LOCUS       NM_002922               1352 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 1 (RGS1), mRNA.
ACCESSION   NM_002922
VERSION     NM_002922.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1352)
  AUTHORS   Xun,J., Ma,Y., Wang,B., Jiang,X., Liu,B., Gao,R., Zhai,Q.,
            Cheng,R., Wu,X., Wu,Y. and Zhang,Q.
  TITLE     RGS1 targeted by miR-191-3p inhibited the stemness properties of
            esophageal cancer cells by suppressing CXCR4/PI3K/AKT signaling
  JOURNAL   Acta Histochem 126 (5-7), 152190 (2024)
   PUBMED   39173233
  REMARK    GeneRIF: RGS1 targeted by miR-191-3p inhibited the stemness
            properties of esophageal cancer cells by suppressing CXCR4/PI3K/AKT
            signaling.
REFERENCE   2  (bases 1 to 1352)
  AUTHORS   Yamada,C., Okada,K., Odaira,K., Tokoro,M., Iwamoto,E., Sanada,M.,
            Noura,M., Okamoto,S., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     RGS1 and CREB5 are direct and common transcriptional targets of
            ZNF384-fusion proteins
  JOURNAL   Cancer Med 13 (14), e7471 (2024)
   PUBMED   39015025
  REMARK    GeneRIF: RGS1 and CREB5 are direct and common transcriptional
            targets of ZNF384-fusion proteins.
REFERENCE   3  (bases 1 to 1352)
  AUTHORS   Liu,K., Xia,D., Bian,H., Peng,L., Dai,S., Liu,C., Jiang,C.,
            Wang,Y., Jin,J. and Bi,L.
  TITLE     Regulator of G protein signaling-1 regulates immune infiltration
            and macrophage polarization in clear cell renal cell carcinoma
  JOURNAL   Int Urol Nephrol 56 (2), 451-466 (2024)
   PUBMED   37735297
  REMARK    GeneRIF: Regulator of G protein signaling-1 regulates immune
            infiltration and macrophage polarization in clear cell renal cell
            carcinoma.
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   Flynn,A.L., Gans,J., Escobedo,J., Zhu,C., Florescu,A.M.,
            Shankara,S., Madden,S.L., Kim,P.S. and Pao,L.I.
  TITLE     RGS1 Modulates Autophagic and Metabolic Programs and Is a Critical
            Mediator of Human Regulatory T Cell Function
  JOURNAL   J Immunol 211 (11), 1656-1668 (2023)
   PUBMED   37850953
  REMARK    GeneRIF: RGS1 Modulates Autophagic and Metabolic Programs and Is a
            Critical Mediator of Human Regulatory T Cell Function.
REFERENCE   5  (bases 1 to 1352)
  AUTHORS   Wang,B., Jiang,B., Du,L., Chen,W., Zhang,Q., Chen,W., Ding,M.,
            Cao,W., Gao,J., Deng,Y., Fu,Y., Li,Y., Xiao,Y., Diao,W. and Guo,H.
  TITLE     Tumor-intrinsic RGS1 potentiates checkpoint blockade response via
            ATF3-IFNGR1 axis
  JOURNAL   Oncoimmunology 12 (1), 2279800 (2023)
   PUBMED   38264343
  REMARK    GeneRIF: Tumor-intrinsic RGS1 potentiates checkpoint blockade
            response via ATF3-IFNGR1 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1352)
  AUTHORS   Bowman,E.P., Campbell,J.J., Druey,K.M., Scheschonka,A., Kehrl,J.H.
            and Butcher,E.C.
  TITLE     Regulation of chemotactic and proadhesive responses to
            chemoattractant receptors by RGS (regulator of G-protein signaling)
            family members
  JOURNAL   J Biol Chem 273 (43), 28040-28048 (1998)
   PUBMED   9774420
REFERENCE   7  (bases 1 to 1352)
  AUTHORS   Heximer,S.P., Cristillo,A.D. and Forsdyke,D.R.
  TITLE     Comparison of mRNA expression of two regulators of G-protein
            signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood
            mononuclear cells
  JOURNAL   DNA Cell Biol 16 (5), 589-598 (1997)
   PUBMED   9174164
REFERENCE   8  (bases 1 to 1352)
  AUTHORS   Druey,K.M., Blumer,K.J., Kang,V.H. and Kehrl,J.H.
  TITLE     Inhibition of G-protein-mediated MAP kinase activation by a new
            mammalian gene family
  JOURNAL   Nature 379 (6567), 742-746 (1996)
   PUBMED   8602223
REFERENCE   9  (bases 1 to 1352)
  AUTHORS   Newton,J.S., Deed,R.W., Mitchell,E.L., Murphy,J.J. and Norton,J.D.
  TITLE     A B cell specific immediate early human gene is located on
            chromosome band 1q31 and encodes an alpha helical basic
            phosphoprotein
  JOURNAL   Biochim Biophys Acta 1216 (2), 314-316 (1993)
   PUBMED   8241276
REFERENCE   10 (bases 1 to 1352)
  AUTHORS   Hong,J.X., Wilson,G.L., Fox,C.H. and Kehrl,J.H.
  TITLE     Isolation and characterization of a novel B cell activation gene
  JOURNAL   J Immunol 150 (9), 3895-3904 (1993)
   PUBMED   8473738
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG536972.1, BC015510.1 and
            AL136987.11.
            
            On Nov 22, 2018 this sequence version replaced NM_002922.3.
            
            Summary: This gene encodes a member of the regulator of G-protein
            signalling family. This protein is located on the cytosolic side of
            the plasma membrane and contains a conserved, 120 amino acid motif
            called the RGS domain. The protein attenuates the signalling
            activity of G-proteins by binding to activated, GTP-bound G alpha
            subunits and acting as a GTPase activating protein (GAP),
            increasing the rate of conversion of the GTP to GDP. This
            hydrolysis allows the G alpha subunits to bind G beta/gamma subunit
            heterodimers, forming inactive G-protein heterotrimers, thereby
            terminating the signal. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.75274.1,
                                           SRR1163658.201085.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367459.8/ ENSP00000356429.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               BG536972.1         47-449
            404-740             BC015510.1         382-718
            741-1352            AL136987.11        94820-95431
FEATURES             Location/Qualifiers
     source          1..1352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..1352
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /note="regulator of G protein signaling 1"
                     /db_xref="GeneID:5996"
                     /db_xref="HGNC:HGNC:9991"
                     /db_xref="MIM:600323"
     exon            1..157
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..650
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /note="regulator of G-protein signalling 1;
                     immediate-early response 1, B-cell specific; B-cell
                     activation protein BL34; early response protein 1R20;
                     epididymis secretory protein Li 87"
                     /codon_start=1
                     /product="regulator of G-protein signaling 1"
                     /protein_id="NP_002913.3"
                     /db_xref="CCDS:CCDS1375.2"
                     /db_xref="GeneID:5996"
                     /db_xref="HGNC:HGNC:9991"
                     /db_xref="MIM:600323"
                     /translation="MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPK
                     TFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSF
                     LKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTA
                     KKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK"
     exon            158..238
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /inference="alignment:Splign:2.1.0"
     exon            239..300
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /inference="alignment:Splign:2.1.0"
     exon            301..464
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /inference="alignment:Splign:2.1.0"
     exon            465..1352
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1252..1257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /note="hexamer: ATTAAA"
     polyA_site      1271
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /note="major polyA site"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /note="hexamer: AATAAA"
     polyA_site      1352
                     /gene="RGS1"
                     /gene_synonym="1R20; BL34; HEL-S-87; IER1; IR20"
                     /note="major polyA site"
ORIGIN      
        1 gcatatttgc taagagcacc atgcgcgcag cagccatctc cactccaaag ttagacaaaa
       61 tgccaggaat gttcttctct gctaacccaa aggaattgaa aggaaccact cattcacttc
      121 tagacgacaa aatgcaaaaa aggaggccaa agacttttgg aatggatatg aaagcatacc
      181 tgagatctat gatcccacat ctggaatctg gaatgaaatc ttccaagtcc aaggatgtac
      241 tttctgctgc tgaagtaatg caatggtctc aatctctgga aaaacttctt gccaaccaaa
      301 ctggtcaaaa tgtctttgga agtttcctaa agtctgaatt cagtgaggag aatattgagt
      361 tctggctggc ttgtgaagac tataagaaaa cagagtctga tcttttgccc tgtaaagcag
      421 aagagatata taaagcattt gtgcattcag atgctgctaa acaaatcaat attgacttcc
      481 gcactcgaga atctacagcc aagaagatta aagcaccaac ccccacgtgt tttgatgaag
      541 cacaaaaagt catatatact cttatggaaa aggactctta tcccaggttc ctcaaatcag
      601 atatttactt aaatcttcta aatgacctgc aggctaatag cctaaagtga ctggtccctg
      661 gctgaaggga attaacagat agtatcaagc gcagaaggaa tgtgccagta tggctccctg
      721 ggtgaacagc ttggcctttt ttgggtgtct tgacaggcca agaagaacaa atgactcaga
      781 atggattaac atgaaagtta tccaggcgca gagttgaaga agcataagca agacaaaaac
      841 agagagaccg cagaaggagg aagatactgt ggtactgtca taaaaaacag tggagctctg
      901 tattagaaag cccctcagaa ctgggaaggc caggtaactc tagttacaca gaaactgtga
      961 ctaaagtcta tgaaactgat tacaacagac tgtaagaatc aaagtcaact gacatctatg
     1021 ctacatatta ttatatagtt tgtactgagc tattgaagtc ccattaactt aaagtatatg
     1081 ttttcaaatt gccattgcta ctattgcttg tcggtgttat tttattttat tgtttttgac
     1141 tttggaagag atgaactgtg tatttaactt aagctattgc tcttaaaacc agggagtcag
     1201 aatatatttg taagttaaat cattggtgct aataataaat gtggattttg tattaaaata
     1261 tatagaagca atttctgttt acatgtcctt gctactttta aaaacttgca tttattcctc
     1321 agattttaaa aataaataaa taattcattt aa
//
