LOCUS       NM_002928               2408 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens regulator of G protein signaling 16 (RGS16), mRNA.
ACCESSION   NM_002928
VERSION     NM_002928.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Shen,H., Yuan,J., Tong,D., Chen,B., Yu,E., Chen,G., Peng,C.,
            Chang,W., E,J. and Cao,F.
  TITLE     Regulator of G protein signaling 16 restrains apoptosis in
            colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK
            signaling
  JOURNAL   Cell Death Dis 15 (6), 438 (2024)
   PUBMED   38906869
  REMARK    GeneRIF: Regulator of G protein signaling 16 restrains apoptosis in
            colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK
            signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Zhang,Y., Zhu,Q., Cao,X. and Ni,B.
  TITLE     RGS16 regulates Hippo-YAP activity to promote esophageal cancer
            cell proliferation and migration
  JOURNAL   Biochem Biophys Res Commun 675, 122-129 (2023)
   PUBMED   37473526
  REMARK    GeneRIF: RGS16 regulates Hippo-YAP activity to promote esophageal
            cancer cell proliferation and migration.
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Wang,C., Xue,H., Zhao,R., Sun,Z., Gao,X., Qi,Y., Wang,H., Xu,J.,
            Deng,L. and Li,G.
  TITLE     RGS16 regulated by let-7c-5p promotes glioma progression by
            activating PI3K-AKT pathway
  JOURNAL   Front Med 17 (1), 143-155 (2023)
   PUBMED   36414916
  REMARK    GeneRIF: RGS16 regulated by let-7c-5p promotes glioma progression
            by activating PI3K-AKT pathway.
REFERENCE   4  (bases 1 to 2408)
  AUTHORS   Shriebman,Y., Yitzhaky,A., Kosloff,M. and Hertzberg,L.
  TITLE     Gene expression meta-analysis in patients with schizophrenia
            reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10
  JOURNAL   Eur J Neurosci 57 (2), 360-372 (2023)
   PUBMED   36443250
  REMARK    GeneRIF: Gene expression meta-analysis in patients with
            schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann
            Area 10.
REFERENCE   5  (bases 1 to 2408)
  AUTHORS   Zhu,F., Qin,Y., Wang,Y., Zhang,F., Xu,Z., Dai,F., Chu,W., Wang,Y.
            and Zhou,G.
  TITLE     Critical roles of RGS16 in the mucosal inflammation of ulcerative
            colitis
  JOURNAL   Eur J Gastroenterol Hepatol 34 (10), 993-999 (2022)
   PUBMED   35830366
  REMARK    GeneRIF: Critical roles of RGS16 in the mucosal inflammation of
            ulcerative colitis.
REFERENCE   6  (bases 1 to 2408)
  AUTHORS   Snow,B.E., Antonio,L., Suggs,S. and Siderovski,D.P.
  TITLE     Cloning of a retinally abundant regulator of G-protein signaling
            (RGS-r/RGS16): genomic structure and chromosomal localization of
            the human gene
  JOURNAL   Gene 206 (2), 247-253 (1998)
   PUBMED   9469939
  REMARK    Erratum:[Gene 1998 Jun 15;213(1-2):223]
REFERENCE   7  (bases 1 to 2408)
  AUTHORS   Buckbinder,L., Velasco-Miguel,S., Chen,Y., Xu,N., Talbott,R.,
            Gelbert,L., Gao,J., Seizinger,B.R., Gutkind,J.S. and Kley,N.
  TITLE     The p53 tumor suppressor targets a novel regulator of G protein
            signaling
  JOURNAL   Proc Natl Acad Sci U S A 94 (15), 7868-7872 (1997)
   PUBMED   9223279
REFERENCE   8  (bases 1 to 2408)
  AUTHORS   Natochin,M., Lipkin,V.M. and Artemyev,N.O.
  TITLE     Interaction of human retinal RGS with G-protein alpha-subunits
  JOURNAL   FEBS Lett 411 (2-3), 179-182 (1997)
   PUBMED   9271201
REFERENCE   9  (bases 1 to 2408)
  AUTHORS   Chen,C., Zheng,B., Han,J. and Lin,S.C.
  TITLE     Characterization of a novel mammalian RGS protein that binds to
            Galpha proteins and inhibits pheromone signaling in yeast
  JOURNAL   J Biol Chem 272 (13), 8679-8685 (1997)
   PUBMED   9079700
REFERENCE   10 (bases 1 to 2408)
  AUTHORS   Chen,C.K., Wieland,T. and Simon,M.I.
  TITLE     RGS-r, a retinal specific RGS protein, binds an intermediate
            conformation of transducin and enhances recycling
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12885-12889 (1996)
   PUBMED   8917514
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC349953.1, BC006243.2,
            DA060276.1 and AL353778.13.
            
            On Nov 23, 2018 this sequence version replaced NM_002928.3.
            
            Summary: The protein encoded by this gene belongs to the 'regulator
            of G protein signaling' family. It inhibits signal transduction by
            increasing the GTPase activity of G protein alpha subunits. It also
            may play a role in regulating the kinetics of signaling in the
            phototransduction cascade. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U70426.1, SRR1660805.45823.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367558.6/ ENSP00000356529.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DC349953.1         29-42
            15-539              BC006243.2         1-525
            540-801             DA060276.1         282-543
            802-874             BC006243.2         788-860
            875-2408            AL353778.13        4759-6292           c
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..2408
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /note="regulator of G protein signaling 16"
                     /db_xref="GeneID:6004"
                     /db_xref="HGNC:HGNC:9997"
                     /db_xref="MIM:602514"
     exon            1..174
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..739
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /note="regulator of G-protein signalling 16; hRGS-r;
                     retinal-specific RGS; retinally abundant regulator of
                     G-protein signaling"
                     /codon_start=1
                     /product="regulator of G-protein signaling 16"
                     /protein_id="NP_002919.3"
                     /db_xref="CCDS:CCDS1348.1"
                     /db_xref="GeneID:6004"
                     /db_xref="HGNC:HGNC:9997"
                     /db_xref="MIM:602514"
                     /translation="MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEW
                     GSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFK
                     KIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTR
                     TLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT"
     exon            175..285
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /inference="alignment:Splign:2.1.0"
     exon            286..350
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /inference="alignment:Splign:2.1.0"
     exon            351..517
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /inference="alignment:Splign:2.1.0"
     exon            518..2408
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /note="hexamer: AATAAA"
     polyA_site      2408
                     /gene="RGS16"
                     /gene_synonym="A28-RGS14; A28-RGS14P; RGS-R"
                     /note="major polyA site"
ORIGIN      
        1 gcttgcaggc tgctaaaccc aaccgcagtt gactagcacc tgctaccgcg cctttgcttc
       61 ctggcgcacg cggagcctcc tggagcctgc caccatcctg cctactacgt gctgccctgc
      121 gcccgcagcc atgtgccgca ccctggccgc cttccccacc acctgcctgg agagagccaa
      181 agagttcaag acacgtctgg ggatctttct tcacaaatca gagctgggct gcgatactgg
      241 gagtactggc aagttcgagt ggggcagtaa acacagcaaa gagaatagaa acttctcaga
      301 agatgtgctg gggtggagag agtcgttcga cctgctgctg agcagtaaaa atggagtggc
      361 tgccttccac gctttcctga agacagagtt cagtgaggag aacctggagt tctggctggc
      421 ctgtgaggag ttcaagaaga tccgatcagc taccaagctg gcctccaggg cacaccagat
      481 ctttgaggag ttcatttgca gtgaggcccc taaagaggtc aacattgacc atgagaccca
      541 cgagctgacg aggatgaacc tgcagactgc cacagccaca tgctttgatg cggctcaggg
      601 gaagacacgt accctgatgg agaaggactc ctacccacgc ttcctgaagt cgcctgctta
      661 ccgggacctg gctgcccaag cctcagccgc ctctgccact ctgtccagct gcagcctgga
      721 cgagccctca cacacctgag tctccacggc agtgaggaag ccagccggga agagaggttg
      781 agtcacccat ccccgaggtg gctgcccctg tgtgggaggc aggttctgca aagcaagtgc
      841 aagaggacaa aaaaaaaaaa aaaaaaaaaa aaaatgcgct ccagcagcct gtttgggaag
      901 cagcagtctc tccttcagat actgtgggac tcatgctgga gaggagccgc ccacttccag
      961 gacctgtgaa taagggctaa tgatgagggt tggtggggct ctctgtgggg caaaaaggtg
     1021 gtatgggggt tagcactggc tctcgttctc accggagaag gaagtgttct agtgtggttt
     1081 aggaaacatg tggataaagg gaaccatgaa aatgagagga ggaaagacat ccagatcagc
     1141 tgttttgcct gttgctcagt tgactctgat tgcatcctgt tttcctaatt cccagactgt
     1201 tctgggcacg gaagggaccc tggatgtgga gtcttcccct ttggccctcc tcactggcct
     1261 ctgggctagc ccagagtccc ttagcttgta cctcgtaaca ctcctgtgtg tctgtccagc
     1321 cttgcagtca tgtcaaggcc agcaagctga tgtgactctt gccccatgcg agatatttat
     1381 acctcaaaca ctggcctgtg agccctttcc aagtcagtgg agagccctga aaggaggctc
     1441 acttgaatcc agctcagtgc tctgggtggc cccctgcagg tggcccctga ccctgcgttg
     1501 cagcagggtc cacctgtgag caggcccgcc ctggggcctc ttcctggatg tgccctctct
     1561 gagttctgtg ctgtctcttg gaggcagggc ccaggagaac aaagtgtgga ggcctcgggg
     1621 agtggctttt ccagctctca tgccccgcag tgtggaacaa ggcagaaaag gatcctagga
     1681 aataagtctc ttggcggtcc ctgagagtcc tgctgaaatc cagccagtgt tttttgtggt
     1741 atgagaacag gcaaaaagag atgccccgag atagaagggg agccttgtgt ttctttcctg
     1801 cagacgtgag atgaacactg gagtgggcag aggtggccca ggaccatggc acccttagag
     1861 tgcagaagct ggggggagag gctgcttcga agggcaggac tggggataat cagaacctgc
     1921 ctgtcacctc agggcatcac tgaacaaaca tttcctgatg gcaactcctg cggcagagcc
     1981 caggctgggg aagtgaacta cccagggcag cccctttgtg gcccaggata atcaacactg
     2041 ttctctctgt accatgagct cctccaggag attatttaag tgtattgtat cattggtttt
     2101 ctgtgattgt cataacattg tttttgttat tgttggtgct gttgttattt attattgtaa
     2161 tttcagtttg cctctactgg agaatctcag caggggtttc agcctgactg tctccctttc
     2221 tctaccagac tctacctctg aatgtgctgg gaacctcttg gagcctgtca ggaactcctc
     2281 actgtttaaa tatttattta ttgtgacaaa tggagctggt ttcctagata tgaatgatgt
     2341 ttgcaatccc cattttcctg tttcagcatg ttatattctt ataaaataaa agcaaaagtc
     2401 aaatatga
//
