LOCUS       NM_183337               2399 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens regulator of G protein signaling 11 (RGS11),
            transcript variant 1, mRNA.
ACCESSION   NM_183337
VERSION     NM_183337.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Yang,S.H., Li,C.F., Chu,P.Y., Ko,H.H., Chen,L.T., Chen,W.W.,
            Han,C.H., Lung,J.H. and Shih,N.Y.
  TITLE     Overexpression of regulator of G protein signaling 11 promotes cell
            migration and associates with advanced stages and aggressiveness of
            lung adenocarcinoma
  JOURNAL   Oncotarget 7 (21), 31122-31136 (2016)
   PUBMED   27105500
  REMARK    GeneRIF: Overexpression of RGS11 promotes cell migration,
            participates in tumor metastasis, and correlates the
            clinicopathological conditions of patients with lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Barzilay,E., Yung,Y., Shapira,L., Haas,J., Ophir,L.,
            Yerushalmi,G.M., Maman,E. and Hourvitz,A.
  TITLE     Differential expression of poliovirus receptor, regulator of
            G-protein signaling 11 and erythrocyte protein band 4.1-like 3 in
            human granulosa cells during follicular growth and maturation
  JOURNAL   Gynecol Endocrinol 30 (9), 660-663 (2014)
   PUBMED   24828608
  REMARK    GeneRIF: In granulosa cells, there are significant changes in
            expression during follicular maturation.
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Wang,J., Lippman,S.M., Lee,J.J., Yang,H., Khuri,F.R., Kim,E.,
            Lin,J., Chang,D.W., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     Genetic variations in regulator of G-protein signaling genes as
            susceptibility loci for second primary tumor/recurrence in head and
            neck squamous cell carcinoma
  JOURNAL   Carcinogenesis 31 (10), 1755-1761 (2010)
   PUBMED   20627871
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Liu,C.Y., Wu,M.C., Chen,F., Ter-Minassian,M., Asomaning,K.,
            Zhai,R., Wang,Z., Su,L., Heist,R.S., Kulke,M.H., Lin,X., Liu,G. and
            Christiani,D.C.
  TITLE     A Large-scale genetic association study of esophageal
            adenocarcinoma risk
  JOURNAL   Carcinogenesis 31 (7), 1259-1263 (2010)
   PUBMED   20453000
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   7  (bases 1 to 2399)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   8  (bases 1 to 2399)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 2399)
  AUTHORS   Snow,B.E., Krumins,A.M., Brothers,G.M., Lee,S.F., Wall,M.A.,
            Chung,S., Mangion,J., Arya,S., Gilman,A.G. and Siderovski,D.P.
  TITLE     A G protein gamma subunit-like domain shared between RGS11 and
            other RGS proteins specifies binding to Gbeta5 subunits
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13307-13312 (1998)
   PUBMED   9789084
REFERENCE   10 (bases 1 to 2399)
  AUTHORS   Gold,S.J., Ni,Y.G., Dohlman,H.G. and Nestler,E.J.
  TITLE     Regulators of G-protein signaling (RGS) proteins: region-specific
            expression of nine subtypes in rat brain
  JOURNAL   J Neurosci 17 (20), 8024-8037 (1997)
   PUBMED   9315921
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z69667.1, DC423811.1,
            AF035153.1 and CK299324.1.
            
            On Nov 22, 2018 this sequence version replaced NM_183337.2.
            
            Summary: The protein encoded by this gene belongs to the RGS
            (regulator of G protein signaling) family. Members of the RGS
            family act as GTPase-activating proteins on the alpha subunits of
            heterotrimeric, signal-transducing G proteins. This protein
            inhibits signal transduction by increasing the GTPase activity of G
            protein alpha subunits, thereby driving them into their inactive
            GDP-bound form. Alternative splicing occurs at this locus and four
            transcript variants encoding distinct isoforms have been
            identified. [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.24987.1, AF035153.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397770.8/ ENSP00000380876.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 Z69667.1           13544-13544         c
            2-30                DC423811.1         3-31
            31-2395             AF035153.1         1-2365
            2396-2399           CK299324.1         25-28               c
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2399
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /note="regulator of G protein signaling 11"
                     /db_xref="GeneID:8786"
                     /db_xref="HGNC:HGNC:9993"
                     /db_xref="MIM:603895"
     exon            1..96
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1437
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulator of G-protein signalling 11"
                     /codon_start=1
                     /product="regulator of G-protein signaling 11 isoform 1"
                     /protein_id="NP_899180.1"
                     /db_xref="CCDS:CCDS42088.1"
                     /db_xref="GeneID:8786"
                     /db_xref="HGNC:HGNC:9993"
                     /db_xref="MIM:603895"
                     /translation="MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLL
                     VTVIPHAVTGSDVVQWLAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETP
                     YRFQTPYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLV
                     LMQAREQLRAAKQRSKGDRLVIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVL
                     MTKSADFHKREIEYFRKALGRTRVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWIS
                     DNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWE
                     ACEELRYGAQAQVPTLVDAVYEQFLAPGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDA
                     QLHIYMLMKKDSYPRFLKSDMYKALLAEAGIPLEMKRRVFPFTWRPRHSSPSPALLPT
                     PVEPTAACGPGGGDGVA"
     exon            97..193
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            194..244
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            245..351
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            352..403
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            404..462
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            463..539
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            540..621
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            622..690
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            691..720
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            721..782
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            783..896
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1012
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1100
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1239
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1322
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..2399
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2366..2371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /note="hexamer: AATAAA"
     polyA_site      2399
                     /gene="RGS11"
                     /gene_synonym="RS11"
                     /note="major polyA site"
ORIGIN      
        1 gtcggtcatc cccgccggcc tcgccccgca gccatggccg ccggccccgc gccgcccccc
       61 ggccgccccc gggcgcagat gccgcatctg aggaagatgg agcgggtggt cgtgagcatg
      121 caggaccccg accagggcgt gaagatgcgg agccagcgcc tgctggtcac cgtcattccc
      181 cacgcggtga caggcagcga cgtcgtgcag tggttggccc agaagttctg cgtctcggag
      241 gaggaggccc tgcacctggg cgccgtcctg gtgcagcatg gctacatcta cccgctgcgc
      301 gacccccgta gcctcatgct ccggccagac gagacgccct acaggttcca gaccccgtac
      361 ttctggacaa gtaccctgag gccggctgca gagctggact atgccatcta cctggccaag
      421 aagaacatcc gaaaacgggg gaccctggtg gattatgaga aggactgcta tgaccggcta
      481 cacaagaaga tcaaccacgc atgggacctg gtgctgatgc aggcgaggga gcagctgagg
      541 gcagccaagc agcgcagcaa gggggacagg ctggtcattg cgtgccagga gcagacctac
      601 tggctggtga acaggccccc gcccggggcc cccgatgtgc tggagcaggg tccagggcgg
      661 ggatcctgcg ctgccagccg tgtgctcatg accaagagtg cagatttcca taagcgggag
      721 atcgagtact tcaggaaagc gctgggcagg acccgagtga agtcctccgt ctgccttgag
      781 gcgtacctga gtttctgcgg ccagcgtgga ccccacgatc ccctcgtgtc ggggtgcctg
      841 cccagcaatc cctggatctc agacaatgac gcctactggg tcatgaatgc ccccacggtg
      901 gctgccccca cgaagctccg tgtggagaga tggggcttca gcttccggga gctcctggag
      961 gaccccgtgg ggcgggccca cttcatggac tttctgggaa aggagttcag tggagaaaac
     1021 ctcagcttct gggaggcatg tgaggagctt cgatatggag cgcaggccca ggtccccacc
     1081 ctggtggatg ccgtgtacga gcagttcctg gcccccggag ctgcccactg ggtcaacatc
     1141 gacagccgga ccatggagca gaccctggag gggctgcgcc agccccaccg ctatgtcctg
     1201 gatgacgccc agctgcacat atacatgctc atgaagaagg actcctaccc aaggttcctg
     1261 aagtctgaca tgtacaaggc cctcctggca gaggctggga tcccgctgga gatgaagaga
     1321 cgcgtgttcc cgtttacgtg gaggccacgg cactcgagcc ccagccctgc actccttccc
     1381 acccctgtgg agcccacagc ggcttgtggc cctgggggtg gagatggggt ggcctagtgg
     1441 acctggccca tctgccactc tagtccctgc agctcaacgt cctgcgtgaa tgcagcagcc
     1501 acccccgtct tggcccaggt cctgggggct gctgaaccca gcaccagtgt ccccttgtgc
     1561 ccagggggcc cagtcttctg tggggtgcac agcctccctc cctccagcaa gccctccctg
     1621 cccagaagga atgggtccag gtgtggattc ccagggaggg ggttcattgg ctcagcttgg
     1681 gtcagggcag agcctgttac ctgaagagag gtgagaccaa ggccacaggg agctccacct
     1741 tctctggtct tcagtccagc actgggtgcc catccccatc tctaaaacca gtaaatcagc
     1801 cagcgaatac ccggaagcaa gatgcacagg cgggcggctt cccacacacc cgtcacaaga
     1861 cgcggacatg caggtctcgg cgcgagctct gccccgtcca agagcctctc cgctgtcgcc
     1921 cagtgtgagc ctggaagagg acccaagaga gtgccgtgct gaggctgcct cgaggtcact
     1981 gccttccgga gctgcgccta ttcctccctc gccaaacgcg ttccagaatt tgtccacagg
     2041 tgcgccggca cctgctttcc cacctcgagg ccgcggcctc ccccccgatt tatagacaac
     2101 tctgacattg tcaccccact gacgaggccc gattccatag ggtggatcct tgccaggcgt
     2161 ccctgatcct ccctgcccaa gtcttccttc gtgagctggc cttgctcccc atcccccaag
     2221 tgcctcacca gtcccccaga ctgggtgaag gtacagctgg ctcctttcgg gggtgcagct
     2281 tcaactctct cggcggtagg gcggtgccat ccccacccat agggctggct cacatccagt
     2341 cactcccaac agcgtccagc acacaaataa aagacccttg ggccctggct ctgagccca
//
