LOCUS       NM_001039152            1794 bp    mRNA    linear   PRI 30-JUL-2024
DEFINITION  Homo sapiens regulator of G protein signaling 21 (RGS21), mRNA.
ACCESSION   NM_001039152
VERSION     NM_001039152.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Cohen,S.P., Buckley,B.K., Kosloff,M., Garland,A.L., Bosch,D.E.,
            Cheng,G. Jr., Radhakrishna,H., Brown,M.D., Willard,F.S.,
            Arshavsky,V.Y., Tarran,R., Siderovski,D.P. and Kimple,A.J.
  TITLE     Regulator of G-protein signaling-21 (RGS21) is an inhibitor of
            bitter gustatory signaling found in lingual and airway epithelia
  JOURNAL   J Biol Chem 287 (50), 41706-41719 (2012)
   PUBMED   23095746
  REMARK    GeneRIF: RGS21 modulates bitter taste signal transduction.
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Zhang,D., Pang,Z., Li,S., Jiang,W., Wang,S., Thomassen,M.,
            Hjelmborg,J.V., Kruse,T.A., Ohm Kyvik,K., Christensen,K., Zhu,G.
            and Tan,Q.
  TITLE     Genome-wide linkage and association scans for pulse pressure in
            Chinese twins
  JOURNAL   Hypertens Res 35 (11), 1051-1057 (2012)
   PUBMED   22763476
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   Li,X., Chen,L., Ji,C., Liu,B., Gu,J., Xu,J., Zou,X., Gu,S. and
            Mao,Y.
  TITLE     Isolation and expression pattern of RGS21 gene, a novel RGS member
  JOURNAL   Acta Biochim Pol 52 (4), 943-946 (2005)
   PUBMED   16302027
  REMARK    GeneRIF: RGS21 mRNA is expressed ubiquitously in the 16 tissues
            examined, implying general physiological roles.
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   von Buchholtz,L., Elischer,A., Tareilus,E., Gouka,R., Kaiser,C.,
            Breer,H. and Conzelmann,S.
  TITLE     RGS21 is a novel regulator of G protein signalling selectively
            expressed in subpopulations of taste bud cells
  JOURNAL   Eur J Neurosci 19 (6), 1535-1544 (2004)
   PUBMED   15066150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY643711.1, AL357566.12 and AL390957.14.
            
            On Jan 28, 2010 this sequence version replaced NM_001039152.2.
            
            Summary: Regulator of G protein signaling (RGS) proteins are
            regulatory and structural components of G protein-coupled receptor
            complexes. RGS proteins are GTPase-activating proteins for Gi (see
            GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha
            proteins. They accelerate transit through the cycle of GTP binding
            and hydrolysis and thereby accelerate signaling kinetics and
            termination.[supplied by OMIM, Nov 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY643711.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417209.2/ ENSP00000428343.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AY643711.1         2-69
            69-101              AL357566.12        43327-43359
            102-929             AY643711.1         103-930
            930-1049            AL390957.14        33684-33803
            1050-1794           AY643711.1         1051-1795
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..1794
                     /gene="RGS21"
                     /note="regulator of G protein signaling 21"
                     /db_xref="GeneID:431704"
                     /db_xref="HGNC:HGNC:26839"
                     /db_xref="MIM:612407"
     exon            1..114
                     /gene="RGS21"
                     /inference="alignment:Splign:2.1.0"
     exon            115..185
                     /gene="RGS21"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..633
                     /gene="RGS21"
                     /note="regulator of G-protein signalling 21"
                     /codon_start=1
                     /product="regulator of G-protein signaling 21"
                     /protein_id="NP_001034241.1"
                     /db_xref="CCDS:CCDS41448.1"
                     /db_xref="GeneID:431704"
                     /db_xref="HGNC:HGNC:26839"
                     /db_xref="MIM:612407"
                     /translation="MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIFLKSEFS
                     EENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISKNIAE
                     PTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL"
     exon            186..262
                     /gene="RGS21"
                     /inference="alignment:Splign:2.1.0"
     exon            263..429
                     /gene="RGS21"
                     /inference="alignment:Splign:2.1.0"
     exon            430..1794
                     /gene="RGS21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaccactt ggaaaacaat tcatctgaaa gaagcacaga ttttctcatc tatcctgtca
       61 acaaagaagg aatcaagaga gcaaggacag tgatttcccc tgcattgcat ttgtcttgaa
      121 gatcagtcag aaagagaaac tcggcatcat ctgtgacaga cagtggaacg aaaaatgcca
      181 gtgaaatgct gtttctacag gtcaccaact gcggaaacaa tgacatggtc tgaaaatatg
      241 gacacgcttt tagccaacca agctggtcta gatgcttttc gaatatttct aaaatcagag
      301 tttagtgaag aaaatgttga gttctggctt gcctgtgaag actttaagaa aacgaaaaat
      361 gcagacaaaa ttgcttccaa agccaagatg atttattctg aattcattga agctgatgca
      421 cctaaagaga ttaacattga cttcggtacc agagacctca tctcaaagaa tattgctgaa
      481 ccaacactca aatgctttga tgaggctcag aaattaatct attgtctcat ggccaaggat
      541 tctttccctc gatttctgaa gtcagagatt tataaaaaac tggtaaatag ccaacaggtt
      601 ccaaatcata aaaaatggct cccttttttg tgaggaaggt aaaagttaac taatcactat
      661 acttcagggc tacaatattt taaatataca agcatgatgc attgtctttt gttttgtttt
      721 taggatttag aaaacatttt ttacccaaac agatgaataa cgttttatac aacaagcctg
      781 aatttctaac tcagttgttt agaatgtatt tgctttacca gctatttaat ctcctactgg
      841 gggagtacaa agaaagttta tagagataca atatagtctt aaaccaaaac tgaatattct
      901 tattatatta taatgtaagg aattatacat atcttcacgt ggcagaatga aagacttttg
      961 agcatcatat acacaatttt aaataccatt gctttattca aaaaaatctc acttttgtaa
     1021 aaagagaatt tctgaaccaa aatacaagct ttcatttaat atatttaact gttttttttc
     1081 tgccatttct ttccaactat ttctaataat gtggttatga aaactgctac gcctctcaaa
     1141 ttatattttt taaatcacag gaatgtatac acatttatat gtatgtcttg aatgcaccat
     1201 ggaccaaagt ttttcaaaat atatcacttg gctcaattca atggcatcac atataaaatg
     1261 tgatgagtta tgtatgaaaa ggcctcaagg gtggggaata ctgattttct tatgttaaca
     1321 gaaatataaa agaaagtgga agactaagga gcatagataa atccttataa gatgaagtat
     1381 atagcaagtc ataaaattta agaatttgca acattatcta ctcaattgtg gggaagtatc
     1441 tattcactcc ttcagcactg atacttgttt ataaaaccca aacaattttt aaatgcattt
     1501 attttgagat gttcctaaaa ttgtttcatt ctatatgtaa atatcctgtg ataaatacga
     1561 ataatttcat ttcaatatga gaagctgtaa agattcaaca gatctcccac gtttccattt
     1621 tctttgcaca gatttattta tctgcattga tatttctgct tttagattgt ttgaacatta
     1681 aaaaatggag gaaaaatagc atggcttatt ttatgttttc acaaactact catttgatag
     1741 acaaaatttt gtcttccctt catcatgaga aataaacatt taaacatatt caaa
//
