LOCUS       NM_002927               1554 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens regulator of G protein signaling 13 (RGS13),
            transcript variant 1, mRNA.
ACCESSION   NM_002927
VERSION     NM_002927.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1554)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1554)
  AUTHORS   Sengupta,M., Wang,B.D., Lee,N.H., Marx,A., Kusner,L.L. and
            Kaminski,H.J.
  TITLE     MicroRNA and mRNA expression associated with ectopic germinal
            centers in thymus of myasthenia gravis
  JOURNAL   PLoS One 13 (10), e0205464 (2018)
   PUBMED   30308012
  REMARK    GeneRIF: Study demonstrates for the first time that miR-139 and
            miR-452 negatively regulate RGS13 expression which is known to be
            involved in germinal centers regulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1554)
  AUTHORS   Iwaki,S., Lu,Y., Xie,Z. and Druey,K.M.
  TITLE     p53 negatively regulates RGS13 protein expression in immune cells
  JOURNAL   J Biol Chem 286 (25), 22219-22226 (2011)
   PUBMED   21531726
  REMARK    GeneRIF: p53 may modulate immune responses through suppression of
            RGS13 transcription in mast cells and B cells
REFERENCE   4  (bases 1 to 1554)
  AUTHORS   Xie,Z., Yang,Z. and Druey,K.M.
  TITLE     Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase
            inhibits RGS13 degradation
  JOURNAL   J Mol Cell Biol 2 (6), 357-365 (2010)
   PUBMED   20974683
  REMARK    GeneRIF: RGS13 turnover was significantly reduced in cells
            stimulated with cAMP, which was reversed by expression of the
            PKA-specific inhibitory peptide PKI.
REFERENCE   5  (bases 1 to 1554)
  AUTHORS   Wang,J., Lippman,S.M., Lee,J.J., Yang,H., Khuri,F.R., Kim,E.,
            Lin,J., Chang,D.W., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     Genetic variations in regulator of G-protein signaling genes as
            susceptibility loci for second primary tumor/recurrence in head and
            neck squamous cell carcinoma
  JOURNAL   Carcinogenesis 31 (10), 1755-1761 (2010)
   PUBMED   20627871
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1554)
  AUTHORS   Han,J.I., Huang,N.N., Kim,D.U. and Kehrl,J.H.
  TITLE     RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances
            responsiveness to chemoattractants and impairs desensitization
  JOURNAL   J Leukoc Biol 79 (6), 1357-1368 (2006)
   PUBMED   16565322
  REMARK    GeneRIF: RGS1 and RGS13 act together to regulate chemokine receptor
            signaling in human germinal center B lymphocytes and contribute
            significantly to the rapid desensitization of the signaling
            pathway.
REFERENCE   7  (bases 1 to 1554)
  AUTHORS   Islam,T.C., Asplund,A.C., Lindvall,J.M., Nygren,L., Liden,J.,
            Kimby,E., Christensson,B., Smith,C.I. and Sander,B.
  TITLE     High level of cannabinoid receptor 1, absence of regulator of G
            protein signalling 13 and differential expression of Cyclin D1 in
            mantle cell lymphoma
  JOURNAL   Leukemia 17 (9), 1880-1890 (2003)
   PUBMED   12970790
  REMARK    GeneRIF: Down-Regulation of regulator of G-protein signalling 13 is
            associated with mantle cell lymphoma
REFERENCE   8  (bases 1 to 1554)
  AUTHORS   Johnson,E.N. and Druey,K.M.
  TITLE     Functional characterization of the G protein regulator RGS13
  JOURNAL   J Biol Chem 277 (19), 16768-16774 (2002)
   PUBMED   11875076
  REMARK    GeneRIF: Functional characterization of the G protein regulator
            RGS13
REFERENCE   9  (bases 1 to 1554)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   10 (bases 1 to 1554)
  AUTHORS   Druey,K.M., Blumer,K.J., Kang,V.H. and Kehrl,J.H.
  TITLE     Inhibition of G-protein-mediated MAP kinase activation by a new
            mammalian gene family
  JOURNAL   Nature 379 (6567), 742-746 (1996)
   PUBMED   8602223
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596119.5 and AL136454.6.
            
            On Mar 29, 2019 this sequence version replaced NM_002927.4.
            
            Summary: The protein encoded by this gene is a member of the
            regulator of G protein signaling (RGS) family. RGS family members
            share similarity with S. cerevisiae SST2 and C. elegans egl-10
            proteins, which contain a characteristic conserved RGS domain. RGS
            proteins accelerate GTPase activity of G protein alpha-subunits,
            thereby driving G protein into their inactive GDP-bound form, thus
            negatively regulating G protein signaling. RGS proteins have been
            implicated in the fine tuning of a variety of cellular events in
            response to G protein-coupled receptor activation. The biological
            function of this gene, however, is unknown. Two transcript variants
            encoding the same isoform exist. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030107.2, SRR5189667.188565.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391995.7/ ENSP00000375853.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AL596119.5         30992-31162
            172-242             AL596119.5         32435-32505
            243-282             AL596119.5         33009-33048
            283-351             AL596119.5         39176-39244
            352-413             AL596119.5         42771-42832
            414-580             AL136454.6         4979-5145
            581-1554            AL136454.6         6116-7089
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..1554
                     /gene="RGS13"
                     /note="regulator of G protein signaling 13"
                     /db_xref="GeneID:6003"
                     /db_xref="HGNC:HGNC:9995"
                     /db_xref="MIM:607190"
     exon            1..171
                     /gene="RGS13"
                     /inference="alignment:Splign:2.1.0"
     exon            172..242
                     /gene="RGS13"
                     /inference="alignment:Splign:2.1.0"
     exon            243..282
                     /gene="RGS13"
                     /inference="alignment:Splign:2.1.0"
     exon            283..351
                     /gene="RGS13"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..766
                     /gene="RGS13"
                     /note="regulator of G-protein signalling 13"
                     /codon_start=1
                     /product="regulator of G-protein signaling 13"
                     /protein_id="NP_002918.1"
                     /db_xref="CCDS:CCDS1376.1"
                     /db_xref="GeneID:6003"
                     /db_xref="HGNC:HGNC:9995"
                     /db_xref="MIM:607190"
                     /translation="MSRRNCWICKMCRDESKRPPSNLTLEEVLQWAQSFENLMATKYG
                     PVVYAAYLKMEHSDENIQFWMACETYKKIASRWSRISRAKKLYKIYIQPQSPREINID
                     SSTRETIIRNIQEPTETCFEEAQKIVYMHMERDSYPRFLKSEMYQKLLKTMQSNNSF"
     exon            352..413
                     /gene="RGS13"
                     /inference="alignment:Splign:2.1.0"
     exon            414..580
                     /gene="RGS13"
                     /inference="alignment:Splign:2.1.0"
     exon            581..1554
                     /gene="RGS13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS13"
                     /note="hexamer: AATAAA"
     polyA_site      1503
                     /gene="RGS13"
                     /note="major polyA site"
ORIGIN      
        1 atactgaggc cagagtgcca tcgaaggtaa ttatagagac agtaaaatcc ttttactctg
       61 ggaaaaataa aatgctgggt gtctcacaaa atttcagaac ctgatttcaa acggatcata
      121 acaaagagga gatcaaattt agcatggtgg actgctcgac aggatatatt tgtcaatgga
      181 atgtttccac atattatacc accaacatga gaaaaaaatg atcattgttt atttgaagct
      241 tgatgatatt ctaacgctgc cttttctctt ctcattttag agaaaaatga gcaggcggaa
      301 ttgttggatt tgtaagatgt gcagagatga atctaagagg cccccttcaa accttacttt
      361 ggaggaagta ttacagtggg cccagtcttt tgaaaattta atggctacaa aatatggtcc
      421 agtagtctat gcagcatatt taaaaatgga gcacagtgac gagaatattc aattctggat
      481 ggcatgtgaa acctataaga aaattgcctc acggtggagc agaatttcta gggcaaagaa
      541 gctttataag atttacatcc agccacagtc ccctagagag attaacattg acagttcgac
      601 aagagagact atcatcagga acattcagga acccactgaa acatgttttg aagaagctca
      661 gaaaatagtc tatatgcata tggaaaggga ttcctacccc agatttctaa agtcagaaat
      721 gtaccaaaaa cttttgaaaa ctatgcagtc caacaacagt ttctgactac aactcaaaag
      781 tttaaataga aaacagtata ttgaaagtgg tgggtttgat ctttttattt agaaacccac
      841 aaaatcagaa acacagtaca aataaaacag aaatcaaact ataagttgac ttttagttcc
      901 taaaaagaaa catatttcaa aagcaatgga atctagaatt cttataacat gaataacaaa
      961 atgtacagca agcctatgta gttcaattaa tatataagga aaaggaaggt ctttcttcat
     1021 gatacaagca ttataaagtt tttactgtag tagtcaatta atggatattt ccttgttaat
     1081 aaaattttgt gtcataattt acaaattagt tctttaaaaa ttgttgttat atgaattgtg
     1141 tttctagcat gaatgttcta tagagtactc taaataactt gaatttatag acaaatgcta
     1201 ctcacagtac aatcaattgt attataccat gagaaaatca aaaaggtgtt cttcagagac
     1261 attttatcta taaaattttc ctactattat gttcattaac aaacttcttt atcacatgta
     1321 tcttctacat gtaaaacatt tctgatgatt ttttaacaaa aaatatatga atttcttcat
     1381 ttgctcttgc atctacattg ctataaggat ataaaatgtg gtttctatat tttgagatgt
     1441 tttttcctta caatgtgaac tcatcgtgat cttggaaatc aataaagtca aatatcaact
     1501 aaagacttac attatctttc tcaaagacaa aataaatata ttttccagta caaa
//
