LOCUS       NM_006480               2323 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens regulator of G protein signaling 14 (RGS14),
            transcript variant 1, mRNA.
ACCESSION   NM_006480
VERSION     NM_006480.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2323)
  AUTHORS   Sneddon,W.B., Ramineni,S., Van Doorn,G.E., Hepler,J.R. and
            Friedman,P.A.
  TITLE     Distinct and overlapping RGS14 and RGS12 actions regulate
            NPT2A-mediated phosphate transport
  JOURNAL   Biochem Biophys Res Commun 733, 150700 (2024)
   PUBMED   39293332
  REMARK    GeneRIF: Distinct and overlapping RGS14 and RGS12 actions regulate
            NPT2A-mediated phosphate transport.
REFERENCE   2  (bases 1 to 2323)
  AUTHORS   Wang,J., Guo,Y., He,Y., Qin,Y., Li,X., Yang,L., Liu,K. and Xiao,L.
  TITLE     Hepatic regulator of G protein signaling 14 ameliorates NAFLD
            through activating cAMP-AMPK signaling by targeting Gialpha1/3
  JOURNAL   Mol Metab 80, 101882 (2024)
   PUBMED   38237897
  REMARK    GeneRIF: Hepatic regulator of G protein signaling 14 ameliorates
            NAFLD through activating cAMP-AMPK signaling by targeting
            Gialpha1/3.
REFERENCE   3  (bases 1 to 2323)
  AUTHORS   Montanez-Miranda,C., Bramlett,S.N. and Hepler,J.R.
  TITLE     RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia:
            Implications for human brain physiology and disease
  JOURNAL   Hippocampus 33 (3), 166-181 (2023)
   PUBMED   36541898
  REMARK    GeneRIF: RGS14 expression in CA2 hippocampus, amygdala, and basal
            ganglia: Implications for human brain physiology and disease.
            Review article
REFERENCE   4  (bases 1 to 2323)
  AUTHORS   Friedman,P.A., Sneddon,W.B., Mamonova,T., Montanez-Miranda,C.,
            Ramineni,S., Harbin,N.H., Squires,K.E., Gefter,J.V., Magyar,C.E.,
            Emlet,D.R. and Hepler,J.R.
  TITLE     RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal
            phosphate uptake via binding to the NHERF1 scaffolding protein
  JOURNAL   J Biol Chem 298 (5), 101836 (2022)
   PUBMED   35307350
  REMARK    GeneRIF: RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated
            renal phosphate uptake via binding to the NHERF1 scaffolding
            protein.
REFERENCE   5  (bases 1 to 2323)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2323)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   7  (bases 1 to 2323)
  AUTHORS   Kimple,R.J., De Vries,L., Tronchere,H., Behe,C.I., Morris,R.A.,
            Gist Farquhar,M. and Siderovski,D.P.
  TITLE     RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with
            guanine nucleotide dissociation inhibitor Activity
  JOURNAL   J Biol Chem 276 (31), 29275-29281 (2001)
   PUBMED   11387333
REFERENCE   8  (bases 1 to 2323)
  AUTHORS   Cho,H., Kozasa,T., Takekoshi,K., De Gunzburg,J. and Kehrl,J.H.
  TITLE     RGS14, a GTPase-activating protein for Gialpha, attenuates Gialpha-
            and G13alpha-mediated signaling pathways
  JOURNAL   Mol Pharmacol 58 (3), 569-576 (2000)
   PUBMED   10953050
REFERENCE   9  (bases 1 to 2323)
  AUTHORS   Traver,S., Bidot,C., Spassky,N., Baltauss,T., De Tand,M.F.,
            Thomas,J.L., Zalc,B., Janoueix-Lerosey,I. and Gunzburg,J.D.
  TITLE     RGS14 is a novel Rap effector that preferentially regulates the
            GTPase activity of galphao
  JOURNAL   Biochem J 350 Pt 1 (Pt 1), 19-29 (2000)
   PUBMED   10926822
REFERENCE   10 (bases 1 to 2323)
  AUTHORS   Snow,B.E., Antonio,L., Suggs,S., Gutstein,H.B. and Siderovski,D.P.
  TITLE     Molecular cloning and expression analysis of rat Rgs12 and Rgs14
  JOURNAL   Biochem Biophys Res Commun 233 (3), 770-777 (1997)
   PUBMED   9168931
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014094.2.
            
            On Nov 22, 2018 this sequence version replaced NM_006480.4.
            
            Summary: This gene encodes a member of the regulator of G-protein
            signaling family. This protein contains one RGS domain, two
            Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The
            protein attenuates the signaling activity of G-proteins by binding,
            through its GoLoco domain, to specific types of activated,
            GTP-bound G alpha subunits. Acting as a GTPase activating protein
            (GAP), the protein increases the rate of conversion of the GTP to
            GDP. This hydrolysis allows the G alpha subunits to bind G
            beta/gamma subunit heterodimers, forming inactive G-protein
            heterotrimers, thereby terminating the signal. Alternate
            transcriptional splice variants of this gene have been observed but
            have not been thoroughly characterized. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014094.2, SRR1660809.255985.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408923.8/ ENSP00000386229.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2323              BC014094.2         52-2374
FEATURES             Location/Qualifiers
     source          1..2323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2323
                     /gene="RGS14"
                     /note="regulator of G protein signaling 14"
                     /db_xref="GeneID:10636"
                     /db_xref="HGNC:HGNC:9996"
                     /db_xref="MIM:602513"
     exon            1..146
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1802
                     /gene="RGS14"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="regulator of G-protein signaling 14 isoform 1"
                     /protein_id="NP_006471.2"
                     /db_xref="CCDS:CCDS43405.1"
                     /db_xref="GeneID:10636"
                     /db_xref="HGNC:HGNC:9996"
                     /db_xref="MIM:602513"
                     /translation="MPGKPKHLGVPNGRMVLAVSDGELSSTTGPQGQGEGRGSSLSIH
                     SLPSGPSSPFPTEEQPVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACER
                     FQQIPASDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWLGEEVLAEPRPDMFRAQQL
                     QIFNLMKFDSYARFVKSPLYRECLLAEAEGRPLREPGSSRLGSPDATRKKPKLKPGKS
                     LPLGVEELGQLPPVEGPGGRPLRKSFRRELGGTANAALRRESQGSLNSSASLDLGFLA
                     FVSSKSESHRKSLGSTEGESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICEK
                     RGLSLPDIKVYLVGNEQALVLDQDCTVLADQEVRLENRITFELELTALERVVRISAKP
                     TKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDTLPGVKIS
                     KARDKSPCRSQGCPPRTQDKATHPPPASPSSLVKVPSSATGKRQTCDIEGLVELLNRV
                     QSSGAHDQRGLLRKEDLVLPEFLQLPAQGPSSEETPPQTKSAAQPIGGSLNSTTDSAL
                     "
     exon            147..168
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            169..347
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            348..440
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            441..584
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            585..728
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            729..840
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            841..950
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1154
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1228
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1355
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1437
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1484
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1599
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..2323
                     /gene="RGS14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS14"
                     /note="hexamer: AATAAT"
     polyA_site      2323
                     /gene="RGS14"
                     /note="major polyA site"
ORIGIN      
        1 ctctccactg cctgcccgcc accgtgcaag ctctggccgg cgctgcccac agtccccatg
       61 gtgggcagcc cccgcggcgg ggacccctga tcggcagcgg catgccaggg aagcccaagc
      121 acctgggcgt ccccaacggg cgcatggttc tggctgtgtc agatggagag ctgagcagca
      181 cgacggggcc ccagggccag ggcgagggcc gcggcagctc tctcagcatc cacagcctcc
      241 ccagtggtcc cagcagcccc ttcccaaccg aggagcagcc tgtggccagc tgggccctgt
      301 ccttcgagcg gctgttgcag gacccgctgg gcctggctta cttcactgag ttcctgaaga
      361 aggagttcag cgcggaaaac gtgactttct ggaaggcctg cgagcgcttc cagcagatcc
      421 cggccagcga tacccagcag ctagctcagg aggcccgcaa catctaccag gagttcctgt
      481 ccagccaggc gctgagccca gtgaacatcg accgtcaggc ctggcttggc gaggaggtgc
      541 tggccgagcc ccggccggac atgtttcggg cacagcagct tcagatcttc aacttgatga
      601 agttcgacag ctatgcgcgc ttcgtcaagt ccccgctgta ccgcgagtgc ctgctagccg
      661 aagccgaggg acgccctctg cgggaacctg gctcctcgcg cctcggcagc cctgacgcca
      721 cgaggaagaa gccgaagctg aagcccggga agtcgctgcc gctgggtgtg gaggagttgg
      781 ggcagctgcc acccgttgag ggtcctgggg gccgccctct ccgcaagtcc ttccgccggg
      841 agctgggcgg gactgcaaac gccgccttgc gccgagagtc tcagggctcc ctcaactcct
      901 ccgccagcct ggaccttggc ttcctagcct tcgtcagcag caaatctgag agccaccgga
      961 agagccttgg gagcacggag ggtgaaagtg aaagccggcc agggaagtac tgctgtgtgt
     1021 acctgcccga tggcacagcc tccttggccc tggccagacc tggcctcacc atccgagaca
     1081 tgctggcagg gatctgtgag aaacgaggcc tctctctacc tgacatcaag gtctacctgg
     1141 tgggcaatga acaggccctg gtcctggatc aggactgcac cgtgctggcg gatcaggaag
     1201 tgcggctgga aaacaggatc accttcgagc tggagctgac ggcgctggag cgcgtggtac
     1261 gaatctcagc caagcccacc aagcggctgc aggaggcgct gcagcccatt ctggagaagc
     1321 acggcttgag cccgctagag gtggtgctgc accggccagg cgagaaacag cctctggatc
     1381 tggggaagct agtgagctcg gtggcggccc agagactggt tttggacact cttccaggtg
     1441 tgaagatctc caaagcccgt gacaaatctc cctgccgcag ccagggctgc ccacctagaa
     1501 ctcaggataa ggccacccat ccccctccag cgtcccccag ttctctggtg aaggtgccca
     1561 gtagtgccac tggaaagcgg cagacctgtg acatcgaagg cctggtggag ctgctgaacc
     1621 gggtgcagag cagcggggcc cacgaccaga ggggccttct gaggaaagag gacctggtac
     1681 ttccagaatt tctgcagctg cccgcccaag ggcccagctc cgaggagacc ccaccacaga
     1741 ccaaatcagc agcccagccc atcgggggat ccttgaactc caccaccgac tcagccctct
     1801 gacagctacc caacagtcca ggacagctgc atggcacccg gcgggccgag catgccatgg
     1861 gtccgctctg catgccctgt ctgtgccatg agtgtccctg gccccttcct gccatgggca
     1921 ggcccgcagg aagagccggt aggggtggaa aggggactca gatgagacac accccacagc
     1981 tgccaccgcc ttgtccctca acaagctcac ccccaatccc ttgcagccag gccacaatgg
     2041 gggaggtgag tccagcccct tggaacaggc ttgcccaaca tggagggatg gcgttggcag
     2101 tgccagcctc cccagcctgt gccaagcttc aacaggggca agaggagggg ccggcccctc
     2161 ctcaggaagc tggtatgagt aaggccttga gggtgcaggc aggcagccct gtaccccacc
     2221 cacatagact atactgtaca tacagatttt gcagtaggct tggggcagct gggtttgtcc
     2281 ttgatgtatg atactgttat tataataatt attattattc tgc
//
