LOCUS       NM_002926               5571 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens regulator of G protein signaling 12 (RGS12),
            transcript variant 2, mRNA.
ACCESSION   NM_002926
VERSION     NM_002926.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5571)
  AUTHORS   Sneddon,W.B., Ramineni,S., Van Doorn,G.E., Hepler,J.R. and
            Friedman,P.A.
  TITLE     Distinct and overlapping RGS14 and RGS12 actions regulate
            NPT2A-mediated phosphate transport
  JOURNAL   Biochem Biophys Res Commun 733, 150700 (2024)
   PUBMED   39293332
  REMARK    GeneRIF: Distinct and overlapping RGS14 and RGS12 actions regulate
            NPT2A-mediated phosphate transport.
REFERENCE   2  (bases 1 to 5571)
  AUTHORS   Yuan,G., Yang,S. and Yang,S.
  TITLE     RGS12 represses oral squamous cell carcinoma by driving M1
            polarization of tumor-associated macrophages via controlling
            ciliary MYCBP2/KIF2A signaling
  JOURNAL   Int J Oral Sci 15 (1), 11 (2023)
   PUBMED   36797232
  REMARK    GeneRIF: RGS12 represses oral squamous cell carcinoma by driving M1
            polarization of tumor-associated macrophages via controlling
            ciliary MYCBP2/KIF2A signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5571)
  AUTHORS   Yuan,G., Fu,C., Yang,S.T., Yuh,D.Y., Hajishengallis,G. and Yang,S.
  TITLE     RGS12 Drives Macrophage Activation and Osteoclastogenesis in
            Periodontitis
  JOURNAL   J Dent Res 101 (4), 448-457 (2022)
   PUBMED   34796776
  REMARK    GeneRIF: RGS12 Drives Macrophage Activation and Osteoclastogenesis
            in Periodontitis.
REFERENCE   4  (bases 1 to 5571)
  AUTHORS   Yuan,G., Huang,Y., Yang,S.T., Ng,A. and Yang,S.
  TITLE     RGS12 inhibits the progression and metastasis of multiple myeloma
            by driving M1 macrophage polarization and activation in the bone
            marrow microenvironment
  JOURNAL   Cancer Commun (Lond) 42 (1), 60-64 (2022)
   PUBMED   34931491
  REMARK    GeneRIF: RGS12 inhibits the progression and metastasis of multiple
            myeloma by driving M1 macrophage polarization and activation in the
            bone marrow microenvironment.
REFERENCE   5  (bases 1 to 5571)
  AUTHORS   Li,Y., Liu,M., Yang,S., Fuller,A.M., Karin Eisinger-Mathason,T.S.
            and Yang,S.
  TITLE     RGS12 is a novel tumor suppressor in osteosarcoma that inhibits
            YAP-TEAD1-Ezrin signaling
  JOURNAL   Oncogene 40 (14), 2553-2566 (2021)
   PUBMED   33686240
  REMARK    GeneRIF: RGS12 is a novel tumor suppressor in osteosarcoma that
            inhibits YAP-TEAD1-Ezrin signaling.
REFERENCE   6  (bases 1 to 5571)
  AUTHORS   Schiff,M.L., Siderovski,D.P., Jordan,J.D., Brothers,G., Snow,B., De
            Vries,L., Ortiz,D.F. and Diverse-Pierluissi,M.
  TITLE     Tyrosine-kinase-dependent recruitment of RGS12 to the N-type
            calcium channel
  JOURNAL   Nature 408 (6813), 723-727 (2000)
   PUBMED   11130074
REFERENCE   7  (bases 1 to 5571)
  AUTHORS   Chatterjee,T.K. and Fisher,R.A.
  TITLE     Novel alternative splicing and nuclear localization of human RGS12
            gene products
  JOURNAL   J Biol Chem 275 (38), 29660-29671 (2000)
   PUBMED   10869340
REFERENCE   8  (bases 1 to 5571)
  AUTHORS   Frohme,M., Scharm,B., Delius,H., Knecht,R. and Hoheisel,J.D.
  TITLE     Use of representational difference analysis and cDNA arrays for
            transcriptional profiling of tumor tissue
  JOURNAL   Ann N Y Acad Sci 910, 85-104 (2000)
   PUBMED   10911908
  REMARK    Review article
REFERENCE   9  (bases 1 to 5571)
  AUTHORS   Snow,B.E., Hall,R.A., Krumins,A.M., Brothers,G.M., Bouchard,D.,
            Brothers,C.A., Chung,S., Mangion,J., Gilman,A.G., Lefkowitz,R.J.
            and Siderovski,D.P.
  TITLE     GTPase activating specificity of RGS12 and binding specificity of
            an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain
  JOURNAL   J Biol Chem 273 (28), 17749-17755 (1998)
   PUBMED   9651375
REFERENCE   10 (bases 1 to 5571)
  AUTHORS   Snow,B.E., Antonio,L., Suggs,S., Gutstein,H.B. and Siderovski,D.P.
  TITLE     Molecular cloning and expression analysis of rat Rgs12 and Rgs14
  JOURNAL   Biochem Biophys Res Commun 233 (3), 770-777 (1997)
   PUBMED   9168931
  REMARK    GeneRIF: shows chromosomal mapping information for human locus.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645949.16 and AL590235.23.
            
            On Apr 5, 2021 this sequence version replaced NM_002926.4.
            
            Summary: This gene encodes a member of the 'regulator of G protein
            signaling' (RGS) gene family. The encoded protein may function as a
            guanosine triphosphatase (GTPase)-activating protein as well as a
            transcriptional repressor. This protein may play a role in
            tumorigenesis. Multiple transcript variants encoding distinct
            isoforms have been identified for this gene. Other alternative
            splice variants have been described but their biological nature has
            not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF035152.1, SRR14038196.798418.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2142363 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AL645949.16        99824-99962         c
            140-2121            AL645949.16        96722-98703         c
            2122-2238           AL645949.16        71720-71836         c
            2239-2260           AL645949.16        28336-28357         c
            2261-2430           AL645949.16        532-701             c
            2431-2451           AL645949.16        1-21                c
            2452-2523           AL590235.23        157175-157246       c
            2524-2667           AL590235.23        155898-156041       c
            2668-2847           AL590235.23        154927-155106       c
            2848-3001           AL590235.23        154478-154631       c
            3002-3078           AL590235.23        151301-151377       c
            3079-3273           AL590235.23        149449-149643       c
            3274-3347           AL590235.23        149041-149114       c
            3348-3474           AL590235.23        148378-148504       c
            3475-3571           AL590235.23        146459-146555       c
            3572-3651           AL590235.23        143850-143929       c
            3652-3805           AL590235.23        143308-143461       c
            3806-5571           AL590235.23        139847-141612       c
FEATURES             Location/Qualifiers
     source          1..5571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..5571
                     /gene="RGS12"
                     /note="regulator of G protein signaling 12"
                     /db_xref="GeneID:6002"
                     /db_xref="HGNC:HGNC:9994"
                     /db_xref="MIM:602512"
     exon            1..139
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            140..2121
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..4371
                     /gene="RGS12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     regulator of G-protein signalling 12"
                     /codon_start=1
                     /product="regulator of G-protein signaling 12 isoform 2"
                     /protein_id="NP_002917.1"
                     /db_xref="CCDS:CCDS3367.1"
                     /db_xref="GeneID:6002"
                     /db_xref="HGNC:HGNC:9994"
                     /db_xref="MIM:602512"
                     /translation="MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVL
                     SCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRF
                     ESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASN
                     SEPLKLKQRSLSESAATRFDVGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDD
                     FALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKI
                     MHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALR
                     TSCHVFMVDPDLFNHKIHQGIARRFGFECTADPDTNGCLEFPASSLPVLQFISVLYRD
                     MGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRH
                     GPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPV
                     EVPPASLRSSVPPSKRGTVGAGCGFNQRWLPVHVLREWQCGHTSDQDSYTDSTDGWSS
                     INCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKE
                     DKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGELTGADLKD
                     CVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEE
                     NILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLRAP
                     HPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS
                     LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKRE
                     HGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKATKHCCIHLPDGT
                     SCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLE
                     KRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLG
                     APISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATGEERTLGKS
                     NSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADD
                     QRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQWE
                     PVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWKRQ
                     SQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGTSRF"
     exon            2122..2238
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2260
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2430
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2523
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2667
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2847
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3001
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3078
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3273
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3347
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3474
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3571
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3651
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3805
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..5571
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5551..5556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS12"
                     /note="hexamer: AATAAA"
     polyA_site      5571
                     /gene="RGS12"
                     /note="major polyA site"
ORIGIN      
        1 agaagagact acacagcagg cccgagacca tcctgagagg cctgtgtgca aggctggccc
       61 cccgctggtg tcaggacggt gcccaccacc ctcaatgaag aggggctccc tgtgcttagc
      121 tgcttgtgtg gggaacaagg gcactgtttg aagaagcaaa catggtagca tcaagcattc
      181 cttgaaatat ggctccaagg gaacaatgag acgtgctctt ggtcttggaa gctcatcaga
      241 atgtttagag ctggggaggc ctccaaacgc ccattgcctg ggccgtcgcc cccaagggtg
      301 cggagtgtgg aggttgcccg ggggagggcc ggctacggat tcacgctttc gggacaggca
      361 ccctgtgtgc tcagctgcgt catgagaggg agccctgcgg atttcgtggg cctccgagct
      421 ggagaccaga tacttgctgt caatgaaatc aacgtgaaaa aagcatctca tgaagatgta
      481 gtgaaattaa ttgggaagtg ctctggtgtc cttcacatgg tgattgctga aggcgtcggc
      541 cgcttcgaat cctgttccag tgatgaagaa gggggactct atgaaggaaa aggctggctg
      601 aagcccaagc tggattctaa agcactaggt ataaacagag cagagcgagt cgtggaggaa
      661 atgcagtctg gtggaatttt caatatgatt tttgaaaacc cgagcctttg tgcgagcaat
      721 tcagagccct tgaaattgaa acaaagatcc ctttcagagt cggccgcaac tcgatttgat
      781 gttggacatg aaagtataaa taatccaaat cccaacatgc tttctaagga ggaaatatca
      841 aaagttattc atgatgattc ggttttcagc attggactag aaagtcatga cgattttgca
      901 ttggatgcaa gtattttaaa cgtggcgatg atcgtgggct acttaggctc cattgagctt
      961 ccttccacga gctccaacct ggagtccgac agcttgcaag ccatccgcgg ctgcatgcgg
     1021 cgcctgcggg cagagcagaa aatccactcg ctggtgacca tgaagatcat gcacgactgt
     1081 gtgcagctga gcactgacaa ggctggagtc gtggccgagt acccggccga gaagctggcc
     1141 ttcagcgccg tgtgcccgga cgaccggcga tttttcgggt tggttaccat gcagacgaat
     1201 gacgacggga gcctggccca ggaggaggag ggcgccctgc ggacttcctg ccacgtgttc
     1261 atggtggacc cagacttgtt taatcacaag atccaccaag gcattgctcg gcggtttggg
     1321 tttgagtgca cggccgaccc agacaccaat ggctgtctgg aattcccggc gtcctccctc
     1381 cccgtcctgc agttcatctc tgtcctgtac cgagacatgg gtgagctgat tgagggcatg
     1441 cgggcccgcg cctttctgga cggggacgcc gatgcccacc agaacaacag caccagcagc
     1501 aacagtgaca gcggcattgg gaacttccac caggaggaga agagcaaccg ggtccttgtg
     1561 gtggacctgg gtgggagctc gagcagacac ggccccggag gcagcgcgtg ggacggtgtg
     1621 ggtgggaggg gtgcccagcc ctggggtgct ccctggactg ggcccttctg tccggacccc
     1681 gaagggagcc ccccatttga ggccgctcat cagactgaca ggttctggga cctaaacaag
     1741 cacctagggc cagcctctcc tgtggaggtg cccccagctt ccttgaggag ctcagtcccc
     1801 ccttccaaga ggggcaccgt gggtgctggc tgtggtttca accagcgctg gctcccggtc
     1861 cacgtgctcc gggagtggca gtgcggacac accagcgacc aggactctta cacagattcc
     1921 accgatggct ggtccagcat caactgcggc acactgcccc ctcctatgag caagatcccc
     1981 gcagaccgct acagggtgga gggcagcttc gcgcagcccc cgctgaatgc cccgaagagg
     2041 gagtggtcca ggaaggcctt tggaatgcaa agcatttttg gtccccatcg aaatgttcga
     2101 aagactaagg aagataaaaa gggctcaaaa tttgggcggg gaactggact cactcagcct
     2161 tctcaacgca cgtctgctcg gagatcattt gggagatcca agagattcag tatcactcgc
     2221 tcccttgatg atcttgagtc tgcaactgtg tctgatggcg agttgacggg cgccgacctg
     2281 aaggactgcg tcagcaacaa cagcctgagc agcaatgcca gcctccccag cgtgcagagc
     2341 tgccggcgcc tgcgtgagag gagggtcgcc agctgggccg tgtcctttga gcgcctgctg
     2401 caggaccccg tcggtgtccg ctacttctct gattttctaa ggaaagaatt cagtgaagaa
     2461 aacattttat tctggcaggc ctgtgaatat tttaatcatg ttcctgcaca tgacaaaaag
     2521 gagctttcct acagggcccg ggagattttc agtaagtttc tctgcagcaa agccaccacc
     2581 ccggtcaaca tcgacagcca ggcccagcta gcagacgacg tcctccgcgc acctcaccca
     2641 gacatgttca aggagcagca gctgcagatc ttcaatctca tgaagtttga tagctacact
     2701 cgctttctga agtccccgct gtaccaggaa tgcatcctgg cggaagtgga gggccgtgca
     2761 ctcccggact cgcagcaggt ccccagcagc ccggcttcca agcacagcct cggttcagac
     2821 cactccagtg tgtccacgcc aaaaaagtta agtggaaaat caaaatccgg ccgatccctg
     2881 aatgaagagc tgggggatga ggacagcgag aagaagcgga aaggcgcgtt tttctcgtgg
     2941 tcgcggacca ggagcaccgg gaggtcccag aaaaagaggg agcacgggga ccacgcagac
     3001 gacgccctgc atgccaatgg aggcctgtgt cgccgagagt cgcagggctc tgtgtcctct
     3061 gcggggagcc tggacctgtc ggaggcctgc aggactttgg cacccgagaa ggacaaggcc
     3121 accaagcact gctgcattca tctcccggat gggacatcct gcgtggtggc tgtcaaggcg
     3181 ggcttctcca tcaaagacat cctgtccgga ctctgtgagc ggcatggcat caacggggcg
     3241 gccgcggacc tcttcctggt gggcggggac aagcctctgg tgctgcacca agacagtagc
     3301 atcttggagt caagggacct gcgcctagaa aagcgcacct tgtttcggct ggatcttgtt
     3361 ccgattaacc ggtcagtggg actcaaggcc aagcccacca agcccgtcac ggaggtgctg
     3421 cggcccgtgg tggccagata cggcctggac ctcagtggcc tgctggtgag gctgagtgga
     3481 gagaaggagc ccctggacct tggcgcccct atatcgagtc tggacggaca gcgggttgtc
     3541 ttggaggaga aggatccttc cagaggaaag gcatccgcag ataaacagaa aggtgtgcca
     3601 gtgaaacaga acacagctgt aaattccagc tccagaaacc actcggctac gggagaggaa
     3661 agaacactag gcaagtctaa ttctattaaa ataaaaggag aaaatggaaa aaatgctagg
     3721 gatccccggc tttcaaagag agaagaatct attgcaaaga ttgggaaaaa aaaatatcag
     3781 aaaattaatt tggacgaagc agaggagttt tttgagctta tttccaaagc tcagagcaac
     3841 agagcagatg accaacgtgg gctgctaagg aaggaagacc tggtgttgcc agagttcctc
     3901 cgtttacctc ctggttccac agaactcacc ctccccactc cagctgctgt ggccaagggc
     3961 tttagcaaga gaagcgccac aggcaacggc cgggagagcg cctcccagcc tggcgagcag
     4021 tgggagccag tccaggagag cagcgacagc ccgtccacca gcccgggctc agcctccagc
     4081 ccccctggac ctcctgggac gacccccccc gggcagaagt ctcccagcgg gcccttctgc
     4141 actccccagt cccccgtctc cctcgcgcag gagggcaccg cccagatctg gaagaggcag
     4201 tctcaggaag tggaggccgg gggcatccag acggtggagg atgagcacgt ggccgagctg
     4261 accctgatgg gggaggggga catcagcagc cccaacagca ccttgctgcc gccgccctcc
     4321 accccccagg aagtgccagg accttccaga ccaggtacct ccaggttctg atccctccac
     4381 cttggccccg taagcgtggt ctgctcagct tccagtcaga aaggacagtg ggcccccggc
     4441 tgccactgtt tgctggtggt ctccgtgacc ccctcctcac ctgctggttg ggggcttcct
     4501 tggccctctt ggaaaggagg ggctcgtgtg gccccaggcc agtgtctgtc aggatggtcc
     4561 ccccgaggcg ctctgggcag gcatcctggt gtcctgagag gctcttgcag gaatgatacg
     4621 tggcagtgcc tgcagcgagg tctgggaaca ccctgggtga ggcctggggg tttccgaaaa
     4681 tggaggcatt cctttccaaa tctggacagc gatcgttttt agtgtttctg tctcaagact
     4741 ggaaaacaat agcatttgtc ttgagtgagg aagtgaagcc cgctgtgttc atagcaggag
     4801 agggctccca gacacaggcc cgtcctcgga agagccttga gagtgcagct cggacccacc
     4861 ggcggccccc gtagcaggtg gtgtgggtgc tcgggagtgg aggtgacgtc agcagcgctc
     4921 tctgaccgcg ggtgtcacgg gcatttctca aaggaagcag gggattcagt gagtgtgaag
     4981 gtgaacagga tggcctggca gcagggatgt ttccgtgagc cacaaatacc agaaactgag
     5041 gcgaggctcc cagcagccgg tagggaaagg tgtttccagg ggtccgaggg ccgtggcctg
     5101 cgtggccatc ccctggagag aggagccgct cagggtgcgc gtcatggagt gtgctcaggg
     5161 gtgcgtggac acctctgctg tggtttgctg ctgggggcga tgggagcgcc tctccgtcct
     5221 gtgccctggt ccaggatgct gacagcagtg agaggcctgc cgtgaggttt ggtcttgtca
     5281 gacctgtagc ctggacctcg ccgggggacc agggagtgca cgtctgtaga tctgtacata
     5341 tctgggcctt tggaggccac gtgtggcatg ggaggggcta cctggtccct ttcacagcca
     5401 ggacacgcct ggatgagaaa gcctgaggtg cctggcatgc ccaccggtgc cactctgcag
     5461 cctccacccc tggcctgagt ccccctccat ccgtcttggt ggacacctgt gtggctctca
     5521 cctgcgtttt gagtctgttc ttccaggagt aataaattct ggacatcatc a
//
