LOCUS       NM_001024457            6692 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens RANBP2 like and GRIP domain containing 1 (RGPD1),
            transcript variant 2, mRNA.
ACCESSION   NM_001024457 XM_496559
VERSION     NM_001024457.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6692)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 6692)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 6692)
  AUTHORS   Ciccarelli,F.D., von Mering,C., Suyama,M., Harrington,E.D.,
            Izaurralde,E. and Bork,P.
  TITLE     Complex genomic rearrangements lead to novel primate gene function
  JOURNAL   Genome Res 15 (3), 343-351 (2005)
   PUBMED   15710750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111200.7 and CR749330.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001024457.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749330.1, SRR14038197.2518703.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC111200.7         83729-83792
            65-129              AC111200.7         117410-117474
            130-241             AC111200.7         119056-119167
            242-394             AC111200.7         119612-119764
            395-625             AC111200.7         123820-124050
            626-771             AC111200.7         124396-124541
            772-967             AC111200.7         129143-129338
            968-1055            AC111200.7         135342-135429
            1056-1265           AC111200.7         137861-138070
            1266-1447           AC111200.7         140187-140368
            1448-1623           AC111200.7         140452-140627
            1624-1747           AC111200.7         140795-140918
            1748-1906           AC111200.7         141842-142000
            1907-2044           AC111200.7         142267-142404
            2045-2191           AC111200.7         142667-142813
            2192-2371           AC111200.7         143694-143873
            2372-2455           AC111200.7         143962-144045
            2456-2573           AC111200.7         147197-147314
            2574-2668           AC111200.7         150868-150962
            2669-4804           AC111200.7         151690-153825
            4805-6692           CR749330.1         4805-6692
FEATURES             Location/Qualifiers
     source          1..6692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..6692
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /note="RANBP2 like and GRIP domain containing 1"
                     /db_xref="GeneID:400966"
                     /db_xref="HGNC:HGNC:32414"
                     /db_xref="MIM:612704"
     exon            1..64
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..5263
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RANBP2-like and GRIP domain-containing protein 1;
                     RANBP2-like and GRIP domain-containing protein 1/2;
                     ranBP2-like 6; ran-binding protein 2-like 6; ranBP2-like
                     2/6; ran-binding protein 2-like 2/6"
                     /codon_start=1
                     /product="RANBP2-like and GRIP domain-containing protein 1
                     isoform 2"
                     /protein_id="NP_001019628.3"
                     /db_xref="GeneID:400966"
                     /db_xref="HGNC:HGNC:32414"
                     /db_xref="MIM:612704"
                     /translation="MNVMGFNTDRLAWTRNKLRGFYFAKLYYEAKEYDLAKKYVCTYL
                     SVQERDPRAHRFLGLLYELEENTEKAVECYRRSLELNPPQKDLVLKIAELLCKNDVTD
                     GRAKYWVERAAKLFPGSPAIYKLKEHLLDCEGEDGWNKLFDWIQSELYVRPDDVHMNI
                     RLVELYRSNKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSD
                     WRATNTDLLLAYANLMLLTLSTRDVQESRELLESFDSALQSAKSSLGGNDELSATFLE
                     MKGHFYMHAGSLLLKMGQHGNNVQWQALSELAALCYVIAFQVPRPKIKLIKGEAGQNL
                     LEMMACDRLSQSGHMLLNLSRGKQDFLKEVVETFANKSGQSVLYNALFSSQSSKDTSF
                     LGSDDIGNIDVQEPELEDLARYDVGAIQAHNGSLQHLTWLGLQWNSLPALPGIRKWLK
                     QLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLP
                     LPVCKRLCTERQKSWWDAVCTLIHRKAVPGNSAELRLVVQHEINTLRAQEKHGLQPAL
                     LVHWAKCLQKMGRGLNSSYDQQEYIGRSVHYWKKVLPLLKIIKKNSIPEPIDPLFKHF
                     HSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVTAFESIKSVVSYWNLALIFHRKA
                     EDIENDAVFPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLESVKEMLKSV
                     MQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQ
                     NSLRKMICQEVKAITKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATT
                     GPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIAVSADGFKFGISEP
                     GNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGK
                     KDPNFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDACKTEDSDDIHFEPVVQMPE
                     KVELVTGEEGEKVLYSQGVKLFRFDAEISQWKERGLGNLKILKNEVNGKPRMLMRRDQ
                     VLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLERLAAQFKTPELAEEFKQ
                     KFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEE
                     NKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDNVSSSSVHDSPLASSPV
                     RKNIFRFDESTTGFNFSFKSALSLSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFE
                     PVVPLPDLVEVSSGEENEQVVFSHRAELYRYDKDVGQWKERGIGDIKILQNYDNKQVR
                     IVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQD
                     VADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQG
                     DDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSNPFAFGNSSATGS
                     LFGFSFNAPLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFP
                     MEESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSADQLNGLLRETEATSAVLM
                     EQIKLLKSEIRRLERNQEESAANVEHLKNVLLQFIFLKPGSERESLLPVINTMLQLSP
                     EEKGKLAAVAQGLQETSIPKKK"
     exon            65..129
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            130..241
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..394
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..625
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..771
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..967
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1055
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1265
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1447
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1623
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1747
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1906
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2044
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2191
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2371
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2455
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2573
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2668
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..4892
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            4893..5032
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5228
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            5229..6692
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5357..5362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /note="hexamer: ATTAAA"
     polyA_site      5382
                     /gene="RGPD1"
                     /gene_synonym="RanBP2L2; ranBP2L6; RGP1; RGPD2"
                     /note="major polyA site"
ORIGIN      
        1 atttgtgact tgtctcatga acgtgatggg ttttaacaca gaccgcttag catggactag
       61 aaataagttg agaggattct attttgcaaa gctgtattat gaagctaaag aatatgatct
      121 tgctaaaaaa tacgtatgta cttaccttag tgtgcaagag agggatccca gagctcacag
      181 atttctgggt cttctttatg aattggaaga aaacacagag aaagccgttg aatgttacag
      241 gcgttcactg gaattaaacc caccacaaaa agatcttgtg ttgaagattg cagaattgct
      301 ttgtaaaaat gatgttactg atggaagagc aaaatactgg gttgaaaggg cagcgaaact
      361 tttcccagga agtcctgcaa tttataaact aaaggaacat cttctagatt gtgaaggtga
      421 agatggatgg aataaacttt ttgactggat tcagtcagaa ctttatgtaa gacctgatga
      481 cgtccatatg aacatccggc tagtggagtt gtatcgctca aataaaagat tgaaggatgc
      541 tgtggcccgc tgccatgagg cagagaggaa catagctttg cgttcaagtt tagagtggaa
      601 ttcgtgtgtt gtacagaccc ttaaggaata tctggagtct ttacagtgtt tggagtctga
      661 taaaagtgac tggcgagcaa ccaatacaga cttactgctg gcctatgcta atcttatgct
      721 tcttacgctt tccactagag atgtgcagga aagtagagaa ttactggaaa gttttgatag
      781 tgctcttcag tctgcaaaat cttctttggg tggaaatgat gaactgtcag ctactttctt
      841 agaaatgaaa ggacatttct acatgcatgc tggttctctg ctcttgaaga tgggtcagca
      901 tggtaataat gttcaatggc aagctctttc tgagctggct gcattgtgct atgtcatagc
      961 atttcaggtt ccaagaccaa agattaaatt aataaaaggt gaagctggac aaaatctgct
     1021 ggaaatgatg gcctgtgacc gactgagcca atcagggcat atgttgctaa acttaagtcg
     1081 tggcaagcaa gattttttaa aagaggttgt tgaaactttt gccaacaaaa gcgggcagtc
     1141 tgtgttatat aatgctctgt tttctagtca gtcatctaag gatacatctt ttcttggtag
     1201 cgatgatatt ggaaacattg atgtacaaga accagagctt gaagatttgg ctagatacga
     1261 tgttggtgct attcaagcac ataatggtag tcttcagcac cttacttggc ttggcttaca
     1321 gtggaattca ttgcctgctt tacctggaat ccgaaaatgg ctaaaacagc ttttccatca
     1381 tttgccccag gaaacctcaa ggcttgaaac aaatgcacct gaatcaatat gtattttaga
     1441 tcttgaagta tttctccttg gagtagtata taccagccac ttacaattaa aggagaaatg
     1501 taattctcac cacagctcct atcagccgtt atgcctgccc cttcctgtgt gtaaacggct
     1561 ttgtacagag agacaaaaat cttggtggga tgcggtttgt actctgattc acagaaaagc
     1621 agtacctgga aactcagcag aattgagact tgtagttcag catgaaataa acactctaag
     1681 agcccaggaa aaacatggcc ttcaacctgc tctgcttgta cattgggcaa aatgccttca
     1741 gaaaatgggc aggggtctta attcttctta tgatcaacaa gaatacatag ggagaagtgt
     1801 tcattattgg aagaaagttt tgccattgtt gaagataata aagaagaaca gtattcctga
     1861 acctattgat cctctgttta aacattttca tagtgtagac attcaggcat cagaaattgt
     1921 tgagtatgaa gaagatgcac acataacttt tgctatattg gatgcagtac atggaaatat
     1981 agaagatgct gtgactgctt ttgaatctat aaaaagtgtt gtttcttatt ggaatcttgc
     2041 actgattttt cacaggaaag cagaagacat tgaaaatgat gccgtttttc ctgaagaaca
     2101 agaagaatgc aaaaattatc tgagaaagac cagggactac ctaataaaga ttatagatga
     2161 cagtgattca aatctttcag tggtcaagaa attgcctgtg cccctggagt ctgtaaaaga
     2221 gatgcttaag tcagtcatgc aggaactcga agactatagt gaaggaggtc ctctctataa
     2281 aaatggttct ttgcgaaatg cagattcaga aataaaacat tctacaccat ctcctaccaa
     2341 atattcacta tcaccaagta aaagttacaa gtattctccc aaaacaccac ctcgatgggc
     2401 agaagatcag aattctttac ggaaaatgat ttgccaagaa gtaaaggcca ttacgaaact
     2461 aaatagcagt aagtcagcat cccgtcatcg ttggcccaca gagaattatg gaccagactc
     2521 ggtgcctgat ggatatcagg ggtcacagac atttcatggg gctccactaa cagttgcaac
     2581 tactggccct tcagtatatt atagtcagtc accagcatat aattcccagt atcttctcag
     2641 accagcagct aatgttactc ccacaaaggg ttcttctaat acagaattta agtcaaccaa
     2701 agaaggattt tccatcgctg tgtctgctga tggatttaaa tttggcattt cggaaccagg
     2761 aaatcaagaa aagaaaagtg aaaagcctct tgaaaatgat actggcttcc aggctcagga
     2821 tattagtggc cagaagaatg gccgtggtgt gatttttggc caaacaagta gcacttttac
     2881 atttgcagat gttgcaaaat caacttcagg agaaggattt cagtttggca aaaaagaccc
     2941 caatttcaag ggattttcag gtgctggaga aaaattattc tcatcacaat gcggtaaaat
     3001 ggccaataaa gcaaacactt ccggtgactt tgagaaagat gatgatgcct gtaagactga
     3061 ggacagcgat gacatccatt ttgaaccagt agttcaaatg cctgaaaaag tagaacttgt
     3121 aacaggagaa gaaggtgaaa aagttctgta ttcacagggg gtaaaactat ttagatttga
     3181 tgctgagata agtcagtgga aagaaagggg cttggggaac ttaaaaattc tcaaaaatga
     3241 ggtcaatggc aaaccaagaa tgctgatgcg aagagaccaa gtactaaaag tgtgtgctaa
     3301 tcattggata acaactacaa tgaacctgaa gcccctctct ggatcagata gagcatggat
     3361 gtggttagcc agtgatttct ctgatggtga tgccaaacta gagcggttgg cagcacaatt
     3421 taaaacacca gagctggctg aagaattcaa gcagaaattt gaggaatgcc agcggcttct
     3481 gttagacata ccacttcaaa ctccccataa acttgtagat actggcagag ctgccaagct
     3541 aatacagaga gctgaagaaa tgaagagtgg actgaaagat ttcaaaacgt ttttgacaaa
     3601 tgatcaaaca aaagtcactg aggaagaaaa taagggttca ggtacaggtg cagccggtgc
     3661 ctcagacaca acaataaaac ccaatcctga aaacactggg cccacattag aatgggataa
     3721 ctatgattta agggaagatg ctttggatga taatgttagt agtagctcag tacatgattc
     3781 tccgttggca agtagccctg tgagaaaaaa tattttccgc tttgatgagt caacaacagg
     3841 atttaacttc agttttaaat ctgctttgag tctatctaag tctcctgcca agttgaatca
     3901 gagtgggact tcagttggca ctgatgaaga atctgatgtt actcaagaag aagagagaga
     3961 tggacagtac tttgaacctg ttgttccttt acctgatcta gttgaagtat ccagtggtga
     4021 ggaaaatgaa caagttgttt ttagtcacag ggcagaactc tacagatatg ataaagatgt
     4081 tggtcaatgg aaagaaaggg gcattggtga tataaagatt ttacagaatt atgataataa
     4141 gcaagttcgt atagtgatga gaagggacca agtattaaaa ctttgtgcca atcacagaat
     4201 aactccagac atgagtttgc aaaatatgaa agggacagaa agagtatggg tgtggactgc
     4261 atgtgatttt gcagatggag aaagaaaagt agagcattta gctgttcgtt ttaaactaca
     4321 ggatgttgca gactcattta agaaaatttt tgatgaagca aaaacagccc aggaaaaaga
     4381 ttctttgata acacctcatg tttctcggtc aagcactccc agagagtcac catgtggcaa
     4441 aattgctgta gctgtattag aagaaaccac aagagagagg acagatgtta ttcagggtga
     4501 tgatgtagca gatgcagctt cagaagttga agtgtctagc acatctgaaa caacaacaaa
     4561 agcagtggtt tctcctccaa agtttgtatt tggttcagag tctgttaaaa gaatttttag
     4621 tagtgaaaaa tcaaacccat ttgcatttgg caacagttct gccactgggt ctttgtttgg
     4681 atttagtttt aatgcacctt tgaaaagtaa cgatagtgaa actagttcag tagcccagag
     4741 tggatctgaa agcaaagtgg aacctaaaaa atgtgaactg tcaaagaact ctgatatcga
     4801 acagtcttca gatagcaaag tcaaaaatct ctctgcttcc tttccaatgg aagaatcttc
     4861 aatcaactac acatttaaaa caccagaaaa ggagcctcca ttatggcatg ctgaatttac
     4921 caaagaagaa ttggttcaga agctcagttc caccacaaaa agtgcagatc agttaaacgg
     4981 cctgcttcgg gaaacagagg caaccagtgc agtccttatg gagcaaatta agcttctcaa
     5041 aagtgaaata agaagattgg aaaggaatca agaggagtct gcagctaacg tggaacactt
     5101 gaagaacgtc ttgctgcagt tcattttctt gaagccaggt agtgagagag agagccttct
     5161 tcctgttata aatacgatgt tgcagctcag ccctgaagaa aagggaaaac ttgctgcggt
     5221 tgctcaaggt cttcaagaaa cctccatacc caagaaaaaa tagaaagcaa ccatgttcta
     5281 ctatggtgcc aaaaatagtt gaacatcgac atcaaaaaga ttctttctgt ctgcttattc
     5341 acatattctg gtttgaatta aaagtgatga aattatccta aatacagttg gccctctgta
     5401 tccatgggtt ccacatccac aaattcaacc aactgtggat ggaaaagact tgaaaaagat
     5461 gagagaaaat aacaatatga caataaaaca taatacaaat aaaaacaata cagtataaca
     5521 acgattacat agcatttaca ttatattagg gattgcacaa gagaaggtat gtaggttata
     5581 tgcaaatact gcaccatttt acataaggga cttgagaagc atggattttg gtagccacag
     5641 gggtcctgga accaatccct cacagacaca gacggacact ttacagtaga tgaacacaaa
     5701 gatgaaagga aaagtctgac ctaggtttgc ggggagaagt ggaactccat ttttgacagg
     5761 tgatgccatt ttttgttttg gacatcgtcc ctctgtagtt ctttccattc ccagtcttgc
     5821 actctgaaag atacactgaa ggaaagtcca cacagtggtc aaagtctttc acaagacacc
     5881 acgtgaaggt ctgcacagca cagtcacatt gagaaaaaga tctcatgcac cagaccccct
     5941 gtttctgctt tctaaaagat catcttttgc acctgcaaaa aggctgcagt aaactgggcc
     6001 attccatact ttgattcatg tattcaaatg ctacttatga gctctctgtg tattgagccc
     6061 caccaggatg ctggggacac acggggcaca gtgcagccag aggcttggcc atcatagagc
     6121 tcacattcta gtggaatcag acaggggggt tacaggaaat attcaagtaa acaatataaa
     6181 atgagatcac ttgatgatac atggatacat gttacataca tgatgagaca gagtaagaga
     6241 atggggaaag ggtttttaga tgggggaatg gcaggctttt ccgaggctga aagagatcca
     6301 acccacttct atttcttcag gctcccagtg atatgaaaaa gtgccaaaca ggactataaa
     6361 attgtggtct actgtaaatg gtttgcagta aaagttctca accagcttcc actcaaccaa
     6421 ctcaccagtt agacaatggg ccctctcctg tgtttaaaac agtccggtgc ccacctgggt
     6481 ccacatgcag ctggcaggtg tttgctagtg tgcccaccca tgtctgttcc ccccacgtga
     6541 gttatgtgct tacaacgagt cgtttctttg cattttccaa ctttcttaca tttatattta
     6601 attaaagatg atctaaactg agaaatgaat gtgaaaagaa acaaagctct tttttgtttg
     6661 gtttttaact aaattaaatg tttttaacaa gt
//
