LOCUS       NM_005873               1619 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens regulator of G protein signaling 19 (RGS19),
            transcript variant 1, mRNA.
ACCESSION   NM_005873
VERSION     NM_005873.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Ke,S., Lu,S., Xu,Y., Bai,M., Yu,H., Yin,B., Wang,C., Feng,Z.,
            Li,Z., Huang,J., Li,X., Qian,B., Hua,Y., Fu,Y., Sun,B., Wu,Y. and
            Ma,Y.
  TITLE     RGS19 activates the MYH9/beta-catenin/c-Myc positive feedback loop
            in hepatocellular carcinoma
  JOURNAL   Exp Mol Med 56 (6), 1412-1425 (2024)
   PUBMED   38825640
  REMARK    GeneRIF: RGS19 activates the MYH9/beta-catenin/c-Myc positive
            feedback loop in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Liu,Y., Lou,W., Chen,G., Ding,B., Kuang,J., Zhang,Y., Wang,C.,
            Duan,S., Deng,Y. and Lu,X.
  TITLE     Genome-wide screening for the G-protein-coupled receptor (GPCR)
            pathway-related therapeutic gene RGS19 (regulator of G protein
            signaling 19) in bladder cancer
  JOURNAL   Bioengineered 12 (1), 5892-5903 (2021)
   PUBMED   34482807
  REMARK    GeneRIF: Genome-wide screening for the G-protein-coupled receptor
            (GPCR) pathway-related therapeutic gene RGS19 (regulator of G
            protein signaling 19) in bladder cancer.
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Solis,G.P., Kozhanova,T.V., Koval,A., Zhilina,S.S.,
            Mescheryakova,T.I., Abramov,A.A., Ishmuratov,E.V., Bolshakova,E.S.,
            Osipova,K.V., Ayvazyan,S.O., Lebon,S., Kanivets,I.V., Pyankov,D.V.,
            Troccaz,S., Silachev,D.N., Zavadenko,N.N., Prityko,A.G. and
            Katanaev,V.L.
  TITLE     Pediatric Encephalopathy: Clinical, Biochemical and Cellular
            Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant
            Disease
  JOURNAL   Cells 10 (10), 2749 (2021)
   PUBMED   34685729
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1619)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1619)
  AUTHORS   Hwang,J., Kim,H.S., Kang,B.S., Kim,D.H., Ryoo,Z.Y., Choi,S.U. and
            Lee,S.
  TITLE     RGS19 converts iron deprivation stress into a growth-inhibitory
            signal
  JOURNAL   Biochem Biophys Res Commun 464 (1), 168-175 (2015)
   PUBMED   26116529
  REMARK    GeneRIF: RGS19 senses cellular iron availability and is stabilized
            under iron-depleted conditions, resulting in the induction of a
            growth-inhibitory signal.
REFERENCE   6  (bases 1 to 1619)
  AUTHORS   Wang,J., Ducret,A., Tu,Y., Kozasa,T., Aebersold,R. and Ross,E.M.
  TITLE     RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane
            association, regulation by Galphaz phosphorylation, and
            relationship to a Gz gtpase-activating protein subfamily
  JOURNAL   J Biol Chem 273 (40), 26014-26025 (1998)
   PUBMED   9748280
REFERENCE   7  (bases 1 to 1619)
  AUTHORS   De Vries,L., Elenko,E., McCaffery,J.M., Fischer,T., Hubler,L.,
            McQuistan,T., Watson,N. and Farquhar,M.G.
  TITLE     RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G
            proteins, is located on clathrin-coated vesicles
  JOURNAL   Mol Biol Cell 9 (5), 1123-1134 (1998)
   PUBMED   9571244
REFERENCE   8  (bases 1 to 1619)
  AUTHORS   Ogier-Denis,E., Petiot,A., Bauvy,C. and Codogno,P.
  TITLE     Control of the expression and activity of the Galpha-interacting
            protein (GAIP) in human intestinal cells
  JOURNAL   J Biol Chem 272 (39), 24599-24603 (1997)
   PUBMED   9305927
REFERENCE   9  (bases 1 to 1619)
  AUTHORS   De Vries,L., Elenko,E., Hubler,L., Jones,T.L. and Farquhar,M.G.
  TITLE     GAIP is membrane-anchored by palmitoylation and interacts with the
            activated (GTP-bound) form of G alpha i subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (26), 15203-15208 (1996)
   PUBMED   8986788
REFERENCE   10 (bases 1 to 1619)
  AUTHORS   De Vries,L., Mousli,M., Wurmser,A. and Farquhar,M.G.
  TITLE     GAIP, a protein that specifically interacts with the trimeric G
            protein G alpha i3, is a member of a protein family with a highly
            conserved core domain
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11916-11920 (1995)
   PUBMED   8524874
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590548.22, AF285097.1 and
            BC063010.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005873.2.
            
            Summary: G proteins mediate a number of cellular processes. The
            protein encoded by this gene belongs to the RGS (regulators of
            G-protein signaling) family and specifically interacts with G
            protein, GAI3. This protein is a guanosine
            triphosphatase-activating protein that functions to down-regulate
            Galpha i/Galpha q-linked signaling. Alternatively spliced
            transcript variants encoding the same protein isoform have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.83188.1,
                                           SRR3476690.598730.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395042.2/ ENSP00000378483.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL590548.22        17938-17963         c
            27-38               AF285097.1         317-328
            39-1619             BC063010.1         1-1581
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1619
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /note="regulator of G protein signaling 19"
                     /db_xref="GeneID:10287"
                     /db_xref="HGNC:HGNC:13735"
                     /db_xref="MIM:605071"
     exon            1..225
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            226..323
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..947
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /note="G alpha interacting protein; regulator of G-protein
                     signalling 19; G protein signalling regulator 19; guanine
                     nucleotide binding protein alpha inhibiting activity
                     polypeptide 3 interacting protein"
                     /codon_start=1
                     /product="regulator of G-protein signaling 19"
                     /protein_id="NP_005864.1"
                     /db_xref="CCDS:CCDS13555.1"
                     /db_xref="GeneID:10287"
                     /db_xref="HGNC:HGNC:13735"
                     /db_xref="MIM:605071"
                     /translation="MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWC
                     CCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRS
                     VFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSR
                     VREGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA"
     exon            324..445
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..520
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            521..755
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1619
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1619
                     /gene="RGS19"
                     /gene_synonym="GAIP; RGSGAIP"
                     /note="major polyA site"
ORIGIN      
        1 ggatctggca gccactcagc ccttcgagct gtaggggagg cgctgcgccc ccggccccag
       61 ccgatcgggg gctcctggcg ctagcctccc tccagagcgc cgcaggagtc cctcctgccg
      121 tctgacttga gtccctgctg ctgcagtgca cgccccttcg gcagccaggg tggggcccag
      181 acccaacctg gcccctcctg cccccacccc gcctttgggt cgctgacccc caggctgtgg
      241 tgagggtctg agagctggta ccacggagcc tgggcaacct cctccgccca cccatgccca
      301 ccccgcatga ggctgagaag cagatcacag ggccagagga ggcggaccgg cccccttcaa
      361 tgtccagtca tgatacagcc tctccagcgg cccccagccg caacccctgc tgcctgtgct
      421 ggtgctgctg ctgtagctgc tcctggaacc aagagcggcg gcgcgcgtgg caggcctccc
      481 gggagagcaa gctgcagccc ctccccagct gtgaagtatg tgccacgcca agtcctgagg
      541 aggtgcagag ctgggcgcag tcttttgaca agctgatgca cagcccagcg ggacgcagcg
      601 tgttccgggc gttcctgcgg acagagtaca gcgaggagaa catgctcttc tggttggcct
      661 gcgaggagct gaaggccgag gccaaccagc atgtggtaga cgagaaggcg aggctcatct
      721 acgaggacta cgtatccatc ctgtccccca aggaggtgag cctggactcc cgtgtgcggg
      781 agggcatcaa caagaagatg caggagccgt ccgcacacac gttcgacgac gcgcagctgc
      841 agatctacac gctcatgcac cgggactcct acccccgctt cctcagctct cccacctacc
      901 gtgccctgct gctgcagggg ccatcacagt cctcctccga ggcctaggcc gcccccagca
      961 gcacagaccc cgccgcctcc tacggccgac tctgggttcc cttcaggtgt tgttgtcggc
     1021 agggctgtca gggcacatgc ctggccggct ggggtcccca cccgcggaga cggtcctaga
     1081 cccagtgggg agtgctgtgt ctcctgggtc tgcccacccg tggccaagca ggaactccag
     1141 gtgcagggcg ggcctccagg tgcagggcgg gccagaagcc ccctcatcgg cccgcagctg
     1201 gctggcccag tgctcctggc tgggggctct tgcgtggtga gagtaggggt ccccccagga
     1261 gccatgctgg acccatgagc ctcgctgggg cctcctcccc aggcagccaa tgggccccag
     1321 acaagccttt ggtggggaac agaacctccg catcgtgtag ttttgtgaca taaggagacc
     1381 tcctacttga gctgtctgta ccccagaatc aaacacagaa cctcagaacc agatttagga
     1441 cctcagaatc ctgcactcaa ggtggcagga cccaatttct gttttatatg ttcatgaact
     1501 ttaaacctgg aaacatgtcc ttactaggtg ttttatcaaa aaaaagtttt catatttatc
     1561 tctatcccta accccccaaa aataggatgt cttattattg aagatatttt taaagcaaa
//
