LOCUS       NM_012419               7932 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens regulator of G protein signaling 17 (RGS17), mRNA.
ACCESSION   NM_012419
VERSION     NM_012419.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7932)
  AUTHORS   Ren,J., Fang,C., Liu,Y. and Xie,P.
  TITLE     Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates in the
            Pathogenesis of Abdominal Aortic Aneurysm by Regulating the
            Functions of Vascular Smooth Muscle Cells
  JOURNAL   Ann Clin Lab Sci 53 (2), 238-247 (2023)
   PUBMED   37094862
  REMARK    GeneRIF: Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates
            in the Pathogenesis of Abdominal Aortic Aneurysm by Regulating the
            Functions of Vascular Smooth Muscle Cells.
REFERENCE   2  (bases 1 to 7932)
  AUTHORS   Wang,S.L., Dong,X.W., Zhao,F. and Li,C.X.
  TITLE     MiR-203 inhibits cell proliferation, invasion, and migration of
            ovarian cancer through regulating RGS17
  JOURNAL   J Biol Regul Homeost Agents 35 (3), 1109-1115 (2021)
   PUBMED   34002599
  REMARK    GeneRIF: MiR-203 inhibits cell proliferation, invasion, and
            migration of ovarian cancer through regulating RGS17.
REFERENCE   3  (bases 1 to 7932)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 7932)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7932)
  AUTHORS   Hu,P., Zhou,G., Zhang,X., Song,G., Zhan,L. and Cao,Y.
  TITLE     Long non-coding RNA Linc00483 accelerated tumorigenesis of cervical
            cancer by regulating miR-508-3p/RGS17 axis
  JOURNAL   Life Sci 234, 116789 (2019)
   PUBMED   31454494
  REMARK    GeneRIF: Knock-down of Long non-coding RNA Linc00483 inhibited the
            development of cervical cancer by regulating miR-508-3p/RGS17 axis.
REFERENCE   6  (bases 1 to 7932)
  AUTHORS   Larminie,C., Murdock,P., Walhin,J.P., Duckworth,M., Blumer,K.J.,
            Scheideler,M.A. and Garnier,M.
  TITLE     Selective expression of regulators of G-protein signaling (RGS) in
            the human central nervous system
  JOURNAL   Brain Res Mol Brain Res 122 (1), 24-34 (2004)
   PUBMED   14992813
REFERENCE   7  (bases 1 to 7932)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 7932)
  AUTHORS   Fischer,T., De Vries,L., Meerloo,T. and Farquhar,M.G.
  TITLE     Promotion of G alpha i3 subunit down-regulation by GIPN, a putative
            E3 ubiquitin ligase that interacts with RGS-GAIP
  JOURNAL   Proc Natl Acad Sci U S A 100 (14), 8270-8275 (2003)
   PUBMED   12826607
REFERENCE   9  (bases 1 to 7932)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   10 (bases 1 to 7932)
  AUTHORS   Jordan,J.D., Carey,K.D., Stork,P.J. and Iyengar,R.
  TITLE     Modulation of rap activity by direct interaction of Galpha(o) with
            Rap1 GTPase-activating protein
  JOURNAL   J Biol Chem 274 (31), 21507-21510 (1999)
   PUBMED   10419452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356963.17, AF202257.3,
            BC013117.1, AA902430.1, CK902282.1 and AL080276.9.
            
            On Nov 23, 2018 this sequence version replaced NM_012419.4.
            
            Summary: This gene encodes a member of the regulator of G-protein
            signaling family. This protein contains a conserved, 120 amino acid
            motif called the RGS domain and a cysteine-rich region. The protein
            attenuates the signaling activity of G-proteins by binding to
            activated, GTP-bound G alpha subunits and acting as a GTPase
            activating protein (GAP), increasing the rate of conversion of the
            GTP to GDP. This hydrolysis allows the G alpha subunits to bind G
            beta/gamma subunit heterodimers, forming inactive G-protein
            heterotrimers, thereby terminating the signal. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013117.1, AF202257.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000206262.2/ ENSP00000206262.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL356963.17        33630-33657         c
            29-236              AF202257.3         12-219
            237-239             BC013117.1         204-206
            240-1225            AF202257.3         223-1208
            1226-1495           AA902430.1         1-270               c
            1496-1500           CK902282.1         1-5                 c
            1501-7932           AL080276.9         63158-69589         c
FEATURES             Location/Qualifiers
     source          1..7932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.2"
     gene            1..7932
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /note="regulator of G protein signaling 17"
                     /db_xref="GeneID:26575"
                     /db_xref="HGNC:HGNC:14088"
                     /db_xref="MIM:607191"
     exon            1..159
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            160..303
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..817
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /codon_start=1
                     /product="regulator of G-protein signaling 17"
                     /protein_id="NP_036551.3"
                     /db_xref="CCDS:CCDS5244.1"
                     /db_xref="GeneID:26575"
                     /db_xref="HGNC:HGNC:14088"
                     /db_xref="MIM:607191"
                     /translation="MRKRQQSQNEGTPAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVR
                     NEERGENAGRPTHTTKMESIQVLEECQNPTAEEVLSWSQNFDKMMKAPAGRNLFREFL
                     RTEYSEENLLFWLACEDLKKEQNKKVIEEKARMIYEDYISILSPKEVSLDSRVREVIN
                     RNLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKSFVESTAGSSSES"
     exon            304..393
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            394..628
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..7932
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5647..5652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /note="hexamer: AACAAA"
     polyA_site      5663
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
     regulatory      7912..7917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /note="hexamer: AATAAA"
     polyA_site      7932
                     /gene="RGS17"
                     /gene_synonym="hRGS17; RGS-17; RGSZ2"
                     /note="major polyA site"
ORIGIN      
        1 ctccccctcc tctgcatcct cgccgctctc cctctctcct cgcccgctgg gtgctgaagt
       61 tgggcggatg gcagcaaacc ggctccgcta gaggaccgag ccgcccagcc ccgctccccc
      121 ggacccatcg gcgcgctgcc cacacctcca ggcgaccggc caactgggtc ctgaagtagc
      181 tgaaatgcga aaaaggcagc agtcccaaaa tgaaggaaca cctgccgtgt ctcaagctcc
      241 tggaaaccag aggcccaaca acacctgttg cttttgttgg tgctgttgtt gcagctgctc
      301 ctgcctcact gtgaggaatg aagaaagagg ggaaaatgcg ggaagaccca cacacactac
      361 aaaaatggag agtatccagg tcctagagga atgccaaaac cccactgcag aggaagtctt
      421 gtcctggtct caaaattttg acaagatgat gaaggcccca gcaggaagaa accttttcag
      481 agagttcctc cgaacagaat acagtgaaga gaacctactt ttctggcttg cttgtgaaga
      541 cttaaagaag gagcagaaca aaaaagtaat tgaagaaaag gctaggatga tatatgaaga
      601 ttacatttct atactatcac caaaagaggt cagtcttgat tctcgagtta gagaggtgat
      661 caatagaaat ctgttggatc ccaatcctca catgtatgaa gatgcccaac ttcagatata
      721 tactttaatg cacagagatt cttttccaag gtttttgaac tctcaaattt ataagtcatt
      781 tgttgaaagt actgctggct cttcttctga atcttaatgt tcatttaaaa acaatcattt
      841 tggagggctg agatgggaaa taaaagtagt taaataacat cagaaactga gttcctggag
      901 aactacagtt tagcattcct caggctactg tgaaaacaca accgttatgg tctttgtctc
      961 catttttatc aaggttttcc atggttaagt ttggagaaaa taccacacaa aacaatgaat
     1021 tgccaaattg tttgttttat tcaagactca ttctacttgc aagcaaagtg tatttgtagt
     1081 cctatgaaca gtctcctcgt gtatctccag agactgcatg tgcaaagtaa aatgcttcat
     1141 ttgccacata gttgttgtaa tatttaatcc agtagcataa cttatatctg tatttaagga
     1201 cttttgtgca atatggtctt aagaaataat tgccaaaaaa atcggccatg gtttgcattt
     1261 tttaacataa tctaagacag aaaaaaagca atttttacta tgtaacaatg gtattcaaca
     1321 ttctatatac tgtgtttagt acactaattt tgaagccaat atttctgtac atgaaaaaga
     1381 gctatttatc tctgtttgtt ggaaaatcct aatggggatt cctctggttg ttcactgcca
     1441 aaactgtggc attttcatta caggagagtt tactatgcta aaagcaaaaa acaaaaaaaa
     1501 aaaaaaaggg aagaaggaaa aaagcacaaa acaatttgaa gatatcctat ctcaatgaca
     1561 aatcaaaaga gtgatattgc ttttaactgt aatagaagaa aatgaattta tgtatatatc
     1621 agatgtccaa tactgtaatt aatttattaa agactggctc tccagtttta aaatggttgt
     1681 gtaaagttat gtacttcagc aagaaaaaaa taataataag cttgataact tagttttgga
     1741 atataaagaa aaggacttaa taaaggaatg cctacatgta gcactgtaaa acattttgat
     1801 gaatagcatc tgtcctgtgg catattttcc ttgaaagtga aatccaatga aaagctaagt
     1861 ttttaccagg aaaagtttta taagggttat gaagaaaata atcctctact tcagacctta
     1921 actgttttca cataatatct taaggatgac attttaaaga tgtttaaacc aaactattag
     1981 ttttcatcca tcattaaaag gcagtacagt gctcaaatct tccagctgcc atattatttt
     2041 ttataagtac actaaatctt tacgacaaaa cacttgcctg acattgtcat gtacttctga
     2101 ccttcaagga aacaatattc tgtcatgcat aaaagtgata attaaaataa tcagtgtcat
     2161 atttatatca aagtgttaca tttgaatatt aatatcccct gaagactatt tttttaatat
     2221 taaactgaat gaatataata ctgagtaacc taaaatgaaa gttttaaaaa gatttatatc
     2281 cactgagaac actggcctta tattaaggat gatattacag ttacaggttt tctttgtcat
     2341 ttttttaact acctctcatt ttttaattta ttaaacatat tttttaaaaa aacaagtttg
     2401 ggggtttctt tttaaattta ttttacttga aaggttggca tcacaagttt ctttttccat
     2461 aaacttaaaa catttcaaaa atggtttttt taagcaagta tgattttcta atttatatag
     2521 aattcaggag acatgaataa aagggctatt atctattccc tatgcaaata ttttaactgt
     2581 tgcagtgttt gacaaaatgg gattttttaa aaattgcaga gtagaaaaca aaatattctg
     2641 tttacactgg cgttgctgac tatcctacca tattcagcac ttttaaatac gttatttatg
     2701 aaaatgcagt taaaatgcaa gatagaaaat atttataata atcatttctt ttaacaaatg
     2761 cctgtgtttt ctgaaagtgt tagtgtgtta agacatattt tattcatgtc atttaaatac
     2821 tatttgaata agttttcagt aatatgttga aaaaaagata gctatgaaga tgtttacaaa
     2881 aagtcatatt ttttcctaaa gagtaaagaa aaacctaaaa gaatcatcac ttctattgtg
     2941 aagttctatt gttcctaaat tatttaattt ttttcttgct tagaattgag tttattatgc
     3001 tactatgata tatacacatg tatggtgtag tatcatattt gtttctgtgt gtgaggctca
     3061 acaaattggt gcacatgact agaaaatatg taatatactg tgatacactg catgcatcca
     3121 tctttttaaa tgtagacttt atattctcgt tgttactata tatgatggtg acctgctagt
     3181 cataagttat ctttataaga tactttggac tattagatga attgtctgtt tgacaatatc
     3241 tttaatattt taccaaatgt aaaagataag ggccgttata aagagtccta atctctaacc
     3301 tgggcatttg tagaacacag attttaaagt tggtatatcc ttttgaaacc tgatgaggaa
     3361 gttgagttaa aaaagattcg agagcagatt tacacatcag atgttgataa ccatgctatg
     3421 tgagcatttc tgtgctaaac tcgtattttt gggtgagggg agggtttctc atttaagagt
     3481 atgtctgtat atttgcaact ctactaattt tctaagtatg atataattcc ttctgtttaa
     3541 gttacagagc tattataaat aaacaaaaga gccttcaact ggtgtctatg ctaccattcc
     3601 aagagcacaa tatttgtttt cttagaattt gagttttcct agtgagtaaa ttcctccctg
     3661 gggaaaaatt agcactttaa aatggacact ttgtgttttc aattgccaag gtatctttgt
     3721 atactattag aatttgctga tgcacacaga aagagattaa tgcactttct atagtgccta
     3781 actttagatg tatctataaa agaaagtaga ggatacagat tatgtatata taaataaatt
     3841 ggagagccag atttcttcag agattgatct tgtacattaa tcacaccagt aatggatgga
     3901 tggcacttct ttactcgggc tgttatgatg ttatccaaag gtagtagaga tgctctgaca
     3961 gtgttggagt gtgcacatga acaacaagag caaaacacaa ctttgatact aaagttacga
     4021 aatgcagaag tcaagaccat aatgtgatgt tttttttttt tgaaatctta aaatatgtac
     4081 atagaatgac cagttctgat atgccgtctt agtgcatgga tgtttattag tatcctttaa
     4141 tgctgcctag gttctgactt acagaatgaa atacgtgttg tttatctacc tgatagttca
     4201 gttttgccaa aggactatag ggataagtga ataatattta tttattagga gcaaaaatac
     4261 attttcatcc cattaagcta atttaaaata atgcctgatt tttacttttg agtttatcca
     4321 tttttctata cctttaactt atttatactt taaaaaatca tattgtaatt gtgacaaatt
     4381 atatctcaaa aaataccaat tattagatgc tttggtgttg aaatgtaaaa gagaaggaat
     4441 ttaaaataca atcaaaaaag tcaaaaataa aacgtatttg aaaaccacct aaaatttctt
     4501 ggccaggcac agtggctcaa gcctgtaatc ccagcacttt gggaagccaa agagggcgga
     4561 tcacttgagc tcaggagttt gagaccagac tggccaacat ggtgaaaccc cgactctagt
     4621 aaaaatacaa aattagccgg gcatggtggt gggtgccttt aatcccggct acttgagagg
     4681 ctgaggcagg agaatcgctt gaacccagga ggcagaggtc gcagtgagct gatatcatgc
     4741 cactgcactc cagccttggc aacagagtga ctccatctca aaataataat aataattata
     4801 ataataatat ttttaagtct tagacagaaa atgcctatag atagaagcct atcaaacatg
     4861 tattttgaat actttgatct tgacacattg cctaattatt ttgaaagatg gtaaagatat
     4921 ttccaaaaaa tattttcgcc tatctgttta cattgacagt ttacaaccat aattttctaa
     4981 gtatattttt caaacatgta tttttgtgtt ttccatcttc aaatttctga ccaatgggtt
     5041 tgttctcctg caaaaacaat atccaatctg caaaaatttt taattcttca cttgctacaa
     5101 ctgcaaatat ttatcaataa aactgataac ccaaaacttg cttcagattt tccctgcagt
     5161 gcttaaaata tccttgcaac acaagatggt gcacaatgac aagtattatt tctgaatacc
     5221 cagatttgat ttatttatag gtatttttga aattattact cttacaggtg tagtcctctc
     5281 cagccccaag taacatcttt tcagatgaat tcaagaggct gttcaagact ttgactctac
     5341 tgaaaacact acaaaaggca aaatgttgcc ctaggtgata gaaggtccca gtttgggaac
     5401 tgattttctt cctatgacaa aagctataag atgagtaagg ttactaatgg aaatgtatgt
     5461 ccacagattc acttagggag catagtgtaa aaacatcagg aacttaaaat tacaaatttg
     5521 atttcaagtt atatttctgt ctcatgtgac tttgggcaaa tcatttatct tctctgagtt
     5581 catttcctca tctgcaaatg acaaataaaa tacgtaatta tcaggataac tatgagcatt
     5641 aaataaaaca aacgtggaaa gaataaagtg tggcatacat tattatttta tcaaagtgca
     5701 tcacgtcaat aattgttatt gtatacttgt attaaatgtc actttaatgc actttcccct
     5761 atttttttcc aaaacatacg ttaaacatct gatttagcta ctcatcaaaa catacaatca
     5821 tgttttaaga tggaacacta tatcagtgtt actgcttttc tcaataatgt gatcccaaat
     5881 cagtactttc agttcaccat cacctcaaat ctatagaaat gtttctttca atgacataga
     5941 tagatagatg attgatagat agatgataga tagatgataa atggatatac aattataggt
     6001 taaaattaaa gtttaaataa gatcaatcat ttgaaagttt tatttccaaa ggaaataaaa
     6061 caacattccc aaggacagaa ataatatcaa attacttgct aaatatataa atgagttata
     6121 gggctaagac taagttataa gagattgaca attagaaaac actcttttta atattaaggt
     6181 ggtatgattt tctttaacaa ttttacaatg aaaataaaaa cttaataaaa ggtggtaatg
     6241 ggccaggcac ggtggctcac gcatacaatc ccagcacttt gggagactaa ggcgtgagga
     6301 tcacttgagc ccaggagttc cagacatgtc tatgcaacaa agtgagaccc tgactctaag
     6361 aaaaaaataa aatgtataaa atttaaaata gtaatgtgtc cattaaacct tttattttag
     6421 agtagtttta gatttacaga aaaactccaa atagagaggt cccatataca tctatgggca
     6481 ttaatgagcc aatattgatc attacattca tacttcattc agatttcctt agtttataac
     6541 ctaatgtcct ttttctgtcc caggatccca ttcaggatac cacattacat ttagttgtca
     6601 tgtttcctta ggcttccctt ggctgtgaca gtttctgcaa ctttccttgt ttttgatgac
     6661 agttttgaga aataaactgg tattttgtag aatgtccttc tatggggatt cgtctgatgt
     6721 ttttctcgtg actagacaca ggtttttggt ttttgaaaga acacaacggt aaagtgccat
     6781 gctcatcaca tggtatcaaa ggtatatgcc atcaccggga ctcgtcttag ctgtgacagt
     6841 ttctcaaact ttaggctact cttagctgtt gatgttaacc ttgatcactt agctgaggta
     6901 gcatctatta tatttctcca ctgtaaagta atgcgttttt aaagagatta tattgaaggt
     6961 aaattttctg gacatttaca ctgagctaaa caaattctaa acactaatat taggttccac
     7021 taagtgatta ctaataaatg ctataaagaa aatacagtga agtggaaaaa taaaactcca
     7081 gaagtcttag cctgaatatt cacctaatag aggtgaaagt gaatttttcc cttgaactgt
     7141 ctgcgcaatt tacaataatc ctccacatac tttggatatt aaagatctta tcttactaat
     7201 tgtcataaga ggtaatttaa atttaaacta accattttgc ttattgcatt tttatattgc
     7261 cctccactaa tcaatgaaca ctgaatattg aaataatgta aaagacctat ttcccgctag
     7321 ctttaaccga tttgtcataa acacctttct tgtatatgat ttttaaatgt ttgctaaata
     7381 ttaaaaagaa ttcaatgtgt ttggttttgt aaaattacat atcgaatgtg tataattttt
     7441 tactaccatg ttcatcacac ttaatctata tccatatatt gtactccacc aatatttatc
     7501 agtggacaat aaagaagttt tgaatgcatg aatgcaactt aagaggcacc acacttggtt
     7561 attttgcaat gccagaataa cggtgggtat tcacaaattg aatagataat ccagattatg
     7621 tttcctccaa tttaagtttt tctgggtttt tttttccccc ttcctagaat caattttatc
     7681 attttaccta tgtacaataa tatacttctg gaaaatgcta gaattttcac catgtaacag
     7741 aatttgagca tgacagtaat gtaaaaatat tcagaagtct cgaactatag gtttgagttt
     7801 tcaaagtaaa tcaaaataca gctgttttca ttttactaga ttgtggaaac ctatggatgt
     7861 tattgtaaaa tgcatatgca ttacactgac tttcttaaaa tgttttgaat taataaagaa
     7921 ttcaacaatg ta
//
