LOCUS       NM_002923               1348 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens regulator of G protein signaling 2 (RGS2), mRNA.
ACCESSION   NM_002923
VERSION     NM_002923.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   Tang,C., Jin,M., Ma,B., Cao,B., Lin,C., Xu,S., Li,J. and Xu,Q.
  TITLE     RGS2 promotes estradiol biosynthesis by trophoblasts during human
            pregnancy
  JOURNAL   Exp Mol Med 55 (1), 240-252 (2023)
   PUBMED   36653442
  REMARK    GeneRIF: RGS2 promotes estradiol biosynthesis by trophoblasts
            during human pregnancy.
REFERENCE   2  (bases 1 to 1348)
  AUTHORS   Shriebman,Y., Yitzhaky,A., Kosloff,M. and Hertzberg,L.
  TITLE     Gene expression meta-analysis in patients with schizophrenia
            reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10
  JOURNAL   Eur J Neurosci 57 (2), 360-372 (2023)
   PUBMED   36443250
  REMARK    GeneRIF: Gene expression meta-analysis in patients with
            schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann
            Area 10.
REFERENCE   3  (bases 1 to 1348)
  AUTHORS   Yang,S., Sun,B., Li,W., Yang,H., Li,N. and Zhang,X.
  TITLE     Fatty acid metabolism is related to the immune microenvironment
            changes of gastric cancer and RGS2 is a new tumor biomarker
  JOURNAL   Front Immunol 13, 1065927 (2022)
   PUBMED   36591293
  REMARK    GeneRIF: Fatty acid metabolism is related to the immune
            microenvironment changes of gastric cancer and RGS2 is a new tumor
            biomarker.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1348)
  AUTHORS   Xu,X.H., Sun,J.M., Chen,X.F., Zeng,X.Y. and Zhou,H.Z.
  TITLE     MicroRNA-494-3p facilitates the progression of bladder cancer by
            mediating the KLF9/RGS2 axis
  JOURNAL   Kaohsiung J Med Sci 38 (11), 1070-1079 (2022)
   PUBMED   36098468
  REMARK    GeneRIF: MicroRNA-494-3p facilitates the progression of bladder
            cancer by mediating the KLF9/RGS2 axis.
REFERENCE   5  (bases 1 to 1348)
  AUTHORS   Jin,M., Xu,S., Cao,B., Xu,Q., Yan,Z., Ren,Q., Lin,C. and Tang,C.
  TITLE     Regulator of G protein signaling 2 is inhibited by
            hypoxia-inducible factor-1alpha/E1A binding protein P300 complex
            upon hypoxia in human preeclampsia
  JOURNAL   Int J Biochem Cell Biol 147, 106211 (2022)
   PUBMED   35430356
  REMARK    GeneRIF: Regulator of G protein signaling 2 is inhibited by
            hypoxia-inducible factor-1alpha/E1A binding protein P300 complex
            upon hypoxia in human preeclampsia.
REFERENCE   6  (bases 1 to 1348)
  AUTHORS   Druey,K.M., Blumer,K.J., Kang,V.H. and Kehrl,J.H.
  TITLE     Inhibition of G-protein-mediated MAP kinase activation by a new
            mammalian gene family
  JOURNAL   Nature 379 (6567), 742-746 (1996)
   PUBMED   8602223
REFERENCE   7  (bases 1 to 1348)
  AUTHORS   Siderovski,D.P., Hessel,A., Chung,S., Mak,T.W. and Tyers,M.
  TITLE     A new family of regulators of G-protein-coupled receptors?
  JOURNAL   Curr Biol 6 (2), 211-212 (1996)
   PUBMED   8673468
REFERENCE   8  (bases 1 to 1348)
  AUTHORS   Wu,H.K., Heng,H.H., Shi,X.M., Forsdyke,D.R., Tsui,L.C., Mak,T.W.,
            Minden,M.D. and Siderovski,D.P.
  TITLE     Differential expression of a basic helix-loop-helix phosphoprotein
            gene, G0S8, in acute leukemia and localization to human chromosome
            1q31
  JOURNAL   Leukemia 9 (8), 1291-1298 (1995)
   PUBMED   7643615
REFERENCE   9  (bases 1 to 1348)
  AUTHORS   Siderovski,D.P., Heximer,S.P. and Forsdyke,D.R.
  TITLE     A human gene encoding a putative basic helix-loop-helix
            phosphoprotein whose mRNA increases rapidly in
            cycloheximide-treated blood mononuclear cells
  JOURNAL   DNA Cell Biol 13 (2), 125-147 (1994)
   PUBMED   8179820
REFERENCE   10 (bases 1 to 1348)
  AUTHORS   Siderovski,D.P., Blum,S., Forsdyke,R.E. and Forsdyke,D.R.
  TITLE     A set of human putative lymphocyte G0/G1 switch genes includes
            genes homologous to rodent cytokine and zinc finger
            protein-encoding genes
  JOURNAL   DNA Cell Biol 9 (8), 579-587 (1990)
   PUBMED   1702972
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD700013.1, BC007049.1 and
            BI912389.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002923.3.
            
            Summary: Regulator of G protein signaling (RGS) family members are
            regulatory molecules that act as GTPase activating proteins (GAPs)
            for G alpha subunits of heterotrimeric G proteins. RGS proteins are
            able to deactivate G protein subunits of the Gi alpha, Go alpha and
            Gq alpha subtypes. They drive G proteins into their inactive
            GDP-bound forms. Regulator of G protein signaling 2 belongs to this
            family. The protein acts as a mediator of myeloid differentiation
            and may play a role in leukemogenesis. [provided by RefSeq, Aug
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1095256.1,
                                           SRR3476690.817888.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000235382.7/ ENSP00000235382.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CD700013.1         19-20
            3-1347              BC007049.1         2-1346
            1348-1348           BI912389.1         355-355
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..1348
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /note="regulator of G protein signaling 2"
                     /db_xref="GeneID:5997"
                     /db_xref="HGNC:HGNC:9998"
                     /db_xref="MIM:600861"
     exon            1..143
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..669
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /note="G0 to G1 switch regulatory 8, 24kD; cell
                     growth-inhibiting protein 31; G0/G1 switch regulatory
                     protein 8; cell growth-inhibiting gene 31 protein;
                     regulator of G-protein signaling 2, 24kDa"
                     /codon_start=1
                     /product="regulator of G-protein signaling 2"
                     /protein_id="NP_002914.1"
                     /db_xref="CCDS:CCDS1377.1"
                     /db_xref="GeneID:5997"
                     /db_xref="HGNC:HGNC:9998"
                     /db_xref="MIM:600861"
                     /translation="MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTR
                     LSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLK
                     SEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQ
                     NIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT"
     exon            144..245
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /inference="alignment:Splign:2.1.0"
     exon            246..307
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /inference="alignment:Splign:2.1.0"
     exon            308..474
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1348
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /note="hexamer: AATAAA"
     polyA_site      1348
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /note="major polyA site"
ORIGIN      
        1 gcaaacagcc ggggctccag cgggagaacg ataatgcaaa gtgctatgtt cttggctgtt
       61 caacacgact gcagacccat ggacaagagc gcaggcagtg gccacaagag cgaggagaag
      121 cgagaaaaga tgaaacggac ccttttaaaa gattggaaga cccgtttgag ctacttctta
      181 caaaattcct ctactcctgg gaagcccaaa accggcaaaa aaagcaaaca gcaagctttc
      241 atcaagcctt ctcctgagga agcacagctg tggtcagaag catttgacga gctgctagcc
      301 agcaaatatg gtcttgctgc attcagggct tttttaaagt cggaattctg tgaagaaaat
      361 attgaattct ggctggcctg tgaagacttc aaaaaaacca aatcacccca aaagctgtcc
      421 tcaaaagcaa ggaaaatata tactgacttc atagaaaagg aagctccaaa agagataaac
      481 atagattttc aaaccaaaac tctgattgcc cagaatatac aagaagctac aagtggctgc
      541 tttacaactg cccagaaaag ggtatacagc ttgatggaga acaactctta tcctcgtttc
      601 ttggagtcag aattctacca ggacttgtgt aaaaagccac aaatcaccac agagcctcat
      661 gctacatgaa atgtaaaagg gagcccagaa atggaggaca tttcattctt tttcctgagg
      721 ggaaggactg tgacctgcca taaagactga ccttgaattc agcctgggtg ttcaggaaac
      781 atcactcaga actattgatt caaagttggg tagtgaatca ggaagccagt aactgactag
      841 gagaagctgg tatcagaaca gcttccctca ctgtgtacag aacgcaagaa gggaataggt
      901 ggtctgaacg tggtgtctca ctctgaaaag caggaatgta agatgatgaa agagacaatg
      961 taatactgtt ggtccaaaag catttaaaat caatagatct gggattatgt ggccttaggt
     1021 agctggttgt acatctttcc ctaaatcgat ccatgttacc acatagtagt tttagtttag
     1081 gattcagtaa cagtgaagtg tttactatgt gcaacggtat tgaagttctt atgaccacag
     1141 atcatcagta ctgttgtctc atgtaatgct aaaactgaaa tggtccgtgt ttgcattgtt
     1201 aaaaatgatg tgtgaaatag aatgagtgct atggtgttga aaactgcagt gtccgttatg
     1261 agtgccaaaa atctgtcttg aaggcagcta cactttgaag tggtctttga atacttttaa
     1321 taaatttatt ttgataaata atattgaa
//
