LOCUS       NM_001005339             923 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens regulator of G protein signaling 10 (RGS10),
            transcript variant 1, mRNA.
ACCESSION   NM_001005339
VERSION     NM_001005339.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 923)
  AUTHORS   Caldiran,F., Deveci,K. and Cacan,E.
  TITLE     Epigenetic insights into Familial Mediterranean Fever: Increased
            RGS10 expression and histone modifications accompanies inflammation
            in familial Mediterranean fever disease
  JOURNAL   Gene 906, 148222 (2024)
   PUBMED   38331118
  REMARK    GeneRIF: Epigenetic insights into Familial Mediterranean Fever:
            Increased RGS10 expression and histone modifications accompanies
            inflammation in familial Mediterranean fever disease.
REFERENCE   2  (bases 1 to 923)
  AUTHORS   Caldiran,F.Y. and Cacan,E.
  TITLE     RGS10 suppression by DNA methylation is associated with low
            survival rates in colorectal carcinoma
  JOURNAL   Pathol Res Pract 236, 154007 (2022)
   PUBMED   35810565
  REMARK    GeneRIF: RGS10 suppression by DNA methylation is associated with
            low survival rates in colorectal carcinoma.
REFERENCE   3  (bases 1 to 923)
  AUTHORS   Houser,M.C., Caudle,W.M., Chang,J., Kannarkat,G.T., Yang,Y.,
            Kelly,S.D., Oliver,D., Joers,V., Shannon,K.M., Keshavarzian,A. and
            Tansey,M.G.
  TITLE     Experimental colitis promotes sustained, sex-dependent,
            T-cell-associated neuroinflammation and parkinsonian neuropathology
  JOURNAL   Acta Neuropathol Commun 9 (1), 139 (2021)
   PUBMED   34412704
  REMARK    GeneRIF: Experimental colitis promotes sustained, sex-dependent,
            T-cell-associated neuroinflammation and parkinsonian
            neuropathology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 923)
  AUTHORS   Chinn,I.K., Xie,Z., Chan,E.C., Nagata,B.M., Koval,A., Chen,W.S.,
            Zhang,F., Ganesan,S., Hong,D.N., Suzuki,M., Nardone,G., Moore,I.N.,
            Katanaev,V.L., Balazs,A.E., Liu,C., Lupski,J.R., Orange,J.S. and
            Druey,K.M.
  TITLE     Short stature and combined immunodeficiency associated with
            mutations in RGS10
  JOURNAL   Sci Signal 14 (693) (2021)
   PUBMED   34315806
  REMARK    GeneRIF: Short stature and combined immunodeficiency associated
            with mutations in RGS10.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 923)
  AUTHORS   Kucuk,B., Kibar,B. and Cacan,E.
  TITLE     A broad analysis in clinical and in vitro models on regulator of
            G-protein signalling 10 regulation that is associated with ovarian
            cancer progression and chemoresistance
  JOURNAL   Cell Biochem Funct 39 (3), 413-422 (2021)
   PUBMED   33354811
  REMARK    GeneRIF: A broad analysis in clinical and in vitro models on
            regulator of G-protein signalling 10 regulation that is associated
            with ovarian cancer progression and chemoresistance.
REFERENCE   6  (bases 1 to 923)
  AUTHORS   Popov,S.G., Krishna,U.M., Falck,J.R. and Wilkie,T.M.
  TITLE     Ca2+/Calmodulin reverses phosphatidylinositol 3,4,
            5-trisphosphate-dependent inhibition of regulators of G
            protein-signaling GTPase-activating protein activity
  JOURNAL   J Biol Chem 275 (25), 18962-18968 (2000)
   PUBMED   10747990
REFERENCE   7  (bases 1 to 923)
  AUTHORS   Tu,Y., Popov,S., Slaughter,C. and Ross,E.M.
  TITLE     Palmitoylation of a conserved cysteine in the regulator of G
            protein signaling (RGS) domain modulates the GTPase-activating
            activity of RGS4 and RGS10
  JOURNAL   J Biol Chem 274 (53), 38260-38267 (1999)
   PUBMED   10608901
REFERENCE   8  (bases 1 to 923)
  AUTHORS   Tu,Y., Wang,J. and Ross,E.M.
  TITLE     Inhibition of brain Gz GAP and other RGS proteins by palmitoylation
            of G protein alpha subunits
  JOURNAL   Science 278 (5340), 1132-1135 (1997)
   PUBMED   9353196
REFERENCE   9  (bases 1 to 923)
  AUTHORS   Popov,S., Yu,K., Kozasa,T. and Wilkie,T.M.
  TITLE     The regulators of G protein signaling (RGS) domains of RGS4, RGS10,
            and GAIP retain GTPase activating protein activity in vitro
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7216-7220 (1997)
   PUBMED   9207071
REFERENCE   10 (bases 1 to 923)
  AUTHORS   Hunt,T.W., Fields,T.A., Casey,P.J. and Peralta,E.G.
  TITLE     RGS10 is a selective activator of G alpha i GTPase activity
  JOURNAL   Nature 383 (6596), 175-177 (1996)
   PUBMED   8774883
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012468.10, CB124184.1,
            BC009361.2, BF685740.1, BM914660.1, BM782346.1, BG763741.1,
            AL547312.3, CB112318.1, AI219612.1 and AL355273.30.
            
            On Nov 22, 2018 this sequence version replaced NM_001005339.1.
            
            Summary: Regulator of G protein signaling (RGS) family members are
            regulatory molecules that act as GTPase activating proteins (GAPs)
            for G alpha subunits of heterotrimeric G proteins. RGS proteins are
            able to deactivate G protein subunits of the Gi alpha, Go alpha and
            Gq alpha subtypes. They drive G proteins into their inactive
            GDP-bound forms. Regulator of G protein signaling 10 belongs to
            this family. All RGS proteins share a conserved 120-amino acid
            sequence termed the RGS domain. This protein associates
            specifically with the activated forms of the two related G-protein
            subunits, G-alphai3 and G-alphaz but fails to interact with the
            structurally and functionally distinct G-alpha subunits. Regulator
            of G protein signaling 10 protein is localized in the nucleus. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.501958.1,
                                           SRR5189661.1739.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369103.3/ ENSP00000358099.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC012468.10        3317-3325           c
            10-285              CB124184.1         1-276
            286-813             BC009361.2         222-749
            814-815             BF685740.1         750-751
            816-819             BM914660.1         805-808
            820-821             BF685740.1         756-757
            822-822             BM782346.1         464-464
            823-823             BG763741.1         771-771
            824-824             AL547312.3         764-764
            825-825             CB112318.1         494-494
            826-877             CB112318.1         496-547
            878-913             AI219612.1         7-42                c
            914-923             AL355273.30        120519-120528       c
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..923
                     /gene="RGS10"
                     /note="regulator of G protein signaling 10"
                     /db_xref="GeneID:6001"
                     /db_xref="HGNC:HGNC:9992"
                     /db_xref="MIM:602856"
     exon            1..130
                     /gene="RGS10"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..627
                     /gene="RGS10"
                     /note="isoform a is encoded by transcript variant 1;
                     regulator of G-protein signalling 10"
                     /codon_start=1
                     /product="regulator of G-protein signaling 10 isoform a"
                     /protein_id="NP_001005339.1"
                     /db_xref="CCDS:CCDS31294.1"
                     /db_xref="GeneID:6001"
                     /db_xref="HGNC:HGNC:9992"
                     /db_xref="MIM:602856"
                     /translation="MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLEN
                     LLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKA
                     SSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEE
                     EEEDLPDAQTAAKRASRIYNT"
     exon            131..249
                     /gene="RGS10"
                     /inference="alignment:Splign:2.1.0"
     exon            250..336
                     /gene="RGS10"
                     /inference="alignment:Splign:2.1.0"
     exon            337..480
                     /gene="RGS10"
                     /inference="alignment:Splign:2.1.0"
     exon            481..923
                     /gene="RGS10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      775..780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS10"
                     /note="hexamer: AGTAAA"
     regulatory      803..808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS10"
                     /note="hexamer: CATAAA"
     polyA_site      812
                     /gene="RGS10"
                     /note="major polyA site"
     regulatory      817..822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS10"
                     /note="hexamer: AATAAT"
     polyA_site      824
                     /gene="RGS10"
                     /note="major polyA site"
     polyA_site      869
                     /gene="RGS10"
     regulatory      893..898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS10"
                     /note="hexamer: ATTAAA"
     polyA_site      923
                     /gene="RGS10"
ORIGIN      
        1 ctcctcctcc tcctcgcctt cctccggctc agccgccgcg ccgccgggct gctccttctt
       61 cctcctcggg cgcccgcggc gatgttcaac cgcgccgtga gccggctgag caggaagcgg
      121 ccgccgtcag acatccacga cagcgatggc agttccagca gcagccacca gagcctcaag
      181 agcacagcca aatgggcggc atccctggag aatctgctgg aagacccaga aggcgtgaaa
      241 agatttaggg aatttttaaa aaaggaattc agtgaagaaa atgttttgtt ttggctagca
      301 tgtgaagatt ttaagaaaat gcaagataag acgcagatgc aggaaaaggc aaaggagatc
      361 tacatgacct ttctgtccag caaggcctca tcacaggtca acgtggaggg gcagtctcgg
      421 ctcaacgaga agatcctgga agaaccgcac cctctgatgt tccagaaact ccaggaccag
      481 atctttaatc tcatgaagta cgacagctac agccgcttct taaagtctga cttgttttta
      541 aaacacaagc gaaccgagga agaggaagaa gatttgcctg atgctcaaac tgcagctaaa
      601 agagcttcca gaatttataa cacatgagcc cccaaaaagc cgggactggc agctttaaga
      661 agcaaaggaa tttcctctca ggaccgtgcc gggtttatca ttgctttgtt atttgtaagg
      721 actgaaatgt acaaaaccct tcaatgggat gtgtgtttta ttaactgctt caccagtaaa
      781 ttttgcatga tggctaagct aacataaaaa aagaataata ataacttgga agttttagtt
      841 tacaaaacag agattccttc aacactggac acgtcgagca ttttgtagct taattaaacc
      901 tcatgtaagg ccacaaggtg aaa
//
