LOCUS       NM_130782               2145 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens regulator of G protein signaling 18 (RGS18), mRNA.
ACCESSION   NM_130782
VERSION     NM_130782.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Meng,Y., Qiu,S.Q., Wang,Q. and Zuo,J.L.
  TITLE     Regulator of G protein signalling 18 promotes osteocyte
            proliferation by activating the extracellular signal-regulated
            kinase signalling pathway
  JOURNAL   Int J Mol Med 53 (3) (2024)
   PUBMED   38214344
  REMARK    GeneRIF: Regulator of G protein signalling 18 promotes osteocyte
            proliferation by activating the extracellular signal-regulated
            kinase signalling pathway.
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Kim,J.O., Lee,K.O., Kim,H.W., Park,H.S., Kim,J., Sung,J.H., Oh,D.,
            Kim,O.J. and Kim,N.K.
  TITLE     Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent
            brain infarction based on whole-exome sequencing
  JOURNAL   Mol Med Rep 21 (4), 1973-1983 (2020)
   PUBMED   32319632
  REMARK    GeneRIF: Association between KCNQ2, TCF4 and RGS18 polymorphisms
            and silent brain infarction based on wholeexome sequencing.
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Kim,K., Lee,J. and Ghil,S.
  TITLE     The regulators of G protein signaling RGS16 and RGS18 inhibit
            protease-activated receptor 2/Gi/o signaling through distinct
            interactions with Galpha in live cells
  JOURNAL   FEBS Lett 592 (18), 3126-3138 (2018)
   PUBMED   30117167
  REMARK    GeneRIF: Data show that bothregulator of G protein signaling (RGS16
            and RGS18) inhibit protease-activated receptor 2 (PAR2)/G-protein,
            Gi-Go subunits (Galphai/o) -mediated signaling.
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Gegenbauer,K., Elia,G., Blanco-Fernandez,A. and Smolenski,A.
  TITLE     Regulator of G-protein signaling 18 integrates activating and
            inhibitory signaling in platelets
  JOURNAL   Blood 119 (16), 3799-3807 (2012)
   PUBMED   22234696
  REMARK    GeneRIF: These findings indicate cross-talk between platelet
            activation and inhibition pathways at the level of RGS18 and Gq.
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Ma,P., Cierniewska,A., Signarvic,R., Cieslak,M., Kong,H.,
            Sinnamon,A.J., Neubig,R.R., Newman,D.K., Stalker,T.J. and
            Brass,L.F.
  TITLE     A newly identified complex of spinophilin and the tyrosine
            phosphatase, SHP-1, modulates platelet activation by regulating G
            protein-dependent signaling
  JOURNAL   Blood 119 (8), 1935-1945 (2012)
   PUBMED   22210881
  REMARK    GeneRIF: Data show that that SPL/RGS/SHP1 complexes are present in
            resting platelets where constitutive phosphorylation of SPL(Y398)
            creates an atypical binding site for SHP-1.
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Gagnon,A.W., Murray,D.L. and Leadley,R.J.
  TITLE     Cloning and characterization of a novel regulator of G protein
            signalling in human platelets
  JOURNAL   Cell Signal 14 (7), 595-606 (2002)
   PUBMED   11955952
  REMARK    GeneRIF: molecular cloning and characterization of RGS18 as a
            regulator of G protein signalling in human platelets
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 2145)
  AUTHORS   Yowe,D., Weich,N., Prabhudas,M., Poisson,L., Errada,P.,
            Kapeller,R., Yu,K., Faron,L., Shen,M., Cleary,J., Wilkie,T.M.,
            Gutierrez-Ramos,C. and Hodge,M.R.
  TITLE     RGS18 is a myeloerythroid lineage-specific regulator of
            G-protein-signalling molecule highly expressed in megakaryocytes
  JOURNAL   Biochem J 359 (Pt 1), 109-118 (2001)
   PUBMED   11563974
REFERENCE   9  (bases 1 to 2145)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   10 (bases 1 to 2145)
  AUTHORS   Park,I.K., Klug,C.A., Li,K., Jerabek,L., Li,L., Nanamori,M.,
            Neubig,R.R., Hood,L., Weissman,I.L. and Clarke,M.F.
  TITLE     Molecular cloning and characterization of a novel regulator of
            G-protein signaling from mouse hematopoietic stem cells
  JOURNAL   J Biol Chem 276 (2), 915-923 (2001)
   PUBMED   11042171
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV715708.1, BC020632.1,
            AF268036.1 and AF076642.1.
            
            On Nov 22, 2018 this sequence version replaced NM_130782.2.
            
            Summary: This gene encodes a member of the regulator of G-protein
            signaling family. This protein is contains a conserved, 120 amino
            acid motif called the RGS domain. The protein attenuates the
            signaling activity of G-proteins by binding to activated, GTP-bound
            G alpha subunits and acting as a GTPase activating protein (GAP),
            increasing the rate of conversion of the GTP to GDP. This
            hydrolysis allows the G alpha subunits to bind G beta/gamma subunit
            heterodimers, forming inactive G-protein heterotrimers, thereby
            terminating the signal. Alternate transcriptional splice variants
            of this gene have been observed but have not been thoroughly
            characterized. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF076642.1, AF268036.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367460.4/ ENSP00000356430.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AV715708.1         6-13
            9-865               BC020632.1         1-857
            866-1485            AF268036.1         852-1471
            1486-2142           BC020632.1         1478-2134
            2143-2145           AF076642.1         2117-2119
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..2145
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /note="regulator of G protein signaling 18"
                     /db_xref="GeneID:64407"
                     /db_xref="HGNC:HGNC:14261"
                     /db_xref="MIM:607192"
     exon            1..295
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..884
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /note="regulator of G-protein signalling 18; regulator of
                     G-protein signalling 13"
                     /codon_start=1
                     /product="regulator of G-protein signaling 18"
                     /protein_id="NP_570138.1"
                     /db_xref="CCDS:CCDS1374.1"
                     /db_xref="GeneID:64407"
                     /db_xref="HGNC:HGNC:14261"
                     /db_xref="MIM:607192"
                     /translation="METTLLFFSQINMCESKEKTFFKLIHGSGKEETSKEAKIRAKEK
                     RNRLSLLVQKPEFHEDTRSSRSGHLAKETRVSPEEAVKWGESFDKLLSHRDGLEAFTR
                     FLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEV
                     ITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRS
                     FTCNEFQDVQSDVAIWL"
     exon            296..397
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /inference="alignment:Splign:2.1.0"
     exon            398..459
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /inference="alignment:Splign:2.1.0"
     exon            460..626
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /inference="alignment:Splign:2.1.0"
     exon            627..2145
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2127..2132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /note="hexamer: AATAAA"
     polyA_site      2145
                     /gene="RGS18"
                     /gene_synonym="RGS13"
                     /note="major polyA site"
ORIGIN      
        1 agttctgcat ttctgcagag acagaaagaa acgcagctct tgacttcttt tttgtaaaca
       61 ttactgtaag agttgtgata actttttatt ctactatgta tatgtatgga atagtattaa
      121 taaatgaact agggaaggat gtaataaatt agacatctct tcattttaga gagaagatgg
      181 aaacaacatt gcttttcttt tctcaaataa atatgtgtga atcaaaagaa aaaacttttt
      241 tcaagttaat acatggttca ggaaaagaag aaacaagcaa agaagccaaa atcagagcta
      301 aggaaaaaag aaatagacta agtcttcttg tgcagaaacc tgagtttcat gaagacaccc
      361 gctccagtag atctgggcac ttggccaaag aaacaagagt ctcccctgaa gaggcagtga
      421 aatggggtga atcatttgac aaactgcttt cccatagaga tggactagag gcttttacca
      481 gatttcttaa aactgaattc agtgaagaaa atattgaatt ttggatagcc tgtgaagatt
      541 tcaagaaaag caagggacct caacaaattc accttaaagc aaaagcaata tatgagaaat
      601 ttatacagac tgatgcccca aaagaggtta accttgattt tcacacaaaa gaagtcatta
      661 caaacagcat cactcaacct accctccaca gttttgatgc tgcacaaagc agagtgtatc
      721 agctcatgga acaagacagt tatacacgtt ttctgaaatc tgacatctat ttagacttga
      781 tggaaggaag acctcagaga ccaacaaatc ttaggagacg atcacgctca tttacctgca
      841 atgaattcca agatgtacaa tcagatgttg ccatttggtt ataaagaaaa ttgattttgc
      901 tcatttttat gacaaactta tacatctgct tctaacatat cgcatgttta tgttaagatt
      961 tggtcccatc ctttaaactg aaatatgtca tgtgaaatta ttttaaaaat gtaaaaacaa
     1021 aactttctgc taacaaaata catacagtat ctgccagtat attctgtaaa accttctatt
     1081 tgatgtcatt ccatttataa tcagaaaaaa aacttatttc ttaatcaaaa ggcagtacaa
     1141 aaaaagtaat aatgttttat aagattgtag agttaagtaa aagttaagct tttgcaaagt
     1201 tgtcaaaagt tcaaacaaaa gtctagttgg gattttttac caaagcagca taatatgtgt
     1261 tatataaaca taataatact cagatatcca aatgttcaga tagcattttt cataatgaat
     1321 gttctctttt ttttggtaat agtgtagaag tgatctggtt cttacaatgg gagatgaaga
     1381 acatttatta ttgggttact actaaccctg tcccaagaat agtaatatca cctctagtta
     1441 taagccagca acaggaactt ttgtgaagac acattcatct ctacagaact tcagattaaa
     1501 tataatctag attaatgact gagaataaga tccacatttg aactcattcc taagtgaaca
     1561 tggacgtacc cagttataca aagtacttct gttggtcaca gaaacatgac cagattttgc
     1621 atatctccag gtagggaact aagtagacta ccttatcacc ggctaagaaa acttgctact
     1681 aaactattag gccatcaatg gcttgaataa aaaccagaga aggtttttcc caggacgtct
     1741 catgtttggc cctttagaat tggggtagaa atcagaaatg agatgagggg aagaagcaag
     1801 gagtctaagg ccctagcgat ttgggcatct gccacattgg ttcatattca gaaagtgtta
     1861 tctcattgat tatattcttg ttaagcaaat ctccttaagt aattattatt caaataagat
     1921 tatactcata catctatatg tcactgtttt aaagagatat ttaattttta atgtgtgtta
     1981 catggtctgt aaatatttgt atttaaaaat gccatgcatt aggctttgga aatttaatgt
     2041 tagttgaaat gtaaaatgtg aaaactttag atcatttgta gtaataaata tttttaactt
     2101 cattcataca gttaagttta tctgacaata aaagctctga ctgaa
//
