LOCUS       NM_001080496            7028 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RGP1 homolog, RAB6A GEF complex partner 1 (RGP1),
            mRNA.
ACCESSION   NM_001080496 XM_376830
VERSION     NM_001080496.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7028)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7028)
  AUTHORS   Lindstrom,S., Thompson,D.J., Paterson,A.D., Li,J., Gierach,G.L.,
            Scott,C., Stone,J., Douglas,J.A., dos-Santos-Silva,I.,
            Fernandez-Navarro,P., Verghase,J., Smith,P., Brown,J., Luben,R.,
            Wareham,N.J., Loos,R.J., Heit,J.A., Pankratz,V.S., Norman,A.,
            Goode,E.L., Cunningham,J.M., deAndrade,M., Vierkant,R.A., Czene,K.,
            Fasching,P.A., Baglietto,L., Southey,M.C., Giles,G.G., Shah,K.P.,
            Chan,H.P., Helvie,M.A., Beck,A.H., Knoblauch,N.W., Hazra,A.,
            Hunter,D.J., Kraft,P., Pollan,M., Figueroa,J.D., Couch,F.J.,
            Hopper,J.L., Hall,P., Easton,D.F., Boyd,N.F., Vachon,C.M. and
            Tamimi,R.M.
  TITLE     Genome-wide association study identifies multiple loci associated
            with both mammographic density and breast cancer risk
  JOURNAL   Nat Commun 5, 5303 (2014)
   PUBMED   25342443
  REMARK    Erratum:[Nat Commun. 2015 Sep 09;6:8358. doi: 10.1038/ncomms9358..
            PMID: 26349435]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7028)
  AUTHORS   Pusapati,G.V., Luchetti,G. and Pfeffer,S.R.
  TITLE     Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the
            late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B
            GTPase
  JOURNAL   J Biol Chem 287 (50), 42129-42137 (2012)
   PUBMED   23091056
  REMARK    GeneRIF: Ric1-Rgp1 complex is a guanine nucleotide exchange factor
            for the late Golgi Rab6A GTPase and an effector of the medial Golgi
            Rab33B GTPase.
REFERENCE   4  (bases 1 to 7028)
  AUTHORS   Simonis,N., Rual,J.F., Lemmens,I., Boxus,M., Hirozane-Kishikawa,T.,
            Gatot,J.S., Dricot,A., Hao,T., Vertommen,D., Legros,S., Daakour,S.,
            Klitgord,N., Martin,M., Willaert,J.F., Dequiedt,F., Navratil,V.,
            Cusick,M.E., Burny,A., Van Lint,C., Hill,D.E., Tavernier,J.,
            Kettmann,R., Vidal,M. and Twizere,J.C.
  TITLE     Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses
  JOURNAL   Retrovirology 9, 26 (2012)
   PUBMED   22458338
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7028)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK289566.1 and AL133410.32.
            
            On May 17, 2019 this sequence version replaced NM_001080496.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87447.1, AK289566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378078.5/ ENSP00000367318.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-889               AK289566.1         1-889
            890-890             AL133410.32        71622-71622
            891-1710            AK289566.1         891-1710
            1711-7028           AL133410.32        73149-78466
FEATURES             Location/Qualifiers
     source          1..7028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..7028
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /note="RGP1 homolog, RAB6A GEF complex partner 1"
                     /db_xref="GeneID:9827"
                     /db_xref="HGNC:HGNC:21965"
                     /db_xref="MIM:615742"
     exon            1..122
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            123..257
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1317
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /note="retrograde Golgi transport protein RGP1 homolog;
                     RGP1 retrograde golgi transport homolog"
                     /codon_start=1
                     /product="RAB6A-GEF complex partner protein 2"
                     /protein_id="NP_001073965.2"
                     /db_xref="CCDS:CCDS47964.2"
                     /db_xref="GeneID:9827"
                     /db_xref="HGNC:HGNC:21965"
                     /db_xref="MIM:615742"
                     /translation="MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAW
                     ASAQIHCQFHASESRVALPPPDSSQPDVQPDSQTVFLPHRGERGQCILSTPPKILFCD
                     LRLDPGESKSYSYSEVLPIEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLV
                     LTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLAELAGERLMAATSCRSLHLYNISD
                     GRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAG
                     GVPSVSHVTHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREP
                     GLVLLPPVEQPEPTTWTGPEQVPVDTFSWDLPIKVLPTSPTLASYAAPGPSTSTITI"
     exon            258..394
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            395..478
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            479..628
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            629..775
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            776..903
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1093
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..7028
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3642..3647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /note="hexamer: TATAAA"
     polyA_site      3666
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
     regulatory      6358..6363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /note="hexamer: AATAAA"
     polyA_site      6380
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /note="major polyA site"
     regulatory      6641..6646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /note="hexamer: AATAAA"
     polyA_site      6664
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /note="major polyA site"
     regulatory      6955..6960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
                     /note="hexamer: TATAAA"
     polyA_site      6975
                     /gene="RGP1"
                     /gene_synonym="KIAA0258"
ORIGIN      
        1 agtcccgcct ctaccgccca gcggacgccg ccgccgccgc cgccgccgcg tacctagcca
       61 ggtccctgag gggcgggcag atgaggccta ggggtgccga tccctagtgt cgactatgcg
      121 agatctgatt ccggagctgc catgattgaa gtggtagcag agctcagccg gggtcctgta
      181 tttttggctg gggaggcgct ggagtgtgta gtgaccgtca ccaaccccct tccgcccacg
      241 gccacttctg catccagtga ggccctggcc tgggccagtg cccaaatcca ctgccagttc
      301 catgccagtg agagtcgagt agcactgcct cctcctgact ctagtcagcc agatgtccag
      361 cccgacagcc agactgtctt tctgccacac cgaggtgaga ggggccagtg tatcctttct
      421 actccaccga aaattctatt ctgtgacctg aggcttgatc ctggagagtc caaatcatac
      481 tcctacagtg aagtgctgcc catagaggga ccaccctcct ttcggggtca gtcagtcaag
      541 tacgtctaca aactgaccat tggctgccag cgtgtcaact cccctatcac tttactcaga
      601 gtccctctga gggttcttgt gctgactggc cttcaggatg tccggtttcc ccaggatgag
      661 gctgtagccc catccagtcc attcttggag gaggatgaag gtgggaagaa agattcatgg
      721 ctagctgagc tggctgggga acgcctaatg gctgccacat cctgccgcag cctccatcta
      781 tacaatatca gtgatggccg agggaaagtt gggacgtttg gcatcttcaa atctgtgtac
      841 agacttggcg aggacgtggt ggggacctta aacttagggg aaggaaccgt agcttgtttg
      901 cagttttcag tcagcttaca gaccgaggag cgtgtacagc ctgagtacca gcggcgacgt
      961 ggggcagggg gtgtcccctc tgtgtcacat gtgactcacg cccggcacca ggaatcctgc
     1021 ctacatacaa ctagaaccag cttctccctc ccaatccctc tcagctccac cccaggcttc
     1081 tgtacagcca ttgtgtcctt gaagtggaga ttgcattttg aatttgtaac gtcccgagaa
     1141 ccaggattgg tactcctacc ccctgtggaa cagcccgaac ctaccacctg gacaggacct
     1201 gagcaagtac ctgtagacac cttcagctgg gacctgccca tcaaggtgct gcctactagc
     1261 cccaccctgg cctcatatgc tgccccaggc cccagcacca gcaccataac catctgaaac
     1321 tggcccaccc tggtgctagt tccttccgga tactgagaac tcagcacctg gactctaatg
     1381 ggacccactt tttccacctg gggtccaatg tcgtggacag tgagagtcgg gctttcagct
     1441 atagcattaa tttatttgtt cagaatacat tggcagctgc tagtggtttc cctggaagtg
     1501 gcagcagcag tgagcagtca gcagatggat gatcagttga gtttagctgg agtggggagc
     1561 aggagcccca ggaacagggg tgttggctga gccccattct gggtcaggcc ctcccccttt
     1621 gcagggcagc cgagggtcag atttttgcac caaggagaac tggcaggttc ctgcctcctg
     1681 acgtacctca cacccagccg ggaagtcgat gggatgctgg gacctgggga accaaggata
     1741 ggggaaggag tcagcacagt gaaaggctgc ctttatccct gcccacatgt tccctctctc
     1801 acagttttcc ccccacagag cccctttcag tggccccttg gtcctcctaa ctaagctgtc
     1861 acctaccata tgtgggcctt tttgttttat aacaggagta ttttctctcc aggtccaccc
     1921 caacctcccc tgatttatag cctgaagcct tatctttcac actagtgttg gtcccttcag
     1981 gtttggccca tcttgtattg ctcttctgtt cattcttaca tcacagcaat ctagtcactc
     2041 cctggtcatc cctcagtcac tcatatcaga gtcattctct ctggccatct ttggtcactc
     2101 acgtgtcaca gcagcccacg ccaacaggat gcagacaggt gcaatggaaa cagtccttgc
     2161 ggagccaaga ctcacccagg gtaaaatatt tcccctcata gtgacagggg gctagggaag
     2221 aacgggaaat gttagtaggt gtaggagtgc tgatgagagg cagaggctct tctggtctgg
     2281 ggtggagaca gtaagtacgc actatccccg tatttagttt gtctttcctg tttcacagct
     2341 ggaggaagcc tgggtatttt gacacgggat catctgtaag gccccatcct ccctgtgccc
     2401 tctctgctgc tcctccattc ctaacgcttc accccacttt accttgagct tggaagtagc
     2461 acttgctgta gactcctggg tgctggagga gtagagacat caccaagcag atgatccccc
     2521 agcctcctag gatccccttg gcctgtccag cccagagcat ccttagggcc attgctgctg
     2581 cacagccctc tcagaccctt cttggcctct gctcagctac tctggtcttg actccttgac
     2641 tttgctttgc gttgctcctt gagtcttagt ttctgtcttt ctcccctggg ctcctgtctc
     2701 acactatctc cctgccctct gctctcacag gctggggatg tttataaagt gaggaccctg
     2761 gccccctgct gagtagagct ggaaaagttg taactctgtt tcctgaggtg agggcatgaa
     2821 aacaagaggt ctagctttaa caagctgtga gagctgattc atgccccggc acagctagag
     2881 ggagggaggt ggccatggag ggggcactgg actgggcact tccccagcaa ggaggcagga
     2941 ggggcgaggg cccccaggtg gtccccagat ctcttccctg acctggagag aaggaagcat
     3001 tccaccttcc ccctttctcc cccactgcca ccaccagggg tgtgtatgct gggatccctg
     3061 cctggaccgg agggaggcat ttcctgggga tggttaatcc tgtgccccag ccaaacccag
     3121 gagctgcaat agggtgcgac ggccagaagc tccaggagag tgagcaggca cctggagtgg
     3181 agactgtgtt tccctcagat cctagggcag ggtttcccta atgtatccaa gaaatagggc
     3241 tgcccctcag agatggtggg gagggtctct tttcctcagg cattccagag gtgaactgtc
     3301 cattgcttat caccttcaaa catacagcag atgtgggatc accccacatc tggggatggt
     3361 tctttcccct ttcaaagagg agcatctcta agtgccctga tgggatgaat cactccaggt
     3421 tcacagaggt gtcctctctt tcctcccata tataatggag tgaggttttt aggaatttat
     3481 catttggcat cctctgagtt tcccacaggt tctggaggag cccaggatgg attattgaga
     3541 gcatgggctg tagagacagt cttcttggat tcagatcctg actccactta gctatgtaac
     3601 ctggtcagat tacttcacct ctctgagcct gtttcctcat ctataaattg gggatagtaa
     3661 tgccaactca ttgggctgtt atgaggatta ctgagataat gcgtgcagtg ctcttatcac
     3721 catctctggt gcgtaagcgt caggaaatag cagttgctgt gattggggct aaagctctga
     3781 ggcaaaatgg gcgacattat tttctttgaa tgacattaag cagtttgtgc atagctgagg
     3841 gcttctattg gggatggctg tctcctggca tagacctctg cacctttcac actcatactc
     3901 cttgtcagca gtccccaacc tttttggtac cagggaccgg ttttgtggaa aacaattttt
     3961 ccaccagtgg atggaggggg atagcagcgg ggagatgatt ttgggatgaa actgtttcat
     4021 ctcagatcat caggcattag attctcataa ggagtgtgca atctagatcc cttgcatgcg
     4081 gagttcacag tggggtttgc actcctgtga gaatctaatg cctctgctga tctgccagga
     4141 ggaggagctc aggcggtaat gctcactcgc ctgccgccca cctcctgctt tgtgctcccg
     4201 cttcctaaca ggccacagac tggtactggc ctgtggcctg ggggatggag acccctaatc
     4261 catgtcacct ttcccacctc tttcaaaaac aggtacctcc aggaacattt tggttttggc
     4321 ccttgtattg acttctgaat gtctagtttg agaaactgtt cccaataagc cttcttcccc
     4381 cagatctgca ccctcgcctc taccctagga caagatgtcc ttttctcatc atcctgccag
     4441 gctaacttta agtctcctgc tttttctcac ttggatttgg atccatttct tcctatttcc
     4501 gctcatgtga actctccagt tctcctttct caccactctc ctgctagcca tctctttggc
     4561 actaaaggcc ctggtcaaat tggatttctt tcatttttcc acacttcaaa gacccatgtt
     4621 ctaggtattc tccataggga tagtctcttt ggcatttatt tggtttttct acgttttcag
     4681 tcccatttac tccaagactc actccctgcc acctagtgca tcagatacag ctacttctgg
     4741 ctgacttttc aagggggacc accctacctg tcatctcttc actgttcaga aatgactgtg
     4801 tcagtgcacc tcaaactccc ttgctgtcct tttccaagga gacagctaag gtggatggag
     4861 atgcagaatg gacctcacgt tcgccctagt caggactgat accctttccg tttcagagga
     4921 ttgccaagaa aaaactcaca gttgaggcag ggtgctctga ggtcggctgc ggtgtgggag
     4981 gcacggcctg ggcctgctct ctgggctgga gcaggtggat tcgaaggcct gtctagcacg
     5041 agggcccaaa ggtcttgtca gtggccagta gctctgccgc ctttcccaga gagggggtcc
     5101 aggggacatc ctggaaggct gggccctggg ccaccttctg ctcttgcaag ctagagccag
     5161 cccaataggg ggcggatgtg agtggggagc tggggcgcat gaaggtgggg gtgatgccga
     5221 aggggaaggg atcgccagtg gggattggtg cgtgtgcgga aacggggaca gaagtgaagg
     5281 ttcatcgcct ataacgaaga tgaggtaggc atataggggc ttctggaaag ctagaggctg
     5341 ggctgagcca ggagtcctct cccagaagtt ggggggcggt gcagaggtgt gggtcgagcc
     5401 cgcatgcgtg cctgctgggg agggggtgag tggtgaggac caggcccgct gggtcctggg
     5461 ggcgcggtgg ctggcgcgca ggtcccggag ggggcggctg gcgcgcacta cacgcttggg
     5521 aacaaggaaa acatccgccg gaggcccggc cgggcggcgc tccagcctcg gggcaggtgc
     5581 gcggagagga agtgagagca ttccggcccc cccaccccaa ccccggccgc tggccctctg
     5641 gtgagtcaca gccgaccccc gccgccggag ggagagggga gctgcgggcc agagccccgg
     5701 agggtctgga ggagccagga gggtttctgg gagcagaggg tcacttagtg ggcttctgtc
     5761 gtggtgtcgc tacgggcgcg aaacggacac tgaacacagt ctgactgtat ggaggcaggt
     5821 ggggagggat cccctgggag aacttggcgg gccgagagca gaccccaggg caaggagggg
     5881 cccccgaggg ggaaaccggg agtcgggcag gtggcgtaac ccagaaaggg aaggagagcc
     5941 ggattgattg gggtgagaga ggaaggaagc acgccaagtt aggcctggga gaactgaggg
     6001 acctgaggag ggaggaggga gaccaacaca gggtgggaag gcggaaatgg ccaaacccca
     6061 ggcatcaggt ctgtccagag gctgacgtag acagtgaagg gtgaagggta ggttttagga
     6121 gtagggggag ttatgattat ttggttacat tttgggatta tttggtctca caggtagaag
     6181 ggagcctgct ggtctctgtg taacggatgg cttaaaagca aggttgtctg cgtcttggat
     6241 tactgtctgc cattcagcct ttgccaaaaa atttggcact gatctgcaca tttttatagt
     6301 catttaaaat tgtatgactc tgtcaaatga tttaagtaat tttggtggat ttttaaaaat
     6361 aaaaaaataa aaatagaaaa gttgcacaat ctaattcaat atttgactta aaaccaaaag
     6421 tgaggctctc agattggtaa tatggtattc agcctttttc ttgtttggct tttgtgccat
     6481 ttgcccctca ctgacttgat tgaattcttt gtggctgatg cctcagtttt tctggatcag
     6541 tagtgctgca cttccacttt tcctctccct cattttactg tctttatttt tagccttttt
     6601 tctgtgtagc cctctaacct gccctttata ttttgaacca aataaaacat ttcttggaat
     6661 gggagctttg gactacagta tacagacaaa caactcacaa ttttagcata tgaggctact
     6721 atcttctgtg gatgtgtatg taattataca gtttctgtat ttatcctgtg gctgatagaa
     6781 aaagttaaag ctgtttaatt caccatagta tttctacaac acagcaattt attagtctga
     6841 cttctcttct aaaatcaact ctaaaatggt attttgtact tgtctcagag acgaattctg
     6901 ccatgatcct tatgatctgt gttatgttgg gccaaaggtg attactttat aaattataaa
     6961 gatccctaaa ctctgcattg cctttggtcc caaacaagca aatctgggtc aattaatgaa
     7021 aaaaaaaa
//
