ttccaacctt ttcagaggca attagattta atgcagatta tggagttttt gaagtagcta
      301 atgatgctcc acaatttctg gaaaaacaac tgaaaaaaat tctacaaaac cagcaacctc
      361 gaaatcccat ttatgatgtt gtaaggaaag gaaagaatga ggttaaacct gttcaaatga
      421 atgcccccga tgaagatgag accattaatg tcaactacaa tattatgtgt ctcagtcgtg
      481 aagaaggtat taagtggatc aaaaaagaaa gacttccagc atttctggaa agtgattgtt
      541 actttgaata caggttagcc aaattggtct cacaagtaag atggagcaag tccggcatga
      601 atttcacagt aggatcaaat ttttctccct ggatcgtgaa aaaaccaccc agtctaccac
      661 ctcctgccac tgaagaagat aatcttgtaa ttatgaaaaa gttctatgta tcacttggtg
      721 aggcttccta tactcaaaca aaagattggt ttgcattagc aaaacaaagt cagcaaacag
      781 tatcaacctt ttcgttaccc tgttgtgtac cctacaacaa acttaaatca ccagctattt
      841 catctgtttc tgagaatttt atctttgatg atggagttca ccctaggaca aaaaaggacc
      901 catctaaaac caacaaattg atttctgaat ttgaagaaga agaaggagaa gaagaagagg
      961 tgtctgtatc tctacaagac actccttctc aagctcttct gagagtatac cttgaaaaga
     1021 aacaggatgt tgatgaaagc ctgacaatgc atttctcaac atgtgaagaa tttttaagct
     1081 cctatatata ctttattttg agaggagcaa ttcagcaaat tgttggaaag ccagttggag
     1141 aaaccccaga ctatataaac ttcaacaata taacaaaagt gtcatttgat gattgttttg
     1201 agtctattca tggcaagaat tttttaagtg aattagttca aactacaaag gagaggtcag
     1261 aagagataga acaaacaagt ttaagttcaa agaatgagag cgctggacca gagagcaggg
     1321 cggactggtg tatttctcat aggacttatg acattggcaa tagaaaggag tttgaaagat
     1381 ttaagaaatt tataaaaggt acattgggag agagatattg gtggctatgg atggatattg
     1441 agaggttaaa agttcttaag gatcctggaa gacatcaaag acatcttgag aagatgaaaa
     1501 aatgctatct agtgagcaat ggagattact acctttctgc agaaatctta tcaaaattta
     1561 aactgttaga tggatcacag tggaatgaag agcatttaag aaatattcag tctgaagttt
     1621 taaaaccttt acttctgtat tgggcaccaa gattctgtgt tactcattca gcctcaacaa
     1681 aatatgctag tgctgaactg aaattctggc acctccgtca agcaaaacca aggaaggata
     1741 ttgacccttt tccacaaatg gcaaccctct tgccattaag acccaaatct tgcattccac
     1801 agatacctga gatccagaaa gaagaattca gcttatcaca acctcctaaa tctcccaata
     1861 aatcacctga agtaaaaaca gcaactcaaa agccttggaa gcgggagctt ttgtatccag
     1921 gttcttctaa ggatgatgtg attgagaaag ggtcaaagta catgtcagaa agcagcaaag
     1981 tcattcattt aacatctttt actgacattt ctgaatgtct caagccccag ctggatagaa
     2041 gatacgctta tacagaagaa cctagggtta aaaccgtgtc agatgttggt gccttgggag
     2101 gatctgacat ggaaaatttg ttgcaatctt tgtatgtaga aaatagagct ggattcttct
     2161 ttactaaatt ctgcgagcat tcagggaaca agttgtggaa gaacagtgtg tacttttggt
     2221 ttgacctgca ggcttatcat cagcttttct accaagaaac acttcagcct tttaaagtat
     2281 gcaagcaagc gcaatatctt tttgccacat acgttgctcc ttctgccact cttgacattg
     2341 gactccaaca ggaaaagaaa aaagaaattt atatgaaaat acagccacca tttgaagacc
     2401 tttttgacac agcagaggaa tatatccttc tcctccttct tgagccatgg acaaagatgg
     2461 taaaatcgga ccaaattgct tataaaaagg tggagctggt ggaagaaact cgacagttag
     2521 actccacata cttcagaaag ctacaggctt tgcataaaga gacattttcc aagaaagctg
     2581 aggacaccac ttgtgaaatt ggaactggca ttttatcact ctctaacgtc tctaaacgaa
     2641 cagaatattg ggataatgtt cctgcagaat acaagcattt taagtttagt gatctgctta
     2701 acaacaaact ggagtttgaa catttccgtc agtttcttga gactcattct tcaagcatgg
     2761 atcttatgtg ctggacagac attgagcagt tccggagaat aacttacaga gatcgaaatc
     2821 aaaggaaggc aaaatctata tacattaaaa acaaatacct taataaaaaa tatttctttg
     2881 gacccaacag tccagcttct ctgtatcagc agaaccaggt aatgcattta agtggtggct
     2941 gggggaagat tcttcatgag cagcttgatg cacctgttct agttgaaatc cagaagcatg
     3001 tgcaaaatag gctagaaaat gtatggctgc cattgtttct tgcaagtgaa cagtttgcag
     3061 cacgtcagaa gataaaggta cagatgaaag acatagcaga agagctctta ctacagaagg
     3121 ctgaaaagaa aatcggggtc tggaagcctg tggagagtaa gtggatctct tcatcttgta
     3181 aaatcattgc ttttcgcaaa gcattattga atccagttac ttcaagacaa tttcaacgtt
     3241 ttgtggctct aaaaggagat ttattggaaa atggtttact cttttggcaa gaagtacaaa
     3301 aatataagga cttgtgccat tctcattgtg atgagtctgt catccagaag aagattacaa
     3361 ctattatcaa ctgctttatt aattccagta ttccaccagc tttacaaatt gacattccag
     3421 tagagcaagc ccagaagatt attgaacacc ggaaggagtt aggaccatat gtatttagag
     3481 aggcacagat gacaattttt ggggttctgt ttaaattctg gcctcagttc tgtgagttta
     3541 ggaagaattt aacagatgaa aatattatga gtgttttaga gagaagacaa gaatataata
     3601 agcagaaaaa aaaattggca gtcctagaag acgaaaaatc tggaaaggat ggaatcaaac
     3661 aatatgcaaa tacttcagtg cctgctatca aaactgcttt actcagtgat tccttcctag
     3721 gcctccaacc atatggccga cagccaacct ggtgctactc aaagtatata gaagccttag
     3781 aacaggagag aattcttctt aagatccaag aagaactaga aaaaaagttg tttgcaggct
     3841 tgcaacctct cacaaatttt aaggctagct cttcaactat gtctttgaaa aagaatatgt
     3901 ctgcccacag cagccagaag tgacagcatt cttgtgaatg tttacatcct gctgctgata
     3961 ggttcaagga attctttaaa ccagattctg ctgacatgag aagctccagt gatttgtttt
     4021 tttgaaggtc tgtatcagag caagcctaac atctaaataa agtttgattc tggattttcc
     4081 aggtgggaaa taaataaaga aaatttggct tgtcttactc tcgcagtttt aaaattatag
     4141 ctattctgta cacatgacat acaagactat aagaactgtt taacttattt agaataaaac
     4201 aactactatc taggtttgaa gaaccaaaa
//
