LOCUS       NM_005054               7268 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RANBP2 like and GRIP domain containing 5 (RGPD5),
            transcript variant 1, mRNA.
ACCESSION   NM_005054
VERSION     NM_005054.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7268)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7268)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7268)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 7268)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7268)
  AUTHORS   Ciccarelli,F.D., von Mering,C., Suyama,M., Harrington,E.D.,
            Izaurralde,E. and Bork,P.
  TITLE     Complex genomic rearrangements lead to novel primate gene function
  JOURNAL   Genome Res 15 (3), 343-351 (2005)
   PUBMED   15710750
REFERENCE   6  (bases 1 to 7268)
  AUTHORS   Cai,Y., Gao,Y., Sheng,Q., Miao,S., Cui,X., Wang,L., Zong,S. and
            Koide,S.S.
  TITLE     Characterization and potential function of a novel testis-specific
            nucleoporin BS-63
  JOURNAL   Mol Reprod Dev 61 (1), 126-134 (2002)
   PUBMED   11774384
  REMARK    Erratum:[Mol Reprod Dev 2002 Feb;61(2):279]
REFERENCE   7  (bases 1 to 7268)
  AUTHORS   Cai,Y., Miao,S.Y. and Wang,L.F.
  TITLE     [Determination of the binding site of testis-specific nucleoporin
            BS-63 to transportin (karopherin beta 2) and the proof of their
            combination in vitro]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23 (5), 462-466 (2001)
   PUBMED   12905863
REFERENCE   8  (bases 1 to 7268)
  AUTHORS   Wang,L.F., Zhu,H.D., Miao,S.Y., Cao,D.F., Wu,Y.W., Zong,S.D. and
            Koide,S.S.
  TITLE     Molecular cloning and characterization of a novel testis-specific
            nucleoporin-related gene
  JOURNAL   Arch Androl 42 (2), 71-84 (1999)
   PUBMED   10101573
REFERENCE   9  (bases 1 to 7268)
  AUTHORS   Nothwang,H.G., Rensing,C., Kubler,M., Denich,D., Brandl,B.,
            Stubanus,M., Haaf,T., Kurnit,D. and Hildebrandt,F.
  TITLE     Identification of a novel Ran binding protein 2 related gene
            (RANBP2L1) and detection of a gene cluster on human chromosome
            2q11-q12
  JOURNAL   Genomics 47 (3), 383-392 (1998)
   PUBMED   9480752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013271.4, U64675.2,
            AL136868.1, AL044843.1, BU631831.1 and CA446006.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005054.2.
            
            Summary: RAN is a small GTP-binding protein of the RAS superfamily
            that is associated with the nuclear membrane and is thought to
            control a variety of cellular functions through its interactions
            with other proteins. This gene shares a high degree of sequence
            identity with RANBP2, a large RAN-binding protein localized at the
            cytoplasmic side of the nuclear pore complex. It is believed that
            this RANBP2 gene family member arose from a duplication event 3 Mb
            distal to RANBP2. Alternative splicing has been observed for this
            locus and two variants are described. Additional splicing is
            suggested but complete sequence for further transcripts has not
            been determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longest transcript
            encoding the largest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.54313.1,
                                           SRR1660805.213301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000016946.8/ ENSP00000016946.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC013271.4         143391-143474       c
            85-406              U64675.2           1-322
            407-2512            AL136868.1         780-2885
            2513-2838           U64675.2           2429-2754
            2839-3346           AL044843.1         62-569
            3347-4995           AC013271.4         99824-101472        c
            4996-5545           BU631831.1         14-563              c
            5546-6562           AC013271.4         80780-81796         c
            6563-7249           CA446006.1         18-704              c
            7250-7268           AC013271.4         80074-80092         c
FEATURES             Location/Qualifiers
     source          1..7268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..7268
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /note="RANBP2 like and GRIP domain containing 5"
                     /db_xref="GeneID:84220"
                     /db_xref="HGNC:HGNC:32418"
                     /db_xref="MIM:612708"
     exon            1..233
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..5459
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RANBP2-like and GRIP domain-containing protein 5;
                     RANBP2-like and GRIP domain-containing protein 5/6; sperm
                     membrane protein BS-63; ranBP2L1; ranBP2-like 1;
                     ran-binding protein 2-like 1; ranBP2-like 1/2; ran-binding
                     protein 2-like 1/2; epididymis luminal protein 161"
                     /codon_start=1
                     /product="RANBP2-like and GRIP domain-containing protein
                     5/6 isoform 1"
                     /protein_id="NP_005045.2"
                     /db_xref="CCDS:CCDS2082.1"
                     /db_xref="GeneID:84220"
                     /db_xref="HGNC:HGNC:32418"
                     /db_xref="MIM:612708"
                     /translation="MRRSKADVERYVASVLGLTPSPRQKSMKGFYFAKLYYEAKEYDL
                     AKKYICTYINVQERDPKAHRFLGLLYELEENTEKAVECYRRSVELNPTQKDLVLKIAE
                     LLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYV
                     RPDDVHVNIRLVELYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESL
                     QCLESDKSDWQATNTDLLLAYANLMLLTLSTRDVQENRELLESFDSALQSAKSSLGGN
                     DELSATFLEMKGHFYMYAGSLLLKMGQHGNNVQWRALSELAALCYLIAFQVPRPKIKL
                     REGKAGQNLLEMMACDRLSQSGHMLLSLSRGKQDFLKEVVETFANKIGQSALYDALFS
                     SQSPKDTSFLGSDDIGKIDVQEPELEDLARYDVGAIRAHNGSLQHLTWLGLQWNSLPA
                     LPGIRKWLKQLFHRLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHH
                     SSYQPLCLPFPVCKQLCTERQKSWWDAVCTLIHRKAVPGNLAKLRLLVQHEINTLRAQ
                     EKHGLQPALLVHWAKYLQKTGSGLNSFYGQLEYIGRSVHYWKKVLPLLKIIKKNSIPE
                     PIDPLFKHFHSVDIQASEIVEYEEDAHITFAMLDAVNGNIEDAVTAFESIKSVVSYWN
                     LALIFHRKAEDIENDALSPEEQEECRNYLTKTRDYLIKIIDDGDSNLSVVKKLPVPLE
                     SVKQMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPE
                     TPPRWTEDRNSLLNMICQQVEAIKKEMQELKLNSSKSASRHRWPTENYGPDSVPDGYQ
                     GSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFS
                     IPVSADGFKFGISEPGNQEKKREKPLENDTGFQAQDISGRKKGRGVIFGQTSSTFTFA
                     DVAKSTSGEGFQFGKKDLNFKGFSGAGEKLFSSRYGKMANKANTSGDFEKDDDAYKTE
                     DSDDIHFEPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEVRQWKERGLGNLKILK
                     NEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWSASDFSDGDAKLERL
                     AAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDF
                     KTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNAENTGPTLEWDNYDLREDALDDSV
                     SSSSVHASPLASSPVRKNLFRFDESTTGSNFSFKSALSLSKSPAKLNQSGTSVGTDEE
                     SVVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAEIYRYDKDVGQWKERGI
                     GDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADG
                     ERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVA
                     ILEETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSE
                     KSKPFVFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIE
                     QSSDSKVKNLSASFPTEESSINYTFKTPEKEPPLWHAEFTKEELVQKLRSTTKSADHL
                     NGLLREIEATNAVLMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGS
                     ERERLLPVINTMLQLSPEEKGKLAAVAQDEEENASRSSG"
     exon            234..301
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            302..413
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            414..566
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            567..797
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            798..943
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1139
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1227
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1437
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1619
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1795
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1919
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2078
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2216
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2363
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2543
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2627
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2763
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2858
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..5082
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5083..5222
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5223..5424
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5425..7268
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7043..7048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /note="hexamer: AATATA"
     polyA_site      7064
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /note="major polyA site"
     regulatory      7144..7149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /note="hexamer: GATAAA"
     polyA_site      7169
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
     regulatory      7230..7235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
                     /note="hexamer: ATTAAA"
     polyA_site      7268
                     /gene="RGPD5"
                     /gene_synonym="BS-63; BS63; HEL161; RGP5"
ORIGIN      
        1 acagtgggcc tccgtgggcg gcgccgcacg ctcgtcacag tgggcctccg ccggctacgc
       61 cgctgcttca gtggcttgca ggcactttcc tcttggaagt ggcgactgct gcggggctga
      121 gcggtgctcg cacgcgtctc gggagccagg ttggcggcgc gatgaggcgc agcaaggccg
      181 atgtggagcg gtacgtcgcc tcggtgctgg gtctcacccc gtcgcctcga cagaagtcaa
      241 tgaaaggatt ctattttgca aagctgtatt atgaagctaa agaatatgat cttgctaaaa
      301 aatacatatg tacttacatt aatgtgcaag agagggatcc caaagctcac agatttctgg
      361 gtcttcttta tgaattggaa gaaaacacag agaaagccgt tgaatgttac aggcgttcag
      421 tggaattaaa cccaacacaa aaagatcttg tgttgaagat tgcagaattg ctttgtaaaa
      481 atgatgttac tgatggaaga gcaaaatact gggtcgaaag agcagcaaaa cttttcccag
      541 gaagtcctgc aatttataaa ctaaaggaac agcttctaga ttgtgaaggt gaagatggat
      601 ggaataaact ttttgacttg attcagtcag aactttatgt aagacctgat gacgtccatg
      661 tgaacatccg gctagtggag ttgtatcgct caactaaaag attgaaggat gctgtggccc
      721 actgccatga ggcagagagg aacatagctt tgcgttcaag tttagagtgg aattcgtgtg
      781 ttgtacagac ccttaaggaa tatctggagt ctttacagtg tttggagtct gataaaagtg
      841 actggcaagc aaccaataca gacttactgc tggcctatgc taatcttatg cttcttacgc
      901 tttccactag agatgtgcag gaaaatagag aattactgga aagttttgat agtgctcttc
      961 agtctgcgaa atcttctttg ggtggaaatg atgaactgtc agctactttc ttagaaatga
     1021 aaggacattt ctatatgtat gctggttctc tgctcttgaa gatgggtcag catggtaata
     1081 atgttcaatg gcgagctctt tctgagctgg ctgcattgtg ctatctcata gcatttcagg
     1141 ttccaagacc aaagattaaa ttaagagaag gtaaagctgg acaaaatctg ctggaaatga
     1201 tggcctgtga ccgactgagc caatcagggc acatgttgct aagcttaagt cgtggcaagc
     1261 aagatttctt aaaagaggtt gttgaaactt ttgccaacaa aattgggcag tctgcgttat
     1321 atgatgctct gttttctagt cagtcaccta aggatacatc ttttcttggt agcgatgata
     1381 ttggaaaaat tgatgtacaa gaaccagagc ttgaagattt ggctagatac gatgttggtg
     1441 ctattcgagc acataatggt agtcttcagc atcttacttg gcttggctta cagtggaatt
     1501 cattgcctgc tttacctgga atccgaaaat ggctaaaaca gcttttccat cgtttgcccc
     1561 atgaaacctc aaggcttgaa acaaatgcgc ctgaatcaat atgtatttta gatcttgaag
     1621 tatttctcct tggagtagta tataccagcc acttacaatt aaaggagaaa tgtaattctc
     1681 accatagctc ctatcagccg ttatgcctgc cctttcctgt gtgtaaacag ctttgtacag
     1741 aaagacaaaa atcttggtgg gatgcggttt gtactctgat tcacagaaaa gcagtacctg
     1801 gaaacttggc aaaattgaga cttctagttc agcatgaaat aaacactcta agagcccagg
     1861 aaaaacatgg ccttcaacct gctctgcttg tacattgggc aaaatacctt cagaaaacgg
     1921 gcagcggtct taattctttt tatggtcaac tagaatacat agggagaagt gttcattatt
     1981 ggaagaaagt tttgccattg ttgaagataa taaagaagaa cagtattcct gaacctattg
     2041 atcctctgtt taaacatttt catagtgtag acattcaggc atcagaaatt gttgaatatg
     2101 aagaagacgc acacataact tttgctatgt tggatgcagt aaatggaaat atagaagatg
     2161 ctgtgactgc ttttgaatct ataaaaagtg ttgtttctta ttggaatctt gcactgattt
     2221 ttcacaggaa ggcagaagac attgaaaatg atgccctttc tcctgaagaa caagaagaat
     2281 gcagaaatta tctgacaaag accagggact acctaataaa gattatagat gacggtgatt
     2341 caaatctttc agtggtcaag aaattgcctg tgcccctgga gtctgtaaaa cagatgctta
     2401 attcagtcat gcaggaactc gaagactata gtgaaggagg tcctctctat aaaaatggtt
     2461 ctttgcgaaa tgcagattca gaaataaaac attctacacc gtctcctacc aaatattcac
     2521 tatcaccaag taaaagttac aagtattctc ccgaaacacc acctcgatgg acagaagatc
     2581 ggaattcttt actgaatatg atttgccaac aagtagaggc cattaagaaa gaaatgcagg
     2641 agttgaaact aaatagcagt aagtcagcat cccgtcatcg ttggcccaca gagaattatg
     2701 gaccagactc ggtgcctgat ggatatcagg ggtcacagac atttcatggg gctccactaa
     2761 cagttgcaac tactggccct tcagtatatt atagtcagtc accagcatat aattcccagt
     2821 atcttctcag accagcagct aatgttactc ccacaaaggg ttcttctaat acagaattta
     2881 agtcaaccaa agaaggattt tccatccctg tgtctgctga tggatttaaa tttggcattt
     2941 cggaaccagg aaatcaagaa aagaaaaggg aaaagcctct tgaaaatgat actggcttcc
     3001 aggctcagga tattagtggc cggaagaagg gccgtggtgt gatttttggc caaacaagta
     3061 gcacttttac atttgcagat gttgcaaaat caacttcagg agaaggattt cagtttggca
     3121 aaaaagacct caatttcaag ggattttcag gtgctggaga aaaattattc tcatcacgat
     3181 acggtaaaat ggccaataaa gcaaacactt ccggtgactt tgagaaagat gatgatgcct
     3241 ataagactga ggacagcgat gacatccatt ttgaaccagt agttcaaatg cctgaaaaag
     3301 tagaacttgt aacaggagaa gaaggtgaaa aagttctgta ttcacagggg gtaaaactat
     3361 ttagatttga tgctgaggta aggcagtgga aagaaagggg cttggggaac ttaaaaattc
     3421 tcaaaaacga ggtcaatggc aaactaagaa tgctgatgcg aagagaacaa gtactaaaag
     3481 tgtgtgctaa tcattggata acgactacaa tgaacctgaa gcccctctct ggatcagata
     3541 gagcatggat gtggtcagcc agtgatttct ctgacggtga tgccaaacta gagcggttgg
     3601 cagcaaaatt taaaacacca gagctggctg aagaattcaa gcagaaattt gaggaatgcc
     3661 agcggcttct gttagacata ccacttcaaa ctccccataa acttgtagat actggcagag
     3721 ctgccaagtt aatacagaga gctgaagaaa tgaagagtgg actgaaagat ttcaaaacat
     3781 ttttgacaaa tgatcaaaca aaagtcactg aggaagaaaa taagggttca ggtacaggtg
     3841 cggccggtgc ctcagacaca acaataaaac ccaatgctga aaacactggg cccacattag
     3901 aatgggataa ctatgactta agggaagatg ctttggatga tagtgtcagt agtagctcag
     3961 tacatgcttc tccattggca agtagccctg tgagaaaaaa tcttttccgc tttgatgagt
     4021 caacaacagg atctaacttc agttttaaat ctgctttgag tctatctaag tctcctgcca
     4081 agttgaatca gagtgggact tcagttggca ctgatgaaga atctgttgtt actcaagaag
     4141 aagagagaga tggacagtac tttgaacctg ttgttccttt acctgatcta gttgaagtat
     4201 ccagtggtga ggaaaatgaa caagttgttt ttagtcacag ggcagaaatc tacagatatg
     4261 ataaagatgt tggtcaatgg aaagaaaggg gcattggtga tataaagatt ttacagaatt
     4321 atgataataa gcaagttcgt atagtgatga gaagggacca agtattaaaa ctttgtgcca
     4381 atcacagaat aactccagac atgagtttgc aaaatatgaa agggacagaa agagtatggg
     4441 tgtggactgc atgtgatttt gcagatggag aaagaaaagt agagcattta gctgttcgtt
     4501 ttaaactaca ggatgttgca gactcgttta agaaaatttt tgatgaagca aaaacagccc
     4561 aggaaaaaga ttctttgata acacctcatg tttctcggtc aagcactccc agagagtcac
     4621 catgtggcaa aattgctgta gctatattag aagaaaccac aagagagagg acagatgtta
     4681 ttcagggtga tgatgtagca gatgcagctt cagaagttga agtgtctagc acatctgaaa
     4741 caacaacaaa agcagtggtt tctcctccaa agtttgtatt tgtttcagag tctgttaaaa
     4801 gaatttttag tagtgaaaaa tcaaaaccat ttgtatttgg caacagttct gccactgggt
     4861 ctttgtttgg atttagtttt aatgcacctt tgaaaagtaa caatagtgaa actagttcag
     4921 tagcccagag tggatctgaa agcaaagtgg aacctaaaaa atgtgaactg tcaaagaact
     4981 ctgatatcga acagtcttca gatagcaaag tcaaaaatct ctctgcttcc tttccaacgg
     5041 aagaatcttc aatcaactac acatttaaaa caccagaaaa ggagcctcca ttatggcatg
     5101 ctgaatttac caaagaagaa ttggttcaga agctccgttc caccacaaaa agtgcagatc
     5161 acttaaacgg cctgcttcgg gaaatagagg caaccaatgc agtccttatg gagcaaatta
     5221 agcttctcaa aagtgaaata agaagattgg aaaggaatca agagcgagag aagtctgcag
     5281 ctaacctgga atacttgaag aacgtcttgc tgcagttcat tttcttgaag ccaggtagtg
     5341 aaagagagag acttcttcct gttataaata cgatgttgca gctcagccct gaagaaaagg
     5401 gaaaacttgc tgcggttgct caagatgagg aagaaaatgc ttcccgttct tctggatgag
     5461 catcctatct tcgtagttgg tttggacttc gataggttga tggaaggaat acttctatta
     5521 accaaataga atctgtttac aaaaatggtt cgtgtgtgtt accattattc ttttgtcaaa
     5581 aagtgtgtat atatgtttgc atttacatat atttgtacat ctgtatgaca gatgtatttt
     5641 aaaagtttca acttgaagta aaagtacaac agcttgaagt gttgatacca ggccacagcc
     5701 ctctaactca tgtgatctcc catgcatgct gccagaataa aaccaccagg aatgaattca
     5761 ctccccactt ctctggaacc tcaggacccg cccatttctc ggcagtactg tgaattttga
     5821 agttaaacta aattttggta ccataccaac tggaatttag gctttaaaaa taatgtttca
     5881 aggccaggtg tggtgattca tgcctgaaat cccactactt tgggaggctg aggctggaga
     5941 atcgcttgag gctagtgagc tgtgattgta ccactgcact ccagctcggg gaacagagcg
     6001 agaccttgtc tctaaaaata ataatagtaa taaaaataac gttttatgac tatttattgc
     6061 aaggtcagat ttacagattg ttataaattg ttgagaaatt tttgtgatta gaatatgaag
     6121 gaaaaagctt tgttggtaaa agtgacatgt taaggggcta tgaagtaaat atgctgcagt
     6181 taattgtgct aagttaaaat acagtttagt tatttgcttt aaaataaact cttctttttt
     6241 tctttaaagt atactacctc aaaactcatt atgttgtcag agccctagag ctggctagtg
     6301 taacactgac tatgagtagg tgggcccacc acttgagttg aggtgatttc atggtgtctt
     6361 tccaggctct tgatagggtg tcactgcatg caagccatga atctgttttg agaatcctct
     6421 ccattttccc aaataaaaac ctatcccaac agtgactata tcactcagca ttggatctaa
     6481 atataaaagt ggtgctttca gtgtttttgg cagatagtgt tccataacct ttccatcaga
     6541 agggatttta gacaccttag aggtccgtgc tacatcttca cagttcctcc gaataacctt
     6601 aggtggtagt gttacttgcc tttgacacct gtgcatatgt tttaatgact agatccaaac
     6661 tgtgttgttc ttaaatcaaa aattggataa tttttaatat ttatgtatta atcacacagt
     6721 gtgctctctg aagttctctt aagccttcag tttatactct taattttctt tctgagctgg
     6781 ggaactgact ttgcactttg gttacacaga acattggttt ccaatttagt ttaactgaaa
     6841 tttgctgctg atatgttgag tttgttcttt aaaaaatatc tcatatatct cgtctttcct
     6901 ccttagaaga acagacctaa ctagcgaatg tatgaatgaa aatgcatcta tttcagagcc
     6961 gacatgaaga gtttagtttt tttactttat aaactgtgaa tatgagtatg ccagctgcat
     7021 tagatgtaac taatcatatt taaatatatt tcactttgac tttagacctt ttgaagtctg
     7081 tataaacttg ttttgaaata cagtctccac ttacgaatgt cataacaaaa tacttttttg
     7141 catgataaaa aattactttg attacaaaag gcatattctt tcatggtttc tgcaatgaga
     7201 ggaagtgtaa tgattatttt aatatttcta ttaaaactgt atatttttat ggctgctctt
     7261 ttatgtta
//
