LOCUS       NM_001382344            6819 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RANBP2 like and GRIP domain containing 1 (RGPD1),
            transcript variant 1, mRNA.
ACCESSION   NM_001382344
VERSION     NM_001382344.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6819)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 6819)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 6819)
  AUTHORS   Ciccarelli,F.D., von Mering,C., Suyama,M., Harrington,E.D.,
            Izaurralde,E. and Bork,P.
  TITLE     Complex genomic rearrangements lead to novel primate gene function
  JOURNAL   Genome Res 15 (3), 343-351 (2005)
   PUBMED   15710750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111200.7.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2142853 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641458.2/ ENSP00000492954.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC111200.7         108232-108422
            192-256             AC111200.7         117410-117474
            257-368             AC111200.7         119056-119167
            369-521             AC111200.7         119612-119764
            522-752             AC111200.7         123820-124050
            753-898             AC111200.7         124396-124541
            899-1094            AC111200.7         129143-129338
            1095-1182           AC111200.7         135342-135429
            1183-1392           AC111200.7         137861-138070
            1393-1574           AC111200.7         140187-140368
            1575-1750           AC111200.7         140452-140627
            1751-1874           AC111200.7         140795-140918
            1875-2033           AC111200.7         141842-142000
            2034-2171           AC111200.7         142267-142404
            2172-2318           AC111200.7         142667-142813
            2319-2498           AC111200.7         143694-143873
            2499-2582           AC111200.7         143962-144045
            2583-2700           AC111200.7         147197-147314
            2701-2795           AC111200.7         150868-150962
            2796-5019           AC111200.7         151690-153913
            5020-5159           AC111200.7         160955-161094
            5160-5355           AC111200.7         163677-163872
            5356-6819           AC111200.7         178627-180090
FEATURES             Location/Qualifiers
     source          1..6819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..6819
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /note="RANBP2 like and GRIP domain containing 1"
                     /db_xref="GeneID:400966"
                     /db_xref="HGNC:HGNC:32414"
                     /db_xref="MIM:612704"
     exon            1..191
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..5390
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RANBP2-like and GRIP domain-containing protein 1;
                     RANBP2-like and GRIP domain-containing protein 1/2;
                     ranBP2-like 6; ran-binding protein 2-like 6; ranBP2-like
                     2/6; ran-binding protein 2-like 2/6"
                     /codon_start=1
                     /product="RANBP2-like and GRIP domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001369273.1"
                     /db_xref="CCDS:CCDS92800.1"
                     /db_xref="GeneID:400966"
                     /db_xref="HGNC:HGNC:32414"
                     /db_xref="MIM:612704"
                     /translation="MRRSKAYGERYVASVQGSAPSPGKKLRGFYFAKLYYEAKEYDLA
                     KKYVCTYLSVQERDPRAHRFLGLLYELEENTEKAVECYRRSLELNPPQKDLVLKIAEL
                     LCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEHLLDCEGEDGWNKLFDWIQSELYVR
                     PDDVHMNIRLVELYRSNKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEYLESLQ
                     CLESDKSDWRATNTDLLLAYANLMLLTLSTRDVQESRELLESFDSALQSAKSSLGGND
                     ELSATFLEMKGHFYMHAGSLLLKMGQHGNNVQWQALSELAALCYVIAFQVPRPKIKLI
                     KGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEVVETFANKSGQSVLYNALFSS
                     QSSKDTSFLGSDDIGNIDVQEPELEDLARYDVGAIQAHNGSLQHLTWLGLQWNSLPAL
                     PGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHS
                     SYQPLCLPLPVCKRLCTERQKSWWDAVCTLIHRKAVPGNSAELRLVVQHEINTLRAQE
                     KHGLQPALLVHWAKCLQKMGRGLNSSYDQQEYIGRSVHYWKKVLPLLKIIKKNSIPEP
                     IDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVTAFESIKSVVSYWNL
                     ALIFHRKAEDIENDAVFPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLES
                     VKEMLKSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPKT
                     PPRWAEDQNSLRKMICQEVKAITKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHG
                     APLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIAVSADG
                     FKFGISEPGNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTS
                     GEGFQFGKKDPNFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDACKTEDSDDIHF
                     EPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEISQWKERGLGNLKILKNEVNGKP
                     RMLMRRDQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLERLAAQFKTP
                     ELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTND
                     QTKVTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDNVSSSSVHD
                     SPLASSPVRKNIFRFDESTTGFNFSFKSALSLSKSPAKLNQSGTSVGTDEESDVTQEE
                     ERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAELYRYDKDVGQWKERGIGDIKILQ
                     NYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHL
                     AVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTR
                     ERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSNPFAF
                     GNSSATGSLFGFSFNAPLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKV
                     KNLSASFPMEESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSADQLNGLLRET
                     EATSAVLMEQIKLLKSEIRRLERNQEESAANVEHLKNVLLQFIFLKPGSERESLLPVI
                     NTMLQLSPEEKGKLAAVAQGLQETSIPKKK"
     exon            192..256
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..368
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..521
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..752
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..898
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1094
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1182
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1392
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1574
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1750
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1874
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2033
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2171
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2318
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2498
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2582
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2700
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2795
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..5019
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            5020..5159
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            5160..5355
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            5356..6819
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5484..5489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /note="hexamer: ATTAAA"
     polyA_site      5509
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /note="major polyA site"
ORIGIN      
        1 tcacagtggt cctccgccgg ctacgtcagt ggctttcagg cgctttcctg ttggaattgg
       61 cgactgctgc ggggctgagc gctggtttca cgcgtctcgg gagccaggtt ggcggtgcga
      121 tgaggcgcag caaggcctac ggggagcggt acgtcgcctc ggtgcagggc tccgccccgt
      181 cgcctggaaa gaagttgaga ggattctatt ttgcaaagct gtattatgaa gctaaagaat
      241 atgatcttgc taaaaaatac gtatgtactt accttagtgt gcaagagagg gatcccagag
      301 ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagagaaa gccgttgaat
      361 gttacaggcg ttcactggaa ttaaacccac cacaaaaaga tcttgtgttg aagattgcag
      421 aattgctttg taaaaatgat gttactgatg gaagagcaaa atactgggtt gaaagggcag
      481 cgaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacatctt ctagattgtg
      541 aaggtgaaga tggatggaat aaactttttg actggattca gtcagaactt tatgtaagac
      601 ctgatgacgt ccatatgaac atccggctag tggagttgta tcgctcaaat aaaagattga
      661 aggatgctgt ggcccgctgc catgaggcag agaggaacat agctttgcgt tcaagtttag
      721 agtggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta cagtgtttgg
      781 agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc tatgctaatc
      841 ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta ctggaaagtt
      901 ttgatagtgc tcttcagtct gcaaaatctt ctttgggtgg aaatgatgaa ctgtcagcta
      961 ctttcttaga aatgaaagga catttctaca tgcatgctgg ttctctgctc ttgaagatgg
     1021 gtcagcatgg taataatgtt caatggcaag ctctttctga gctggctgca ttgtgctatg
     1081 tcatagcatt tcaggttcca agaccaaaga ttaaattaat aaaaggtgaa gctggacaaa
     1141 atctgctgga aatgatggcc tgtgaccgac tgagccaatc agggcatatg ttgctaaact
     1201 taagtcgtgg caagcaagat tttttaaaag aggttgttga aacttttgcc aacaaaagcg
     1261 ggcagtctgt gttatataat gctctgtttt ctagtcagtc atctaaggat acatcttttc
     1321 ttggtagcga tgatattgga aacattgatg tacaagaacc agagcttgaa gatttggcta
     1381 gatacgatgt tggtgctatt caagcacata atggtagtct tcagcacctt acttggcttg
     1441 gcttacagtg gaattcattg cctgctttac ctggaatccg aaaatggcta aaacagcttt
     1501 tccatcattt gccccaggaa acctcaaggc ttgaaacaaa tgcacctgaa tcaatatgta
     1561 ttttagatct tgaagtattt ctccttggag tagtatatac cagccactta caattaaagg
     1621 agaaatgtaa ttctcaccac agctcctatc agccgttatg cctgcccctt cctgtgtgta
     1681 aacggctttg tacagagaga caaaaatctt ggtgggatgc ggtttgtact ctgattcaca
     1741 gaaaagcagt acctggaaac tcagcagaat tgagacttgt agttcagcat gaaataaaca
     1801 ctctaagagc ccaggaaaaa catggccttc aacctgctct gcttgtacat tgggcaaaat
     1861 gccttcagaa aatgggcagg ggtcttaatt cttcttatga tcaacaagaa tacataggga
     1921 gaagtgttca ttattggaag aaagttttgc cattgttgaa gataataaag aagaacagta
     1981 ttcctgaacc tattgatcct ctgtttaaac attttcatag tgtagacatt caggcatcag
     2041 aaattgttga gtatgaagaa gatgcacaca taacttttgc tatattggat gcagtacatg
     2101 gaaatataga agatgctgtg actgcttttg aatctataaa aagtgttgtt tcttattgga
     2161 atcttgcact gatttttcac aggaaagcag aagacattga aaatgatgcc gtttttcctg
     2221 aagaacaaga agaatgcaaa aattatctga gaaagaccag ggactaccta ataaagatta
     2281 tagatgacag tgattcaaat ctttcagtgg tcaagaaatt gcctgtgccc ctggagtctg
     2341 taaaagagat gcttaagtca gtcatgcagg aactcgaaga ctatagtgaa ggaggtcctc
     2401 tctataaaaa tggttctttg cgaaatgcag attcagaaat aaaacattct acaccatctc
     2461 ctaccaaata ttcactatca ccaagtaaaa gttacaagta ttctcccaaa acaccacctc
     2521 gatgggcaga agatcagaat tctttacgga aaatgatttg ccaagaagta aaggccatta
     2581 cgaaactaaa tagcagtaag tcagcatccc gtcatcgttg gcccacagag aattatggac
     2641 cagactcggt gcctgatgga tatcaggggt cacagacatt tcatggggct ccactaacag
     2701 ttgcaactac tggcccttca gtatattata gtcagtcacc agcatataat tcccagtatc
     2761 ttctcagacc agcagctaat gttactccca caaagggttc ttctaataca gaatttaagt
     2821 caaccaaaga aggattttcc atcgctgtgt ctgctgatgg atttaaattt ggcatttcgg
     2881 aaccaggaaa tcaagaaaag aaaagtgaaa agcctcttga aaatgatact ggcttccagg
     2941 ctcaggatat tagtggccag aagaatggcc gtggtgtgat ttttggccaa acaagtagca
     3001 cttttacatt tgcagatgtt gcaaaatcaa cttcaggaga aggatttcag tttggcaaaa
     3061 aagaccccaa tttcaaggga ttttcaggtg ctggagaaaa attattctca tcacaatgcg
     3121 gtaaaatggc caataaagca aacacttccg gtgactttga gaaagatgat gatgcctgta
     3181 agactgagga cagcgatgac atccattttg aaccagtagt tcaaatgcct gaaaaagtag
     3241 aacttgtaac aggagaagaa ggtgaaaaag ttctgtattc acagggggta aaactattta
     3301 gatttgatgc tgagataagt cagtggaaag aaaggggctt ggggaactta aaaattctca
     3361 aaaatgaggt caatggcaaa ccaagaatgc tgatgcgaag agaccaagta ctaaaagtgt
     3421 gtgctaatca ttggataaca actacaatga acctgaagcc cctctctgga tcagatagag
     3481 catggatgtg gttagccagt gatttctctg atggtgatgc caaactagag cggttggcag
     3541 cacaatttaa aacaccagag ctggctgaag aattcaagca gaaatttgag gaatgccagc
     3601 ggcttctgtt agacatacca cttcaaactc cccataaact tgtagatact ggcagagctg
     3661 ccaagctaat acagagagct gaagaaatga agagtggact gaaagatttc aaaacgtttt
     3721 tgacaaatga tcaaacaaaa gtcactgagg aagaaaataa gggttcaggt acaggtgcag
     3781 ccggtgcctc agacacaaca ataaaaccca atcctgaaaa cactgggccc acattagaat
     3841 gggataacta tgatttaagg gaagatgctt tggatgataa tgttagtagt agctcagtac
     3901 atgattctcc gttggcaagt agccctgtga gaaaaaatat tttccgcttt gatgagtcaa
     3961 caacaggatt taacttcagt tttaaatctg ctttgagtct atctaagtct cctgccaagt
     4021 tgaatcagag tgggacttca gttggcactg atgaagaatc tgatgttact caagaagaag
     4081 agagagatgg acagtacttt gaacctgttg ttcctttacc tgatctagtt gaagtatcca
     4141 gtggtgagga aaatgaacaa gttgttttta gtcacagggc agaactctac agatatgata
     4201 aagatgttgg tcaatggaaa gaaaggggca ttggtgatat aaagatttta cagaattatg
     4261 ataataagca agttcgtata gtgatgagaa gggaccaagt attaaaactt tgtgccaatc
     4321 acagaataac tccagacatg agtttgcaaa atatgaaagg gacagaaaga gtatgggtgt
     4381 ggactgcatg tgattttgca gatggagaaa gaaaagtaga gcatttagct gttcgtttta
     4441 aactacagga tgttgcagac tcatttaaga aaatttttga tgaagcaaaa acagcccagg
     4501 aaaaagattc tttgataaca cctcatgttt ctcggtcaag cactcccaga gagtcaccat
     4561 gtggcaaaat tgctgtagct gtattagaag aaaccacaag agagaggaca gatgttattc
     4621 agggtgatga tgtagcagat gcagcttcag aagttgaagt gtctagcaca tctgaaacaa
     4681 caacaaaagc agtggtttct cctccaaagt ttgtatttgg ttcagagtct gttaaaagaa
     4741 tttttagtag tgaaaaatca aacccatttg catttggcaa cagttctgcc actgggtctt
     4801 tgtttggatt tagttttaat gcacctttga aaagtaacga tagtgaaact agttcagtag
     4861 cccagagtgg atctgaaagc aaagtggaac ctaaaaaatg tgaactgtca aagaactctg
     4921 atatcgaaca gtcttcagat agcaaagtca aaaatctctc tgcttccttt ccaatggaag
     4981 aatcttcaat caactacaca tttaaaacac cagaaaagga gcctccatta tggcatgctg
     5041 aatttaccaa agaagaattg gttcagaagc tcagttccac cacaaaaagt gcagatcagt
     5101 taaacggcct gcttcgggaa acagaggcaa ccagtgcagt ccttatggag caaattaagc
     5161 ttctcaaaag tgaaataaga agattggaaa ggaatcaaga ggagtctgca gctaacgtgg
     5221 aacacttgaa gaacgtcttg ctgcagttca ttttcttgaa gccaggtagt gagagagaga
     5281 gccttcttcc tgttataaat acgatgttgc agctcagccc tgaagaaaag ggaaaacttg
     5341 ctgcggttgc tcaaggtctt caagaaacct ccatacccaa gaaaaaatag aaagcaacca
     5401 tgttctacta tggtgccaaa aatagttgaa catcgacatc aaaaagattc tttctgtctg
     5461 cttattcaca tattctggtt tgaattaaaa gtgatgaaat tatcctaaat acagttggcc
     5521 ctctgtatcc atgggttcca catccacaaa ttcaaccaac tgtggatgga aaagacttga
     5581 aaaagatgag agaaaataac aatatgacaa taaaacataa tacaaataaa aacaatacag
     5641 tataacaacg attacatagc atttacatta tattagggat tgcacaagag aaggtatgta
     5701 ggttatatgc aaatactgca ccattttaca taagggactt gagaagcatg gattttggta
     5761 gccacagggg tcctggaacc aatccctcac agacacagac ggacacttta cagtagatga
     5821 acacaaagat gaaaggaaaa gtctgaccta ggtttgcggg gagaagtgga actccatttt
     5881 tgacaggtga tgccattttt tgttttggac atcgtccctc tgtagttctt tccattccca
     5941 gtcttgcact ctgaaagata cactgaagga aagtccacac agtggtcaaa gtctttcaca
     6001 agacaccacg tgaaggtctg cacagcacag tcacattgag aaaaagatct catgcaccag
     6061 accccctgtt tctgctttct aaaagatcat cttttgcacc tgcaaaaagg ctgcagtaaa
     6121 ctgggccatt ccatactttg attcatgtat tcaaatgcta cttatgagct ctctgtgtat
     6181 tgagccccac caggatgctg gggacacacg gggcacagtg cagccagagg cttggccatc
     6241 atagagctca cattctagtg gaatcagaca ggggggttac aggaaatatt caagtaaaca
     6301 atataaaatg agatcacttg atgatacatg gatacatgtt acatacatga tgagacagag
     6361 taagagaatg gggaaagggt ttttagatgg gggaatggca ggcttttccg aggctgaaag
     6421 agatccaacc cacttctatt tcttcaggct cccagtgata tgaaaaagtg ccaaacagga
     6481 ctataaaatt gtggtctact gtaaatggtt tgcagtaaaa gttctcaacc agcttccact
     6541 caaccaactc accagttaga caatgggccc tctcctgtgt ttaaaacagt ccggtgccca
     6601 cctgggtcca catgcagctg gcaggtgttt gctagtgtgc ccacccatgt ctgttccccc
     6661 cacgtgagtt atgtgcttac aacgagtcgt ttctttgcat tttccaactt tcttacattt
     6721 atatttaatt aaagatgatc taaactgaga aatgaatgtg aaaagaaaca aagctctttt
     6781 ttgtttggtt tttaactaaa ttaaatgttt ttaacaagt
//
