LOCUS       NM_001394154            4753 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens regulator of G protein signaling 12 (RGS12),
            transcript variant 4, mRNA.
ACCESSION   NM_001394154 XM_006713905
VERSION     NM_001394154.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4753)
  AUTHORS   Sneddon,W.B., Ramineni,S., Van Doorn,G.E., Hepler,J.R. and
            Friedman,P.A.
  TITLE     Distinct and overlapping RGS14 and RGS12 actions regulate
            NPT2A-mediated phosphate transport
  JOURNAL   Biochem Biophys Res Commun 733, 150700 (2024)
   PUBMED   39293332
  REMARK    GeneRIF: Distinct and overlapping RGS14 and RGS12 actions regulate
            NPT2A-mediated phosphate transport.
REFERENCE   2  (bases 1 to 4753)
  AUTHORS   Yuan,G., Yang,S. and Yang,S.
  TITLE     RGS12 represses oral squamous cell carcinoma by driving M1
            polarization of tumor-associated macrophages via controlling
            ciliary MYCBP2/KIF2A signaling
  JOURNAL   Int J Oral Sci 15 (1), 11 (2023)
   PUBMED   36797232
  REMARK    GeneRIF: RGS12 represses oral squamous cell carcinoma by driving M1
            polarization of tumor-associated macrophages via controlling
            ciliary MYCBP2/KIF2A signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4753)
  AUTHORS   Yuan,G., Fu,C., Yang,S.T., Yuh,D.Y., Hajishengallis,G. and Yang,S.
  TITLE     RGS12 Drives Macrophage Activation and Osteoclastogenesis in
            Periodontitis
  JOURNAL   J Dent Res 101 (4), 448-457 (2022)
   PUBMED   34796776
  REMARK    GeneRIF: RGS12 Drives Macrophage Activation and Osteoclastogenesis
            in Periodontitis.
REFERENCE   4  (bases 1 to 4753)
  AUTHORS   Yuan,G., Huang,Y., Yang,S.T., Ng,A. and Yang,S.
  TITLE     RGS12 inhibits the progression and metastasis of multiple myeloma
            by driving M1 macrophage polarization and activation in the bone
            marrow microenvironment
  JOURNAL   Cancer Commun (Lond) 42 (1), 60-64 (2022)
   PUBMED   34931491
  REMARK    GeneRIF: RGS12 inhibits the progression and metastasis of multiple
            myeloma by driving M1 macrophage polarization and activation in the
            bone marrow microenvironment.
REFERENCE   5  (bases 1 to 4753)
  AUTHORS   Li,Y., Liu,M., Yang,S., Fuller,A.M., Karin Eisinger-Mathason,T.S.
            and Yang,S.
  TITLE     RGS12 is a novel tumor suppressor in osteosarcoma that inhibits
            YAP-TEAD1-Ezrin signaling
  JOURNAL   Oncogene 40 (14), 2553-2566 (2021)
   PUBMED   33686240
  REMARK    GeneRIF: RGS12 is a novel tumor suppressor in osteosarcoma that
            inhibits YAP-TEAD1-Ezrin signaling.
REFERENCE   6  (bases 1 to 4753)
  AUTHORS   Schiff,M.L., Siderovski,D.P., Jordan,J.D., Brothers,G., Snow,B., De
            Vries,L., Ortiz,D.F. and Diverse-Pierluissi,M.
  TITLE     Tyrosine-kinase-dependent recruitment of RGS12 to the N-type
            calcium channel
  JOURNAL   Nature 408 (6813), 723-727 (2000)
   PUBMED   11130074
REFERENCE   7  (bases 1 to 4753)
  AUTHORS   Chatterjee,T.K. and Fisher,R.A.
  TITLE     Novel alternative splicing and nuclear localization of human RGS12
            gene products
  JOURNAL   J Biol Chem 275 (38), 29660-29671 (2000)
   PUBMED   10869340
REFERENCE   8  (bases 1 to 4753)
  AUTHORS   Frohme,M., Scharm,B., Delius,H., Knecht,R. and Hoheisel,J.D.
  TITLE     Use of representational difference analysis and cDNA arrays for
            transcriptional profiling of tumor tissue
  JOURNAL   Ann N Y Acad Sci 910, 85-104 (2000)
   PUBMED   10911908
  REMARK    Review article
REFERENCE   9  (bases 1 to 4753)
  AUTHORS   Snow,B.E., Hall,R.A., Krumins,A.M., Brothers,G.M., Bouchard,D.,
            Brothers,C.A., Chung,S., Mangion,J., Gilman,A.G., Lefkowitz,R.J.
            and Siderovski,D.P.
  TITLE     GTPase activating specificity of RGS12 and binding specificity of
            an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain
  JOURNAL   J Biol Chem 273 (28), 17749-17755 (1998)
   PUBMED   9651375
REFERENCE   10 (bases 1 to 4753)
  AUTHORS   Snow,B.E., Antonio,L., Suggs,S., Gutstein,H.B. and Siderovski,D.P.
  TITLE     Molecular cloning and expression analysis of rat Rgs12 and Rgs14
  JOURNAL   Biochem Biophys Res Commun 233 (3), 770-777 (1997)
   PUBMED   9168931
  REMARK    GeneRIF: shows chromosomal mapping information for human locus.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645949.16 and AL590235.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 5, 2021 this sequence version replaced XM_006713905.1.
            
            Summary: This gene encodes a member of the 'regulator of G protein
            signaling' (RGS) gene family. The encoded protein may function as a
            guanosine triphosphatase (GTPase)-activating protein as well as a
            transcriptional repressor. This protein may play a role in
            tumorigenesis. Multiple transcript variants encoding distinct
            isoforms have been identified for this gene. Other alternative
            splice variants have been described but their biological nature has
            not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.1593993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336727.8/ ENSP00000338509.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AL645949.16        121674-121752       c
            80-2061             AL645949.16        96722-98703         c
            2062-2178           AL645949.16        71720-71836         c
            2179-2200           AL645949.16        28336-28357         c
            2201-2370           AL645949.16        532-701             c
            2371-2391           AL645949.16        1-21                c
            2392-2463           AL590235.23        157175-157246       c
            2464-2607           AL590235.23        155898-156041       c
            2608-2787           AL590235.23        154927-155106       c
            2788-2941           AL590235.23        154478-154631       c
            2942-3018           AL590235.23        151301-151377       c
            3019-3213           AL590235.23        149449-149643       c
            3214-3287           AL590235.23        149041-149114       c
            3288-3414           AL590235.23        148378-148504       c
            3415-3511           AL590235.23        146459-146555       c
            3512-3591           AL590235.23        143850-143929       c
            3592-3745           AL590235.23        143308-143461       c
            3746-4294           AL590235.23        141064-141612       c
            4295-4753           AL590235.23        132106-132564       c
FEATURES             Location/Qualifiers
     source          1..4753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..4753
                     /gene="RGS12"
                     /note="regulator of G protein signaling 12"
                     /db_xref="GeneID:6002"
                     /db_xref="HGNC:HGNC:9994"
                     /db_xref="MIM:602512"
     exon            1..79
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            80..2061
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..4524
                     /gene="RGS12"
                     /note="isoform 1 is encoded by transcript variant 4;
                     regulator of G-protein signalling 12"
                     /codon_start=1
                     /product="regulator of G-protein signaling 12 isoform 1"
                     /protein_id="NP_001381083.1"
                     /db_xref="CCDS:CCDS3366.1"
                     /db_xref="GeneID:6002"
                     /db_xref="HGNC:HGNC:9994"
                     /db_xref="MIM:602512"
                     /translation="MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVL
                     SCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRF
                     ESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASN
                     SEPLKLKQRSLSESAATRFDVGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDD
                     FALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKI
                     MHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALR
                     TSCHVFMVDPDLFNHKIHQGIARRFGFECTADPDTNGCLEFPASSLPVLQFISVLYRD
                     MGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRH
                     GPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPV
                     EVPPASLRSSVPPSKRGTVGAGCGFNQRWLPVHVLREWQCGHTSDQDSYTDSTDGWSS
                     INCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKE
                     DKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGELTGADLKD
                     CVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEE
                     NILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLRAP
                     HPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS
                     LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKRE
                     HGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKATKHCCIHLPDGT
                     SCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLE
                     KRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLG
                     APISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATGEERTLGKS
                     NSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADD
                     QRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQWE
                     PVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWKRQ
                     SQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGSGTHGS
                     RDLPVNRIIDVDLVTGSAPGRDGGIAGAQAGPGRSQASGGPPTSDLPGLGPVPGEPAK
                     PKTSAHHATFV"
     exon            2062..2178
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2200
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2370
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2463
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2607
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2787
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2941
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3018
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3213
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3287
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3414
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3511
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3591
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3745
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..4294
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     exon            4295..4753
                     /gene="RGS12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4730..4735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS12"
                     /note="hexamer: AATAAA"
     polyA_site      4753
                     /gene="RGS12"
                     /note="major polyA site"
ORIGIN      
        1 ggctgccgag gcgaccgttg cgcgcgcggg cggtggcgcg ggccgaagcg cccggagcgg
       61 gagcgagcgg cgcggcccgg gcactgtttg aagaagcaaa catggtagca tcaagcattc
      121 cttgaaatat ggctccaagg gaacaatgag acgtgctctt ggtcttggaa gctcatcaga
      181 atgtttagag ctggggaggc ctccaaacgc ccattgcctg ggccgtcgcc cccaagggtg
      241 cggagtgtgg aggttgcccg ggggagggcc ggctacggat tcacgctttc gggacaggca
      301 ccctgtgtgc tcagctgcgt catgagaggg agccctgcgg atttcgtggg cctccgagct
      361 ggagaccaga tacttgctgt caatgaaatc aacgtgaaaa aagcatctca tgaagatgta
      421 gtgaaattaa ttgggaagtg ctctggtgtc cttcacatgg tgattgctga aggcgtcggc
      481 cgcttcgaat cctgttccag tgatgaagaa gggggactct atgaaggaaa aggctggctg
      541 aagcccaagc tggattctaa agcactaggt ataaacagag cagagcgagt cgtggaggaa
      601 atgcagtctg gtggaatttt caatatgatt tttgaaaacc cgagcctttg tgcgagcaat
      661 tcagagccct tgaaattgaa acaaagatcc ctttcagagt cggccgcaac tcgatttgat
      721 gttggacatg aaagtataaa taatccaaat cccaacatgc tttctaagga ggaaatatca
      781 aaagttattc atgatgattc ggttttcagc attggactag aaagtcatga cgattttgca
      841 ttggatgcaa gtattttaaa cgtggcgatg atcgtgggct acttaggctc cattgagctt
      901 ccttccacga gctccaacct ggagtccgac agcttgcaag ccatccgcgg ctgcatgcgg
      961 cgcctgcggg cagagcagaa aatccactcg ctggtgacca tgaagatcat gcacgactgt
     1021 gtgcagctga gcactgacaa ggctggagtc gtggccgagt acccggccga gaagctggcc
     1081 ttcagcgccg tgtgcccgga cgaccggcga tttttcgggt tggttaccat gcagacgaat
     1141 gacgacggga gcctggccca ggaggaggag ggcgccctgc ggacttcctg ccacgtgttc
     1201 atggtggacc cagacttgtt taatcacaag atccaccaag gcattgctcg gcggtttggg
     1261 tttgagtgca cggccgaccc agacaccaat ggctgtctgg aattcccggc gtcctccctc
     1321 cccgtcctgc agttcatctc tgtcctgtac cgagacatgg gtgagctgat tgagggcatg
     1381 cgggcccgcg cctttctgga cggggacgcc gatgcccacc agaacaacag caccagcagc
     1441 aacagtgaca gcggcattgg gaacttccac caggaggaga agagcaaccg ggtccttgtg
     1501 gtggacctgg gtgggagctc gagcagacac ggccccggag gcagcgcgtg ggacggtgtg
     1561 ggtgggaggg gtgcccagcc ctggggtgct ccctggactg ggcccttctg tccggacccc
     1621 gaagggagcc ccccatttga ggccgctcat cagactgaca ggttctggga cctaaacaag
     1681 cacctagggc cagcctctcc tgtggaggtg cccccagctt ccttgaggag ctcagtcccc
     1741 ccttccaaga ggggcaccgt gggtgctggc tgtggtttca accagcgctg gctcccggtc
     1801 cacgtgctcc gggagtggca gtgcggacac accagcgacc aggactctta cacagattcc
     1861 accgatggct ggtccagcat caactgcggc acactgcccc ctcctatgag caagatcccc
     1921 gcagaccgct acagggtgga gggcagcttc gcgcagcccc cgctgaatgc cccgaagagg
     1981 gagtggtcca ggaaggcctt tggaatgcaa agcatttttg gtccccatcg aaatgttcga
     2041 aagactaagg aagataaaaa gggctcaaaa tttgggcggg gaactggact cactcagcct
     2101 tctcaacgca cgtctgctcg gagatcattt gggagatcca agagattcag tatcactcgc
     2161 tcccttgatg atcttgagtc tgcaactgtg tctgatggcg agttgacggg cgccgacctg
     2221 aaggactgcg tcagcaacaa cagcctgagc agcaatgcca gcctccccag cgtgcagagc
     2281 tgccggcgcc tgcgtgagag gagggtcgcc agctgggccg tgtcctttga gcgcctgctg
     2341 caggaccccg tcggtgtccg ctacttctct gattttctaa ggaaagaatt cagtgaagaa
     2401 aacattttat tctggcaggc ctgtgaatat tttaatcatg ttcctgcaca tgacaaaaag
     2461 gagctttcct acagggcccg ggagattttc agtaagtttc tctgcagcaa agccaccacc
     2521 ccggtcaaca tcgacagcca ggcccagcta gcagacgacg tcctccgcgc acctcaccca
     2581 gacatgttca aggagcagca gctgcagatc ttcaatctca tgaagtttga tagctacact
     2641 cgctttctga agtccccgct gtaccaggaa tgcatcctgg cggaagtgga gggccgtgca
     2701 ctcccggact cgcagcaggt ccccagcagc ccggcttcca agcacagcct cggttcagac
     2761 cactccagtg tgtccacgcc aaaaaagtta agtggaaaat caaaatccgg ccgatccctg
     2821 aatgaagagc tgggggatga ggacagcgag aagaagcgga aaggcgcgtt tttctcgtgg
     2881 tcgcggacca ggagcaccgg gaggtcccag aaaaagaggg agcacgggga ccacgcagac
     2941 gacgccctgc atgccaatgg aggcctgtgt cgccgagagt cgcagggctc tgtgtcctct
     3001 gcggggagcc tggacctgtc ggaggcctgc aggactttgg cacccgagaa ggacaaggcc
     3061 accaagcact gctgcattca tctcccggat gggacatcct gcgtggtggc tgtcaaggcg
     3121 ggcttctcca tcaaagacat cctgtccgga ctctgtgagc ggcatggcat caacggggcg
     3181 gccgcggacc tcttcctggt gggcggggac aagcctctgg tgctgcacca agacagtagc
     3241 atcttggagt caagggacct gcgcctagaa aagcgcacct tgtttcggct ggatcttgtt
     3301 ccgattaacc ggtcagtggg actcaaggcc aagcccacca agcccgtcac ggaggtgctg
     3361 cggcccgtgg tggccagata cggcctggac ctcagtggcc tgctggtgag gctgagtgga
     3421 gagaaggagc ccctggacct tggcgcccct atatcgagtc tggacggaca gcgggttgtc
     3481 ttggaggaga aggatccttc cagaggaaag gcatccgcag ataaacagaa aggtgtgcca
     3541 gtgaaacaga acacagctgt aaattccagc tccagaaacc actcggctac gggagaggaa
     3601 agaacactag gcaagtctaa ttctattaaa ataaaaggag aaaatggaaa aaatgctagg
     3661 gatccccggc tttcaaagag agaagaatct attgcaaaga ttgggaaaaa aaaatatcag
     3721 aaaattaatt tggacgaagc agaggagttt tttgagctta tttccaaagc tcagagcaac
     3781 agagcagatg accaacgtgg gctgctaagg aaggaagacc tggtgttgcc agagttcctc
     3841 cgtttacctc ctggttccac agaactcacc ctccccactc cagctgctgt ggccaagggc
     3901 tttagcaaga gaagcgccac aggcaacggc cgggagagcg cctcccagcc tggcgagcag
     3961 tgggagccag tccaggagag cagcgacagc ccgtccacca gcccgggctc agcctccagc
     4021 ccccctggac ctcctgggac gacccccccc gggcagaagt ctcccagcgg gcccttctgc
     4081 actccccagt cccccgtctc cctcgcgcag gagggcaccg cccagatctg gaagaggcag
     4141 tctcaggaag tggaggccgg gggcatccag acggtggagg atgagcacgt ggccgagctg
     4201 accctgatgg gggaggggga catcagcagc cccaacagca ccttgctgcc gccgccctcc
     4261 accccccagg aagtgccagg accttccaga ccaggaagtg ggacccatgg cagccgagac
     4321 ctcccagtca acagaatcat cgatgtggat cttgtaactg gctcggcgcc cgggcgggat
     4381 ggtggcatag cgggggcaca ggctggccct gggaggtcgc aggccagtgg tgggcctcct
     4441 acatcagacc tccctggctt gggccccgtc ccgggtgagc ctgctaagcc caagaccagc
     4501 gctcaccacg ccaccttcgt ctgagctgcc ctggcctggc caactctcct gtggacatgt
     4561 cggggtgggg cagcccaggt ggattctgtg ggcctcaggg gggccaccct ggccaccaca
     4621 ccctcaggag cccagccagg agggcagggg gtgacctcgc tggaggcact ggccccggac
     4681 attcgccatg ctggccatgg ggctccctgg ccctggcctc ctgctgccca ataaagcatt
     4741 tctgaggacc caa
//
