LOCUS       NP_002914                211 aa            linear   PRI 01-JUN-2024
DEFINITION  regulator of G-protein signaling 2 [Homo sapiens].
ACCESSION   NP_002914
VERSION     NP_002914.1
DBSOURCE    REFSEQ: accession NM_002923.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 211)
  AUTHORS   Tang,C., Jin,M., Ma,B., Cao,B., Lin,C., Xu,S., Li,J. and Xu,Q.
  TITLE     RGS2 promotes estradiol biosynthesis by trophoblasts during human
            pregnancy
  JOURNAL   Exp Mol Med 55 (1), 240-252 (2023)
   PUBMED   36653442
  REMARK    GeneRIF: RGS2 promotes estradiol biosynthesis by trophoblasts
            during human pregnancy.
REFERENCE   2  (residues 1 to 211)
  AUTHORS   Shriebman,Y., Yitzhaky,A., Kosloff,M. and Hertzberg,L.
  TITLE     Gene expression meta-analysis in patients with schizophrenia
            reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10
  JOURNAL   Eur J Neurosci 57 (2), 360-372 (2023)
   PUBMED   36443250
  REMARK    GeneRIF: Gene expression meta-analysis in patients with
            schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann
            Area 10.
REFERENCE   3  (residues 1 to 211)
  AUTHORS   Yang,S., Sun,B., Li,W., Yang,H., Li,N. and Zhang,X.
  TITLE     Fatty acid metabolism is related to the immune microenvironment
            changes of gastric cancer and RGS2 is a new tumor biomarker
  JOURNAL   Front Immunol 13, 1065927 (2022)
   PUBMED   36591293
  REMARK    GeneRIF: Fatty acid metabolism is related to the immune
            microenvironment changes of gastric cancer and RGS2 is a new tumor
            biomarker.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 211)
  AUTHORS   Xu,X.H., Sun,J.M., Chen,X.F., Zeng,X.Y. and Zhou,H.Z.
  TITLE     MicroRNA-494-3p facilitates the progression of bladder cancer by
            mediating the KLF9/RGS2 axis
  JOURNAL   Kaohsiung J Med Sci 38 (11), 1070-1079 (2022)
   PUBMED   36098468
  REMARK    GeneRIF: MicroRNA-494-3p facilitates the progression of bladder
            cancer by mediating the KLF9/RGS2 axis.
REFERENCE   5  (residues 1 to 211)
  AUTHORS   Jin,M., Xu,S., Cao,B., Xu,Q., Yan,Z., Ren,Q., Lin,C. and Tang,C.
  TITLE     Regulator of G protein signaling 2 is inhibited by
            hypoxia-inducible factor-1alpha/E1A binding protein P300 complex
            upon hypoxia in human preeclampsia
  JOURNAL   Int J Biochem Cell Biol 147, 106211 (2022)
   PUBMED   35430356
  REMARK    GeneRIF: Regulator of G protein signaling 2 is inhibited by
            hypoxia-inducible factor-1alpha/E1A binding protein P300 complex
            upon hypoxia in human preeclampsia.
REFERENCE   6  (residues 1 to 211)
  AUTHORS   Druey,K.M., Blumer,K.J., Kang,V.H. and Kehrl,J.H.
  TITLE     Inhibition of G-protein-mediated MAP kinase activation by a new
            mammalian gene family
  JOURNAL   Nature 379 (6567), 742-746 (1996)
   PUBMED   8602223
REFERENCE   7  (residues 1 to 211)
  AUTHORS   Siderovski,D.P., Hessel,A., Chung,S., Mak,T.W. and Tyers,M.
  TITLE     A new family of regulators of G-protein-coupled receptors?
  JOURNAL   Curr Biol 6 (2), 211-212 (1996)
   PUBMED   8673468
REFERENCE   8  (residues 1 to 211)
  AUTHORS   Wu,H.K., Heng,H.H., Shi,X.M., Forsdyke,D.R., Tsui,L.C., Mak,T.W.,
            Minden,M.D. and Siderovski,D.P.
  TITLE     Differential expression of a basic helix-loop-helix phosphoprotein
            gene, G0S8, in acute leukemia and localization to human chromosome
            1q31
  JOURNAL   Leukemia 9 (8), 1291-1298 (1995)
   PUBMED   7643615
REFERENCE   9  (residues 1 to 211)
  AUTHORS   Siderovski,D.P., Heximer,S.P. and Forsdyke,D.R.
  TITLE     A human gene encoding a putative basic helix-loop-helix
            phosphoprotein whose mRNA increases rapidly in
            cycloheximide-treated blood mononuclear cells
  JOURNAL   DNA Cell Biol 13 (2), 125-147 (1994)
   PUBMED   8179820
REFERENCE   10 (residues 1 to 211)
  AUTHORS   Siderovski,D.P., Blum,S., Forsdyke,R.E. and Forsdyke,D.R.
  TITLE     A set of human putative lymphocyte G0/G1 switch genes includes
            genes homologous to rodent cytokine and zinc finger
            protein-encoding genes
  JOURNAL   DNA Cell Biol 9 (8), 579-587 (1990)
   PUBMED   1702972
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD700013.1, BC007049.1 and
            BI912389.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Regulator of G protein signaling (RGS) family members are
            regulatory molecules that act as GTPase activating proteins (GAPs)
            for G alpha subunits of heterotrimeric G proteins. RGS proteins are
            able to deactivate G protein subunits of the Gi alpha, Go alpha and
            Gq alpha subtypes. They drive G proteins into their inactive
            GDP-bound forms. Regulator of G protein signaling 2 belongs to this
            family. The protein acts as a mediator of myeloid differentiation
            and may play a role in leukemogenesis. [provided by RefSeq, Aug
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1095256.1,
                                           SRR3476690.817888.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000235382.7/ ENSP00000235382.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     Protein         1..211
                     /product="regulator of G-protein signaling 2"
                     /note="G0 to G1 switch regulatory 8, 24kD; cell
                     growth-inhibiting protein 31; G0/G1 switch regulatory
                     protein 8; cell growth-inhibiting gene 31 protein;
                     regulator of G-protein signaling 2, 24kDa"
                     /calculated_mol_wt=24251
     Region          14..33
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41220.1)"
     Region          32..66
                     /region_name="Necessary for membrane association.
                     /evidence=ECO:0000269|PubMed:11278586"
                     /note="propagated from UniProtKB/Swiss-Prot (P41220.1)"
     Region          49..68
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41220.1)"
     Region          79..116
                     /region_name="Necessary to inhibit protein synthesis.
                     /evidence=ECO:0000269|PubMed:19736320"
                     /note="propagated from UniProtKB/Swiss-Prot (P41220.1)"
     Region          84..197
                     /region_name="RGS_RGS2"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS2 protein; cd08709"
                     /db_xref="CDD:188664"
     Site            order(103..106,108..109,143..145,147..153,180,182..185,
                     188)
                     /site_type="other"
                     /note="G-alpha interaction site [polypeptide binding]"
                     /db_xref="CDD:188664"
     CDS             1..211
                     /gene="RGS2"
                     /gene_synonym="G0S8"
                     /coded_by="NM_002923.4:34..669"
                     /db_xref="CCDS:CCDS1377.1"
                     /db_xref="GeneID:5997"
                     /db_xref="HGNC:HGNC:9998"
                     /db_xref="MIM:600861"
ORIGIN      
        1 mqsamflavq hdcrpmdksa gsghkseekr ekmkrtllkd wktrlsyflq nsstpgkpkt
       61 gkkskqqafi kpspeeaqlw seafdellas kyglaafraf lksefceeni efwlacedfk
      121 ktkspqklss karkiytdfi ekeapkeini dfqtktliaq niqeatsgcf ttaqkrvysl
      181 mennsyprfl esefyqdlck kpqittepha t
//
